Com a evolucao da tecnologia, os meios eletronicos de contratacao se tornaram praticas comerciais usuais. No caso dos contratos bancarios realizados pelos consumidores diretamente no autoatendimento dos bancos, por exemplo, a apresentacao de telas, por vezes, e o unico meio pelo qual as instituicoes financeiras tem para comprovar contratacoes. Embora atualmente a tecnologia esteja extremamente avancada – inclusive com a implementacao de Inteligencia Artificial pelo Supremo Tribunal Federal – ainda muitos magistrados resistem em aceitar estas telas sistemicas como prova. O objetivo desta pesquisa e discutir o acolhimento de provas digitais em acoes judiciais, especialmente no direito bancario. Como metodologia de estudo sera utilizado metodo hermeneutico e bibliografico, com pesquisa das obras relacionadas ao tema objeto de estudo, e dedutivo. Como resultado da pesquisa demonstrou-se que a utilizacao de provas digitais bancarias e segura, pois a manipulacao de dados internos, alem de ilegais, podem gerar diversos danos com relacao a credibilidade das instituicoes financeiras, fato que, obviamente, nao e de interesse destas.

ABSTRACT Although diverse European policy initiatives have been developed to integrate young NEETs – “Not in Employment, Education or Training”, it is particularly relevant to question how NEETs are perceived by their counterparts who are actively engaged in society. For this reason, we aimed to examine the Social Representations (SRs) of NEETs in France, using the classic free evocation technique. French NEETs (n = 71) and matched controls (n = 66; people employed, in education or in training) were interviewed. Results showed the scope of SRs for the semantic field of the term NEET and its associated terms. The need to develop effective communication to talk about work, education, and training with NEETs and implications for career counselling are discussed.

We present phenomenological study of the most minimal realistic SU(5) model that owns its predictivity solely to the gauge symmetry and the representational content. The model is built entirely out of the fields residing in the first five lowest dimensional representations that transform non-trivially under the SU(5) gauge group. It has eighteen real parameters and fourteen phases, all in all, to address experimental observables of the Standard Model fermions and accomplishes that via simultaneous use of three different mass generation mechanisms. Furthermore, it inextricably links the origin of the neutrino mass to the experimentally observed difference between the down-type quark and charged lepton masses. The main predictions of the model are that (i) the neutrinos are Majorana particles, (ii) one neutrino is massless, (iii) the neutrinos have normal mass ordering, and (iv) there are four new scalar multiplets at or below a 120TeV mass scale. A one-loop analysis demonstrates that an improvement of the current p→ πe partial lifetime limit by a factor of 2, 15, and 96 would require these four scalar multiplets to reside at or below the 100TeV, 10TeV, and 1TeV mass scales, respectively.

Self‐rating scales are frequently used to screen for anxiety and depression in patients with irritable bowel syndrome (IBS). Different cutoff values are recommended in literature, and guidelines have suggested the use of other screening instruments over time. The aim of this study was to assess the correlation between the most commonly used psychological screening instruments for anxiety and depression in IBS and to compare custom cutoff scores for these instruments.

