Antibody-drug conjugates represent a new class of highly potent antineoplastic drugs built by attaching a small molecule of an anticancer drug (payload) or another therapeutic agent to an antibody recognizing an epitope on the targeted cells. Trophoblast cell-surface antigen-2 (Trop-2) was originally described in trophoblasts and fetal tissues, but subsequently its overexpression has been demonstrated in various solid malignancies. Sacituzumab govitecan (SG), a conjugate of anti-Trop-2 antibody and SN-38 payload (an active metabolite of irinotecan), is the first in the class that has been clinically validated and approved by the Food and Drug Administration for the treatment of metastatic triple-negative breast (2020) and urothelial carcinomas (2021). In the current review, we summarize and critically appraise the most recent advances with regard to SG, emphasizing the predictive biomarker analysis.

Penalties in judo result from negative actions that are not in line with judo combat regulations. The aim of the research was to determine the differences in penalties between winner and non-winner competitors in judo. A total of 1799 (men=1133 and women=666) matches with penalties were evaluated during 2017, 2018 and 2019 World Judo Championships. The variables were expressed as proportions and compared with the Chi-Square test with pairwise Z-tests. The ratio of receiving the first and second shido was the same in men and women athletes ( p >.05), but it was different for weight categories ( p .05), the ratio of forbidden actions in the first and second shido differed ( p <.05). The difference in the penalty ratios in winner and non-winner athletes, especially the difference in forbidden actions leading to first and second shido may reflect some tactical differences. The results of this research can significantly contribute to the understanding of the significance of judo penalties both in training and in competition, as well as to the further study of judo penalties.

Conflict is an integral part of sport, and it implies a normal occurrence in communication and relationship between athletes and coaches. The main aim of this paper was to present a conflict analysis of the coach-athletes relationship, but also its impact on the achievement of sports results. The review article analysed nine works that directly studied interpersonal relationships between coaches and athletes. Research results suggest that conflict is evident and inevitable, as well as expected since coaches spend a lot of time with athletes, and pass through the training process, but also the competition period, when athletes are exposed to greater pressure because of the competition itself. Timely response and adequate response to conflict can greatly contribute to improving relations and even better sports results.

ABSTRACT Vaccination coverage in the Federation of Bosnia and Herzegovina, in Bosnia and Herzegovina, has been declining since 2014. This qualitative study aimed to identify barriers and drivers to childhood vaccination for parents. The COM-B (capability-opportunity-motivation-behavior) model was the underpinning theoretical framework. Face-to-face interviews with 22 parents of fully (n = 6), delayed/partially vaccinated (n = 9) and unvaccinated (n = 7) children were conducted. Interviews explored individual factors (capability–knowledge and skills; motivation–attitudes, confidence and trust) and context factors (physical opportunity–information, access, health systems; and social opportunity – social support, norms). Data were analyzed in NVivo using content analysis exploring differences in COM factors by vaccination status and location. Parents of fully vaccinated children typically reported individual and context drivers to vaccination. They accepted vaccination, trusted health workers, and were content with services. Parents of delayed/partially vaccinated children fell into two subgroups: (1) Those who accepted vaccination and attributed delays to their organizational skills or frustration with appointment times. (2) Those fitting the profile of “vaccine hesitant” – generally valuing vaccination and health worker advice, yet with concerns often triggered by media/social media. Parents of unvaccinated children mentioned individual and context barriers to vaccination, notably significant concerns about safety, some distrust of health workers and resentment of mandatory vaccination. Urban/rural differences included urban parents being more likely to report experiences with vaccine shortages and very few had received information leaflets. The study identified complex and inter-related barriers and drivers to parents’ childhood vaccination behaviors. These insights have informed the development of tailored interventions to improve coverage.

This paper proposes a systematic literature review on ethics and CoviD-19, aiming to understand the impact and the perception of the pandemic during the first wave (January-June 2020) and the consequences one year later. PubMed was systematically searched up May 2020 to identify studies that took into consideration various ethical issues that have been arising from the Covid-19 outbreak. The eligibility of the papers was determined by two authors, who screened the results mediated by a third author. In order to facilitate the screening, the titles were divided into five sub-thematic macro-areas, namely allocation, policy, specialist, clinical trials, and technology and, when possible, per geographical area. Specifically, a posteriori, we decided to focus on the papers referring to policies and technology, as they highlighted ethical issues that are not overused and worthy of particular attention. Thus, 38 studies out of 233 met our inclusion criteria and were fully analysed. Accordingly, this review touches on themes such as fairness, equity, transparency of information, the duty of care, racial disparities, the marginalisation of the poor, and privacy and ethical concerns. Overall, it was found that despite the increased awareness of interdisciplinarity and the essential reference to ethics, many scientific articles use it with little competence, considering it only a "humanitarian" enrichment. In fact, as we understand, reflecting a year after the outbreak of the pandemic, although Covid-19 is leading scientists to increasingly recognise the importance of ethical issues, there is still a lot of confusion that could be helped by establishing international guidelines to act as a moral compass in times of crisis.

