Background A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein N-glycome is implicated in both lipid metabolism and T2DM risk. Hence, we first investigate the relationship between the N-glycome and postprandial metabolism and then explore the mediatory role of the plasma N-glycome in the relationship between postprandial lipaemia and T2DM. Methods We included 995 individuals from the ZOE-PREDICT 1 study with plasma N-glycans measured by ultra-performance liquid chromatography at fasting and triglyceride, insulin, and glucose levels measured at fasting and following a mixed-meal challenge. Linear mixed models were used to investigate the associations between plasma protein N-glycosylation and metabolic response (fasting, postprandial ( C _max), or change from fasting). A mediation analysis was used to further explore the relationship of the N-glycome in the prediabetes (HbA1c = 39–47 mmol/mol (5.7–6.5%))–postprandial lipaemia association. Results We identified 36 out of 55 glycans significantly associated with postprandial triglycerides ( C _max β ranging from -0.28 for low-branched glycans to 0.30 for GP26) after adjusting for covariates and multiple testing ( p _adjusted < 0.05). N-glycome composition explained 12.6% of the variance in postprandial triglycerides not already explained by traditional risk factors. Twenty-seven glycans were also associated with postprandial glucose and 12 with postprandial insulin. Additionally, 3 of the postprandial triglyceride–associated glycans (GP9, GP11, and GP32) also correlate with prediabetes and partially mediate the relationship between prediabetes and postprandial triglycerides. Conclusions This study provides a comprehensive overview of the interconnections between plasma protein N-glycosylation and postprandial responses, demonstrating the incremental predictive benefit of N-glycans. We also suggest a considerable proportion of the effect of prediabetes on postprandial triglycerides is mediated by some plasma N-glycans.

The rise in artificial intelligence (AI) and machine learning (ML) in cryptocurrency trading has precipitated complex ethical considerations, demanding a thorough exploration of responsible regulatory approaches. This research expands upon this need by employing a consequentialist theoretical framework, emphasizing the outcomes of AI and ML’s deployment within the sector and its effects on stakeholders. Drawing on critical case studies, such as SBF and FTX, and conducting an extensive review of relevant literature, this study explores the ethical implications of AI and ML in the context of cryptocurrency trading. It investigates the necessity for novel regulatory methods that address the unique characteristics of digital assets alongside existing legalities, such as those about fraud and insider trading. The author proposes a typology framework for AI and ML trading by comparing consequentialism to other ethical theories applicable to AI and ML use in cryptocurrency trading. By applying a consequentialist lens, this study underscores the significance of balancing AI and ML’s transformative potential with ethical considerations to ensure market integrity, investor protection, and overall well-being in cryptocurrency trading.

The cyclic voltammogram recorded in the potential range between 0 V and 800 mV with scan rate of 100 mV s −1 was used to determine the measure of antioxidants content (antioxidant capacity) present in Sambucus nigra L. extract. The antioxidant capacity of the extract was 4.06 mg GAE g −1 fw (mg of gallic acid equivalents per gram of fresh weight of the extract). The corrosion inhibition efficiency of Sambucus nigra L. extract on aluminium, copper, and bronze in 3 % NaCl solution was studied by potentiodynamic polarization and electrochemical impedance spectroscopy. Polarization data showed that extract acted as a mixed-type inhibitor, that the corrosion inhibition process was spontaneous physical adsorption (Δ G ≈ –16 kJ mol –1 ) of the extract molecules on metals surfaces and followed Freundlich isotherm. Impedance spectroscopy studies revealed that increasing the concentration of extract reduced the double-layer capacitance and increased the charge transfer resistance. The highest inhibition efficiencies (Cu: ~ 57 %, CuSn14: ~74 % and Al: ~58 %) were achieved for an extract concentration of 1.0 g L –1 .

Aims: Cystic fibrosis is an autosomal recessive multisystem disease caused by a mutation of the CFTR gene. To date, more than 1900 mutations of this gene are known. Studies have shown that the most common mutation is delF508. In Bosnia and Herzegovina, the prevalence of individual mutations in the general population has not been thoroughly studied, so this study aimed to determine the prevalence of the mutation concerning the countries of the region and the rest of the world. Study Design: Retrospective study. Place and Duration of Study: Thirty-nine subjects with suspected Cystic fibrosis were referred to the Center for Genetics of the Medical Faculty in Sarajevo between 2018-2020. Methodology: 29 common CFTR gene mutations were analysed with the ELUCIGENE CF29 v2 kit (Elucigene Diagnostics, UK) using four multiplex PCR. Results: The most common mutation in our study was the F508 deletion, present in 14 subjects (73.68%). R347P and G542X mutations were confirmed in two subjects in the heterozygous state in combination with delF508 (M) 5.26% of each of these mutations. 621+1G>T was found in a homozygous state in one subject, while in another, it was in a heterozygous state in combination with delF508(M) mutation, 10.52%. Mutation 2184 delA was found in one subject in the homozygous state with a total frequency of 5.26%. Conclusion: Subjects with cystic fibrosis in Bosnia and Herzegovina are most often carriers of the delF508 mutation. Considering the existence of many mutations and that it is difficult to test them all, targeting the most common mutations in a clinical environment might help in approving therapy, and increasing patients’ quality of life.

