This article addresses the issue of reliability in the Industrial Internet of Things (IIoT) in case of missing sensors measurements due to network or hardware problems. We propose to support the fault detection and classification modules, which are the two critical components of a monitoring system for IIoT, with a generative model. The latter is responsible for imputing missing sensor measurements so that the monitoring system performance is robust to missing data. In particular, we adopt generative adversarial networks (GANs) to generate missing sensor measurements and we propose to fine-tune the training of the GAN based on the impact that the generated data have on the fault detection and classification modules. We conduct a thorough evaluation of the proposed approach using the extended Tennessee Eastman Process data set. Results show that the GAN-imputed data mitigate the impact on the fault detection and classification even in the case of persistently missing measurements from sensors that are critical for the correct functioning of the monitoring system.

Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, and Slovenia) to assess the main characteristics of their NBS programs and their future plans. Their cumulative population at that time was ~52,5 million. At that time, none of the countries had an expanded NBS program, while phenylketonuria screening was not introduced in four and congenital hypothyroidism in three of 11 countries. We repeated the survey in 2020 inviting the same 11 countries, adding Cyprus, Greece, Hungary, and Malta (due to their geographical position in the wider region). The aims were to assess the current state, to evaluate the change in the period, and to identify the main obstacles impacting the implementation of expanded NBS and/or reaching a wider population. Responses were collected from 12 countries (BIH—Federation of BIH, BIH—Republic of Srpska, Bulgaria, Croatia, Greece, Hungary, Kosovo, North Macedonia, Malta, Montenegro, Romania, Serbia, Slovenia) with a population of 68.5 million. The results of the survey showed that the regional situation regarding NBS only modestly improved in this period. All of the surveyed countries except Kosovo screened for at least congenital hypothyroidism, while phenylketonuria was not screened in four of 12 countries. Croatia and Slovenia implemented an expanded NBS program using tandem mass spectrometry from the time of last survey. In conclusion, the current status of NBS programs in Southeastern Europe is very variable and is still underdeveloped (or even non-existent) in some of the countries. We suggest establishing an international task-force to assist with implementation and harmonization of basic NBS services where needed.

Supposed risk of malignant transformation of salivary gland pleomorphic adenoma (SGPA) is an important reason for aggressive retreatment in recurrent pleomorphic adenoma (RPA). However, although the diagnostic category ‘carcinoma ex‐pleomorphic adenoma’ suggests that malignant transformation of a pleomorphic adenoma is a regular event, this has to date not been shown to occur in sequential lesions of one patient. Here, we show the molecular events in transformation to malignancy of a pleomorphic adenoma of the parotid gland. Detailed molecular analysis revealed an LIFR/PLAG1 translocation characteristic for pleomorphic adenoma and, next to this, a PIK3R1 frameshift mutation and several allelic imbalances. In subsequent malignant recurrences, the same LIFR/PLAG1 translocation, PIK3R1 frameshift mutation, and allelic imbalances were present in addition to TP53 mutations. Thus, this case not only shows malignant transformation of SGPA, but also demonstrates that molecular analysis can be of help in recognising malignancy in the rare instance of RPA.

The present study addresses the short-term effects of different harvest intensities under close-to-nature selective management on the upper soil layers in Slovenian and Bosnian Dinaric karst fir-beech forests. The different harvest intensities coincided with the single-tree and irregular shelterwood management, common in the region. The effect of harvesting intensity on the upper soil layers (Ol, Of, Ol and 0–10 cm mineral soil) was investigated by a repeated measurements experiment in Slovenia on 27 research plots in close-to nature managed forests. The properties of the upper layers (concentration of SOC and TN, C/N ratio, weights, BD and SOC stocks) were analyzed twice, before (2011) and after (2014) treatment of 50% and 100% harvest intensity in relation to the total standing growing stock of trees. As a control, we used no-treatment <20% harvesting intensity plots. To extend this experiment, we added three comparable plots from the Bosnian site: one in an old-growth forest with 0% harvest intensity and two in the managed forest with <20% harvest intensity. The results of the assessment of mean differences indicated a significant influence of harvesting intensity on the decrease in SOC, TN concentrations, weights and SOC stocks in the organic layers and the increase in BD and SOC stocks in the 0–10 cm mineral soil. The highest relative decreases in Ol, Of and Oh SOC stocks occurred in 50% (−10 and −38%) and 100% (−16 and −49%) harvest intensities. Negligible relative differences in both organic and 0–10 cm mineral layers were found for the <20% harvest intensity in the region. The change in forest light conditions resulting from differences in canopy openness as a function of applied harvest intensity explained the significant difference in the properties of the upper soil layers. The impact of the short-term losses in SOC stocks, in terms of overall soil productivity, may depend on the regeneration dynamics and melioration methods.

