Abstract Phase unbalance is a common issue encountered in LV electricity distribution networks, caused by uneven allocation of single-phase loads among phases. This paper analyses a part of a real LV distribution network, situated in Bosnia and Herzegovina. The impact of single-phase customers and single-phase charging of electric vehicles was analysed. To reduce unbalance and improve the voltage profiles, Phase Balance Optimization in DIgSILENT PowerFactory software was performed in six scenarios with different customer and electric vehicle unbalance. The goal was to find a method with the least number of changes in the customer and electric vehicle phase connection that fits within defined limits of voltage variations and voltage unbalance of a European norm for power quality (EN 50160). Results showed that all analysed scenarios were improved, with reference to voltage variation and voltage unbalance values, and were found acceptable by the limits from standard EN 50160.

Abstract In the past couple of years, the integration of electrical vehicles (EV) in the power system has been capturing the attention of many researchers, which has led to this being a frequently analysed topic in scientific papers and seminars. Some of the main parameters related to power quality that are observed, while integrating EVs, are voltage variations and voltage unbalance. The low-voltage rural network, of a small settlement located on the outskirts of Zavidovici, has been modelled for the purpose of this paper. Several cases were considered. As the first base case, an analysis was performed when there were no connected vehicles in the network, then the case with 20% penetration, 35% penetration, and 80% vehicle penetration. Practical analysis was done in DIgSILENT Power Factory software. It has been concluded that electrical vehicles cause a voltage drop in the network, while at the same time causing an increase in voltage unbalances.

The aim of the article is to present, primarily to the medical world and also the general public, the personality and work of Maša Živanović (1890–1960), a pioneer in the health care of children and mothers in Bosnia and Herzegovina (BH), a health educator and one of the leaders of the Yugoslav Women’s Rights Movement in the period between the two world wars. She was born in Croatia (then part of the Austro-Hungarian Empire) as Maria Skopszyński, in a family of Polish-Czech origin. After studying at the Temporary Women’s Lyceum in Zagreb and passing the matriculation exam at the boy’s High School (1909), she obtained the title of Doctor of Medicine in Vienna (1916). Her activity in the Women’s Rights Movement has so far generally attracted more attention from researchers than her medical work. However, this work was very important because the general and health education of women, expectant mothers and mothers, after the two World Wars was very poor in BH, and the rates of child morbidity and mortality were high. Maša Živanović spent almost her entire working life in Sarajevo. For 30 years, she was the head of the Dispensary for Mothers and the Children, later the Institute for Maternal and Child Health Care, into which the previous institution grew in 1931. She was among the first followers of the new concept of “comprehensive paediatrics”, which included social care for children, disease prevention and treatment of the sick. She successfully connected the medical mission with the mission of a women’s rights activist, also trying to act as a health educator through articles published in the Women’s Movement magazine (Ženski pokret). For a time, she was the president of the Society for the Education of Woman and Protection of her Rights, i.e. the Women’s Movement, and a delegate at conferences of international feminist organizations. Conclusion. Maša Živanović was a physician, a pioneer in the health care of children and mothers in BH, a long-time director of the Institute for Health Care of Mothers and Children in Sarajevo, and one of the leaders of the Yugoslav Women’s Rights Movement.

Safety risk management in Bosnian-Herzegovinian underground coal mines is not based on a systematic approach and standardized risk management methods. Mostly there is a traditional approach present, i.e. reaction to incidents/accidents that happen. This paper aims to point out the need for proactive approach introduction with an emphasis on importance of ventilation systems failure mechanism simulation analysis in planning of people and property defense and rescue in crisis situations. Based on ventilation parameters measuring results for a given research site (brown coal mine), a model was developed on which a simulation analysis was performed for three characteristic ventilation failure cases: spontaneous oxidation at the longwall exit, collapse at the entrance to the longwall and methane outburst - preparation of a new excavation field. VnetPC and CFD “Fluent” software packages were used to simulate mine ventilation. Keywords: risk management, brown coal mine, safety, ventilation system, longwall, simulation analysis, VnetPC, Fluent.

