Introduction: Cognitive impairment is common finding in individuals with PTSD. Dysfunctional metacognitions in variety of anxiety disorders can represent generic vulnerability for anxiety disorders, as well as elements that contribute to maintaining the disorder. There is little empirical information about metacognition in war veterans with PTSD, and its relation to cognitive and/or social, occupational and psychological functioning. Aim: to determine the values and reciprocal correlations of different aspects of metacognition, with cognitive and global functioning in outpatient war veterans with PTSD. Methods: The study was conducted on 25 war veterans (24 male), with confirmed diagnosis of PTSD by a trained psychiatrist, average age 48,5±6,2 (38-63) years, with average duration of symptoms of 9,9±4,7 (0,5-16) years. We used the Metacognitions questionnaire, Mini Mental Status Examination, and Global Assessment of Functioning Scale to assess metacognition, cognitive impairment, and global functioning. Median values of Metacognitions questionnaire subcomponents, Global Assessment of Functioning Scale and Mini Mental Status Examination were determined, and also reciprocal correlations of all parameters expressed with Spearman Rank Correlation. Results: 12 patients (48%) had impaired cognitive function. Significant negative correlation of score on Mini Mental Status Examination, and negative beliefs about worry is observed (r=-0,4278, p=0,034), as well as non significant correlations between rest of metacognition subscales and score on Mini Mental Status Examination. Cognitive self-consciousness showed high positive correlation with Global Assessment of Functioning Scale (r =0,7436, p<0,0001). Conclusion: Follow up of metacognitions, cognitive and global functioning, and its relations, may have an important role in assessment of war veterans with posttraumatic stress disorder.

Aim To explore the spatial and temporal expression patterns of DAB1 and Reelin in the developing and postnatal healthy human kidneys as potential determinants of kidney development. Methods Paraffin-embedded fetal kidney tissue between the 13/14th and 38th developmental weeks (dw) and postnatal tissue at 1.5 and 7 years were stained with DAB1 and Reelin antibodies by double immunofluorescence. Results During the fetal kidney development and postnatal period, DAB1 and Reelin showed specific spatial expression pattern and diverse fluorescence intensity. During the fetal period, DAB1 was strongly expressed in the distal convoluted tubules (DCT), with strong reactivity, and diversely in the proximal convoluted tubules (PCT) and glomeruli. In the postnatal period, DAB1 expression decreased. The strongest Reelin expression in early fetal stages was observed in the PCT. In the postnatal period, Reelin expression decreased dramatically in all observed structures. These two markers were colocalized during early developmental stages, mostly in PCT, DCT, and podocytes. Conclusion The appearance of DAB1 and Reelin during fetal kidney development confirms their potential significant role in the formation of kidney structure or function. High DAB1 expression in the DCT implies its regulatory role in tubular formation or function maintenance during development. Reelin was highly expressed in human kidneys at early fetal stages, mostly in the PCT, while at later fetal stages and postnatal period its expression decreased.

This paper provides an overview of the combined auxiliary cohorts that were settled at camp on Humac during the period of Principate (1-3 century). After the end of the Great Illyrian revolt (AD 6-9), some of the cohorts that participated in its suppression remained at this camp. Combined Hispanic cohorts (cohors I Lucensiumequitata and cohors I Bracaraugustanorum equitata) and cohors III Alpinorum equitata, that probably played a major role in the building of the camp on Humac, which served as a permanent base for Roman military forces, were among them. Cohors I Belgarum equitata took permanent garrison in the camp at the beginning of the 2nd century. Monuments left by this cohort serve as evidence about the increased participation of local young men in the Roman auxiliary troops, while officers originated from the western parts of the Empire. Also, we discussed the monuments of cohors VIII voluntariorum civium Romanorum in the Ljubuški area, which has not yet been determined with certainty as cohorts equitatae. We dedicated special attention to the issue of marriage between local girls and Roman auxiliary soldiers and officers that, in our opinion, wasn’t adequately treated in current literature. In connection with this, the case of Iulia B, the wife of decurion Flavius Aurelianus, is particularly interesting. She served as an example of Romanization, or how local girls married auxiliaries which were settled in the camp on Humac. Through careful analysis of epigraphic records with their names, we found that previous interpretations of these monuments are not scientifically justified, and that Iulia B[---] is probably from Pannonia, as well as her husband.

