The aim of this study was to assess the ability of oyster mushrooms (Pleurotus ostreatus (Jacq.) P. Kumm.) to absorb heavy metals (Fe, Zn, Cu, Co, Mn, Ni, Cr, Cd, and Pb) from different plant-based substrates and to determine the bioaccumulation factor of the aforementioned heavy metals from the substrate to the oyster mushroom basidiomes. The substrate used in this study were: maize straw, beech sawdust supplemented with wheat bran at a rate of 20%, a mixture of maize straw and spent coffee grounds in a ratio of 70:30, and a mixture of maize straw and spent coffee grounds in a ratio of 50:50. Heavy metal contents in substrate and mushroom samples were analyzed by atomic absorption spectroscopy using the Shimadzu AA-7000 device, while the bioaccumulation factors of oyster mushroom for each investigated heavy metal were calculated from the heavy metal content in mushrooms divided by that found in substrates. The study showed that oyster mushrooms have a high capacity to absorb Zn and Cd from the growing medium and bioaccumulation factor values for Zn and Cd determined in this study strongly support this observation. On the other hand, bioaccumulation factor values for Ni, Fe, and Mn were less than 0.3 and ranged from 0.04 to 0.05, from 0.09 to 0.12, and from 0.10 to 0.25, respectively. In general, the results of this study lead to the conclusion that substrate chemical composition strongly affects the heavy metal accumulation in oyster mushroom basidiomes. The results of this study also showed that oyster mushrooms can be considered a promising species for Cd and Zn bioremediation.

Uvod: Pandemija COVID-19 pokazala je nedostatke zdravstvenih sustava na globalnoj razini, a najveći utjecaj pandemije doživjeli su zdravstveni profesionalci koji rade u izravnom kontaktu s oboljelim pacijentima. Cilj: Cilj je rada ispitati stavove i mišljenja zdravstvenih profesionalaca koji rade u ruralnim i urbanim područjima Kantona Sarajevo o mjerama zaštite na radnom mjestu, zdravstvenom kadru i organizaciji rada tijekom pandemije COVID-19 od strane nadležnih institucija. Metode: Ispitani su zdravstveni profesionalci koji rade u urbanim i ruralnim područjima u Kantonu Sarajevo koristeći anonimne anketne upitnike čija je osnova bila check lista za provjeru spremnosti zdravstvenih ustanova za pandemiju COVID-19 koju je kreirala Svjetska zdravstvena organizacija. Kriterij za uključivanje u studiju bio je dobrovoljni pristanak ispitanika da sudjeluju u istraživanju. Rezultati: Analiza ustanove i spremnosti sustava na COVID-19 pandemiju ukazala je na mnoge nedostatke zdravstvenog sustava u Kantonu Sarajevo. Utvrđen je umjeren rizik kod odgovora zdravstvenog sustava primarne zdravstvene zaštite na području cijelog Kantona, s tim da je značajno veći rizik utvrđen u urbanim dijelovima Kantona. Utvrđena je značajna statistička razlika u ukupnom riziku (p < 0,001). Na skali od 8 do 40, ukupan rizik u urbanim sredinama iznosio je 21,95 (19 – 25), dok je u ruralnim sredinama iznosio 19,3 (16 – 23). Zaključak: Uvažavanje stavova i mišljenja zdravstvenih profesionalaca koji rade u izravnom kontaktu s pacijentima trebalo bi biti temelj za donošenje odluka u javnoj zdravstvenoj politici. U našoj se studiji, ali i ranije opisanim studijama, uočava pojam adaptabilnosti koji ukazuje na to da se, prema prijašnjim iskustvima, trebaju napraviti korektivne mjere kako bi zdravstveni sustav bio spreman za moguće epidemije i pandemije u budućnosti.

