The passenger transport system in cities is the backbone of sustainable urban mobility. The problem faced by the city authorities is the question of choosing the carrier with the best bid in the public call. Services in charge of public transport are often able to choose carriers for one or more lines, and often for the entire area. The basic dilemmas are related to the type of procedure that should be carried out, whether the transport services market is open to competition, what methodology to apply if the transport services market is not declared open to competition, whether the selection procedure should end with the signing of the contract between the city government and the operator, and other questions for which answers are sought.This paper presents an analysis of practices and proposed guidelines for the development and application of the bid operator ranking model in the public selection process.
: This paper presents the influence of complex engineering geological and geotechnical ground conditions on the selection of combined measures for the rehabilitation of landslide on the main road M5. Field and laboratory investigations were conducted to determine the engineering geological and geotechnical conditions of the site. The road is situated on a relatively high embankment within the landslide area, under which a culvert channels a natural stream. The geological substrate is found quite deep, 7 to 8 meters below the surface. Beneath the road, there is a mixture of fill materials of different qualities, indicating that a railway used to run along this route in the past. The slope below the road is relatively steep, approximately 10 meters in height, with a poorly maintained stone wall at its base. The fundamental concept of the proposed solution involves the construction of a support structure comprising piles, a head beam, and a reinforced concrete wall. The designed rehabilitation measures ensure the stability and functionality of the roadway.
Because the spectrum of services available in modern telecommunication networks is constantly expanding, security has become increasingly important. Simultaneously, in an era of constant progress in mathematics and computing, the security of existing cryptographic solutions becomes questionable. Quantum Key Distribution (QKD) is a promising secret key agreement primitive that enables long-awaited practical Information-Theoretical Secure (ITS) communications. The key generation rate, however, is one of the limitations of its widespread application to secure high throughput data flows. This paper addresses the aforementioned limitation by employing perfectly correlated bases selection defined by the output of Pseudo-Random Functions based on the keyed-Hash Message Authentication Code construction. In theory, the proposed variant of the BB84 scheme is ITS, reduces memory requirements, and reduces communication overhead during the post-processing stage. It can benefit QKD networks as a service by increasing capacity and accommodating users with varying security needs.
Key Points Question Can multiple sclerosis (MS) be differentiated from a wide range of non-MS conditions showing brain white matter lesions using solely imaging biomarkers for cortical lesions (CLs) and central vein sign (CVS)? Findings In this cross-sectional study including 1051 participants, the presence of CLs had high specificity and low sensitivity, while application of the 40% CVS rule resulted in high specificity and moderate sensitivity for MS diagnosis. CVS and CLs outperformed the contribution of infratentorial, periventricular, and juxtacortical lesions in supporting the diagnosis of MS. Meaning The findings indicate that CVS and CLs may be valuable tools to increase the accuracy of MS diagnosis.
Purpose Explaining the sources of the differences in social performance among Islamic banks (IBs) is the motivation for this research. Consequently, the purpose of this paper is to investigate the relationship between the development of Islamic finance regulation, the development of an Islamic financial system, the proportions of affected Muslim populations and the level of competition, on the one hand, and the social performance of IBs, on the other. To the best of the authors' knowledge, this is the first study that investigates the impact of the development of regulation and the Islamic financial system on the social performance of IBs. Design/methodology/approach A balanced panel of annual data for 40 banks from 13 countries is applied, spanning 2012–2018. A social performance index with eight dimensions is constructed and measures the social performance of IBs. The index based on qualitative and quantitative data derives from IBs’ annual reports and financial statements. The linear scaling transformation method articulates the quantitative dimensions of the index. In hypotheses testing, the authors use OLS, LSDV, FEM and Random Effect Model to estimate Model (1) and panel-corrected standard errors with Prais–Winsten transformation to estimate Model (2). Findings This unique research confirms the positive impact of the development of Islamic finance regulation on the social performance of IBs. The results show that the development of Islamic finance regulation is consistently significant on all standard significance levels. IBs’ age and the presence of Muslim populations in the country are also significant in most estimators. Research limitations/implications The results of this research highlight a significant value for regulators, shareholders and the management of IBs. Without proper regulation, these banks can hardly operate under the principles and expectations of the Islamic moral economy. Originality/value This is pioneering research that explores the development of Islamic finance regulation and market concentration as a determinant of social performance of IBs. Development of Islamic finance regulation has proved significant in all estimated models, which confirms that a new variable has been discovered among determinants of the social performance of IBs.