The ornate dog tick (Dermacentor reticulatus) shows a recently expanding geographic distribution. Knowledge on its intraspecific variability, population structure, rate of genetic diversity and divergence, including its evolution and geographic distribution, is crucial to understand its dispersal capacity. All such information would help to evaluate the potential risk of future spread of associated pathogens of medical and veterinary concern. A set of 865 D. reticulatus ticks was collected from 65 localities across 21 countries, from Portugal in the west to Kazakhstan and southern Russia in the east. Cluster analyses of 16 microsatellite loci were combined with nuclear (ITS2, 18S) and mitochondrial (12S, 16S, COI) sequence data to uncover the ticks' population structures and geographical patterns. Approximate Bayesian computation was applied to model evolutionary relationships among the found clusters. Low variability and a weak phylogenetic signal showing an east-west cline were detected both for mitochondrial and nuclear sequence markers. Microsatellite analyses revealed three genetic clusters, where the eastern and western cluster gradient was supplemented by a third, northern cluster. Alternative scenarios could explain such a tripartite population structure by independent formation of clusters in separate refugia, limited gene flow connected with isolation by distance causing a "bipolar pattern", and the northern cluster deriving from admixture between the eastern and western populations. The best supported demographic scenario of this tick species indicates that the northern cluster derived from admixture between the eastern and western populations 441 (median) to 224 (mode) generations ago, suggesting a possible link with the end of the Little Ice Age in Europe.

Simple Summary The tumor microenvironment (TME) is defined as the environment surrounding a tumor. There is a close, dynamic relation and interaction between the tumor and its neighboring microenvironment. There are some particularities of the thymus itself and of the TME of thymic epithelial tumors that hinder the routine use of targeted therapies, including immune checkpoint inhibitors. The understanding of the unique characteristics of the TME of thymic epithelial tumors could possibly result in the development of novel promising therapies. Abstract The tumor microenvironment (TME) is a complex and constantly changing entity. The TME consists of stromal cells, fibroblasts, endothelial cells, and innate and adaptive immune cells. Cancer development and progression occurs through this interplay between the tumor and the adjacent stroma. Cancer cells are capable of modifying their microenvironment by secreting various message-carrying molecules, such as cytokines, chemokines, and other factors. This action causes a reprogramming of the neighboring cells, which are enabled to play a crucial role in tumor survival and progression. The study of TME has many clinical implications in terms of cancer therapeutics because many new drugs, such as antibodies, kinase inhibitors, and liposome formulations that can encapsulate anti-cancer drugs, can be developed. Although chemotherapy is considered the standard of treatment for advanced disease, recent research has brought to light immunotherapy as a possible systemic alternative. However, the complex structure and function of the thymus hinders its routine use in clinical practice. The aim of this review paper is to discuss the recent advances in the investigation of the unique characteristics of the TME of thymic epithelial tumors that could possibly lead to the development of novel promising therapies.

This article presents a concept of a TSN Controller NetApp to support diverse vertical applications and provide Quality of Service guarantees during their life-cycle. The NetApp is composed of a Controller entity that receives and processes requests from vertical applications with specific network performance demands, and an Agent entity which applies configurations and monitors the state of network elements. This control architecture has been extended to support wireless TSN communication on top of openwifi, supporting the flexibility required by vertical applications with mobile devices such as drones and automated guided vehicles. We describe the building blocks of the TSNC NetApp supporting wired-wireless TSN deployments and show its experimental results demonstrating the feasibility of our solution.

Pathogenic germline mutations in VHL gene cause von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary cancer syndrome associated with high penetrance of benign and malignant neoplasms, including clear cell renal cell carcinoma (ccRCC), central nervous system haemangioblastomas (CNS-HB), retinal angiomas, phaeochromocytomas and pancreatic neuroendocrine tumours (pNET). Management of VHL disease involves lifelong radiological and biochemical surveillance, often leading to repeat surgical intervention causing significant morbidity and mortality. Systemic therapy that prevents or reduces the need for surgical intervention could improve clinical outcomes and quality of life for affected individuals. Belzutifan is a second-generation small molecule hypoxia-inducible factor 2α (HIF-2α) inhibitor recently approved by US and UK regulators for the treatment of VHL (disease)-associated ccRCC, CNS-HB and pNET. While this is a welcome step forward, it is vital that we consider in what circumstances these drugs are recommended and how they fit into the overall management of VHL disease. In this personal view article, we reflect on the history of the use of systemic therapy in localised VHL disease and consider open questions relating to the use of HIF-2α inhibitors, including the need to involve medical oncologists in the multidisciplinary team moving forward. Indeed, VHL disease is the perfect paradigm for similar settings in the future.

We investigate how an IRS (Intelligent Reflective Surface) deployment within a terahertz (THz) band communication system, can detect and classify indoor vapour clouds expelled in violent expiratory events, such as coughing. This detection is of interest for public health systems. Since indoor spaces are sites for deployment of wireless communication infrastructure in any case, combined sensing and communication is an attractive solution. Using 6G networks to accomplish this while not affecting communication performance, is a relevant and useful application of THz signal’s properties. We use machine learning to distinguish between violent expiratory events and other aerosol emissions.