Introduction: With the continuous aging of the population of Western societies, an increase is expected not only in the number of patients with diabetes but also in the number of patients with comorbidities. Population studies suggest that most patients with diabetes have at least one comorbidity. Comorbidities can profoundly impact a person’s ability to care for himself/herself and can present barriers to adherence to lifestyle changes and compliance with therapy. Methods: The research was conducted in the Public Institution Health Centre of Sarajevo Canton - Health Center Hadžići and Health Center Novi Grad. It included 161 patients diagnosed with diabetes; 96 women and 65 men.The respondents were between 18 and 65 years old (the upper age limit for the working population for both genders). The instruments for conducting the research were a questionnaire on the socio-demographic characteristics of the respondents and Ferrans and Powers index of quality of life, a version for diabetes. Results: The research included 43.48% of respondents with diabetes mellitus (DM) Type II, 31.06% with DM Type I, while even 25.46% of respondents did not know which type of diabetes they suffered from. There were no statistically significant differences in the Total Quality of Life Index (TQLI) (p=0.328) between respondents with different types of diabetes. The average TQLI value in the group with diabetes duration from 1 to 5 years was 22.07 +/- 5.10; in the group from 6 to10 years was 21.23 +/- 6.0; in the group from 11 to 20 years was 21.86 +/- 4.82; in the group from 21 to 30 years was 19.20 +/- 6.81; and in the group with diabetes duration >30 years, was 23.36 +/- 5.46. High blood pressure was present in 60.24% of respondents, followed by elevated blood fats in 51.55% of respondents, and heart/brain blood vessel diseases, in 43.48% of respondents. Neuropathies were present in 38.5%, visual impairment in 26.08%, and malignant diseases were present in a total of 14.28% of respondents. Conclusion: The average value of the quality of life of respondents with 1 comorbidity was 21.30; with 2 comorbidities 20.91; and with 3 comorbidities was 21.94. There was no statistically significant difference in the quality of life of diabetes patients about the presence of one, two, or more comorbidities (p=0.537). The presence of a greater number of comorbidities in patients with diabetes does not contribute to poor quality of life.

BACKGROUND: Perfusion abnormalities in the infarct and salvaged penumbra have been proposed as a potential reason for poor clinical outcome (modified Rankin Scale score >2) despite complete angiographic reperfusion (Thrombolysis in Cerebral Infarction [TICI3]). In this study, we aimed to identify different microvascular perfusion patterns and their association with clinical outcomes among TICI3 patients. METHODS: University Hospital Bern’s stroke registry of all patients between February 2015 and December 2021. Macrovascular reperfusion was graded using the TICI scale. Microvascular reperfusion status was evaluated within the infarct area on cerebral blood volume and cerebral blood flow perfusion maps obtained 24-hour postintervention. Primary outcome was functional independence (90-day modified Rankin Scale score 0–2) evaluated with the logistic regression analysis adjusted for age, sex, and 24-hour infarct volume from follow-up imaging. RESULTS: Based on microvascular perfusion findings, the entire cohort (N=248) was stratified into one of the 4 clusters: (1) normoperfusion (no perfusion abnormalities; n=143/248); (2) hyperperfusion (hyperperfusion on both cerebral blood volume and cerebral blood flow; n=54/248); (3) hypoperfusion (hypoperfusion on both cerebral blood volume and cerebral blood flow; n=14/248); and (4) mixed (discrepant findings, eg, cerebral blood volume hypoperfusion and cerebral blood flow hyperperfusion; n=37/248). Compared with the normoperfusion cluster, patients in the hypoperfusion cluster were less likely to achieve functional independence (adjusted odds ratio, 0.3 [95% CI, 0.1–0.9]), while patients in the hyperperfusion cluster tended to have better outcomes (adjusted odds ratio, 3.3 [95% CI, 1.3–8.8]). CONCLUSIONS: In around half of TICI3 patients, perfusion abnormalities on the microvascular level can be observed. Microvascular hypoperfusion, despite complete macrovascular reperfusion, is rare but may explain the poor clinical course among some TICI3 patients, while a detrimental effect of hyperperfusion after reperfusion could not be confirmed.

Red clover (Trifolium pratense) is a fodder plant grown in many regions of the world. It is also known as a medicinal plant. Red clover contains large amounts of isoflavones, which are, due to their similarity to estrogen, called phytoestrogen; it is believed that they can increase the concentration of estrogen in women. Some studies have refuted this information, but this topic is still being researched. The aim of the work was to produce beer to which red clover is added during the boiling phase and to monitor the transfer of isoflavones from red clover to beer. Red clover was not added to the control sample during boiling. During production and fermentation, the basic physical-chemical properties of wort and beer were monitored, as well as acceptability among potential consumers, which was determined by sensory analysis. The results show that phytoestrogens do end up in beer. The analyzed beer contained biochanin A, formononetin, genistein, and daidzein, in a total concentration of 12.42 µg/mL. The control sample contained none of the aforementioned compounds. Sensory analysis gave promising results, and the tested consumers all approved the taste, smell, and aroma of the produced beer. The most notable aroma that was singled out by consumers was “hay-like”.