Abstract Introduction The main advantage of extraperitoneal cesarean section (EXPCS) is not only less pain, faster recovery, and less potential for infection but also a possible lack of intraperitoneal adhesions. Methods In a 3-year period from 2019 to 2022, 88 EXPCSs were performed. A comparison was made with 90 patients who underwent a standard transperitoneal cesarean section (TPCS). For both groups, the inclusion criterion was uterine inertia and prolonged labor as an indication for cesarean section. Only pregnant women from 37 to 42 weeks were included. After this, 51 patients remained in the EXPCS arm, and 49 remained in the TPCS arm. Results No statistical difference was found in gestational weeks, newborn weight, Apgar score, erythrocyte (Er), hemoglobin (Hgb), and hematocrit (Htc) values and duration of operative time between the EXPCS and TPCS groups. Leukocytes, C-reactive protein (CRP) with fever higher than >38°C on the third postoperative day were found statistically significantly (p=0.005) higher in the TPCS group. The usage of tramadol + metamizole at 3, 6, and 9 hours after delivery and diclofenac at 6, 12, and 18 hours after surgery was statistically significantly (p<0.05) higher in the TPCS group. On the visual analog scale (VAS) 24 hours after surgery, a statistically significant difference was found (p = 0.001) between the two groups. In the small group of patients who underwent a TPCS section after an EXPCS, intraperitoneal adhesions were not found; in another group of patients who underwent a TPCS twice, adhesions were found in 12 patients; Fisher's exact test (p=0.04). Conclusion The protective effect of EXPCS for infection could be proven in prolonged delivery. EXPCS could be a good solution in the fight against adhesions and infection in women who undergo second, third, or even fourth cesarean sections.
The aim of this paper is to identify the basic characteristics of organic production in the agricultural sector of Bosnia and Herzegovina in terms of determining the scope, trends and flows in the selected time period. In terms of competitiveness, special emphasis is placed on the position of Bosnia and Herzegovina in the region. That is, a comparative review with the countries of the region according to the available indicators of organic production within the data of the Research Institute for Organic Production (FiBL). The analysis is focused on the changes of relevant indicators for Bosnia and Herzegovina and the countries of the region in the period from 2010 to 2020. The analysis was made using methods of dynamic analysis (index numbers, average annual rate of change, trend) and comparison methods. The results of the research can be a starting point for policy makers in support of the development of the agricultural sector.
Adherence is a a term that has been prominently used and emphasized recently, representing the connection between a patient and their treatment. Medical adherence has its hierarchical structure, with roots primarily stemming from legislative bodies to the healthcare system, institutions and ultimately healthcare professionals (doctors, nurses, technicians). However, medical adherence faces a significant obstacle in achieving therapy goals and improving treatment outcomes among many patients, especially those with chronic conditions. Social and sociental conditions, as well as the state organization in Bosnia and Herzegovina (BiH), greatly influence the healthcare system and the purchasing power of healthcare service users. Due to significant barriers and challenges regarding adherence, efforts are being made to maintain a system that supports increasing patient adherence levels. Within this research paper, three questionable theses are presented: internal and external education, improvement of the healthcare system and the implementation of systematic data collection on patient adherence. All three questionable thesis recived positive feedback from respondents (200 participants). From the first thesis, 154 respondents voted in favor, for the second thesis, 142 respondents and for the third thesis, 134 respondents agreed with the proposed suggestions. Unfortunately, in BiH insufficinet attention is given to patient adherence and there is no unified strategy to increase adherence levels. Internal and external education would be essential as healthcare workers are not adequately trained, nor are conditions created for its implementation. Increasing the level of adherence can greatly benefit healthcare workers in their daily practice if they have adequate conditions in place. Unfortunately, a significant number of healthcare employees lack the knowledge, experience and a clearly defined strategy on how to increase patient adherence. The complexity of measuring adherence only adds to the intricacy of an already complex problem and the inefficiency and sluggishness of the healthcare system hinder the creation of appropriate activities that should result in increased patient adherence. The patient’s adhrence is influenced by numerous factors for which there is no unique solution or overcoming suggestions. Also, problems in the process of identifying and measuring adherence further complicate the already complex matter and the process of increasing user adherence. Creating a strategy to improve adhrence at the state level in Bosnia and Herzegovina is almost impossible; therefore, the increase in adhrence can only be achived at the level of the patient, healthcare personnel and ideally, at the level of healthcare institutions. Unfortunately, in most cases, conditions and workload do not allow healthcare workers to spend enough time with patients, establish adequate communication and demonstrate that the patient is genuinely important to them. Providing not only the necessary care but also essential information about the illness