In the early Middle Ages Hreša was part of the parish of Vrhbosna, which was in the 14 i 15 century a part of the land Pavlovic. With the first arrival of the Ottoman army, the area of the parish Vrhbosna turned into Bosnian place, later named after the main fortress Vilajet Hodidjed, and then afer a market place Vilajet Saray-ovasi. In 1455 the village Hreša (Hriša) was represented by a timar Isa Bey hizmećara Sufi Jahšija. Already in 1485 he has been separated from timars crew Hodidjed and added to sandžakbegov has.In the central part of Hreša, on the site of Han, stands a medieval necropolis with 22 tombstones, which has already been paid to attention in the literature. This paper emphasis is placed on the decorations represented on the tombstones.

Stećci form a part of an unbroken sepulchral continuity in Bosnia that reaches far back into prehistoric times, and are clearly associated with the older sites of prehistoric settlements and places of worship, agglomerations and burial grounds dating from antiquity, late antique and early medieval churches and fortified towns. They are impressive evidence of the growing eeconomic power of the Bosnian feudal society in the 14th century, the opening of mines, increased urbanization, and the desire of individuals to present their status and power through the outward appearance of a tombstone. Their origins and evolution may be traced back from the mid 12th to the early 16th century. Stećci at Kose are made of local stone and all arerecumbent monoliths. There are 26 stećci on the site and can be divided into three types: slabs (2 monuments), chest-shaped (19 monuments) and gabled or sarcophagus-like (5 monuments). They are oriented southwest-northeast. A feature of the necropolis is that the monuments are relatively large. Of the total number, only on the upper surface of the stećak no.14, an ornament in the shape of a rectangular relief bulge is recorded. There are no other types of decorations or inscriptions on the monuments.  

This paper analyzes monuments of the First Belgian cohort (cohors I Belgarum equitata) from the area of Ljubuški. Of all the cohorts that were settled in Humac, most registered monuments belong to the auxiliaries of this unit. Three officers are among them (centurion, decurion, signifer), and ordinary soldiers whose monuments are mostly fragmented with damaged inscription field. Four monuments of this kind were discovered. Besides these monuments, we analyzed votive monuments mentioning cohors I Belgarum equitata, such as monuments dedicated to Liber, Fortuna Augusta, Mithra and emperor’s genius. We have found that these votive monuments are not adequately interpreted in the current scientific literature, and we offer a new reading. Also, paper discusses the question of marriage of Roman soldiers, as well as recruitment of local young men in the roman auxiliary troops.

Domagoj Tončinić, Spomenici VII. legije na području rimske provincije Dalmacije,Arheološki muzej, Split 2011., 228 str; Salmedin Mesihović, Antiqui Homines Bosnae,Filozofski fakultet Univerziteta u Sarajevu, Sarajevo 2011., 692 str. (Danijel Džino) Miroslav Marić, Primena geografskih informacionih sistema u arheološkoj dokumentaciji,Printshop, Beograd, 2011., 142 str., 44 sl. (Tino Tomas) Maja Petrinec: Groblja od 8. do 11. stoljeća na području ranosrednjovjekovne hrvatske države,Split, 2009. (Midhat Dizdarević) Dubravko Lovrenović, Bosanska kvadratura kruga, Dobra knjiga – Synopsis,Sarajevo – Zagreb, 2012, 496 str. (Enes Dedić) Zbornik radova, Пад Српске деспотовине 1459. године, Српска академија наукаи уметности, Научни скупови, Књига CXXXIV, Одељење историјских наука, Књига 32,Београд 2011, 439 str. (Dženan Dautović)

Purpose Incomplete reperfusion after mechanical thrombectomy (MT) is associated with a poor outcome. Rescue therapy would potentially benefit some patients with an expanded treatment in cerebral ischemia score (eTICI) 2b50/2b67 reperfusion but also harbors increased risks. The relative benefits of eTICI 2c/3 over eTICI 2b50/67 in clinically important subpopulations were analyzed. Methods Retrospective analysis of our institutional database for all patients with occlusion of the intracranial internal carotid artery (ICA) or the M1/M2 segment undergoing MT and final reperfusion of ≥eTICI 2b50 (903 patients). The heterogeneity in subgroups of different time metrics, age, National Institutes of Health Stroke Scale (NIHSS), number of retrieval attempts, Alberta Stroke Programme Early CT Score (ASPECTS) and site of occlusion using interaction terms (p i ) was analyzed. Results The presence of eTICI 2c/3 was associated with better outcomes in most subgroups. Time metrics showed no interaction of eTICI 2c/3 over eTICI 2b50/2b67 and clinical outcomes (onset to reperfusion p i  = 0.77, puncture to reperfusion p i  = 0.65, onset to puncture p i  = 0.63). An eTICI 2c/3 had less consistent association with mRS ≤2 in older patients (>82 years, p i  = 0.038) and patients with either lower NIHSS (≤9) or very high NIHSS (>19, p i  = 0.01). Regarding occlusion sites, the beneficial effect of eTICI 2c/3 was absent for occlusions in the M2 segments (aOR 0.73, 95% confidence interval [CI] 0.33–1.59, p i  = 0.018). Conclusion Beneficial effect of eTICI 2c/3 over eTICI 2b50/2b67 only decreased in older patients, M2-occlusions and patients with either low or very high NIHSS. Improving eTICI 2b50/2b67 to eTICI 2c/3 in those subgroups may be more often futile.

