Introduction: Tumors of spleen are generally rare disorders. The most common primary splenic neoplasm is haemangioma, although very rare. Giant, cavernous splenic haemangioma is extremely rare, less than 100 cases have been reported in the literature. Case report: We present a case of giant haemangioma in a 65 years-old patient. Radiological diagnostic methods were not conclusive. Magnetic resonance imaging showed en expansive, heterogenous lesion with signs of necrosis and haemorrhage in the central part. Those characteristics raised suspicion in malignant neoplasm, especially haemangiosarcoma and metastatic neoplasm. The surgical team performed total splenectomy, with special attention to possible bleeding as a severe complication. Pathohistological finding was undoubted. There were certain signs of benign, cavernous splenic haemangioma with areas of coagulative necrosis. Conclusion: We need to be aware of such rare entity. MRI is the most reliable diagnostic method, but the pathohistological analysis is definitive. Surgery is a treatment of choice.

Abstract Background Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has one of the lowest 5-year cancer survivals. Fifty risk-associated variants within 34 glioma genetic risk regions have been found by genome-wide association studies (GWAS) with a sex difference reported for 8q24.21 region. We conducted an Australian GWAS by glioma subtype and sex. Methods We analyzed genome-wide data from the Australian Genomics and Clinical Outcomes of Glioma (AGOG) consortium for 7 573 692 single nucleotide polymorphisms (SNPs) for 560 glioma cases and 2237 controls of European ancestry. Cases were classified as glioblastoma, non-glioblastoma, astrocytoma or oligodendroglioma. Logistic regression analysis was used to assess the associations of SNPs with glioma risk by subtype and by sex. Results We replicated the previously reported glioma risk associations in the regions of 2q33.3 C2orf80, 2q37.3 D2HGDH, 5p15.33 TERT, 7p11.2 EGFR, 8q24.21 CCDC26, 9p21.3 CDKN2BAS, 11q21 MAML2, 11q23.3 PHLDB1, 15q24.2 ETFA, 16p13.3 RHBDF1, 16p13.3 LMF1, 17p13.1 TP53, 20q13.33 RTEL, and 20q13.33 GMEB2 (P < .05). We also replicated the previously reported sex difference at 8q24.21 CCDC26 (P = .0024) with the association being nominally significant for both sexes (P < .05). Conclusions Our study supports a stronger female risk association for the region 8q24.21 CCDC26 and highlights the importance of analyzing glioma GWAS by sex. A better understanding of sex differences could provide biological insight into the cause of glioma with implications for prevention, risk prediction and treatment.

Introduction: In Australia and New Zealand, liver allocation is needs based (based on model for end-stage liver disease score). An alternative allocation system is a transplant benefit-based model. Transplant benefit is quantified by complex waitlist and transplant survival prediction models. Research Questions: To validate the UK transplant benefit score in an Australia and New Zealand population. Design: This study analyzed data on listings and transplants for chronic liver disease between 2009 and 2018, using the Australia and New Zealand Liver and Intestinal Transplant Registry. Excluded were variant syndromes, hepatocellular cancer, urgent listings, pediatric, living donor, and multi-organ listings and transplants. UK transplant benefit waitlist and transplant benefit score were calculated for listings and transplants, respectively. Outcomes were time to waitlist death and time to transplant failure. Calibration and discrimination were assessed with Kaplan–Meier analysis and C-statistics. Results: There were differences in the UK and Australia and New Zealand listing, transplant, and donor populations including older recipient age, higher recipient and donor body mass index, and higher incidence of hepatitis C in the Australia and New Zealand population. Waitlist scores were calculated for 2241 patients and transplant scores were calculated for 1755 patients. The waitlist model C-statistic at 5 years was 0.70 and the transplant model C-statistic was 0.56, with poor calibration of both models. Conclusion: The UK transplant benefit score model performed poorly, suggesting that UK benefit-based allocation would not improve overall outcomes in Australia and New Zealand. Generalizability of survival prediction models was limited by differences in transplant populations and practices.

