This study evaluated the performance of the COVID-19 Ag-RDT compared to the real-time reverse transcription-polymerase chain reaction (rtRT-PCR) for SARS-CoV-2 detection and its use among patients referred for emergency admission. A total of 120 nasopharyngeal swabs were collected from patients referred for emergency admission and immediately preceded for testing to the Unit of Clinical Microbiology. Out of 60 Ag positive tests, 53 (88.3%) were confirmed by rtRT-PCR, while 7 (11.7%) tested negative (false positives). Out of 60 Ag negative tests, 56 (93.3%) were confirmed negative by rtRT-PCR, and 4 (6.7%) were positive (false negatives). Ct value comparison was performed for 53 samples that were positive by both methods: 8 (15.1%) isolates had Ct value up to 20; 37 (69.8%) 21 to 30 and 8 (15.1%) 31 to 40, respectively. The sensitivity of the analyzed rapid Ag test was 92.9%, and specificity 88.9%. The accuracy of the Ag test was 90.8%. This study has shown that rapid Ag tests can be used in emergency admissions to healthcare facilities. However, rtRT-PCR should be considered after negative antigen test results in symptomatic patients, and after positive antigen test results in asymptomatic persons.

Introduction/Objective Patient safety is defined as the prevention of errors and adverse effects aimed at patients and associated with health care. Patient safety culture (PSC) is "the product of individual and group values, attitudes, perceptions, competencies and patterns of behaviour that determine the commitment to, and the style and proficiency of, an organization's health and safety management." Improving the perception of the PSC within the healthcare sector plays a key role in improving its overall quality, efficacy and productivity. This article aims to point out the importance of the inexhaustible and very interesting topic of safety culture as a basis for further research and strategy creation. Methods This is a qualitative research paper, based on a scientific review of the literature. Relevant articles for this review have been identified by searching digital databases: PubMed, Medline and Google Scholar. The research was retrospective and covered a timeframe of five years. Articles were selected by introducing keywords relevant to the subject. Results The results are based on the analysis and review of 12 published scientific articles from 2017 to 2021. Conclusion Patient safety must be the priority of the healthcare provider. Theoretical foundations should be combined with educational experiences following the development of knowledge, skills and attitudes for effective patient safety. Adverse event reporting should include learning from mistakes, supporting an environment that encourages reporting without blame or fear of punishment. The healthcare system needs to be made as safe as possible for both the patients and all those providing healthcare. Improving and developing the quality of healthcare requires knowledge, selection and application of specific methods and tools tailored to the capabilities of individual healthcare institutions.

Vector-borne diseases occur in the chain pathogen-vector-host, with vectors playing the most prominent role. Vectors transmit pathogens between humans, and more often, from animals to humans so that many vector-borne diseases are categorized as zoonoses. Vector-borne diseases have become more important worldwide, and not exclusively in the tropics as in the past, by causing high morbidity and mortality every year. Out of all infectious diseases, more than 17% are vector-borne. The most significant and widespread vectors are mosquitoes and ticks, and the most significant diseases are West Nile fever, yellow fever, Zika virus fever, tick encephalitis, Lyme borreliosis, Crimean-Congo hemorrhagic fever and rickettsioses. Life and preservation of the vectors, and breakouts and spread of vector-borne diseases are profoundly affected by climate change (rise in temperature and humidity, downfalls, extreme weather conditions), urbanization, deforestation, inadequate waste management, international travel, international commerce and social conditions, with poverty being the most important and directly linked to the rising incidence. In recent years, all factors mentioned above have favoured a rising number of the vectors and their spread, so that vector-borne diseases have become emergent or reemergent, meaning their high incidence have been registered in the countries with no previous breakouts; or they reoccurred in the areas where they had earlier been eradicated. Some extra reasons contributing to the increasing incidence are lowered investments and limited resources for monitoring vector-borne diseases. Most vector-borne diseases are zoonoses, making "One Health" the only appropriate approach, which implies integrated monitoring of the diseases in the sectors of both animal and human health. Prevention of vector-borne diseases should be aimed at raising public awareness on the importance of the vectors, education of the professionals and active involvement of the community as a whole.

Introduction. The most common form of leishmaniasis is cutaneous leishmaniasis. It presents with cutaneous lesions of the unprotected parts of the skin which leave scars later on. The causative agents are protozoae from the Leishmania species , and there are more than 20 of them. Clinical presentation and therapy depend on the type of leishmaniasis. The vectors of leishmaniosis are flies from the Phlebotomus species, and the source of infection is people and animals. Case report. A patient used to work in Iraq. Due to skin lesions that persisted for three months and suspicion of cutaneous leishmaniosis, he was sent by an infectious disease specialist from General hospital, Pancevo to the Public Health Institute of Serbia - PHIS. Lesions were localized on the hands, in the form of plaques with central ulcerations. There were similar cases among his colleagues. Microscopic examination of the skin samples, Giemza stained, showed intracellular amastigote Leishmania. The patient spent two months in the Clinic for infectious and tropical diseases. He was treated with fluconazole and liposomal amphotericin B and discharged with crusts on his hands. Clinical presentation, epidemiologic data, and microbiological diagnosis are very important for the diagnosis of cutaneous leishmaniasis.

Introduction. Epulis is a change in gingival tissue that occurs under the influence of chronic irritation. Histologically, there are several different types of epulis. Fibrous epulis is benign tumor of gingiva that most often occurs in interdental papilla area as a result of local irritation (inadequate restorative fillings, carious teeth, subgingival deposits or the combination of them). The aim of this paper is to present a clinical case of fibrous epulis. Case report. A 25-year-old girl reported to the Specialist Center for Dentistry in Foca. Clinical examination revealed a gingival tissue enlargement in the area of the upper jaw central incisors with speech and chewing function disturbances. Intraoral examination revealed a change above the level of gingiva, reddish-pink in color with smooth surface texture and soft consistency. The size of the change was 1 x 1.5 cm. It was connected to the interdental gingiva between teeth 12 and 21 by a narrower base. Clinically, a significant amount of soft and hard dental deposits surrounded the remaining teeth. Remaining gingiva was swollen, red, bleeding on provocation. The anamnesis did not confirm the presence of other acute and chronic diseases. The patient was not pregnant. She was informed about clinical condition assessment, as well as possible therapeutic procedures. Our patient was treated with non-surgical periodontal therapy and surgical excision of the enlargement. After histopathological examination of the removed tissue, the diagnosis was made: "Fibrous epulis cum ulceration". Conclusion. Clinical examination is insufficient for definite diagnosis. Therefore, a histopathological examination of the tissue is mandatory for fibrous epulis definite diagnosis. Treatment of choice is surgical excision of the enlargement and removal of predisposing factors to avoid recurrence.

Introduction. Hyperdontia or supernumerary teeth are excess number of teeth in comparison to normal dentition. The aim of this study was to present different variants of permanent supernumerary teeth, as well as their observation or elimination in order to prevent possible complications Case report. Six different cases of hyperdontia are presented in this paper. All hyperdontia cases were multidisciplinary evaluated and individual treatment protocols were applied. Already erupted supernumerary teeth were extracted without surgical intervention. Unerupted teeth were surgically removed or left for observation. Conclusion. Early and frequent dental check-ups are very important for children in order to detect possible dentition irregularities and thus timely start with appropriate therapy.