This paper describes the partial wave expansion and integral representation of Bessel beams in free space and in the presence of dispersion. The expansion of the Bessel beam wavepacket with constant spectrum is obtained as well. Furthermore, the sum of a triple Legendre polynomial product of same order but different argument follows naturally from the partial wave expansion. The integration of all Bessel beams over all conical angles is shown to have a simple series representation, which confirms the equivalence between the results for both expansion and integral representation.

Severe pain control is an indispensable and important part of the treatment of children with malignant diseases. The specificity of treatment is connected to the opiate’s metabolism, but it is more difficult to estimate pain and there is fear of side effects, which leads to sub-dosing and poor analgesia. The aim of this study is to show that rational use of opiates secures efficient pain suppression in children in the terminal phase of malignant diseases. Oral morphine with fast impact is the gold standard in the initial phase of severe cancer pain therapy and for the treatment of shooting pain in children. Slow release opiates are suitable for long-term use, as they combine efficiency and compatibility. Rotation of fentanyl transdermal allows simpler usage, decreases side-effects and provides good analgesia for children who cannot take opiates orally. Along with an individual estimate of the child’s condition, it is important to take care of equianalgetic doses of opiates and support therapy.

INTRODUCTION Angiotensin-converting enzyme inhibitors are leading cause of drug-induced angioedema, with incidence of 0.1 to 0.2%. The angioedema is not of immune nature; in predisposed individuals it is caused by accumulation of vasoactive mediators due to reduced activity of angiotensin-converting enzyme. CASE REPORT We presented a 63-year old male patient suffering from hypertension and chronic obstructive pulmonary disease, who had developed two episodes of angioedema during a 5-year long therapy with enalapril. The first episode happened after three, and the second after five years of the therapy. On both occasions, the patient was admitted to the hospital and tracheotomy was avoided in the last moment. CONCLUSION Long-term therapy with angiotensin-converting enzyme inhibitors could be associated with delayed angioedema, especially in patients with inflammation of airways caused by infection or chronic irritation.

Ketoprofen (KP) is a nonsteroidal anti-inflammatory drug, which during UV irradiation rapidly transforms into benzophenone derivatives. Such transformation products may occur after topical application of KP, which is then exposed to sunlight resulting in a photo-allergic reaction. These reactions are mediated by the benzophenone moiety independently of the amount of allergen. The same reactions will also occur during wastewater or drinking water treatment albeit their effect in the aqueous environment is yet to be ascertained. In addition, only a few such transformation products have been recognised. To enable the detection and structural elucidation of the widest range of KP transformation products, this study applies complementary chromatographic and mass spectrometric techniques including gas chromatography coupled to single quadrupole or ion trap mass spectrometry and liquid chromatography hyphenated with quadrupole-time-of-flight mass spectrometry. Based on structural information gained in tandem and multiple MS experiments, and on highly accurate molecular mass measurements, chemical structures of 22 transformation products are proposed and used to construct an overall breakdown pathway. Among the identified transformation products all but two compounds retained the benzophenone moiety--a result, which raises important issues concerning the possible toxic synergistic effects of KP and its transformation products. These findings trigger further research into water treatment technologies that would limit their entrance into environmental or drinking waters.