This paper investigates the influence of the fuel injector nozzle geometry on the liquid fuel contraction coefficient and Reynolds number. The main three fuel injector nozzle geometry parameters: nozzle diameter (d), nozzle length (l) and nozzle inlet radius (r) have a strong influence on the liquid fuel contraction coefficient and Reynolds number. The variation of the nozzle geometry variables at different liquid fuel pressures, temperatures and injection rates was analyzed. The liquid fuel contraction coefficient and Reynolds number increase with an increase in the nozzle diameter, regardless of the fuel injection rate. An increase in the r/d ratio causes an increase in the fuel contraction coefficient, but the increase is not significant after r/d = 0.1. A nozzle length increase causes a decrease in the fuel contraction coefficient. Increase in the nozzle length of 0.5 mm causes an approximately similar decrease in the contraction coefficient at any fuel pressure and any nozzle length. Fuel injectors should operate with minimal possible nozzle lengths in order to obtain higher fuel contraction coefficients.

Introduction. Trichinellosis is a cosmopolitan anthropozoonosis, and is a group of systemic diseases caused by larval forms of Trichinella. This is one of the oldest and most controversial parasitic zoonoses that has been in the forefront of veterinary, medical and biological research for many years. Parasites from the genus Trichinella were diagnosed in more than one hundred species of domestic and wild mammals and birds. The aim of this study was economic evaluation of a program for monitoring and controlling Trichinella in pigs. Materials and Methods. A systematic pest rodent control program deemed suitable for monitoring and controlling Trichinella in pigs was implemented in a representative test zone. The results of the pest rodent control program were analyzed using cost-benefit analysis to determine if a similar program would be suitable for a larger land area. Results and Conclusions. Prior to pest control, the incidence of Trichinella in pigs living in the test zone increased annually, while after systematic pest rodent control, the incidence of Trichinella-positive pigs decreased. These results, as well as relevant economic indicators, enabled us to design two mathematical models describing the control and monitoring of Trichinella in a larger land area. In this area, Srem Region, Serbia, a suitable Trichinella control program in pigs is clearly justified because the profit to cost ratio was positive for both models.

Introduction: Basal cell carcinoma (BCC) is a non-melanocytic skin malignancy arising from basal cells of epidermis or follicular structures. Etiology of BCC is a multifactorial combination of genotype, phenotype, and environmental factors. There are several clinical variants of BCC including nodular, cystic, superficial, morphoeic, keratotic, pigmented and micronodular. Aim: The aim of our study was to analyze the recent clinical trends of basal cell carcinoma by reviewing a single institution’s experience. Methods: Total number of 422 patients clinically diagnosed with basal cell carcinoma were included in the study. Data on age, gender, skin type, personal and family history, duration of disease, localization of lesions, clinical type of lesions, and recurrence rate were collected and analyzed. The data were statistically evaluated. Results: More than 80% of all BCC’s were located on sun-exposed skin areas (p<0.05).The male /female ratio was 1:0.92. The nodular BCC was the most frequent type (59.2%), followed by the superficial (16.1%), pigmented (15.2%) and morphoeic (9.5%) types. The nodular and pigmented types were predominant located on the head and neck, whereas the trunk was the most common location for the superficial type (p<0.05). The tumor is commonly found in concomitance with skin lesion related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. During this study period, 41 cases showed recurrence of the cancer as the overall recurrence rate was 9.7%. There were no cases with metastasis or fatal outcome. Conclusions: The factors related to the development of BCC were older age and exposure to ultraviolet rays both in recreational and in occupational form. The prevention of BCC is based on the knowledge of risk factors, early diagnosis and treatment, particularly in susceptible populations.

Abstract The main aim of this paper is to investigate the productivity changes of microfinance institutions (MFIs) in Bosnia and Herzegovina (BiH) during and after the recent financial crisis. The study covers the period starting from 2008 until 2015. Using the Malmquist Productivity Index (MPI) over the sample of 10 MFIs and a balanced panel dataset of 80 observations, this study explores technical and technological change as well as total factor productivity (TFP) change. The empirical findings indicate a decline in TFP in most of the analyzed periods with an average decrease of 2.5%. The study reveals an average technological decline in the industry of 1.7%, while technical efficiency change is recorded at the level of -0.8%. Overall, crisis efficiency recovery occurred during the period between 2009 and 2013. However, due to technological inefficiencies, average total factor productivity change remains negative. Hence, policy makers need to enhance the technological progress in order to meet their strategic objectives in BiH MFIs.