The study indicates wartime programmed violence's implications within the liberal interpretation of contemporary legislative and human rights debates. It discusses related war theories and practices, problematizing instrumentalization of instilling new global ethics, arguing that humanitarian interventions often became "usable" in the new millennium's geopolitics; wars fatally affect the innocent. It points out that the origins of democracy are structurally violent and that the threat of terrorism, in addition to revealing new forms of "democratic violence," is having a transformative effect on the very character of democracy. How the concept of just cause agrees with armed humanitarian intervention, and whether we have the right to impose democracy by force? Whether the theory of just war in its positivist-legalist paradigm that combines universalist principles with utilitarian harm-weighing versus profit can offer a comprehensive method of morally contemplating current wars. The distinction between liberal cosmopolitan arguments and social democratic ones is apparent. The arbitrariness and the imposition of individual states' views create issues, leading to fragility (human security, socioeconomics, economic development, health). The compulsory international focus and responsibility should incorporate critical medical (children) - "the right to health" and humanitarian goods. Implementing rules to control war's destructiveness is less effective in intercultural conflicts. The doctrine of "just war" application is questionable, and no new victim should suffer even when the goal of the intervention is entirely legitimate and "humane." It cannot be just that it will exempt intervention forces from applying international humanitarian law, nor does the legitimacy of the intervention exempt them from respect for international humanitarian law. The international law concept has evolved from an instrument of promoting peace to an agent of the violent argument of force realization. Ethics is often imposed as politics; human rights ethics transformed into war ethics, leading to human rights violations and civilian casualties. War justice and the moral paradigm within globalization's contemporary forms are questioned. A broader discussion of the assumptions of the universality of Western values that have driven international law for centuries is required.

This paper introduces a novel approach for state-space representation of linear time invariant (LTI) systems, so-called Future Inputs Elimination (FIE) method. It can be applied to single-input-single-output (SISO) or multiple-input-multiple-output (MIMO) systems, continuous-time or discrete-time systems, whose dynamic equations are coupled or separated (uncoupled) in terms of their inputs and outputs. The FIE method closely parallels to the controllable canonical method when restricted to a class of SISO LTI systems. Moreover, it retains an easy implementation and effortless computation even for a class of MIMO LTI systems. The proposed approach may be used for representation of LTI systems with multiple or complex-conjugate poles. Many representative numerical examples are provided in order to illustrate the effectiveness of the elimination state-space method for representation of both SISO and MIMO LTI systems.

An interlaboratory comparison (ILC) was organised to characterise 87Sr/86Sr isotope ratios in geological and industrial reference materials by applying the so‐called conventional method for determining 87Sr/86Sr isotope ratios. Four cements (VDZ 100a, VDZ 200a, VDZ 300a, IAG OPC‐1), one limestone (IAG CGL ML‐3) and one slate (IAG OU‐6) reference materials were selected, covering a wide range of naturally occurring Sr isotopic signatures. Thirteen laboratories received aliquots of these six reference materials together with a detailed technical protocol. The consensus values for the six reference materials and their associated measurement uncertainties were obtained by applying a Gaussian, linear mixed effects model fitted to all the measurement results. By combining the consensus values and their uncertainties with an uncertainty contribution for potential heterogeneity, reference values ranging from 0.708134 mol mol‐1 to 0.729778 mol mol‐1 were obtained with relative expanded uncertainties of ≤ 0.007 %. This study represents an ILC on conventional 87Sr/86Sr isotope ratios, within which metrological principles were considered and the compatibility of measurement results obtained by MC‐ICP‐MS and by MC‐TIMS is demonstrated. The materials characterised in this study can be used as reference materials for validation and quality control purposes and to estimate measurement uncertainties in conventional 87Sr/86Sr isotope ratio measurement.