Early intervention (EI) based on behavioral science is one of the most promising treatment options for children with autism. Ever since Ivar Lovaas study from 1987, researchers are aware of the benefits of intensive early intervention in improving the outcomes of children with autism. Children who receive EI often show remarkable improvements in their social, cognitive, and adaptive skills. These interventions typically involve structured teaching methods, intensive behavioral therapies, and a variety of support services tailored to the individual needs of each child. By addressing the core symptoms of autism early in a child's development, these programs aim to foster better long-term outcomes. In this paper, we presented an overview of the main topics in the field of EI for children with autism published in major scientific journals. For this purpose, we performed a search of the Web of Science citation base and identified 91 articles published in the period 2019-2023 that had the words “early intervention” and “autism” OR “ASD” in their titles. The selected articles dealt with several interesting topics ranging from improving social communication and joint attention to topics dealing with quality of life and parent mediated EI programs. We concluded the paper with a discussion on the future directions of EI research. Despite the significant progress made, there is still much to learn about optimizing these early behavior interventions. Future research should aim to personalize intervention strategies to meet the unique needs of each child with autism and their families. Additionally, more longitudinal studies are needed to understand the long-term impacts of EI on various life outcomes.

With the birth of a child, parents are also born. Parents and children develop, grow, learn and make mistakes together. There is no manual to indicate whether parents are making mistakes in raising another being, nor is there a reward when they do something well. It is a subjective assessment of how good a parent someone is, mistakes in upbringing are often overlooked or it turns out that situations that seemed wrong and unsuccessful resulted in a positive outcome. Questioning the correctness of raising one's own child is a daily routine for parents. However, what happens when hearing parents have a hearing-impaired child? How do they adapt, with the added pressure of how to deal with the new situation and how to raise a child who will understand them and who they will fully understand? Of course, there are differences in raising a deaf child depending on the fact if parents are hearing or deaf, but both are guided by their natural instincts in order to achieve the best possible communication with their own child. According to one definition, communication is the ability to share values, beliefs and feelings. We can communicate verbally and non-verbally. Verbal communication refers to speech, and non-verbal communication refers to visual interaction. The aim of this research was to examine the hearing parents of hearing-impaired children about the challenges they face the most when it comes to communication with their own children and how they solve the issues. The research results showed that hearing parents of deaf children communicate with the child at an early age. However, with all the efforts they make while their child grows up, there is one significant part of the child’s personality that won’t develop properly due to missing verbal communication. For the same reason, there is a distance in mutual communication that cannot be overcome even with the unconditional love they provide. From all of the above, the conclusion emerges that it is necessary to work on the education of hearing parents of deaf children with adequate forms of communication.

In this study we analyzed the effects of swimming on the posture of preschool children. The sample for this study consisted of 153 preschool boys and girls children aged 4-6 years (standard deviation= 1.1 years) living in Canton Sarajevo and divided into two groups of boys and girls, with one attended swimming school (n=61) and other did not (n=92). In order to evaluate the postural status, we used a reduced Napoleon Wolanski method with eight variables for the observed body parts: assessment of head posture (HPA), assessment of shoulder posture (SPA), assessment of scapular posture (SBPA), assessment of chest posture (CPA), scoliotic posture (SCP), assessment of abdominal posture (APA), assessment of leg posture (LPA), and assessment of foot posture (FPA). The results indicated a great effect of swimming on posture. We concluded the paper with some suggestions on how to incorporate swimming programs into regular school curricula.

BACKGROUND The superiority of endovascular thrombectomy (EVT) over medical management was not established in two early basilar artery occlusion (BAO) randomized controlled trials. Despite this, many clinicians recommended EVT for acute BAO under certain circumstances. This paper aims to compare physicians' diagnostic and management strategies of BAO according to gender. METHODS From January to March 2022 an international survey was conducted regarding management strategies in acute BAO. We compared responses between clinicians by identifying gender. Questions were designed to examine clinical and imaging parameters influencing management of patients with BAO. RESULTS Among the 1245 respondents from 73 countries, 311 (25.0%) identified as female. This figure was 13.6% amongst interventionists. Geographically, female respondents were lowest in Asia (14.5%) and North America (23.9%). The proportion of respondents identifying as female was consistent regardless of their years of experience. Female respondents were more likely to choose time of onset as time of first estimated stroke like symptom (48.0% vs. 38.5%, p < .01), were less likely to favor thrombectomy in the V4 segment of vertebrobasilar artery occlusions (31.5% vs. 43.3%, p < .01), and were less likely to find it acceptable to enroll all patients who met trial criteria in the standard medical treatment arm of a clinical trial (41.2% vs. 47.0%, p = .01). Male respondents were more likely to agree that thrombolysis would not alter their decision on proceeding with EVT (93.7% vs. 88.3%, p < .01). CONCLUSIONS Female clinicians appear to be significantly underrepresented in stroke medicine. This is most pronounced amongst interventionists and in Asia. Although male and female opinions were closely aligned on many aspects of BAO management, differences in opinion were observed in a number of significant areas which influence decision making.

