Abstract Objective: To determine the incidence of gliomas in Zenica - Doboj Canton. Moreover, to analyse its potential connection to sociodemographic characteristics and its distribution throughout municipalities of Zenica - Doboj Canton in the period of 2009-2019. Method: This retrospective, descriptive - analytical, 10 - year study included 146 patients from Zenica -Doboj Canton. Data were obtained and reviewed from patient’s medical records. Patients’ sociodemographic characteristics and pathohistological diagnosis were included in the study. Age, gender, and the place of birth were analysed and correlated with types and grades of glial tumors according to the World Health Organisation’s latest classification. Results: The study consisted of 146 patients including 84 (58%) males and 62 (42%) females. The most common pathohistological diagnosis was glioblastoma multiforme, a grade IV glioma in both females (26%) and males (35%), in total 91 (62%) patients, and the rarest was oligoastrocytoma, in 2 (1%) cases. The municipality of Kakanj had the highest incidence of glioma with 29 out of total of 146 cases (0.077%) and the highest incidence in females (0.069%) with 13 cases. The municipality of Vareš had the highest incidence of glioma (0.114%) with 5 out of 84 male cases, while in the cities of Breza and Olovo any cases with glioma were not detected The results showed statistically significant differences in incidences of gliomas according to the region of residence. Conclusion The analysis of data indicated that there are significant connections between the occurrence of gliomas and sociodemographic characteristics of patients from Zenica - Doboj Canton.

In today’s modern world, more than ever before, students are faced with entrepreneurship based on the use of information and communication technology (ICT) as a reasonable and justified career choice. Whether their career choice would be successful or not depends a lot on the level of system support through entrepreneurial ecosystem during their education. The main objective of this paper is to present the current assessment, indicate the problems and possible solutions regarding the entrepreneurial infrastructure, culture and potential of higher education institutions in Banja Luka, Bosnia and Herzegovina. To achieve this, we have researched the level of the system support to students for development and launch of their ICT based start-ups during and after their university education respecting different educational profiles and demographic characteristics. The research covers the sample of 436 students from seven higher education institutions in Banja Luka at their bachelor studies and includes focus groups, survey, descriptive and inferential statistical methods. We have found significant discrepancy between university ICT programs and infrastructure and student needs. For instance, a quite large number of students interested in ICT industry attended some kind of informal education from this domain and at the same time they were unaware that those and similar programs were freely available at their universities. In this paper we have identified those and similar gaps and compared our research results with similar results in other countries.

Introduction: Needlestick injuries (NSIs) are one of the most frequent routes of the transmission of bloodborne pathogens in health care settings and the substantial source of occupationally acquired bloodborne infections. They remain a significant problem for developing countries that lack the ability to implement more reliable technologies and available guidance because of the economic situation. The objectives of the study were to determine the frequency of NSIs among healthcare workers (HCWs) and supporting staff in primary health care, to investigate the factors that caused these injuries and to evaluate a set of implemented guides. Methods: A retrospective study of the Department of infection control records of NSIs between January 2003 and January 2016 was conducted. Incidence proportion (rate of injury risk) was calculated for each profession with reported NSIs. Results: A total of 156 NSIs and sharp injuries were reported to the Department of infection control during the 12-year period. Among the group of HCWs, medical nurses/technicians (54.49%) were the most common injured workers, and the lowest numbers were reported by a physical therapist and dental technicians (0.64%). In a total number of cases, support staff accounted for 16.67%. The most incidents occurred during the use of needles, in 146 (90.6%) cases. Calculated incidence proportion for medical doctors is 0.24%, 5.33% for dentists, and 13.8% for medical and dental nurses/technicians and laboratory technicians. For support staff, the calculated rate is 6.04%. Conclusions: At the primary health care level, the NSIs frequency among all employee profiles is lower and it is suggesting the possibility of underreporting cases. Healthcare facility management should consider introducing new and more reliable technologies to reduce the number of NSIs especially among nurses/technicians, laboratory technicians, and cleaning staff. Additional training and preventive measures should be directed towards the proper disposal of medical waste. Management of the Institution presented engagement to prevent the occurrence of NSIs, and it is a positive example for all countries in transition.

Volatile constituents of Satureja montana L. collected from a natural habitat in the southern region of Bosnia and Herzegovina were isolated by steam distillation and headspace sampling. The relative abundance of volatile compounds from the air-dried fragrant plant was analysed by GC-MS using two columns of different polarity. A total of 28 compounds were identified, constituting 93.5% of the essential oil composition. The GC pattern of headspace was different from that prepared by steam distillation. The former consisted of 14 compounds that made up 84.1% of the components identified. Both samples were dominated by oxygenated monoterpenes ranging from 55.2% for headspace of the plant material to 75.5% for the steam-distilled oil. Eleven alcohols represented the most diverse chemical class in the volatile oil (71.8%), as well as seven alcohols detected in the headspace (57.3%). GC-MS analysis of the volatiles indicates that S. montana belongs to linalool chemotype with its relative content of 38.7% for the essential oil and 23.7% for the headspace. With linalool as the most abundant constituent, the other major components were -terpineol (14.7%) in the essential oil, and cis-sabinene hydrate (21.8%) and p-cymene (17.9%) in the headspace sample. The results prove that the combined approach in the extraction of volatile compounds is reliable for the analysis of the aroma of complex herbal samples.