The order Accipitriformes comprises the largest group of birds of prey with 260 species in four families. So far, 21 haemosporidian parasite species have been described from or reported to occur in accipitriform birds. Only five of these parasite species have been characterized molecular genetically. The first part of this study involved molecular genetic screening of accipitriform raptors from Austria and Bosnia-Herzegovina and the first chromogenic in situ hybridization approach targeting parasites in this host group. The aim of the second part of this study was to summarize the CytB sequence data of haemosporidian parasites from accipitriform raptors and to visualize the geographic and host distribution of the lineages. Blood and tissue samples of 183 accipitriform raptors from Austria and Bosnia-Herzegovina were screened for Plasmodium, Haemoproteus and Leucocytozoon parasites by nested PCR, and tissue samples of 23 PCR-positive birds were subjected to chromogenic in situ hybridization using genus-specific probes targeting the parasites’ 18S rRNAs. All published CytB sequence data from accipitriform raptors were analysed, phylogenetic trees were calculated, and DNA haplotype network analyses were performed with sequences from clades featuring multiple lineages detected in this host group. Of the 183 raptors from Austria and Bosnia-Herzegovina screened by PCR and sequencing, 80 individuals (44%) were infected with haemosporidian parasites. Among the 39 CytB lineages detected, 18 were found for the first time in the present study. The chromogenic in situ hybridization revealed exo-erythrocytic tissue stages of Leucocytozoon parasites belonging to the Leucocytozoon toddi species group in the kidneys of 14 infected birds. The total number of CytB lineages recorded in accipitriform birds worldwide was 57 for Leucocytozoon, 25 for Plasmodium, and 21 for Haemoproteus. The analysis of the DNA haplotype networks allowed identifying numerous distinct groups of lineages, which have not yet been linked to morphospecies, and many of them likely belong to yet undescribed parasite species. Tissue stages of Leucocytozoon parasites developing in accipitriform raptors were discovered and described. The majority of Leucocytozoon and Haemoproteus lineages are specific to this host group, but most Plasmodium lineages were found in birds of other orders. This might indicate local transmission from birds kept at the same facilities (raptor rescue centres and zoos), likely resulting in abortive infections. To clarify the taxonomic and systematic problems, combined morphological and molecular genetic analyses on a wider range of accipitriform host species are needed.

The order Accipitriformes comprises the largest group of birds of prey with 260 species in four families. So far, 21 haemosporidian parasite species have been described from or reported to occur in accipitriform birds. Only five of these parasite species have been characterized molecular genetically. The first part of this study involved molecular genetic screening of accipitriform raptors from Austria and Bosnia-Herzegovina and the first chromogenic in situ hybridization approach targeting parasites in this host group. The aim of the second part of this study was to summarize the CytB sequence data of haemosporidian parasites from accipitriform raptors and to visualize the geographic and host distribution of the lineages. Blood and tissue samples of 183 accipitriform raptors from Austria and Bosnia-Herzegovina were screened for Plasmodium, Haemoproteus and Leucocytozoon parasites by nested PCR, and tissue samples of 23 PCR-positive birds were subjected to chromogenic in situ hybridization using genus-specific probes targeting the parasites’ 18S rRNAs. All published CytB sequence data from accipitriform raptors were analysed, phylogenetic trees were calculated, and DNA haplotype network analyses were performed with sequences from clades featuring multiple lineages detected in this host group. Of the 183 raptors from Austria and Bosnia-Herzegovina screened by PCR and sequencing, 80 individuals (44%) were infected with haemosporidian parasites. Among the 39 CytB lineages detected, 18 were found for the first time in the present study. The chromogenic in situ hybridization revealed exo-erythrocytic tissue stages of Leucocytozoon parasites belonging to the Leucocytozoon toddi species group in the kidneys of 14 infected birds. The total number of CytB lineages recorded in accipitriform birds worldwide was 57 for Leucocytozoon, 25 for Plasmodium, and 21 for Haemoproteus. The analysis of the DNA haplotype networks allowed identifying numerous distinct groups of lineages, which have not yet been linked to morphospecies, and many of them likely belong to yet undescribed parasite species. Tissue stages of Leucocytozoon parasites developing in accipitriform raptors were discovered and described. The majority of Leucocytozoon and Haemoproteus lineages are specific to this host group, but most Plasmodium lineages were found in birds of other orders. This might indicate local transmission from birds kept at the same facilities (raptor rescue centres and zoos), likely resulting in abortive infections. To clarify the taxonomic and systematic problems, combined morphological and molecular genetic analyses on a wider range of accipitriform host species are needed.

