Dimenhydrinate (DMH) is used for the prevention and treatment of nausea, vomiting, dizziness and vertigo associated with motion sickness in a dose of 50 mg 1. It’s made of two drugs in a form of salt, diphenhydramine and 8-chlorotheophylline which synergically decrease motion caused neural excitation 2. DMH is classified as a slightly soluble drug and it belongs to class II of BCS classification as a drug with low solubility and high permeability 3. Cyclodextrins (CDs) are cyclic oligosaccharides formed by α-1,4-linked glucose units with a hydrophilic outer surface and a lipophilic central cavity. Formation of inclusion complex by incorporating a drug in the central CD cavity provides improvement of physicochemical properties without molecular modifications. Solubility and dissolution rate of poorly water-soluble drugs can be increased 4. Aqueous solubility of natural CDs is limited due to their tendency to form H-bonded associations. However, due to multiple reactive hydroxyl groups, their functionality can be greatly increased by chemical modification 5. CDs’ substituted derivates can overcome poor solubility issues and enhance bioavailability. Hydroxypropylβ-CD (HP-β-CD) has good inclusion ability, high water solubility and it’s safe for intravenous and oral administration 6. Stability constant (Ks) and complexation efficacy (CE) are important for assessing the binding characteristics of the drug and CD. They can be determined by the phase solubility studies where the change of the drug solubility is corresponding to the concentration of CD 7. Linear (AL) type of the curve implies that one molecule of the drug forms inclusion complex with one molecule of the CD. Apparent stability constant K1:1 can be calculated from the following equation:

The development process of the knowledge-based engineering (KBE) system for the structural size optimization of external fixation device is presented in this paper. The system is based on algorithms for generative modeling, finite element model (FEM) analysis, and size optimization. All these algorithms are integrated into the CAD/CAM/CAE system CATIA. The initial CAD/FEM model of external fixation device is verified using experimental verification on the real design. Experimental testing is done for axial pressure. Axial stress and displacements are measured using tensometric analysis equipment. The proximal bone segment displacements were monitored by a displacement transducer, while the loading was controlled by a force transducer. Iterative hybrid optimization algorithm is developed by integration of global algorithm, based on the simulated annealing (SA) method and a local algorithm based on the conjugate gradient (CG) method. The cost function of size optimization is the minimization of the design volume. Constrains are given in a form of clinical interfragmentary displacement constrains, at the point of fracture and maximum allowed stresses for the material of the external fixation device. Optimization variables are chosen as design parameters of the external fixation device. The optimized model of external fixation device has smaller mass, better stress distribution, and smaller interfragmentary displacement, in correlation with the initial model.

In Bosnia and Herzegovina, the pluralization of society and the state began during 1990. This is the time when political parties are formed and the first multi-party parliamentary elections are held. Due to the strong influence and domination of the ethnic principle, political parties were formed in Bosnia and Herzegovina in 1990 in two basic forms: as ethnic or people's (national) parties, and as civic (multiethnic) parties. In almost all election cycles from the beginning of the pluralization of Bosnian society until today, ethnic political parties have won the elections. Ethnic political parties have appropriated a monopoly in the promotion of national interests since the 1990 election campaign, guided by the idea of protecting the national interests of “their“ peoples. The continued rule of ethnic parties without a coalition political agenda and agreement has strengthened ethnic pluralism in Bosnia and Herzegovina. Thus, instead of democratic decision-making and competition between the majority and the opposition, the representative bodies in Bosnia and Herzegovina have become an arena and a place of mutual competition and confrontation between the parties that make up the parliamentary majority. The lack of the necessary democratic consensus between the ruling ethnic political parties at the state level was compensated and compensated by the High Representative of the International Community (OHR), who, on the basis of the Bonn powers, promulgated certain laws. Hundreds of laws in Bosnia and Herzegovina have been promulgated by high representatives. This prevented blockages in the work of the Parliamentary Assembly of Bosnia and Herzegovina. In the absence of the necessary consensus of the ruling ethnic parties, it is not possible to develop or strengthen the power of parliaments as the highest representative body of the people and citizens of Bosnia and Herzegovina. Instead of parliamentary democracy, classical partitocracy is at work. The situation is similar at the entity level, and at the cantonal level in the Federation of Bosnia and Herzegovina entity. All this, along with heterogeneous and complicated decision-making procedures and processes, ultimately reflects on the adoption of laws and decisions of importance to society and the state. Complicated forms of decision-making and the existence of a famous mechanism for the protection of vital national interests are some of the obstacles to the development of the state and society. All of these are some of the essential problems, but also the controversies that follow the decision-making processes in the representative bodies in the country. This is especially true of the adoption of important and significant public policies aimed at solving socio-political problems. Only decision-making at the level of local self-government units (municipalities and cities) can serve as a positive example. In general, the local level of government has so far proved to be the most efficient level of government in Bosnia and Herzegovina. The basis for strengthening the democratic decision-making capacities of the representative bodies of the state of Bosnia and Herzegovina is contained in the application of the democratic principle on which parliamentary democracy is established and functions. Applying almost all basic and general scientific research methods, as well as the method of analysis (content) of relevant documentation as a method of data acquisition, will identify key problems and controversies of public decision-making and policy making in Bosnia and Herzegovina, in the period after the Dayton Peace Agreement. today. A conclusion will be drawn on the need to establish a parliamentary majority based on the coalition agreement and the political program of that coalition, which significantly affects the public decision-making processes and the adoption of the necessary state public policy. Bosnia and Herzegovina is required to reconstruct public decisions in the direction of strengthening state public decisions and policies and building European standards, in order to more efficiently compose them with the requirements and directives of the European Union.