The aim of this study is to investigate the determinants of Germany's OFDI in the last 21 years on the set of top ten Germany’s OFDI destination (United States of America, United Kingdom, China, France, Poland, Mexico, India, Turkey, Spain and Russia (Russian Federation)) by using panel data analysis. The research revealed that Germany’s OFDI are driven by market seeking motives (FDI vertical), and also highlighting the importance of the stable political environment, attractive tax environment, more trade openness, and stable macroeconomic environment of the top ten Germany’s partners for attractiveness of the Germany’s OFDI. It indicates that openness of an economy is statistically significant in attracting FDI.

In Serbia, primary education is compulsory, and it lasts eight years with two educational cycles, while in the Czech Republic, primary education lasts nine years with three cycles. Analysis of the teachers` attitudes toward primary education in Serbia and the Czech Republic has a goal to determine the current educational state in the two countries. Also, in this research it has been shown if there are similarities, as well as differences between the two educational systems. Views of the teachers on this topic are significant for this paper, so the survey was used as an instrument. The survey should have revealed whether the primary education was in line with the need of modernization and enhancement of young peple’s intellectual potential. It was necessary to reveal if the education in the two countries is in accordance with the modern world and whether the teachers agree with this. One of the aims of the research was to determine whether there are statistically significant differences in the teachers’ answers and to relate those differences to the general educational situation in Serbia and Czechia.

Objective: During the COVID-19 pandemic, fear, anxiety, and depression have become global concerns among the wider public. This study aimed to examine the occurrence of fear, anxiety and depressive symptoms associated with COVID-19, to assess influencing factors that lead to the development of these mental health conditions and to examine any changes in the mental health patterns of the society since the initial study a year ago in Sarajevo, Bosnia and Herzegovina. Method : An anonymous online survey based on Fear of COVID-19 Scale (FCV-19S), General Anxiety Disorder-7 (GAD-7) and Patients Health Questionnaires (PHQs) was conducted in the general population of Sarajevo in Bosnia and Herzegovina. Results: From 1096 subjects, 81.3% were females, 33.8% had a high school degree, 56.4% were married, 53.4% were engaged in intellectual labor, 42.3% experienced fear, 72.9% had anxiety symptoms and 70.3% had depressive symptoms during the COVID-19 pandemic and their mean age was 35.84 ± 10.86. Half (50.1%) of the subjects were COVID-19 positive and 63.8% had COVID-19 symptoms when responding to the questionnaire. Experiencing COVID-19 related fear (OR = 1.972) and having moderate to severe depressive symptoms (OR = 9.514) were associated with the development of mild to severe anxiety symptoms during the COVID-19 pandemic, which were in turn associated with the development of moderate to severe depressive symptoms (OR = 10.203) and COVID-19 related fear (OR = 2.140), respectively, thus creating a potential circulus vicious. COVID-19 positive subjects (OR = 1.454) were also more likely to develop mild to severe anxiety symptoms during the COVID-19 pandemic. Conclusion: In conclusion, the prevalence of fear, anxiety symptoms and depressive symptoms rose dramatically since the beginning of the COVID-19 pandemic in Bosnia and Herzegovina. They were interconnected and were significantly associated with age, gender, marital status and COVID-19 status. Therefore, an urgent mental health intervention is needed for the prevention of mental health problems.

The development of a bimetallic catalyst for a given reaction requires not only the selection of the appropriate metals M1 and M2 but also the control as far as possible of the distribution of the two metals together and at the support surface in the case of supported catalysts. Preparation methods using redox reactions specifically enable the deposition of a second metal M2 at the surface of monometallic M1 nanoparticles, leading in most cases to core‐shell nanoparticles with strong metal‐metal interactions. Various methods are possible depending on the electrochemical potentials of the species involved: either a direct redox reaction, also named galvanic replacement, or the reduction of an intermediate reducing agent activated at the surface of M1. In this minireview, the fundamental bases of the preparation of bimetallic catalysts by both types of redox reactions and the recent advances in that domain are described.

