The applications of robot are very extended and have already become classic in different branches of mass industrial production such as welding, painting by spraying, antirust protection, etc. Though the operations performed by robots in these fields are very complex, the operations of assembly are even more complex. In fact, robot assembly operations involve the process of direct solving the conflicting situations being not within the classic repetitive work. Investigations treating typical assembly duties started forty years ago (Bohman, 1994). In the meantime, it was offered a series of control mechanism of mating date. Performing assemblies depends on sensation of and appropriate reaction to the forces of contact between mating components date (Wei, 2001). It is shown that with the intelligent techniques, example components can be assembled faster, gentle and more reliably. In order to create robot behaviours that are similarly intelligent, we seek inspiration from human strategies date (Chan, 1995). The working theory is that the human accomplishes an assembly in phases, with a defined behaviour and a subgoal in each phase. The human changes behaviours according to events that occur during the assembly and the behaviour is consistent between the events. The human’s strategy is similar to a discrete event system in that the human progresses through a series of behavioural states separated by recognizable physical events. In achieving acceptably fast robot behavior with assuring contact stability, many promising intelligent-control methods have been investigated in order to learn unstructured uncertainties in robot manipulators date (Chan, 1995), (Miyazaki et al., 1993), (Brignone et al., 2001). For example, (Newman et al., 2001) work describes intelligent mechanical assembly system. First phase for assembly is blind search. In this phase multiple parameters are assigned to rotational search attractor. If sensors register force values higher then thresholds, new parameters are assigned. Intelligent layer is represented on 22-dimensional space of trajectories, and based on blind search parameters (correct and incorrect) neural network is made. Correct assembly path is chosen by using form of Genetic algorithm search, so the new vectors are evolved from most successful “parents”. Using this process, the robot was allowed to generate and test its own program modifications. The primary source of difficulty in automated assembly is the uncertainty in the relative position of the parts being assembled (Vaaler, 1991). The crucial thing in robot assembly is how to enable a robot to accomplish a task successfully in spite of the inevitable uncertainties

The aim of this study was to investigate the discrimination power of standard long-term heart rate variability (HRV) measures for the diagnosis of chronic heart failure (CHF). The authors performed a retrospective analysis on four public Holter databases, analyzing the data of 72 normal subjects and 44 patients suffering from CHF. To assess the discrimination power of HRV measures, an exhaustive search of all possible combinations of HRV measures was adopted and classifiers based on Classification and Regression Tree (CART) method was developed, which is a non-parametric statistical technique. It was found that the best combination of features is: Total spectral power of all NN intervals up to 0.4 Hz (TOTPWR), square root of the mean of the sum of the squares of differences between adjacent NN intervals (RMSSD) and standard deviation of the averages of NN intervals in all 5-min segments of a 24-h recording (SDANN). The classifiers based on this combination achieved a specificity rate and a sensitivity rate of 100.00 and 89.74%, respectively. The results are comparable with other similar studies, but the method used is particularly valuable because it provides an easy to understand description of classification procedures, in terms of intelligible “if … then …” rules. Finally, the rules obtained by CART are consistent with previous clinical studies.

Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. Tumor suppressor mouse models are the most frequently used animal models in cancer research. The anti-tumorigenic functions of TSGs, and their role in development and differentiation, and inhibition of oncogenes are discussed. In this review, we summarize some of the important transgenic and knockout mouse models for TSGs, including Rb, p53, Ink4a/Arf, Brca1/2, and their related genes.