Introduction The workplace can be a source of stress. One of the most stressful professions is the profession of doctor of dental medicine (dentist). Multiple forms of stressors lead to such occupational stress. Objective The research objective was to examine stress levels among dentists in the 25 to 45 year age group. Materials and Methods This cross sectional study included 105 doctors of dental medicine throughout Bosnia and Herzegovina, aged between 25 and 45 years. The research was conducted by means of a confidential on-line survey. All participants signed the informed consent, and voluntarily filled out the survey form. The research used the PERCEIVED STRESS SCALE-PSS 10. The statistical analysis used the IBM Statistics SPSS v.21 statistics packages and Microsoft Excel 2010. Descriptive statistics, X2 test, and T-test were also used. Results Of the total number of respondents, n=105, 66 (63%) of them were female and 39 (37%) male respondents. The mean median value of the score was 23 (Mean = 23.080), as a result of which we can conclude that the respondents in the 25-45 year age population group that participated in this study showed a high level of stress based on the completed questionnaire and the answers received from the respondents. Conclusion The estimated level of stress has been shown to be high in both genders, with no statistically significant difference between genders.

Breast cancer consists of several intrinsic molecular subtypes, providing the basis for clinical treatment decisions. Lately, it is becoming increasingly recognized that factors other than the intrinsic cancer characteristics, such as immune components’ activity in the tumor microenvironment, have important effects on treatment choices and efficacy. bioSyntagma has developed a method, the Molecular Fingerprint (mPrint®), that enables multiplexed analysis of spatially defined regions in formalin-fixed, paraffin-embedded (FFPE) tumor samples allowing for analysis of the gene signatures unique to the tumor microenvironment. This method was applied to molecularly defined sets of breast cancers and used to evaluate four different tumor regions of interest (ROIs): 1) viable carcinoma proper (>90% cancer cells), 2) fibrotic tumor center (sparse cellularity), 3) interface between viable tumor and inflammatory component (tumor and inflammatory microenvironment) and 4) tissue away from the tumor (normal breast tissue). This was compared to the whole tissue scrapes from each patient block. Each ROI and tissue scrape was analyzed by high throughput qPCR for a panel of 248 genes using SmartChip technology (Takara Bio, USA). Sequential tissue slices from each patient were also analyzed using immunohistochemistry (IHC) for three targets and investigated for correlation with qPCR results for validation of the method. Overall, reasonable concordance was observed in general expression trends between selected IHC and RNA expression. qPCR data were further analyzed using hierarchical clustering analysis and showed that morphologically defined ROI’s cluster completely differently than traditional clustering of entire tissue scrapes. Notably, patient clustering based on morphological regions was independent of the intrinsic cancer subtype, as determined by molecular profiling of whole tissue scrapes, as well as independent of trends in Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). These findings suggest that current methods of patient stratification based on whole tumor molecular subtyping may be inferior to stratification based on molecular characteristics of the tumor microenvironment. Citation Format: Colleen Ziegler, Isaiah Slemons, Chris DeSilva, Barbara Witkowski, Alain Mir, Sangeetha Anandakrishnan, Andrew Farmer, Elma Contreras, David Richardson, Semir Vranic, Zoran Gatalica, Dmitry N. Derkach. Novel method for patient stratification in breast carcinoma based upon spatial analysis of tumor microenvironment [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; 2019 Oct 26-30; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B094. doi:10.1158/1535-7163.TARG-19-B094

Value iteration is a method to generate optimal control inputs for generic nonlinear systems and cost functions. Its implementation typically leads to approximation errors, which may have a major impact on the closed-loop system performance. We talk in this case of approximate value iteration (AVI). In this paper, we investigate the stability of systems for which the inputs are obtained by AVI. We consider deterministic discrete-time nonlinear plants and a class of general, possibly discounted, costs. We model the closed-loop system as a family of systems parameterized by tunable parameters, which are used for the approximation of the value function at different iterations, the discount factor and the iteration step at which we stop running the algorithm. It is shown, under natural stabilizability and detectability properties as well as mild conditions on the approximation errors, that the family of closed-loop systems exhibit local practical stability properties. The analysis is based on the construction of a Lyapunov function given by the sum of the approximate value function and the Lyapunov-like function that characterizes the detectability of the system. By strengthening our conditions, asymptotic and exponential stability properties are guaranteed.

We propose a novel triggering policy to implement state-feedback controllers for nonlinear systems via packet-based communication networks. The idea is to generate transmissions between the plant and the controller only when a state-dependent rule has been satisfied for a given amount of time. We refer to this new paradigm as event-holding control, in which a clock variable is thus only running when a state-dependent criterion is verified. This is different from time-regularized event-triggered control, where the clock variable keeps running after each transmission instant until it is reset to zero at the moment a state-based condition is verified. We approach the problem of designing an event-holding controller via emulation. We first synthesize a state-feedback law, which stabilizes the closed-loop system in the absence of the communication network. We then design the event-holding triggering mechanism under a set of general assumptions. The results are applied to two case studies consisting of linear systems and a class of nonlinear systems controlled by backstepping. We also provide a numerical backstepping control example, which demonstrates that the event-holding behaviour can reduce the number of transmissions.