Studies indicate the complex nature of the genetic structure of the European Roma which has been shaped by different effects of their demographic history, while preserving their ancestral Indian origin. The primary aims of this study were to present for the first time the paternal profiles of the Roma from Bosnia and Herzegovina based on the data from Y‐chromosome STR loci, identify the components of non‐Roma paternal gene flow into the Roma, and evaluate the genetic relationships with other European Roma populations.

Cadmium (Cd) is a heavy metal present in atmosphere, rocks, sediments, and soils without a known role in plants. It is relatively mobile and can easily enter from soil into groundwater and contaminate the food chain. Its presence in food in excess amounts may cause severe conditions in humans, therefore prevention of cadmium entering the food chain and its removal from contaminated soils are important steps in preserving public health. In the last several years, several approaches for Cd remediation have been proposed, such as the use of soil amendments or biological systems for reduction of Cd contamination. One of the approaches is phytoremediation, which involves the use of plants for soil clean-up. In this review we summarized current data on the use of different plants in phytoremediation of Cd as well as information about different approaches which have been used to enhance phytoremediation. This includes data on the increasing metal bioavailability in the soil, plant biomass, and plant accumulation capacity as well as seed priming as a promising novel approach for phytoremediation enhancing.

Tetraspanins (Tspans) comprise a membrane protein family structurally defined by four transmembrane domains and intracellular N and C termini that is found in almost all cell types and tissues of eukaryotes. Moreover, they are involved in a bewildering multitude of diverse biological processes such as cell adhesion, motility, protein trafficking, signaling, proliferation, and regulation of the immune system. Beside their physiological roles, they are linked to many pathophysiological phenomena, including tumor progression regulation, HIV-1 replication, diabetes, and hepatitis. Tetraspanins are involved in the formation of extensive protein networks, through interactions not only with themselves but also with numerous other specific proteins, including regulatory proteins in the central nervous system (CNS). Interestingly, recent studies showed that Tspan7 impacts dendritic spine formation, glutamatergic synaptic transmission and plasticity, and that Tspan6 is correlated with epilepsy and intellectual disability (formerly known as mental retardation), highlighting the importance of particular tetraspanins and their involvement in critical processes in the CNS. In this review, we summarize the current knowledge of tetraspanin functions in the brain, with a particular focus on their impact on glutamatergic neurotransmission. In addition, we compare available resolved structures of tetraspanin family members to those of auxiliary proteins of glutamate receptors that are known for their modulatory effects.

Abstract Prior research has highlighted that for teachers to develop robust practices, they need to develop rich professional vision (PV)—the ability to see nuanced issues of teaching and learning in situ, interpret them, and respond. In the context of problem-based learning (PBL), PV involves guiding student-centered learning and understanding when to provide just-in-time scaffolding as students navigate real-world problems. In efforts between teachers and researchers to co-design PBL experiences, design partners co-construct PV as they put forth different ways of seeing and navigate how to support student learning together. We need to better understand how (1) PV is interactionally constructed in these efforts and (2) what tools and designs support this co-construction. We use discourse analysis to explore how joint video analysis in one co-design effort supported the simultaneous development of PV for teacher and researcher. Findings revealed that collaborative video analysis of classroom interaction and student artifacts acted as boundary objects for design partners—a shared space for meaning making. On video, classroom interactions were revisited, and alternative possibilities reimagined. Group artifacts (e.g., drawings and notes) made students’ thinking available for interpretation. Consistent open-ended questions in co-design (e.g., “how are we seeing PBL in action here?”) supported the negotiation and alignment of PVs, setting shared goals, and planning actions for upcoming class periods. This research contributes to our shared understanding of how to support research and practice that is responsive to local context and is mutually beneficial for researcher and teacher.

Our ability to interrogate and manipulate the genome far exceeds our capacity to measure the effects of genetic changes on plant traits. Much effort has been made recently by the plant science research community to address this imbalance. The responses of plants to environmental conditions can now be defined using a variety of imaging approaches. Hyperspectral imaging (HSI) has emerged as a promising approach to measure traits using a wide range of wavebands simultaneously in 3D to capture information in lab, glasshouse, or field settings. HSI has been applied to define abiotic, biotic, and quality traits for optimisation of crop management.