We introduce a new, non-parametric method to infer deprojected 3D mass profiles M(r) of galaxy clusters from weak gravitational lensing observations. The method assumes spherical symmetry and a moderately small convergence, κ≲1. The assumption of spherical symmetry is an important restriction, which is, however, quite common in practice, for example in methods that fit lensing data to an NFW profile. Moreover, with a mild assumption on the probability distributions of the source redshifts, our method relies on spherical symmetry only at radii larger than the radius r at which the mass M is inferred. That is, the method may be useful even for clusters with a non-symmetric inner region, since it correctly estimates the enclosed mass beyond the radius where spherical symmetry is restored. We discuss how to correct, statistically and approximately, for miscentering given that the probability distribution of miscentering offsets is known. We provide an efficient implementation in Julia code that runs in a few milliseconds per galaxy cluster. We explicitly demonstrate the method by using data from KiDS DR4 to infer mass profiles for two example clusters, Abell 1835 and Abell 2744, finding results consistent with existing literature.

Nakaseomyces glabratus (N. glabratus) formerly known as Candida glabrata (C. glabrata), is an endogenous opportunistic pathogen, which is generally located in the gastrointestinal tract but can spread in immunocompromised patients. N. glabratus is the second most common pathogen that causes candidemia in several countries. N. glabratus virulence factors may increase antifungal resistance and reduce the number of available treatment options. High resistance to azoles and increasing resistance to echinocandins have been previously reported in N. glabratus.

The 2023 American College of Rheumatology/EULAR antiphospholipid syndrome (APS) classification criteria development, which aimed to identify patients with high likelihood of APS for research, employed a four‐phase methodology. Phase I and II resulted in 27 proposed candidate criteria, which are organized into laboratory and clinical domains. Here, we summarize the last stage of phase III efforts, employing a consensus‐based multicriteria decision analysis (MCDA) to weigh candidate criteria and identify an APS classification threshold score.

Seeing mathematics teaching as a very demanding and responsible process while having in mind the importance of mathematical knowledge for students of technical faculties, this paper aims to present heuristics for student classification according to their predicted mathematical success. Over the last few decades, the process of informatization of universities has resulted in new challenges universities are faced with. Due to the widespread use of educational databases, which opens new possibilities for educational data mining and analyses, machine learning algorithms have become a very popular tool for predicting students' academic performance. The decision tree algorithm is used in this paper for the classification and prediction of students' mathematical performance and it is trained on the data collected from the educational information system. The experimental results show that the model accuracy is 72% with an error rate of 0.28. The implementation of the Decision Tree Model to predict whether a student will pass, fail or be conditional in mathematical courses is important for both teachers and students, as well as for universities. Students' performance is one of the major keys in evaluating the quality of the teaching process, but also for evaluating the overall success of the university itself. As mathematics is considered a basic and important discipline, it is clear why predicting students' mathematical achievement is crucial for all levels of university organization.

Objective. The goal of this review was to determine the effectiveness of different types of monobloc and bibloc mandibular advancement device (MAD) devices in the treatment of all forms of obstructive sleep apnea (OSA), by reviewing the available literature. Methods. A systematic literature search was performed in PubMed, ResearchGate, NCBI and Google Scholar databases. The search included articles in English, published in the inclusive time period from 2000 to 2024. Results. A total of 13 studies were analyzed that directly compared the effectiveness of monobloc and bibloc devices. The studies were published in the period from 2000 to 2024, and included crossover and parallel randomized controlled trials, as well as cross and parallel cohort studies. Out of the 13 studies, four were classified as RCT parallel studies, six were RCT crossover studies, two cohort parallel studies, and one cohort crossover study. The duration of the studies was variable, ranging from four weeks to one year, with six studies having a so-called “washout period” between the use of monobloc and bibloc MAD devices. Conclusion. Both monobloc and bibloc devices show significant success rates in the treatment of mild to moderate OSA.