Purpose Sustainable development goals (SDGs) are gaining significant importance in the current environment. Many businesses are keen to adopt SDGs to get a competitive edge. There are certain challenges in realigning the present working scenario for sustainable development, which is a primary concern for society. Various firms are adopting sustainable engineering (SE) practices to tackle such issues. Artificial intelligence (AI) is an emerging technology that can help the ineffective adoption of sustainable practices in an uncertain environment. In this regard, there is a need to review the current research practices in the field of SE in AI. The purpose of the present study is to comprehensive review the research trend in the field of SE in AI. Design/methodology/approach This work presents a review of AI applications in SE for decision-making in an uncertain environment. SCOPUS database was considered for shortlisting the articles. Specific keywords on AI, SE and decision-making were given, and a total of 127 articles were shortlisted after implying inclusion and exclusion criteria. Findings Bibliometric study and network analyses were performed to analyse the current research trends and to see the research collaboration between researchers and countries. Emerging research themes were identified by using structural topic modelling (STM) and were discussed further. Research limitations/implications Research propositions corresponding to each research theme were presented for future research directions. Finally, the implications of the study were discussed. Originality/value This work presents a systematic review of articles in the field of AI applications in SE with the help of bibliometric study, network analyses and STM.

BACKGROUND This investigation provides an important insight into Eurasian consumers' food safety beliefs and trust issues influenced by the COVID-19 pandemic. An online survey was conducted in 15 European and Asian countries involving more than 4000 consumers. RESULTS It has confirmed that different socioeconomic characteristics, cultural aspects, and education levels shape food safety perceptions within Eurasian countries. The COVID-19 pandemic influenced their beliefs and trust in food safety, which is relatively low on average. However, it is significantly higher for European consumers (especially EU ones) as compared to their Asian counterparts. Both Asian and European respondents agreed that food fraud and climate changes represent a food safety issue. However, European consumers were less concerned regarding the food safety of genetically modified foods and meat and dairy analogs/hybrids. Asian consumers were, to a greater extent, worried about the risk of getting COVID-19 from food, restaurants, food retail establishments, and home food deliveries. CONCLUSION The greatest extent of trust, when food safety assurance is concerned, Eurasian consumers have put into food scientists and food producers holding a food safety certificate. Broadly, they are uncertain to what extent their federal governments and food inspectors are competent, able, and efficient in ensuring food safety. Higher education of Eurasian consumers was followed by increased food safety confidence in all parts of the food chain. This article is protected by copyright. All rights reserved.

At the beginning of 2020, the Sarajevo-based publishing house El-Kalem, released a biography of Derviš M. Korkut, a Bosniak hero, to whom Yad Vashem posthumously awarded Righteous among the Nations on December 14, 1994. Winston Churchill's words, with which the author begins the biography—that the Balkans produce more history than they can handle—best describe the difficult times in which Korkut lived. For Korkut and his fellow Bosnians, these difficult times lasted from the beginning of the 20th century to its very end. The book is based on exhaustive archival research and reconstructs Korkut’s life very precisely, while the concise overview of the historical circumstances of the 20th century in the Balkans, and in Bosnia and Herzegovina, allows a better understanding of his actions. His defense of his Jewish neighbors began early when the Minister of Interior of the newly established Kingdom of Serbs, Croats, and Slovenes, Milorad Drašković, initiated a procedure for the disenfranchisement of Yugoslav Jews. Korkut took part in the campaign against Drašković’s policies, publicly condemned such a policy, and gave a speech in the town of Derventa, in favor of the Jews When, at the beginning of 1942, Nazi General Johann Hans Fortner came to the National Museum, demanding the handover of the Haggadah—a 15th-century Jewish manuscript brought to Bosnia and Herzegovina by Sephardic Jews who settled in Sarajevo, then part of the Ottoman Empire—Korkut managed to save the Haggadah, risking his own life in doing so (p. 40). Shortly after rescuing the Haggadah, a friend asked Korkut to help a Jewish girl, Donkica Papo (later Mira Baković), whose parents had already been sent to an Ustasha camp. After spending several months hiding in Korkut’s house, he managed to obtain forged documents for her and save her. In 1994, while Bosnia and Herzegovina was ravaged once again by the war, Mira Baković wrote to Yad Vashem, explaining how Derviš and his wife Servet Korkut had saved both her life and the Haggadah. Yad Vashem posthumously awarded him “Righteous Among the Nations” on December 14, 1994 at the Israeli Embassy in Paris (p. 63). This poignant, well-written biography shows not only a life of a truly remarkable man, but also how difficult times throughout the 20th century, reflected on the people in Bosnia and Herzegovina and how they tried to respond to them by preserving the unique Bosnian multi-ethnic, multi-confessional, and multicultural community. The story of Derviš M.Korkut’s life, marked by courage, perseverance, and resistance needs to be given the place in collective memory that it deserves, a task this book achieves. Written in English and thus available to a wider readership, it not only pays tribute to Derviš M. Korkut, but also sheds light on the Sarajevo he sought to preserve at the risk of his life.