Medicinal plants have become an increasing subject of interest worldwide due to the large amount of biologically active substances that have potential beneficial health properties. One of the more interesting popular medicinal plants is hawthorn (Crataegusspp.), a deciduous branched shrub that is increasingly used for health purposes. Various parts of this plant, including berries, flowers and leaves, are rich in nutrients and beneficial bioactive compounds that are effective in the treatment of numerous diseases. Honey is a natural sweetener produced by bees from plant secretions. Known for its nutritional and medicinal values, it gives strength to the body, which is why it is indispensable in the human diet. The combination of these two ingredients represents a significant source of vitamins and minerals in daily use, but also for use in various pharmaceutical and medical purpose. Taking into account all of the above, the aim of the work is to test samples of the mixture of honey and hawthorn in different proportions and determine the physical and chemical characteristics: pH value, electrical conductivity, refractive index, viscosity, water activity, HMF, DPPH. Based on the analysis, appropriate conclusions will be drawn and more information will be obtained about their quality and possible use as a food supplement. On the basis of the conducted analyses, it can be concluded that the parameter values are within the permitted limits defined by the Rulebook (Official Gazette Bosnia and Herzegovina No. 37/09). The analysis of the mentioned parameters showed that the chemical composition of the sample plays a major role in the value of the measurement results, and that Sample III has the best antioxidant properties. KEYWORDS:physicochemical characteristics; honey; hawthorn (Crataegus spp.);mixture; food suplement

Abstract The paper analyses the notion of anomie through various theories presented in the works of classical Greek thinkers up to today’s understanding of this notion. In this regard, the article will touch on some previous understandings of this phenomenon, and the beginnings of modern thought on anomie in the work of Jean-Marie Guyau, and the developed understandings of Robert Merton and Émil Durkheim as the two most prominent authors dealing with this topic. In addition, the attitudes of marginalized writers will be analysed, as well as neglected and underrepresented understandings in criminology and wider science. The purpose of this paper is to find common ground between all previous understandings of the theory of anomie, and to try to find a more specific meaning of the term in order to contribute to the discussion on this topic.

The samples of stinging nettle were collected during June in the Tuzla region. Aqueous extracts were prepared from fresh and dried leaves in order to determinate and compare content of bioactive components and antioxidant potential. Conventional soxhlet, ultrasound assisted extraction and traditional maceration extraction were used as extraction methods. Quantitative determination of phenols and flavonoids was carried out using spectrophotometric methods. Antioxidant activity of nettle aqueous extracts was determined using ferric reducing antioxidant power and DPPH free radical scavenging activity. Extracts obtained by Soxhlet extraction showed the highest total phenolic and flavonoid content and expected the highest antioxidant capacity, while extracts obtained by maceration gave the lowest results. KEYWORDS:stinging nettle extract;bioactive components;extraction;antioxidant

Cardiovascular events occurring in the bloodstream are responsible for about 40% of human deaths in developed countries. Motivated by this fact, we present a new global network architecture for a system for the diagnosis and treatment of cardiovascular events, focusing on problems related to pulmonary artery occlusion, i.e., situations of artery blockage by a blood clot. The proposed system is based on bio-sensors for detection of artery blockage and bio-actuators for releasing appropriate medicines, both types of devices being implanted in pulmonary arteries. The system can be used by a person leading an active life and provides bidirectional communication with medical personnel via nano-nodes circulating in the bloodstream constituting an in-body area network. We derive an analytical model for calculating the required number of nano-nodes to detect artery blockage and the probability of activating a bio-actuator. We also analyze the performance of the body area component of the system in terms of path loss and of wireless links budget. Results show that the system can diagnose a blocked artery in about 3 h and that after another 3-h medicines can be released in the exact spot of the artery occlusion, while with current medical practices the average time for diagnosis varies between 5 and 9 days.

Water is an indispensable part of beer and brewing practice, and therefore it is not even possible to imagine a process in which water quality is neglected. For the purposes of this experiment, several different watersamples were collected from available springs. The basis of the experiment was the colored reaction of iodine on starch, which would prove the hydrolysis of starch granules from grains. This leads to the conclusion that the mineral composition, which affects the hardness of the water, does not have a decisive influence on the work of amylolytic enzymes, at least not to the extent that would significantly affect the production process.

