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S. Founds, J. Catov, M. Gallaher, G. Harger, N. Marković, J. Roberts
14 5. 1. 2011.

Is There Evidence of Separate Inflammatory or Metabolic Forms of Preeclampsia?

Objectives. To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia. Methods. A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMAIR by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted. Results. There was no difference in median HOMAIR by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04). Conclusions. No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.


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