The advantages of massive multiple-input multiple-output (MIMO) techniques depend heavily on the accuracy of channel state information (CSI). In frequency division duplexing (FDD) massive MIMO systems, the user equipment (UE) needs to feed downlink CSI back to the base station (BS) through the feedback link. The excessive feedback overheads and low reconstruction accuracy are the main obstacles for actual deployment of FDD massive MIMO systems. In recent years, deep learning (DL) has been widely used to address the above problems. In this letter, we propose a neural network by utilizing the self-attention learning and dense refine (SALDR), which improves the accuracy of CSI feedback. Furthermore, a unified decoder named SALDR-U is designed to realize different compression ratios for CSI feedback without changing any parameter. Simulation results show that the proposed SALDR and SALDR-U outperform the state-of-the-art network in terms of accuracy and overhead of CSI feedback. The source code for all the experiments is available at GitHub.The code of this letter can be downloaded from GitHub link: https://github.com/XS96/SALDR.

Background: Carotid endarterectomy (CEA) is an effective and safe treatment of stenosed carotid arteries, and is a preventive operation with well-defined indications. It is associated with a loss of the baroreceptor reflex and postoperatively increased hemodynamic parameters. Objective: The aim of the study was to confirm the sensitivity of baroreceptors and the impact on arterial pressure and heart rate in unilateral and bilateral eversion carotid endarterectomies. Methods: A retrospective study was conducted with 30 patients treated with E-CEA in local anesthesia at the Clinic for cardiovascular surgery from December 2019 to May 2021, due to stenosis of the carotid arteries. Patients were divided into two groups: 15 patients in group A (patients with unilateral E-CEA; 15 patients in group B: patients with bilateral E-CEA). Results: Out of the total of 30 patients included in the research, 15 patients in groups A and B respectively, there were no statistically significant differences in regards to gender (p= 0,245) and preoperative risk factors: smoking (p=0,449); hypertension (p=0,388); diabetes (p= 0,714); hyperlipidemia (p=0.388), coronary disease (p=0.461) and symptomatic stenosis of the carotid arteries (p=0.449). Noted were the statistically significant differences in values of systolic and diastolic pressure on the 3rd postoperative days in patients with bilateral E-CEA (p=0,001; p=0,001), a statistically significant difference in the heart rate was not found in the analyzed groups in the postoperative period (p=0,225; p=0,994). Conclusion: This study identified statistically significant differences in values of systolic and diastolic pressure in the early postoperative period. In his period, early detection and correction of these hemodynamic disorders are needed.

Abstract We are witnessing an increasing frequency of illegal actions and fraud in the business of legal entities, which directly reflects on the quality of information presented in financial statements. Internal audit does not primarily deal with the audit of financial statements, but through verifying the application of accounting policies and procedures it helps to gain reasonable assurance that the financial statements are reliable and that they are presented fairly. The role of internal audit in the fraud detection process is reflected in the fraud risk assessment in the internal audit planning process, and through performing work engagements to detecting them. In this paper, we will present risk assessment techniques, which the internal auditor can apply in quantitative and qualitative assessment of fraud risk, and in identifying priority areas/audit processes. The aim of this paper is to point out the importance of the role of internal audit, through the application of techniques, tools and prescribed responsibilities for risk assessment, in the process of detecting fraud in companies that cause incalculable damage on a daily basis.

Background: Dentine hypersensitivity (DH) is a frequent clinical problem that represents a long-term painful discomfort for the patients, and for the dentists, it represents a diagnostic and therapeutic challenge. Objective: The aim of the research is to verify the effect of the treatment with diode laser SiroLaser Blue (660nm) of DH alone or in combination with different impregnating agents. Methods: Fifty patients were included in this research, separated into five groups. All the patients have been asked to define the level of dentine hypersensitivity using VAS (0-10). The first group was treated with Fluor Protector, the second group after the application of Fluor Protector has undergone irradiation with SiroLaser Blue (660nm), the third group was treated with impregnating agent Vivasens, the fourth group, after the application of impregnating agent Vivasens, has had SiroLaser Blue (660nm) irradiation. The fifth group has just been treated with SiroLaser Blue (660nm). The efficiency of the treatment was checked using VAS for every group immediately after the conducted treatment, after 7 days and 1 month. Results: Our results showed that all of the desensitizing agents used in the research alone or in combination with a diode laser (660nm) have shown a reduction of DH. The difference has been proven statistically significant in mean values by groups and examinations. Vivasens and diode laser irradiation have provided the best results in the review of mean values after the first examination and one month after the treatment of DH (p<0,05). In our research, the application of diode laser alone has not proven superior to other treatment methods that have been used in the research. Conclusion: Vivasens plus diode laser irradiation has provided the best results even after one month since the treatment of DH.

Abstract Abdominal injuries are rare in sports, but even minor traumas may result in potentially life-threatening injuries. The most frequent abdominal injury is abdominal wall contusion, following by blunt injuries of the kidneys and spleen. The cases of blunt abdominal injuries in soccer are rarely reported in the literature. We present a case of a grade IV splenic laceration in a 10-year-old soccer goalkeeper caused by the blunt abdominal trauma sustained during the gameplay. The trauma was successfully treated with a nonoperative management approach.

Hans Peterson, MD, PhD, FEFMI, FACMI, FIMIA, FIAHSI (1928-2021), became a certified physician in Sweden in 1958 and was awarded a doctorate in Medicine in 1967 (1-4). He was an ophthalmology fellow at the Karolinska Institute, Stockholm University, and was appointed to faculty positions in Ophthalmology and Medical Informatics at the Karolinska in the late 1970’s.