One of the goals of research in the field of psychotherapy is to improve knowledge about processes and outcomes of psychotherapeutic treatments. Researchers and professionals have been discussing the best methods for evaluating the effectiveness and efficiency of psychotherapeutic treatments for many years. This paper aims to give an overview of the specifics of quantitative and qualitative research methods, by noting the advantages and disadvantages of these methods in the evaluation of psychotherapeutic treatments. Within the quantitative scientific research, three approaches are described: randomized controlled research, mood enhancement by psychoanalytic and cognitive therapies, and meta-analysis. The most common collection methods (observation, interview, other verbal techniques and visual approaches to data collection) and data analysis (comprehensive process analysis, consensual qualitative research and grounded theory) are described within a qualitative scientific methodology. Finally, an approach related to integration of qualitative and quantitative methodology, as well as this related with application of case studies in the evaluation of psychotherapeutic treatments are described. Scientists and professionals in the field of social sciences should use both quantitative and qualitative research methods, separately or in combination, depending on the goal and problems of the research.

Rare b hadron decays are considered excellent probes of new semileptonic four-fermion interactions of microscopic origin. However, the same interactions also correct the high-mass Drell-Yan tails. In this work, we revisit the first statement in the context of this complementarity and chart the space of short-distance new physics that could show up in rare b decays. We analyze the latest b → qℓ ^+ ℓ ^ − measurements, where q = d or s and ℓ = e or μ , including the most recent LHCb R K ∗ $$ {R}_{K^{\left(\ast \right)}} $$ update, together with the latest charged and neutral current high-mass Drell-Yan data, pp → ℓν and pp → ℓ ^+ ℓ ^ − . We implement a sophisticated interpretation pipeline within the flavio framework, allowing us to investigate the multidimensional SMEFT parameter space thoroughly and efficiently. To showcase the new functionalities of flavio, we construct several explicit models featuring either a Z ′ or a leptoquark, which can explain the tension in b → sμ ^+ μ ^ − angular distributions and branching fractions while predicting lepton flavor universality (LFU) ratios to be SM-like, R K ∗ ≈ R K ∗ SM $$ {R}_{K^{\left(\ast \right)}}\approx {R}_{K^{\left(\ast \right)}}^{\textrm{SM}} $$ , as indicated by the recent data. Those models are then confronted against the global likelihood, including the high-mass Drell-Yan, either finding tensions or compatibility.

When migrating to Industry 4.0, organizations face the need to adapt to a new context characterized by high levels of uncertainty and complexity. The main driving force in this process are the meta-competencies that ensure high competitiveness and innovativeness. However, their content, classification levels, intersections, and development potential under the influence of digitalization are insufficiently covered by the literature. This article attempts to fill this gap by analyzing the impact of new technologies on meta-competences. It presents a conceptual model based on the assumption that the degree of digitalization enhances the effects of the interaction between the top-level meta-competencies - Foresight, strategic flexibility, and ambidextrousness. Additional factors, the inclusion of which in the model will allow for a better study of the nature of the relationship under consideration, are proposed.

To improve our understanding of the molecular mechanisms underlaying seed priming, RNA transcriptome analysis was performed using primed and non-primed seeds of Silene sendtneri. Seed priming was performed by submergence in 1% silicic acid for 24h at 4°C, followed by rinsing with sterilised water and desiccation to original moisture content. Silene sendtneri is a species with no sequenced genome and annotation of de novo assembly of transcriptome was done against several species. Gene ontology (GO) analysis indicated that genes related to heavy metal transporters and heat shock proteins are differentially expressed after priming with silicic acid. Within these gene categories, genes such as heavy metal-associated isoprenylated plant protein 26-like (log2fold -8.79) were downregulated, while others such as heavy metal ATPase 5 (log2fold 6.46), heat shock factor protein HSF30-like isoform X1 (log2fold 5.98) were upregulated.