and treatment can directly impact the level of patient adhrence. The healthcare system in developed countries, although technologically possible, lacks and adequate mechanism for collecting, processing and analyzing data related to the adherence level of patients with a specific condition or in a particular geographic region. Data is often collected based on indirect methods that do not provide accurate and precise information, posing a significant challenge in proving the role and importance of medical adhrence in the healthcare system and treatment outcomes. Considering that the adhrence level ranges from 43% to 78%, which is too high for certain treatment regimens, legislative reforms are needed. In addition to the law and its govering body, it is necssary to ensure all essential materials, from medications to specific medical supplies are provided to all healthcare institutions, hospitals and healthcare centres. Both internal and external education are crucial for patient treatment and therefore it sholud be implemented and carried out on a monthly basis. In addition to healthcare professionals, the education of patients with medical conditions is essential, considering they can be divided into those who are not familiar with using modern technologies to educate themselves and understand the role and significance of medical adherence. Moreover, there are patients who are adept at using modern tchnology to research their condition and treatment options, but they lack sufficinet knowledge and information to assess the accuracy of the available data.
Modern technologies enable the presentation of diverse movable and immovable cultural heritage objects in a digital environment in new and creative ways, which at the international level has resulted in the development of numerous and diverse digital collections created by information and other institutions. Since the visibility of such collections in the virtual environment depends on the wealth of metadata assigned to the sources in the collections, as expected, these initiatives were accompanied by development in the metadata domain. In this regard, and considering that the role of metadata in the presentation of turbe as very specific objects of the immovable cultural heritage of Bosnia and Herzegovina in the online environment has not been examined so far, the goal of this research is to identify which metadata standards or their combinations can be used for the description of turbe in Omeka Classic environment, and consequently to create a collection of the selected corpus of turbe, available in open access, whereby the corpus of research refers to turbe (türbe/tomb) that are named as national monuments in Federation of Bosnia and Herzegovina. The results of the research indicate that within the workspace of the Omeka Classic web publishing platform by using the predefined Dublin Core and VRA Core metadata fields in combination, the basic needs of corpus description can be met in a clear, uniform, and informative way, but in this regard, indications of the future development of the collection in the context of its semantic enrichment are also provided.
INTRODUCTION Peritoneal dialysis and hemodialysis are complementary ways of treating end-stage renal failure. Changing the dialysis modality from hemodialysis to peritoneal dialysis is a rare and poorly studied phenomenon. MATERIALS AND METHODS Retrospective cohort study conducted on the population of adult patients with end-stage chronic renal failure who were treated at the Nephrology Clinic of the Clinical Center of the University of Sarajevo in the period from 2006 to 2023. A total of 109 adult patients, whose medical documentation was complete and who were in the peritoneal dialysis program at the Nephrology Clinic of the Clinical Center of the University of Sarajevo during the observed period, were included in this study. One group started the treatment with peritoneal dialysis, and the other with hemodialysis. Demographic data were collected for each patient: age, gender, underlying kidney disease, comorbidities (heart disease and diabetes), duration of treatment modality, data on modality change, complications and treatment outcomes. Data from physical and electronic patient histories were used. RESULTS Total of 109 adult patients were included in this study. They are divided into two groups. Group 1 (n=99) in which peritoneal dialysis was the first treatment modality and Group 2 (n=10) in which haemodialysis was the first treatment modality, but in which patients, after a certain time, were transferred to peritoneal dialysis. The median age of patients in Group 1 was 60 (-/-14.07) years and 54 (-/+12.23) years for Group 2. Within Group 1 the most common cause of terminal renal failure was diabetic nephropathy (n=40, 40.4%) and nephroangiosclerosis (n=24, 24.24%). The mean age of onset of peritoneal dialysis was 60 (-/-14.07) years, while the mean age of cessation of peritoneal dialysis was 63 (±13.69) years. The average duration of peritoneal dialysis treatment was 38.36(±34.14) months. During the stay at peritoneal dialysis, death was recorded in 63 patients (62.38%). The number of patients who replaced peritoneal dialysis treatment with hemodialysis was 26. The most common reason for switching to haemodialysis was insufficiency of peritoneal dialysis (n=13, 14%). After switching to haemodialysis, the average length of staying on it was 10.22 months. The reason for discontinuation of haemodialysis was death (n=17, ) or transplantation (n=1, 3.7%). Kaplan-Meier test shown worse outcome in patients with haemodialyis first than peritoneal dialysis first. CONCLUSION Changing the dialysis modality carries with it a high risk of mortality, especially in the first month. Changing the way of active treatment with dialysis speaks in favor of severe comorbidities.