In this article, we argue that within multilingual polities, whether national or transnational, multilingual parties are all-things-considered more desirable than monolingual parties operating via a lingua franca. First, we develop a taxonomy of what we believe are the main ideal-type models of “linguistic democracy,” that is, of the relationship between language and democracy in multilingual polities. Second, we argue that multilingual parties are in a better position than monolingual parties to formulate conceptions of the common good that take into account diverse linguistic and epistemic perspectives. Third, we claim that such parties can perform an educational role for their members and for citizens in general, by making them aware of the implications of linguistic diversity for democratic life. Fourth, we argue that multilingual parties can offer a linkage between citizens and government via forms of intraparty deliberation that are rendered more inclusive and democratic by the use of multiple languages.

The ability of molecules and systems to make copies of themselves and the ability of molecules to fold into stable, well-defined three-dimensional conformations are of considerable importance in the formation and persistence of life. The question of how, during the emergence of life, oligomerization reactions become selective and channel these reactions toward a small number of specific products remains largely unanswered. Herein, we demonstrate a fully synthetic chemical system where structurally complex foldamers and self-replicating assemblies emerge spontaneously and with high selectivity from pools of oligomers as a result of forming noncovalent interactions. Whether foldamers or replicators form depends on remarkably small differences in building block structures and composition and experimental conditions. We also observed the dynamic transformation of a foldamer into a replicator. These results show that the structural requirements/design criteria for building blocks that lead to foldamers are similar to those that lead to replicators. What determines whether folding or replication takes place is not necessarily the type of noncovalent interaction, but only whether they occur intra- or intermolecularly. This work brings together, for the first time, the fields of replicator and foldamer chemistry.

Originating in the artificial intelligence literature, optimistic planning (OP) is an algorithm that generates near-optimal control inputs for generic nonlinear discrete-time systems whose input set is finite. This technique is, therefore, relevant for the near-optimal control of nonlinear switched systems for which the switching signal is the control, and no continuous input is present. However, OP exhibits several limitations, which prevent its desired application in a standard control engineering context, as it requires, for instance, that the stage cost takes values in <inline-formula><tex-math notation="LaTeX">$[0, 1]$</tex-math></inline-formula>, an unnatural prerequisite, and that the cost function is discounted. In this article, we modify OP to overcome these limitations, and we call the new algorithm <inline-formula><tex-math notation="LaTeX">${\rm OP}_{\text{min}}$</tex-math></inline-formula>. We then analyze <inline-formula><tex-math notation="LaTeX">${\rm OP}_{\text{min}}$</tex-math></inline-formula> under general stabilizability and detectability assumptions on the system and the stage cost. New near-optimality and performance guarantees for <inline-formula><tex-math notation="LaTeX">${\rm OP}_{\text{min}}$</tex-math></inline-formula> are derived, which have major advantages compared to those originally given for OP. We also prove that a system whose inputs are generated by <inline-formula><tex-math notation="LaTeX">${\rm OP}_{\text{min}}$</tex-math></inline-formula> in a receding-horizon fashion exhibits stability properties. As a result, <inline-formula><tex-math notation="LaTeX">${\rm OP}_{\text{min}}$</tex-math></inline-formula> provides a new tool for the near-optimal, stable control of nonlinear switched discrete-time systems for generic cost functions.