Background / Aim. FOLFOX (5fluorouracil, folinic acid, oxaliplatin)/CapOx (capecitabine, oxaliplatin) plus bevacizumab and FOLFIRI (5 fluorouracil, folinic acid, irinotecan) plus bevacizumab are a standard treatment options for a first line treatment of metastatic colorectal carcinoma (mCRC). The aim of this study was to compare overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) in the groups of patients with mCRC who were treated in the first line with FOLFIRI/bev versus FOLFOX/bev. At the same time, it was compared the safety profile in observed groups of patients and investigated optimal treatment duration and characteristics of patients who had the best treatment outcomes. Methods. In a retrospective-prospective study, patients with mCRC were treated with a chemotherapy protocols for the first line in combination with bevacizumab (FOLFOX/bev, respectively, FOLFIRI/bev). Treatment efficacy was evaluated on the basis of overall response rate (ORR), progression-free survival (PFS) and overall survival (OS), and the safety of treatment was evaluated by monitoring adverse drug reactions. Results. ORR was 70% in the FOLFIRI/bev group and 50% in the FOLFOX/bev group. Median PFS for FOLFIRI/bev (n = 30) and for FOLFOX/bev (n = 30) was 15.6 months and 12.1 months respectively (HR, 0.85; 95% confidence interval (CI) 0.47-1.53; P = 0.5591). Median OS for FOLFIRI/bev and for FOLFOX/bev was 24.7 months and 19.9 months respectively (HR, 0.67; 95% confidence interval (CI) 0.37-1.23; P = 0.1552). In both patient groups, the patients who received more than 9 cycles of induction therapy had better treatment response in comparison with patients who received less than 9 cycles of therapy. In FOLFOX/bev group PFS was 16.9 versus 9.7 months and OS was 22.1 versus 17.6 months respectively. In FOLFIRI/bev group PFS was 9 months for patients who received less than 9 cycles of therapy versus 18.8 months for patients who received more than 9 cycles, OS was 18.0 versus 27.7 respectively. The adverse drug reactions grade 3 and 4 were 7% in the FOLFIRI/bev group versus 27% in the FOLFOX/bev group. Conclusion. Patients who received FOLFIRI/bev had better ORR (70 % versus 50 %), PFS (15.6 versus 12.1 months) and OS (24.7 versus 19.9 months). In both patient groups, better treatment response had the patients who received induction therapy for 4-6 months (more than 9 cycles of therapy).

Abstract Computer-aided drug design methods such as molecular dynamic simulations, molecular docking, and virtual screening are extensively and successfully used as a first step to identify crucial interactions of ligands with a drug target, explain activity of the ligands, and propose structural modifications for efficient drug–target interaction. Protein kinases are one of the most extensively studied targets in drug design and discovery. In this chapter are explained, compared, and analyzed structure-based methods used in drug design of kinase inhibitors.

The thiol compound 2,5-dimercapto-1,3,4-thiadiazole is a potential cathode material. The redox reactions of the mentioned thiol compound are slow at room temperature but can be enhanced using electron transfer mediators. The electrochemical oxidation of 2,5-dimercapto-1,3,4-thiadiazole on the surface of carbon electrodes modified with Ruthenium(III) Schiff base complex was studied by voltammetric methods and amperometric flow injection analysis. The electrocatalytic properties of Ruthenium(III) Schiff base complex on glassy carbon and screen printed carbon electrodes are enhanced by the addition of multi-walled carbon nanotubes and Nafion. Voltammetric studies showed that anodic oxidation of DMcT on a modified glassy carbon electrode occurs at a potential of +0.28 V vs. Ag/AgCl in Britton-Robinson buffer (pH 6.50). Flow injection amperometric measurements were performed at +0.20 V vs. Ag/AgCl in Britton-Robinson buffer solutions pH 6.50 at a 0.40 cm3 min−1 flow rate. The results of amperometric measurements for modified screen printed and glassy carbon electrodes showed that the screen printed electrode had a lower value of detection limit (0.38 mg dm−3) and quantification (1.28 mg dm−3), and a linear dynamic range from 1 to 500 mg dm−3 of 2,5-dimercapto-1,3,4-thiadiazole. Modified glassy carbon electrode provided a linear dynamic range up to 750 mg dm−3 of 2,5-dimercapto-1,3,4-thiadiazole with a detection limit of 3.90 mg dm−3 and quantification of 13.20 mg dm−3.

In recent years, the sharing economy has become a new buzzword, providing various business opportunities and challenges to conventional businesses. It is characterized by the transformation of conventional business sectors and many companies are already facing the pressure of adapting their operations to the changing conditions. Human resource management, especially when it comes to experts and knowledge workers, is among the affected business activities. In particular, due to the apparent high demand, this type of workforce has the opportunity to share services among many businesses. Therefore, human resource managers should tackle the issue of cultivating employee organizational identification to increase employee retention and achieve the desired performance. In this regard, this paper proposes a model that binds human resource management practices to employee organizational identification, innovative behaviour, knowledge sharing, and finally, employee job performance. The model is estimated using the survey method and structural equation modelling technique for data analysis. The results imply that selective recruiting, participation in decision-making, and rewarding contribute to employees' organizational identification, while training does not directly affect it. The findings, therefore, indicate that adequate human resource management practices, mainly through the simultaneous impact of the critical capabilities examined by this model, can serve as a foundation for business success in the sharing economy.

