Deep eutectic solvents (DESs), as an alternative to ionic liquids, have greener credentials than ionic liquids and have attracted increasing attention in many applications. Choline chloride-based DESs in combination with different hydrogen bond donors (organic acid, sugars and urea), showed a high extraction efficiency. The aim of this study was to examine the possible effects of choline chloride-based eutectic solvents on the antioxidant and antimicrobial activity of lemon and mandarin orange seed extracts. Lactic acid, glucose, urea and water were used to prepare choline chloride-based Natural Deep Eutectic Solvents (NADESs). Ferric-Reducing Antioxidant Power (FRAP) Assay and 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method were used to determine Original Research Article Kolarević et al.; IRJPAC, 21(23): 120-128, 2020; Article no.IRJPAC.63470 121 antioxidant activity. Antibacterial activity was investigated by diffusion method on reference bacterial strains E. coli, E. faecalis, S. aureus, B. subtilis and L. monocytogenes. The analysis revealed a significant reduction potential of the eutectic solvent based on lactic acid as well as significant antioxidant activity of lemon and mandarin seed extracts. In general, mandarin extracts showed better antioxidant capacity. In vitro antibacterial activity assays showed a complete absence of bacterial growth inhibition of the extracts. However, eutectic solvents with lactic acid have shown a significant antimicrobial effect.

In adults 65 years or older, falls or other neuromotor dysfunctions are often framed as walking-related declines in motor skill; the frequent occurrence of such decline in walking-related motor skill motivates the need for an improved understanding of the motor skill of walking. Simple gait measurements, such as speed, do not provide adequate information about the quality of the body motion’s translation during walking. Gait measures from accelerometers can enrich measurements of walking and motor performance. This review article will categorize the aspects of the motor skill of walking and review how trunk-acceleration gait measures during walking can be mapped to motor skill aspects, satisfying a clinical need to understand how well accelerometer measures assess gait. We will clarify how to leverage more complicated acceleration measures to make accurate motor skill decline predictions, thus furthering fall research in older adults.

In recent years, GraphQL has become a popular way to expose web APIs. With its raise of adoption in industry, the quality of GraphQL APIs must be also assessed, as with any part of a software system, and preferably in an automated manner. However, there is currently a lack of methods to automatically generate tests to exercise GraphQL APIs.In this paper, we propose a method for automatically producing GraphQL queries to test GraphQL APIs. This is achieved using a property-based approach to create a generator for queries based on the GraphQL schema of the system under test.Our evaluation on a real world software system shows that this approach is both effective, in terms of finding real bugs, and efficient, as a complete schema can be covered in seconds. In addition, we evaluate the fault finding capability of the method when seeding known faults. 73% of the seeded faults were found, with room for improvements with regards to domain-specific behavior, a common oracle challenge in automatic test generation.

Energy saving potentials related to steam generation and its usage in the medium size bakery are analyzed and presented. Input data needed for the investigation are gathered through detailed energy audit. Four energy savings measures are analysed in detail: 1) change of heat generator for space heating and domestic hot water preparation from steam boiler to condensing boiler, 2) reduction of heat losses from steam and condensate distribution lines, 3) heat utilization of return condensate and 4) replacement of the old, low efficiency steam boiler with high-efficient one. Implementation of these measures will result in substantial reduction of energy costs, ranging from 2.900 to 26.200 € annually. Interaction of all measures is analysed through energy efficiency improvement scenario, whose implementation will ensure significant energy cost savings, estimated at 40.793 € annually, with simple payback period shorter than 4 years. Implementation of presented measures will improve facility’s energy efficiency, represented through reduction of annual energy performance indicators by 6,14 %. Presented analysis revealed that steam generation and its usage in the industrial facilities offer a substantial potential for reduction of energy use and energy related cost.

In this work we adapt and evaluate different solutions for automatic speech recognition (ASR) to be used as an HMI for the assistant robot. Two on-device solutions: Kaldi (DNN-HMM) and Mozilla's DeepSpeech (end-to-end), and three internet service APIs: IBM Watson, Microsoft Azure and Google Speech to Text are evaluated. The systems are adapted to the domain of robot commands and evaluated on a set of expected inputs. As the goal is to retain the ability to recognise general language, the systems are also evaluated on out of domain data.