Proper selection and knowledge of varieties, processing conditions, and the use of selective yeast cultures during alcoholic fermentation have an important influence on the chemical composition of the distillate. In order to examine the influence of the plum variety on the quality of plum brandy, chemical analysis and sensory evaluation of brandies obtained from different varieties were performed. It was established that the characteristics of plum brandy depend primarily on the variety of plums. The best results were shown by brandies from the Moravka and Čačanska lepotica varieties, while the brandy sample from the Stanley variety was somewhat weaker.

Heavy metals represent a very significant group of environmental pollutants because they are potential metabolic inhibitors. Therefore, a study was conducted where the height of the wheat stem, as well as the surface of the leaves in the budding and leafing stages, were examined when contaminated with a mixture of heavy metals in concentrations of 250 and 500 ppm. The aim of the research was to determine the influence of heavy metals on the initial phenophase of wheat varieties Pobeda and Ljiljana. An experiment was carried out in volumetric flasks where two different concentrations of a mixture of heavy metals 250 ppm and 500 ppm were added under controlled conditions.

Abstract Objective: The coronavirus belongs to the family of Coronaviridae, which are not branched single-stranded RNA viruses. COVID-19 creates respiratory problems and infections ranging from mild to severe. The virus features mechanisms that serve to delay the cellular immune response. The host’s response is responsible for the pathological process that leads to tissue destruction. Temporomandibular disorders are manifested by painful jaw musculature and jaw joint areas, clicks, or creaks when opening or closing the mouth. All these symptoms can be disabling and occur during chewing and when the patient yawns or even speaks. The pandemic situation has exacerbated anxieties and amplified the vulnerability of individuals. Therefore, from this mechanism, how the COVID-19 pandemic may have increased the incidence of temporomandibular disorders is perceived. The purpose of this review is to evaluate whether COVID-19-related anxiety has caused an increase in temporomandibular dysfunction symptoms in adults to children. Methods: PubMed, Web of Science, Lilacs, and Scopus were systematically searched, until 30 July 2022, to identify studies presenting: the connection between COVID-19 with temporomandibular disorders. Results: From 198 papers, 4 studies were included. Literature studies have shown that the state of uncertainty and anxiety has led to an increase in the incidence of this type of disorder, although not all studies agree. Seventy-three studies were identified after viewing all four search engines; at the end of the screening phase, only four were considered that met the PECO, the planned inclusion, and the exclusion criteria. All studies showed a statistically significant correlation between temporomandibular disorders and COVID-19 with a p < 0.05. Conclusions: All studies agreed that there is an association between COVID-19 and increased incidence of temporomandibular disorders.

The microservices architectural style has been increasingly adopted in recent years due to its advantageous characteristics. While there exist design patterns for microservices that are theoretically beneficial for ensuring performance (and anti-patterns that should be avoided), they do not always lead to the expected impact. Some designs are solutions for achieving quality properties other than performance, and while they might be categorized as anti-patterns in theory, their influence on system performance can be minimal, depending on the context. Architects find it hard to reason about these trade-offs and the impact that design decisions will have on performance before implementing them. To solve this problem, in this paper, we propose an approach that enables rapid evaluation of high-level architectural models by combining both static and dynamic analysis. The static analysis identifies the design anti-patterns that are known to hinder system performance and guides the architect in reasoning about these design decisions. The approach then generates source code for the system under study based on the architectural design model for a subsequent dynamic analysis to assess whether the statically detected anti-patterns do indeed have a negative effect on the performance of the analyzed system.

The adoption of autonomous cars requires operational critical functions even in the event of HW faults and/or SW defects, and protection of safety-critical functions against security threats. Defining appropriate safe and secure architectures is challenging and costly. In previous work, we have proposed tools to automate the recommendation of safety and security patterns for safety-critical systems. However, safety and security measures may (negatively) influence system performance, besides introducing additional development effort. We present a design space exploration approach, a model-based engineering workflow and tool prototype for automated guidance on trade-off decisions when applying safety and security patterns on a given (unsafe) baseline architecture. Based on models that abstract the vehicle’s functionality and its software and hardware components, as well as an engine for the automated pattern recommendation, we investigate the optimization of HW/SW deployments, and provide a trade-off analysis for different architecture candidates. We implemented our approach in an open-source tool and evaluate it with a model of the Apollo autonomous driving platform.