Background: The COVID-19 pandemic has had significant different consequences for everyday life of every human being, as well as on the functioning of health, educational and scientific institutions. Objective: The aim of this article is to provide information on impact of the COVID-19 pandemic on scientific research in the biomedical sciences, and publications, as wll as impact on education in medcine and clinical training. Methods: Papers published of influence of the COVID-19 pandemic on the main aim were searched and analyzed. Results: Many basic research labs quickly tuned their priorities and continud to study different aspects of SARS-CoV-2 infection and COVID-19. Biomedical sciences have become an important area in the fight against the SARS-CoV-2 virus, due to the unique challenges posed by the pandemic, including epidemiological aspects, immune mechanisms of the disease, clinical parameters of this essentially multisystem disease, virus properties, infection mechanisms, and later work on finding vaccines and everything that is needed. There are several studies that point to the negative impact of the pandemic on biomedical education, especially in the acquisition of practical clinical skills among medical students. The negative impact, both on basic education in medicine, and also on the acquisition of practical knowledge within various clinical disciplines, especially surgery, unfortunately continues. The COVID-19 pandemic has mobilised researchers worldwide on a scale and timeframe that have never been seen before for one specific disease. The number of COVID-19 manuscripts being submitted for peer review has also greatly increased. Unfortunately, research and publications on COVID-19 has so far often not been of high quality and many unprinted preprints have been rushed to spread without sufficient oversight. The time between submission and publication of articles on COVID-19 has decreased on average by around 50%. This analysis also showed that the time to publication for research not related to COVID-19 has remained unaffected, and that the number of research articles unrelated to COVID-19 has dropped considerably, with COVID-19 predominating in receipt of funding and attention from the research community. Conclusion: Impact of the COVID-19 pandemic on education and scientific research in biomedical sciences are negative. Almost all aspects of medical education were affected by the COVID-19 pandemic. The negative impact, both on basic education in medicine, and also on the acquisition of practical knowledge within various clinical disciplines, especially surgery, unfortunately continues. There has been no disease in the history of medicine about which several professional and scientific articles have been written in a relatively short time. Research and publications on COVID-19 has often not been of high quality. Research articles from many medical field unrelated to COVID-19 were less published. A pandemic with a "paperdemic" will be even more complicated to manage if it progresses in an uncontrolled manner and is not properly scrutinized.

INTRODUCTION Anxiety is a state of feeling helpless and insecure, a state of anticipation and concern that something bad will happen. Fear of pain and the unknown, as well as fear of screening results can increase anxiety. Severe anxiety during magnetic resonance imaging (MRI)can cause patient's movement, leading to poorer imaging and reduction in the quality of the diagnostic test. To determine the anxiety of patients before and after magnetic resonance imaging and to investigate the relationship between the tested anxiety and the socio-demographic characteristics of the patients. METHODS The study was conducted at the Department of Radiology of the University Clinical Hospital Mostar in the period from February 1st 2020 to March 31st 2020. The study included 100 subjects who were prescribed an MRI screening at the time of the study. A socio-demographic questionnaire specifically designed for this study was used to obtain data on subjects such as gender, age, place of residence, smoking, drinking alcohol, economic status, religiosity. The Anxiety Questionnaire as a State-Trait Anxiety Inventory (STAI) was used to examine anxiety. RESULTS A statistically significantly higher degree of anxiety was determined after MRI screening (p<0.001). Male subjects achieved a statistically significantly higher degree of anxiety before (p=0.019) and after (p=0.034) MRI screening. There were no statistically significant correlations between the age of the subjects and the results achieved on the anxiety tests before and after the MRI screening. CONCLUSION Subjects who were prescribed an MRI screening have a statistically significantly higher degree of anxiety after the screening. Male subjects had a statistically significantly higher degree of anxiety on MRI screening.

The funerary stela of Marcus Aurelius Bitus, a soldier of the Legio IV Flavia Felix, was discovered in Palmotićeva Street, Belgrade, during construction work undertaken in 1989-1990. The stela is typologically classified as being of the architectural type, and is topped by a pediment decorated with lions. To date, it remains the only known example of an intact stela with a pediment not only in Singidunum, but also along the entire Upper Moesian Limes. This paper provides evidence of the fact that this type of stelawith-pediment was not uncommon, either within Singidunum itself or throughout its wider surroundings. Additionally, the structural and iconographic features of the stela of Marcus Aurelius Bitus are studied, and the issue of artistic influences from Pannonia and Noricum, which undoubtedly influenced the stela's creation in a local workshop in what was then Singidunum, are also considered