The paper consists of two, methodological and analytical, separate parts, which share the character and work of Aleksa Šantić. The first part tries, through an overview of critical valorisation, to literary critically understand the entire poetic creation of Aleksa Šantić, posing the fundamental research question of why Šantić is considered a great poet, even though his poetry, taken as a whole, viewed from an aesthetic perspective, cannot be qualified as “great”. Above all, based on the insight of criticism into the consideration of the aesthetic value of Šantić’s poetry and the conclusions derived from the comparison of already existing and own reflections, the above question is answered with the hypothesis that Šantić’s “mythical” greatness is the result of the “ordinariness” of his poetry and the ability to give that “ordinariness” a sublime sense of the “topos” of spiritual preoccupation, on the semantic level, and on the syntactic level, expressed in a simple style and phrases close to the cognitive needs of the peoples’ consciousness. The second part of the paper presents a documentary-historical and archival-library contribution to the research of the character and works of Aleksa Šantić, and appears as a separate review of the legacy of manuscript material kept by the National and University Library of Bosnia and Herzegovina within the Department of Special Collections. The legacy consists of letters, correspondence, photographs, letter cards, and postcards. These biographical and historical documents serve as a source for a factual introduction to a part of Šantić’s life and activities. The work is the result of research conducted on the basis of the project “Unification of materials on the cultural and historical heritage of Aleksa Šantić” financed by the Federal Ministry of Education and Science.
<p>S obzirom na značajni utjecaj Rimskog statuta iz 1998. na način na koji<br />Krivični zakon Bosne i Hercegovine definira krivična djela protiv čovječnosti,<br />ratne zločine i zločin genocida, u ovom radu će se razmatrati pravni pojmovi<br />seksualnog nasilja u svojim različitim vrstama pojava, među kojima silovanje,<br />prisilna trudnoća, seksualno ropstvo, prisilna prostitucija i prisilna sterilizacija.<br />Vremenskim i prostornim fokusom na međunarodni oružani sukob u Bosni i<br />Hercegovini, navedeni će oblici seksualnog nasilja biti kontekstualizirani kako<br />bi se istovremeno identificirale i dodatne implikacije na pravnoj ravni, no i na<br />posebne kategorije žrtava koje su nepotpuno ili samo djelomično priznate. Ispitati<br />će se poveznica između statuta međunarodnih sudova i tribunala, na jednoj strani,<br />i posljedičnog bosanskohercegovačkog tumačenja u teoriji i praksi navedenih<br />međunarodnih zločina. Teoretski prostor ogleda se u hronološkome identificiranju<br />razvojnih etapa u izgrađivanju današnjih pravnih koncepcija, odnosno jedna<br />analiza bit će načinjena na više nivoa: ispitat će se lokalne koncepcije naspram<br />međunarodnih, te naknadno na zasebnim nivoima Suda Bosne i Hercegovine,<br />Međunarodnoga krivičnoga tribunala za bivšu Jugoslaviju i ostalih sudova i<br />tribunala. Korištenjem komparativnih i kategorizacijskih zaključaka iz prije<br />navedene sekcije, problematizirat će se i pitanja poput sudskoga tumačenja<br />spolnoga aspekta u pogledu analiziranih slučajeva, kao i svakodnevnih posljedica<br />žrtava pojedinih kategorija. Iako se rad dominantno fokusira na pravnu dimenziju<br />seksualnog nasilja u oružanom sukobu, istovremeno se nudi i analiza s aspekta<br />tranzicijske pravde u Bosni i Hercegovini, odnosno, problematizira se primjena<br />reparacija žrtava kao mehanizma tranzicijske pravde.</p>