Abstract Forest policy and forest ownership patterns in Slovenia and the Federation of Bosnia and Herzegovina (FBiH) have changed considerably in recent decades due to unprecedented scale of social, political and economic change. The distribution of ownership types varies between the countries – in Slovenia private forest ownership predominates (77%), while in FBiH only about 20% of forest is private-owned. In both countries, private forest properties are small-scale and fragmented, which affects management opportunities and the scale at which policy interventions need to be made. This paper analyses the Slovenian and Central Bosnia Cantonal Law on Forests to assess how the regulatory framework affects private forest owners’ (PFOs) rights, forest management and accelerates cooperation of PFOs. Both laws impose exclusive rights and responsibilities of PFOs, as well as limitation on how they can use their forests. In both countries, legislation contains detailed regulations for forest management activities and stipulate that mandatory forest management plans (FMPs) are an important tool that supports the implementation of sustainable forest management. In Slovenia, FMPs are prepared as common plans for all forests regardless the ownership, while in FBiH the Cantonal Law prescribes a separate forest management planning system for private forests. To improve the efficiency of private forest management, both laws support voluntary cooperation of PFOs. From the analysis, it can be concluded that there is a need for better harmonisation of public and private interests in relation to forest resources, especially in the case of FBiH, and that the deregulation of property right is needed as well as that the level of involvement of PFOs in the forest policy making process is unsatisfactory, in most cases only formal.

Intent-based networking (IBN) solutions to managing complex ICT systems have become one of the key enablers of intelligent and autonomous network management. As the number of machine learning (ML) techniques deployed in IBN increases, it becomes increasingly important to understand their expected performance. Whereas IBN concepts are generally specific to the use case envisioned, the underlying platforms are generally heterogenous, comprised of complex processing units, including CPU/GPU, CPU/FPGA and CPU/TPU combinations, which needs to be considered when running the ML techniques chosen. We focus on a case study of IBNs in the so-called ICT supply chain systems, where multiple ICT artifacts are integrated in one system based on heterogeneous hardware platforms. Here, we are interested in the problem of benchmarking the computational performance of ML technique defined by the intents. Our benchmarking method is based on collaborative filtering techniques, relying on ML-based methods like Singular Value Decomposition and Stochastic Gradient Descent, assuming initial lack of explicit knowledge about the expected number of operations, framework, or the device processing characteristics. We show that it is possible to engineer a practical IBN system with various ML techniques with an accurate estimated performance based on data from a few benchmarks only.