Introduction: Rapid-onset obesity, hypoventilation, hypothalamic dysfunction and autonomic dysregulation (ROHHAD) is a rare syndrome beginning at 3-6 years of age with approximately 150 cases described. Additional features include eye abnormalities, neurobehavioral dysfunction and paraneoplastic tumors. The etiology of the complex phenotype remains unknown. Methods: This study aims to investigate the genetic landscape of this complex phenotype by whole exome sequencing (WES) and copy number variation (CNV) analysis. We recruited 33 families (27 trios, 1 duo and 5 singletons) with a proband with ROHHAD syndrome (Ize-Ludlow 2007, Pediatrics). WES of 89 individuals was performed at the Center for Mendelian Genomics, Broad Institute. The Illumina platform with a mean coverage of ~100X (> 90% targets 20x) and Infinium Global Screening Array BeadChip 24v1.0 were used. Results: This report includes 28 probands (female = 18, 64%) with rapid onset obesity (100%), hypoventilation (88%), hypothalamic dysfunction (69%), eye disorders (62%) and neurobehavioral abnormalities (76%). Neuroendocrine tumor, ganglioneuroblastoma, was present in 38% (n=13). No unifying causative single gene or CNV was identified, but a number of sequence variants are prioritized. ARNT2, which encodes for a helix-loop-helix transcription factor, plays a role in the development of the hypothalamic-pituitary axis, postnatal brain growth, and visual and renal function. The de novo monoallelic missense variant was found in a 14-year old white girl (BMIz +3.25) with extreme obesity and a neurobehavioral phenotype. OCRL1, a multi-domain protein involved in cytoskeleton-plasma membrane adhesion, endosomal trafficking and in primary cilium assembly. Mutations in this gene have also been known to cause Lowe syndrome. A hemizygous X-linked frameshift variant in a 5-year old white boy with extreme obesity (BMIz +5.48), central hypoventilation neurobehavioral dysfunction and ganglioneuroblastoma. A monoallelic missense variant in NSD1, a transcriptional intermediary factor acting as a histone methyltransferase, was identified in a 8-year old Hispanic girl with severe obesity (BMIz +2.91), neurobehavioral disorder, pituitary and eye dysfunction and ganglioneuroblastoma. NSD1 is known to cause Sotos and Beckwith-Wiedemann. Compound heterozygous variants in KIF7, a key component of the Hedgehog signaling pathway, were identified in a 14-year old white girl with severe obesity (BMIz +3.00), autistic behavior, pituitary dysfunction and central hypoventilation. This gene is known to cause autosomal recessive hydrolethalis and acroscallosal syndromes with mutations also noted in Bardet-Biedl, Meckel and Joubert syndromes. Conclusion: While no unifying genetic cause has been identified in ROHHAD syndrome, it is possible that the phenotype represents a collection of complex genetic syndromes.

By successfully solving the problem of forecasting, the processes in the work of various companies are optimized and savings are achieved. In this process, the analysis of time series data is of particular importance. Since the creation of Facebook’s Prophet, and Amazon’s DeepAR+ and CNN-QR forecasting models, algorithms have attracted a great deal of attention. The paper presents the application and comparison of the above algorithms for sales forecasting in distribution companies. A detailed comparison of the performance of algorithms over real data with different lengths of sales history was made. The results show that Prophet gives better results for items with a longer history and frequent sales, while Amazon’s algorithms show superiority for items without a long history and items that are rarely sold.

Replication is an important tool used to test and develop scientific theories. Areas of biomedical and psychological research have experienced a replication crisis, in which many published findings failed to replicate. Following this, many other scientific disciplines have been interested in the robustness of their own findings. This chapter examines replication in primate cognitive studies. First, it discusses the frequency and success of replication studies in primate cognition and explores the challenges researchers face when designing and interpreting replication studies across the wide range of research designs used across the field. Next, it discusses the type of research that can probe the robustness of published findings, especially when replication studies are difficult to perform. The chapter concludes with a discussion of different roles that replication can have in primate cognition research.

Replications are widely considered an essential tool to evaluate scientific claims. However, many fields have recently reported that replication rates are low and - when they are conducted - many findings do not successfully replicate. These circumstances have led to widespread debates about the value of replications for research quality, credibility of research findings, and factors contributing to current problems with replicability. This special issue brings together researchers from various areas within the field of animal behavior to offer their perspective on the status and value of replications in animal behavior science.

Societal importance and the quality of scientific research highly depend on the usefulness of the results of research for the societal and scientific community. The wish to allocate the funds to high-quali-ty research and to establish right criteria for scientific evaluation and academic career progression, make scientific criteria increasingly important to measure the quality of research and knowledge valorization. However, it is very difficult to apply the right criteria which can objectively assess scientific research. For many years, there has been a great interest in scientific ranking and evaluation of scientific journals, but also of sci-entific contribution of scientists. It is generally accepted that the IF (WoS) and the total number of citations of articles published in the journal, are the most relevant parameters of the journal's significance. However, the significance of a scientist and the value of their scientific production are much more complicated to evaluate and they cannot be directly reflected by the importance of the journals in which their articles are published. In this article, the authors describe and evaluate the most known scientific databases which are used in science. The majority of existing science metric systems, which evaluate the achievement of scientists are focused solely on the number of citations of their articles. For example, H-index, which is calculated as the lowest ranked ar-ticle which number of citations matches its ranking number, has considerable shortcoming because it does not take into account the individual contribution of each author and allows expanding author lists with authors whose contribution may be insignificant or none. Therefore, the authors propose Z-score, as a new science met-ric system, which takes into account the author's contribution to the scientific article and greatly remedy major discrepancies in evaluating scientific production of individual authors and institutions.