This paper presents a low-cost, single sensor autonomous mobile robot. The proposed system is able to map an indoor environment, while at the same time localizing itself within it, and solving the SLAM (Simultaneous Localization and Mapping) problem using data gathered from the sensor. It is able to navigate the environment, choosing safe paths for exploration based on the data acquired by mapping and localization. The system is based on commercially available, in-expensive hardware, while the software is developed with open-source ROS (Robot Operating System) packages. The ability for autonomous navigation of the proposed system has been verified through real-world experiments. The system offers a simple to build platform, which can easily be extended.

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed individuals as well as exposed family members and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative family members and individuals with a history of asymptomatic or mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.

We clarify open issues in relating low- and high-energy observables, at next-to-leading order accuracy, in models with a massive leptoquark embedded in a flavor nonuniversal SU(4)×SU(3)×SU(2)×U(1) gauge group. Extending previous work on this subject, we present a complete analysis of the O(αs) corrections to the matching conditions of semileptonic operators at the high scale. These corrections are not negligible, but they do not exceed the 10% level and are subleading compared to the O(α4) corrections proportional to the leading leptoquark coupling, which is expected to be much larger than the QCD coupling in the parameter space region of phenomenological interest. We further analyze the impact of radial modes, both at O(α4) and at O(αs) accuracies, highlighting their role in the renormalization of the theory.

Although the Internet has become the essence of communication, from an advertiser’s perspective digital advertising remains underexplored. This paper examines the effects of digital media buying efforts on advertisers in Bosnia and Herzegovina, while looking into the methodology of digital media usage behind the actual effects. A combination of secondary research analysis and qualitative research techniques was used. The empirical part is based on in-depth interviews with advertisers and representatives from the digital advertising industry.Perceptions and knowledge of digital advertising are the key drivers for a successful implementation of digital media buying, and advertisers in Bosnia and Herzegovina are aware of its most distinctive qualities. The success of the media buying campaigns relies on brand objectives and choosing the means suited for fulfilling the given goals, which in turn leads to the findings that the focus of companies’ strategies is directed towards the cost-efficient medium usage, rather than solely performance-oriented ones. Measurement of the effects and return on the investment depends on the success of setting up a goal and isolating digital from other marketing efforts.

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed whole-genome genotypes and 16S fecal microbiome data from 18,473 individuals (25 cohorts). Microbial composition showed high variability across cohorts: we detected only 9 out of 410 genera in more than 95% of the samples. A genome-wide association study (GWAS) of host genetic variation in relation to microbial taxa identified 30 loci affecting microbome taxa at a genome-wide significant (P<5×10-8) threshold. Just one locus, the lactase (LCT) gene region, reached study-wide significance (GWAS signal P=8.6×10−21); it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.94×10−10<P<5×10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization analyses identified enrichment of microbiome trait loci SNPs in the metabolic, nutrition and environment domains and indicated food preferences and diseases as mediators of genetic effects.

: A numerical and an empirical method for calculating nonlinear load-settlement curves for shallow foundations on sand are examined and used in a new methodology. Both methods have merits and drawbacks. The drawbacks are overcome by the methodology proposed and verified in the paper. This methodology combines the merits of each method. For this purpose, a modification of the empirical method is proposed that accounts for the finite initial soil stiffness at very small strains. Computer programs with sophisticated nonlinear stress-strain relationships, such as Hardening Soil Small in Plaxis 2D, which are versatile in solving complex foundation problems, can cover strains from very small to large. When the foundation soil is layered, it is proposed to fit such a numerical load-settlement curve against the modified empirical relationship for each sand layer separately. This requires cone penetration tests, measurements of the shear wave velocity, and basic laboratory tests. The methodology is described and applied at two locations where load tests on footings were carried out. At one location there was a top layer of clay, which was also taken into account. The results of the application of the proposed methodology are very good.

: This paper presents a hydraulic analysis of unsteady flow due to a possible dam break of the Tribistovo reservoir located in the Municipality of Posušje, Bosnia and Herzegovina. Flood wave propagation is calculated and flood maps are derived for different dam break scenarios. The methodology adopted for the development of the flood wave propagation model is based on the use of available tools for collection, processing and graphical display of geospatial data and tools for hydrodynamic modeling of transient flow. The selected approach is conservative and results are, as a rule, the worst case scenarios. Flood areas are obtained on the basis of hydraulic calculations with the most unfavorable assumptions: maximum water level in the reservoir, maximum inflow in the reservoir (with the return period of T = 10 000 years), instantaneous/gradual and total dam break, all of which result in extreme flooding.