This paper analyzes the most important trends in the manifestation of terrorism inspired by radical Islamic discourse since its appearance in the Middle East and North Africa in the 1980s until the present day. Considering the very specific historical context of this region, an insight into it was unavoidable, in an attempt to identify the key factors that favored the emergence of this type of terrorism, as well as its gradual affirmation in regional and international frameworks. The trends in the manifestation of terrorism inspired by radical Islamic discourse are viewed in this paper through two main time periods. The first covers the period from 1980. to 2000, when this type of terrorism began to appear in the countries of the MENA region, with gradual regional affirmation and expressed ambitions to extend the radius of activity of the newly formed radical Islamist organization to the international level. The second period commenced after the brutal terrorist attacks on American targets on September 11, 2001 and the declaration of war on terrorism, which, based on the indicators presented in this paper, inaugurated the era of progressive and extremely worrying rise of terrorism inspired by radical Islamic discourse, especially from the moment the entry of the Islamic State of Iraq and the Levant (ISIL) onto the international stage in mid-June 2014.

The concept of radicalization is very actual and presents an attempt to gain a deeper understanding of the contemporary terrorism. Our knowledge of the factors that lead to radicalization and shape the mind of  the prospective terrorists is an important analytical tool for practical policy in terms of proactive work and development of strategies for terrorism prevention. The problem arises in the attempt of its conceptual determination of the radicalization and violent extremism. The concept of  radicalization is focused on the individual and, to a certain extent, on ideology and the group, while structural factors and efforts to address the causes of the phenomenon remain outside the epistemological range. In this paper author(s) use case study method as an empirical study of the social phenomenon of radicalism, extremism and violent extremism leading to terrorism and its impact on the subcultural behaviors of radical communities, the security situation where the boundary between the real phenomenon and the real life context are explored. In this paper, case study resewargh method will brighten radical and extremist movements that are deeply rooted in Bosnian society, their connection with the countries of the region and the processing of empirical data on various forms of discrimination and Islamophobia will be discussed. The problem of this research is the impact of radicalism and extremism on the security situation in Bosnia and Herzegovina and the current security position of  Bosnia and Herzegovina vis-à-vis its neighbors with social focus and the importance of the restructuring a conceptualization of radicalism, extremism and violent extremism leading to terrorism, destruction, human casualties and high media coverage of such acts. Period of terrosim implicatication on Bosnia covering 2010-2020. Results will precise essential weakness of the concept(s) of prevention in fight against violent etremism in addition to other methodological uncertainties addressed in this paper. The paper seeks to examine the leading positions in scientifc literature and critically review the epistemological and practical value of the concept of radicalization that leads to terrorism. From theoretical  perspective this concept lacks solid grounding base and should be subject of critical rethinking. The establishment of effective mechanisms for deradicalization is one of the vital programs that Bosnia and Herzegovina will have to recognize and implement, especially through work with young people, which will involve various social actors, all in order to spread tolerance and equality in order to achieve greater degree in the creation of a free democratic society.

For a manifold $M$ and an integer $r>1$, the space of $r$-immersions of $M$ in $\mathbb {R}^n$ is defined to be the space of immersions of $M$ in $\mathbb {R}^n$ such that the preimage of every point in $\mathbb {R}^n$ contains fewer than $r$ points. We consider the space of $r$-immersions when $M$ is a disjoint union of $k$ $m$-dimensional discs, and prove that it is equivalent to the product of the $r$-configuration space of $k$ points in $\mathbb {R}^n$ and the $k^{\text {th}}$ power of the space of injective linear maps from $\mathbb {R}^m$ to $\mathbb {R}^n$. This result is needed in order to apply Michael Weiss's manifold calculus to the study of $r$-immersions. The analogous statement for spaces of embeddings is “well-known”, but a detailed proof is hard to find in the literature, and the existing proofs seem to use the isotopy extension theorem, if only as a matter of convenience. Isotopy extension does not hold for $r$-immersions, so we spell out the details of a proof that avoids using it, and applies to spaces of $r$-immersions.