Is There Evidence of Separate Inflammatory or Metabolic Forms of Preeclampsia?
Objectives. To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia. Methods. A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMAIR by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted. Results. There was no difference in median HOMAIR by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04). Conclusions. No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.