This article introduces a computational design framework for obtaining three‐dimensional (3D) periodic elastoplastic architected materials with enhanced performance, subject to uniaxial or shear strain. A nonlinear finite element model accounting for plastic deformation is developed, where a Lagrange multiplier approach is utilized to impose periodicity constraints. The analysis assumes that the material obeys a von Mises plasticity model with linear isotropic hardening. The finite element model is combined with a corresponding path‐dependent adjoint sensitivity formulation, which is derived analytically. The optimization problem is parametrized using the solid isotropic material penalization method. Designs are optimized for either end compliance or toughness for a given prescribed displacement. Such a framework results in producing materials with enhanced performance through much better utilization of an elastoplastic material. Several 3D examples are used to demonstrate the effectiveness of the mathematical framework.

Bosnia-Herzegovina and southern-coastal/hinterland-region of Dalmatia, Republic of Croatia are a part of the same seismo-tectonic province and share a considerable and real threat of high-magnitude earthquakes. Numerous Magnitude 6 (Richter) and above earthquakes have been recorded in the past 500 years and some of them have resulted in a considerable loss of life, material and even prestige or geopolitical significance (e.g. the demise of Ragusa in the earthquake of 1667). Given the propensity of the region for destructive earthquakes, complex geomorphological framework and challenging infrastructure, still recovering in parts from the Yugoslav civil wars of the 1990s., the region may yield a “perfect” crisis in the aftermath of a major earthquake event. Taking into consideration unchecked development of several metropolitan areas, lack of oversight and permitting, decaying infrastructure as well as unresolved political ambiguities and territorial disputes, a potential destructive earthquake may create several cascading crises, especially if it coincides with some other challenging events (e.g. winter storms). This study is taking into consideration several scenarios, their possible effects and resulting conditions upon which cascading crises may arise in the aftermath of a magnitude 7+ earthquake affecting several major urban areas in southern and central Bosnia-Herzegovina and the southern Dalmatian region of Croatia. These scenarios are intended to provide training aids and risk assessments in countering the destructive forces after the earthquake, expected to test the current crisis-management models. 

Bosnia-Herzegovina and Republic of Croatia share 931km of border (494km land and 425km riverine), which has been contentious for the greater part of the modern European history and represented one of the hardest and most-militarized border demarcating the frontiers of the major empires. Nowadays, it is in the process of becoming another hard-border between the Schengen-Zone EU and non-EU Western Balkans. In this study we are considering several strategic elements required for planning of effective and constructive border security, while countering variety of pseudo-hybrid warfare operations as well as tactical considerations when responding to crisis, communications and overall control of the fluid frontier. Strategic elements taken into consideration are:  a) overall contiguity of the border, b) communications network / trafficability at border-crossing and c) geospatial support in the intelligence preparation of the area. Tactical elements considered are a) real-time geospatial support during operations b) alternative communications and vetting of alternative communications c) defensive operations (e.g. drone defense, jamming defense, incursion prevention). We are considering lessons-learned from the hostilities and frozen-conflicts in Yugoslavia, Ukraine, Afghanistan, Yemen and potential future conflagrations in Trans-Dnistria, Bosnia-Herzegovina, Kosovo* and the Baltics. We are using several criteria in understanding the required geospatial preparations required to undertake or defend against mass-migrations and potential hybrid threats such as unresolved territorial issues, population density information, infrastructure condition, land-use and overall completeness and availability of geospatial data. * Designation without prejudice to positions on status, and is in line with UNSCR 1244 and the ICJ Opinion on the Kosovo Declaration of Independence

Bosnia and Herzegovina has witnessed continuous depopulation since 1991. Depopulation was foreseen even without the emergence of war, but not nearly to that extent or that early. Bosnia and Herzegovina is in a worse demographic position than the European Union countries that show similar demographic trends. Very low birth rates, low fertility and low natural population growth have been recorded in the time of weaker economic development, which increasingly accelerates the emigration of the educated population in particular, and permanently adversely affects the reproductive potential of the country. This paper considers a hidden mutual relationship between the demographic situation (natural change, population ageing) in Bosnia and Herzegovina and its citizens' system of values. According to the survey conducted on 614 respondents, Bosnia and Herzegovina's citizens have fewer children than they would like.

The online platform is a platform of the future, both in the world and in Bosnia and Herzegovina. “The World Without a Label” is the first counseling center of this kind in BiH, because it brings together experts from behavioral, psychological, and psychiatric problems in one place. As a special problem of sociopolitical context is victims of sexual violence, war rape crimes. A case study shows a young boy is accompanied by a parent due to behavioral problems manifested by extremely bad social interaction with peers and for spending most of his free time on his computer playing video games. The boy’s mother had previously been treated in a psychiatric clinic’s day hospital, where she shared her own trauma of rape in group psychotherapy and the painful problems she faced in her early 20s, where Republika Srpska Army soldiers systematically raped captured Bosniaks. The father is a former member of the Bosnian army, and he himself had lot of war traumas. Experience in working in the Counseling Centers like this one, as well as with all the scientific and technological achievements, we have enabled the development of procedures for solving mental health problems through online platforms and standardization of those procedures.

