Growing popularity of recreational skiing and snowboarding in this region has directed this corpus-based study towards getting an insight into standardization requirements of the ski register in Serbian within the framework of today’s angloglobalized world of sport. The corpus consists of 292 ski terms in English and Serbian. After a brief overview of the creation of ski terms, the paper deals with a contrastive analysis of the corpus from the aspect of adaptation of English terms into the system of Serbian at the level of form, i.e. respelling and at the level of content, i.e. translation. Guided by the results of this analysis, the following sections deal with the requirements related to the standardization of ski terms in Serbian. 

Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogeneity to infer evolutionary dynamics. A growing number of studies have used these approaches to link cancer evolution with clinical progression and response to therapy. Although the inference of tumor phylogenies is rapidly becoming standard practice in cancer genome analyses, standards for evaluating them are lacking. To address this need, we systematically assess methods for reconstructing tumor subclonality. First, we elucidate the main algorithmic problems in subclonal reconstruction and develop quantitative metrics for evaluating them. Then we simulate realistic tumor genomes that harbor all known clonal and subclonal mutation types and processes. Finally, we benchmark 580 tumor reconstructions, varying tumor read depth, tumor type and somatic variant detection. Our analysis provides a baseline for the establishment of gold-standard methods to analyze tumor heterogeneity. Methods for reconstructing tumor evolution are benchmarked in the DREAM Somatic Mutation Calling Tumour Heterogeneity Challenge.

Avelumab, an anti–programmed death‐ligand 1 monoclonal antibody approved for the treatment of metastatic Merkel cell carcinoma and platinum‐treated urothelial carcinoma, was initially approved with a 10 mg/kg weight‐based dose. We report pharmacokinetic (PK)/pharmacodynamic analyses for avelumab comparing weight‐based dosing and a flat 800 mg dose, developed using data from 1,827 patients enrolled in 3 clinical trials (NCT01772004, NCT01943461, and NCT02155647). PK metrics were simulated for weight‐based and flat‐dosing regimens and summarized by quartiles of weight. Derived exposure metrics were used in simulations of exposure‐safety (various tumors) and exposure‐efficacy (objective responses; Merkel cell or urothelial carcinoma). Flat dosing was predicted to provide similar exposure to weight‐based dosing, with slightly lower variability. Exposure‐safety and exposure‐efficacy simulations suggested similar benefit:risk profiles for the two dosing regimens. These pharmacometric analyses provided the basis for the US Food and Drug Administration approval of a flat dose of avelumab 800 mg every 2 weeks in approved indications.

Alepski bor (Pinus halepensis Mill.) se koristio u pošumljavanju krša šibenske regije od sredine 19. stoljeća, te se zbog toga ova vrsta često javlja u ranije zasnovanim parkovima. Upravo zbog poznatih dekorativnih karakteristika, te kulturološke vrijednosti, cilj rada je izvršiti inventarizaciju i predočiti estetsku ocjenu zelenih površina s alepskim borom. U tu svrhu provedena je taksonomska analiza vrsta na zelenim površinama s alepskim borom. Florističko i anketno istraživanje je provedeno tijekom 2013. godine na području grada Šibenika. S obzirom na tip habitusa po Erhardtu i sur., 2002. dominiraju grmolike forme i alohtone dendrološke svojte. Temeljem rezultata istraživanja vizualnog dojma „geštalta”, putem anketnog ispitivanja, zaključak je da ispitanici ugodno doživljavaju parkovne prostore s alepskim borom.

Fresh sausages are highly perishable, and the preservatives allowed in these types of meat preparations are limited. Balkan-style fresh sausages were prepared in triplicate without antimicrobials (Control), with an aqueous hops extract (30 mL/kg), with Zataria multiflora Boiss essential oil (1 mL/kg), or a combination of both (15 and 0.5 mL/kg, respectively), and refrigerator-stored under a 20% CO2 and 80% N2 atmosphere. The spoilage microbial growth, i.e., lactic acid bacteria (LAB), Brochothrix thermosphacta, Enterobacteriaceae, Micrococcaceae, molds and yeasts, the pH value, and the production of biogenic amines in the sausages were monitored weekly and compared with a control sausage during a 35-day storage period. Furthermore, 349 colonies of presumptive LAB (isolated from the De Mann, Rogose-Sharpe agar plates) were identified using a MALDI-TOF-based method. Growth levels to ≈ 9 Log colony forming units (CFU) per g were reached by LAB, with a predominance of Lactobacillus sakei. Enterobacteriaceae and B. thermosphacta also showed significant growth (up to 6 Log CFU/g). Biogenic amine levels increased, and tyramine values overcame 250 mg/kg. The study could not demonstrate a significant effect of antimicrobial source treatments in any of the characteristics studied, and thus, the shelf-life of sausages.

Background: The aim of the article was to create an appropriate computer model based on the real status of the mortar operator's workplace and to analyze the workplace. After that, for any possible exceedances from the aspect of the organism's load and safety, the aim is to redesign the workplace and bring it within the limits of the permissible load, and therefore the required safety. The aim is also to identify the characteristic work movements performed by the soldier and to carry out an ergonomic analysis of the soldier's efforts and to propose appropriate improvements. Methods: The analysis is performed on a total of 20 soldiers, from which is determined an average model of the following characteristics: 180 cm in height and 85 kg in weight. The task is to take a mine from the shell containing the mines, then transfer it to the mortar and fill the mortar barrel. The weight of the 120 mm mortar grenade is 14.8 kg. The average soldier is 26 years old and his military exercise lasts 4 hours. The CATIA software package (Dassault Systemes, Velizy-Villacoublay, France) is used for analysis. By knowing the anthropometric and work environment data, with ergonomic design and analysis, the following analyses were made: biomechanical analysis, rapid upper limb assessment (RULA) and carry analysis (option from CATIA software). Results: The proposed modification of the position resulted in a decrease in the L4/L5 torque from 316 Nm to 154 Nm along with decreasing of the compression force on the L4/ L5 from 5779 N to 3038 N (the compression force allowed is 3400 N), and while the RULA analysis is from the red color position 1 (score 7; maximum load requiring rapid repositioning of such position), revised final score 4 made in yellow (a solution acceptable for this work place). Conclusions: By ergonomic analysis, obtained proposal will lead to less chance of injury, prevention of burn out syndrome, fewer chances of illness, decreasing the fatigue, greater safety, less energy spent and better preparedness for all necessary tasks.

Predatory journals refer to journals that recruit articles through aggressive marketing and spam emails, promising a quick, but not robust, review and fast open-access (OA) publication, thus compromising scholarly publishing standards.1–5 Their key motive is a financial benefit via article processing charges (APCs) and other additional fees.1 3 4 The number of OA journals has dramatically risen over the past 15 years,6 reaching 11 376 journals, indexed in the Directory of Open Access Journals (DOAJ) in 2018 (available at https://doaj.org). This expansion was parallel to the increase in the number of predatory publishers.7 8 Predatory journals have become more prevalent than ever due to massive internet expansion and extensive spam email soliciting.2 4 9 Since 2011, when Jeffrey Beall launched his first list of potential predatory OA publishers and journals, predatory journals have come into focus.3 4 Recent studies have highlighted the significant burden of potentially predatory journals in several biomedical specialties, including neuroscience/neurology, urology, emergency medicine, physical medicine, orthopaedics, rehabilitation, as well as anaesthesiology.7 8 10–13 No study on predatory journals in pathology has been conducted so far. As previously suggested, we explored Beall’s list of predatory journals as an initial database of suspected journals related to pathology.2 8 The term predatory was only applied after assessing each journal separately. The assessment was based on the recommended …