Using extensive and comprehensive databases to select a subset of research papers, we aim to critically analyze previous empirical studies to identify certain patterns in determining the optimal number of stocks in well-diversified portfolios in different markets, and to compare how the optimal number of stocks has changed over different periods and how it has been affected by market turmoil such as the Global Financial Crisis (GFC) and the current COVID-19 pandemic. The main methods used are bibliometric analysis and systematic literature review. Evaluating the number of assets which lead to optimal diversification is not an easy task as it is impacted by a huge number of different factors: the way systematic risk is measured, the investment universe (size, asset classes and features of the asset classes), the investor’s characteristics, the change over time of the asset features, the model adopted to measure diversification (i.e., equally weighted versus optimal allocation), the frequency of the data that is being used, together with the time horizon, conditions in the market that the study refers to, etc. Our paper provides additional support for the fact that (1) a generalized optimal number of stocks that constitute a well-diversified portfolio does not exist for whichever market, period or investor. Recent studies further suggest that (2) the size of a well-diversified portfolio is larger today than in the past, (3) this number is lower in emerging markets compared to developed financial markets, (4) the higher the stock correlations with the market, the lower the number of stocks required for a well-diversified portfolio for individual investors, and (5) machine learning methods could potentially improve the investment decision process. Our results could be helpful to private and institutional investors in constructing and managing their portfolios and provide a framework for future research.

The paper investigates the impact of fiscal policy on economic growth, foreign direct investment and employment in Bosnia and Herzegovina. The focus of research is fiscal policy, which as a lever of economic policy that affects economic growth and development. The aim of the research is to determine the impact of fiscal policy on the economy of Bosnia and Herzegovina and propose solutions for higher growth and development, a higher degree of foreign direct investment and reducing the unemployment rate. The results of the research show that the fiscal policy for the years that are the subject of the research, has affected the public debt of the state. High taxes and contributions have contributed to the spread of the gray economy, fiscal discipline is at a low level due to the management in this way of this lever of economic policy. Public financial management should be one of the key macroeconomic goals, with special emphasis on fiscal policy. The research went in the direction of analyzing current trends and proposals for improving the situation. The research aims to show the current statistical impact of variables on gross domestic product, on growth and development and the impact after the application of expansionary fiscal policy on the same variables. It is recommended that economic policy be conducted in the direction of releasing additional funds through the redistribution of taxes in favor of workers, in the direction of capital investments that will repay themselves, to reduce the rate of taxes and contributions on wages and with incentives for investors, to go towards stimulating production and tax reliefs for export-oriented activities with an effort to try to produce products whose production is possible in our conditions, and all this is mostly possible with the implementation of an expansive fiscal policy.

So far, recent literary criticism has paid attention exclusively to the poetry of Amir Brka. This work deals with prose creation, with constant emphasis on the compatibility of poetry and prose, and then prose and opinion journalism, for which the city of Tesanj is the motif backbone. The methodology of the work is based on mnemonics, under the hypothesis that Amir Brka, through a polyvalent opus, deconstructing the “dejected” space of the Bosnian town, reconstructed the timeless and all-spatial mnemotope of the city. In this way, Brka symbolically made a spatial turn in Bosnian literature, especially through the works Monograph of the City, Black Notebook and the book Jerej, which are, each in its own way, a fight against wrong ideologies and inputs that the text and book based on truth are the only credible mnemotopes.

The paper is the analysis of Ćopić’s novel Delije na Bihaću, i. e. of its marked lexis, which is divided into emotionally-expressive lexis and stylistically marked lexis. There are different typologies of lexis in our language (see e. g. Halilović/Tanović/Šehović 2009). This study, however, employs the classification offered by Katnić-Bakaršić (2007). The analysis includes idioms, loanwords and diminutives extracted from Ćopić’s final novel. Seeking the best way to describe experiences and impressions, Ćopić opted for emotive, inherently expressive language. The analysis of native idiomatic and lexical specifics of the novel reveals the extent to which the use of authentic lexis contributes to a more convincing and credible characterization of characters and gives a clearer picture of the social and linguistic aspects in Krajina during that particular period.

Recent Bosnian criticism, directly or indirectly, deals with the issue of classification and systematization of Tvrtko Kulenović's literary work, which due to its specificity can hardly be reduced to usual conventions. This paper gives an overview of the very specificity of that, above all, polyvalent literary work, which encompasses travelogues, plays (dramas), essays and novels – genres that sometimes act separately, and sometimes represent a habitus, i.e. a unique textual universe of Tvrtko Kulenović.