In this paper, the authors analyse the legal nature of criminal procedure in Bosnia and Herzegovina, with the special emphasis on reform processes of criminal procedure legislation and adoption and acceptance of new legal solutions over the past two decades, acknowledging the aspiration for effectiveness and protection of basic human rights and freedoms. For the purpose of effective criminal procedure, it identifies the main and secondary actors in criminal proceedings whose role is crucial from the aspect of shedding light on and resolving a certain criminal matter, as well as issuing a judicial decision. To that end, the role and importance of those actors in taking procedural actions to carry out a criminal procedure task is emphasised for the purpose of understanding the legal nature, structure and course of the criminal procedure, and achieving the scope of legally prescribed rights of the suspect, that is, the defendant. In addition, special attention is paid to the specific procedural situation and status of an underage person in the criminal law as the perpetrator and injured parties in a criminal case, taking into account their age as the basis for the differentiation and protection in relation to adults.

Abstract Biomedical signals carry signature rhythms of complex physiological processes that control our daily bodily activity. The properties of these rhythms indicate the nature of interaction dynamics among physiological processes that maintain a homeostasis. Abnormalities associated with diseases or disorders usually appear as disruptions in the structure of the rhythms which makes isolating these rhythms and the ability to differentiate between them, indispensable. Computer aided diagnosis systems are ubiquitous nowadays in almost every medical facility and more closely in wearable technology, and rhythm or event detection is the first of many intelligent steps that they perform. How these rhythms are isolated? How to develop a model that can describe the transition between processes in time? Many methods exist in the literature that address these questions and perform the decoding of biomedical signals into separate rhythms. In here, we demystify the most effective methods that are used for detection and isolation of rhythms or events in time series and highlight the way in which they were applied to different biomedical signals and how they contribute to information fusion. The key strengths and limitations of these methods are also discussed as well as the challenges encountered with application in biomedical signals.

Embora reconhecida como comportamento de extrema importância na saúde da população, a prática de atividade física regular ainda é um grande desafio. Objetivo: verificar o nível de atividade física no lazer e possíveis fatores correlatados em uma comunidade acadêmica do nordeste brasileiro. Metodologia: trata-se de um estudo transversal, constituído por discentes, docentes e técnicos administrativos, utilizou-se como instrumento “Mapa de Atividade Física e Saúde-MAFIS”, realizou-se estatística descritiva, teste de Qui quadrado, com posterior montagem do modelo de regressão logística. Resultados: 52,1% atingiram as recomendações de atividade física (AF), os homens apresentam 65,3% (OR: 1,65; IC95%: 1,29-2,11) mais chance de serem ativos, quem gosta de AF tem duas (OR: 2,02; IC95%: 0,82-4,96) a 4,8 (OR: 4,84; IC95%: 1,99-11,8) vezes mais chance de praticar AF, achar importante fazer AF (OR: 2,23; IC95%: 0,48-10,4) e menos dias sentado aumenta de 48,3% (OR: 1,48; IC95%: 1,032- 2,130) a 53,3% (OR: 1,53; IC95%: 1,09-2,13) a chance de fazer AF e quem pensa em fazer AF (OR: 0,362; IC: 0,203-0,645) tem menos chance de ser ativo. Conclusão: Gostar, considerar importante e menos dias sentados aumentam as chances de fazer atividade física, já pensar sempre em fazer, diminui a chance de ser ativo no lazer.

This paper explores the use of the meshfree computational mechanics method, the Material Point Method (MPM), to model the composition and damage of typical renal calculi, or kidney stones. Kidney stones are difficult entities to model due to their complex structure and failure behavior. Better understanding of how these stones behave when they are broken apart is a vital piece of knowledge to medical professionals whose aim is to remove these stone by breaking them within a patient’s body. While the properties of individual stones are varied, the common elements and proportions are used to generate synthetic stones that are then placed in a digital experiment to observe their failure patterns. First a more traditional engineering model of a Brazil test is used to create a tensile fracture within the center of these stones to observe the effect of stone consistency on failure behavior. Next a novel application of MPM is applied which relies on an ultrasonic wave being carried by surrounding fluid to model the ultrasonic treatment of stones commonly used by medical practitioners. This numerical modeling of Extracorporeal Shock Wave Lithotripsy (ESWL) reveals how these different stones failure in a more real-world situation and could be used to guide further research in this field for safer and more effective treatments.