伴有破骨样巨细胞的胰腺未分化癌（UCPOGC）是胰腺导管腺癌的一种罕见的特殊亚型。肿瘤成分复杂，其中可见3种细胞类型：肿瘤细胞、单核组织细胞和破骨样巨细胞。肿瘤细胞异型性显著，通常不表达或仅灶性表达上皮标志物，而弥漫表达间叶源性标志物波形蛋白，因此常被误诊为肉瘤；后两者表达组织细胞标志物，缺乏上皮分化。现报道2例UCPOGC，分析临床病理学特征，并查阅相关文献，重点讨论其组织起源及预后相关因素，以提高临床与病理医师对该肿瘤的认识水平。.

Abstract Background Parental education is one of the best predictors of child school achievement. Higher parental education is not only associated with higher child intelligence, but children from highly educated parents also perform better in school due to other family related factors. This study evaluates the relation between parental education, child non-verbal intelligence and parenting practices with child school achievement. Methods Longitudinal data from a large population-based, multi-ethnic cohort of children in the Netherlands (63% Dutch origin) followed from birth to age 13 years (3547 children; 52.3% girls) were analyzed. School achievement was measured at the end of primary school (12 years of age) with a national Dutch academic test score. Parental education was assessed at age 3 years. The non-verbal intelligence of the child was measured at age 6 years and a full intelligence was measured at age 13 years. Maternal and paternal family routines, harsh parenting and corporal punishment were assessed in early and mid-childhood. Mediation analysis was performed with the G-formula and Structural Equation Models. Results Child intelligence partially mediated [B indirect effect =0.54 95% CI (0.46, 0.62) P < 0.001] the association between parental education and child school achievement. Independent of intelligence, family routines [B indirect effect =0.04 95% CI (0.01, 0.07) P < 0.01], but not harsh parenting mediated this association. Conclusions Higher parental education was associated with better school achievement through two independent mechanisms, through higher intelligence of the child and parenting practices.

Flooding is a significant threat to human-life, ecosystems, cultural heritage and society in general. A risk-based safety approach is necessary to support decision making and prioritize intervention measures, either during the response or during the prevention stage. As a consequence of flooding, transport infrastructure and flood protection system can be significantly damaged and cause cascading effects on other infrastructure. In this paper a risk assessment model will be presented for determining the direct and indirect impacts of flooding hazards in the case study area of city of Karlovac. The model is using the novel vulnerability assessment methods for embankments and bridges exposed to different flood hazard scenarios. The consequence analysis is using an improved quantification model for direct and indirect impacts of different flood hazard scenarios. These scenarios are then used for flood risk mapping, applied on the case study area.

increasingly common occurrence of rain with a significant amount of precipitation in one hour, which causes floods. Floods cause great material and intangible damage per population and often endanger human lives. The road network in such situations has crucial importance to take urgent intervention measures and rescue people, animals and material goods. This paper is focused on the natural flood disaster and its influence on road infrastructure and presents the risk assessment methodology and determines critical road sections of main roads in the Federation of Bosnia and Herzegovina, analyzing data on 100-year floods.

For the purpose of digitization and interoperability of public administration, we researched the organization and challenges in public administration in Bosnia and Herzegovina as well as in general in public administration. We presented parts of public administration as well as the influences of public administration. The effects and influence of digitalization and interoperability in institutions in BIH, strategic approach to the development of public administration, the relationship between Vision and Technology as an indicator of business success in public administration are given. We also presented a view on the provision of digitalized and interoperable public administration services.

Abstract Anatomical complications of the craniofacial regions often present considerable challenges to the surgical repair or replacement of the damaged tissues. Surgical repair has its own set of limitations, including scarcity of the donor tissues, immune rejection, use of immune suppressors followed by the surgery, and restriction in restoring the natural aesthetic appeal. Rapid advancement in the field of biomaterials, cell biology, and engineering has helped scientists to create cellularized skeletal muscle‐like structures. However, the existing method still has limitations in building large, highly vascular tissue with clinical application. With the advance in the three‐dimensional (3D) bioprinting technique, scientists and clinicians now can produce the functional implants of skeletal muscles and bones that are more patient‐specific with the perfect match to the architecture of their craniofacial defects. Craniofacial tissue regeneration using 3D bioprinting can manage and eliminate the restrictions of the surgical transplant from the donor site. The concept of creating the new functional tissue, exactly mimicking the anatomical and physiological function of the damaged tissue, looks highly attractive. This is crucial to reduce the donor site morbidity and retain the esthetics. 3D bioprinting can integrate all three essential components of tissue engineering, that is, rehabilitation, reconstruction, and regeneration of the lost craniofacial tissues. Such integration essentially helps to develop the patient‐specific treatment plans and damage site‐driven creation of the functional implants for the craniofacial defects. This article is the bird's eye view on the latest development and application of 3D bioprinting in the regeneration of the skeletal muscle tissues and their application in restoring the functional abilities of the damaged craniofacial tissue. We also discussed current challenges in craniofacial bone vascularization and gave our view on the future direction, including establishing the interactions between tissue‐engineered skeletal muscle and the peripheral nervous system.

Collaborative graphic ethnography can generate new ways of identifying, materializing, and documenting political possibility in what otherwise seems like an overdetermined world, and in doing so, offers a model for practicing anthropology differently. We come to these insights through our work in the embattled Bosnian detergent factory “Dita,” located on the outskirts of the post-industrial city of Tuzla, whose workers scored an unprecedented victory when they managed to preserve their factory and restart production despite the threat of bankruptcy and liquidation. In researching and telling the story of their struggle and victory through this innovative format, we build upon the historical popularity of comics in former Yugoslavia, as well as contemporary experimentation with the form among anti-corruption activists in Bosnia-Herzegovina. We explore ethnographic and political affordances of sequential art and the graphic form for an engaged or activist anthropology, including its capacity to visualize and materialize the immaterial and overlooked aspects of politics, mitigate anthropology’s extractivist tendencies, enlist the imagination and participation of readers in directions both hoped for and unanticipated, and engage and animate multiple local and international publics.  

Bosnia and Herzegovina has been one of the first European states to introduce a generous consumer collective redress mechanism. It was established under the influence of the EU, the United States and former Yugoslav law. The legislation of Bosnia and Herzegovina provides an excellent opportunity to examine to which extent the collective redress remedies emanating from different legal traditions may co-exist and function together. The number and variety of collective consumer remedies in Bosnia and Herzegovina is quite impressive. But the mechanism has still not been used because of the weaknesses of those who are supposed to trigger it. The very generous solutions for consumer associations and a specialized Ombudsman for Consumer Protection, both with wide powers to initiate collective proceedings, have not proved to be sufficient. The lack of appropriate funding has so far been an obstacle that is too great for any collective initiative. It also does not help that legislation allows traders to file for compensation in the case of unfounded collective claims when the reputation and business of the trader have been seriously harmed. The new EU Directive on consumer representative actions will certainly require further reforms in Bosnia and Herzegovina, especially with regard to collective claims for damages. This will provide the legislator with the opportunity not only to introduce more options for collective redress, but also to add the missing pieces of the jigsaw so that the mechanism finally fulfils its purpose of providing legal protection for consumers.