Nonlinear optics lies at the heart of classical and quantum light generation. The invention of periodic poling revolutionized nonlinear optics and its commercial applications by enabling robust quasi-phase-matching in crystals such as lithium niobate. However, reaching useful frequency conversion efficiencies requires macroscopic dimensions, limiting further technology development and integration. Here we realize a periodically poled van der Waals semiconductor (3R-MoS2). Owing to its large nonlinearity, we achieve a macroscopic frequency conversion efficiency of 0.03% at the relevant telecom wavelength over a microscopic thickness of 3.4 μm (that is, 3 poling periods), 10–100× thinner than current systems with similar performances. Due to intrinsic cavity effects, the thickness-dependent quasi-phase-matched second harmonic signal surpasses the usual quadratic enhancement by 50%. Further, we report the broadband generation of photon pairs at telecom wavelength via quasi-phase-matched spontaneous parametric down-conversion, showing a maximum coincidence-to-accidental ratio of 638 ± 75. This work opens the new and unexplored field of phase-matched nonlinear optics with microscopic van der Waals crystals, unlocking applications that require simple, ultra-compact technologies such as on-chip entangled photon-pair sources for integrated quantum circuitry and sensing. Researchers created a periodically poled van der Waals semiconductor (3R-MoS2) and achieved a macroscopic frequency conversion efficiency of 0.03% over a thickness of 3.4 μm. The quasi-phase-matched second harmonic signal surpasses the usual quadratic enhancement by 50% and broadband generation of photon pairs at telecom wavelength is demonstrated with a coincidence-to-accidental ratio of 638 ± 75.
In this study, a case of plasmacytoma with widespread metastasis in a nine-year-old male Rottweiler dog was described by histopathological and immunohistochemical methods. Macroscopic examination revealed multifocal white or pink-red colored masses ranging in size from 0,5 to 3 cm in the lung, liver, mediastinal and mesenterial lymph nodes, spleen, heart, pancreas, intestine and kidneys. In microscopic examination, tumor foci consisting mostly of atypical plasma cells were observed in the lung, liver, spleen, pancreas, mediastinal and mesenteric lymph nodes, intestine, and kidneys. Tumor-type giant cells were observed in tumor foci in the lung, mitotic figures in tumor foci in other organs, including the lung, and abundant tumor cells in capillary vessels. In Methyl Green Pyronin staining of lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidney sections, the cytoplasm of plasma cells was observed to be stained pink. Congo Red staining applied to liver and spleen sections showed amyloid deposits stained in brick red color. In addition, in the immunohistochemical staining of lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidney sections with Proliferating Cell Nuclear Antigen (PCNA) antibody, severe immunoreactivity was detected in tumor cells. As a result, due to the presence of rarely reported widespread metastases in the lung, liver, spleen, pancreas, mediastinal and mesenterial lymph nodes, intestine and kidneys of the diagnosed plasmacytoma case, it was deemed appropriate to publish the case in order to contribute to the literature by attracting the attention of veterinarians.
Glucagon like peptide-1 (GLP-1) receptor agonists are well established drugs for the treatment of type 2 diabetes (T2D). In addition to glycemic control, GLP-1 receptor agonists have beneficial other effects. They act by binding to GLP-1 receptors, which are widely distributed in the body, including cardiomyocytes and blood vessels. The aim of this article is to provide a comprehensive review of GLP-1 receptor agonists impact on cardiovascular outcomes and risk reduction. In the last decade, several cardiovascular outcomes trials (CVOT) have been conducted in order to explore cardiovascular benefit of GLP-1 receptor agonists. CVOTs primarily proved cardiovascular safety and tolerability of different GLP-1 receptor agonists, but also showed cardiovascular benefit of specific drugs. CVOTs have shown that GLP-1 receptor agonists reduce MACE in patients with T2D compared to placebo. In addition, they have positive impact on several cardiovascular risk factors such as obesity by promoting weight loss, blood pressure and blood lipid levels. Also, they stimulate the endothelium to produce nitric oxide, reduce oxidative stress, and have antiatherogenic and antiinflammatory effects. Studies have shown their positive impact on kidney outcomes in patients with T2D compared to placebo. The results of previous trials are encouraging in terms of multiple positive effects of GLP-1 receptor agonists. However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice.
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