The kinetics of passive transport of ketoprofen and metformin, as model substances for high and low permeability, respectively, across the artificial membrane under the influence of the pH of donor solution was investigated. There was an upward trend in the apparent permeation coefficient (Papp) of ketoprofen with the decrease in pH to a value close to pKa. At the pH value below pKa the permeation coefficient had lower value, due to the higher retention of ketoprofen in the artificial membrane. Metformin is a low permeable compound, and the highest permeation values were recorded at pH 7.4. Two dissociation constants determine that metformin at physiological pH exists as a hydrophilic cationic molecule, i.e. predominantly in ionized form. At pH values below 2.8, metformin mainly exists in diprotonated form, and it was, thus, very poorly permeable. The highest retention, i.e. affinity of both ketoprofen and metformin to the membrane, was at the lowest pH values, which is explained by different mechanisms. At higher pH values of donor compartment the substances showed significantly less affinity to the membrane. The obtained values of apparent permeation coefficients at studied pH values showed good correlation with the obtained experimental values by other in vitro methods.

We present a realization of a didactic robot environment for robot PUMA 560 for educational and research purposes. Robot PUMA 560 is probably the mathematically best-described robot, and therefore it is frequently used for research and educational purposes. A developed control environment consists of a robot controller and teach pendant. The advantage of using a personally developed solution is its open structure, which allows various tests and measurements to be performed, and that is highly convenient for educational and research purposes. The motivation behind the design of this personal didactic robot control environment arose from a survey for students after the first Summer School on Mechatronic Systems. The student questionnaire revealed severe discrepancies between theory and practice in education. Even though the primary purpose of the new control environment for robot PUMA 560 was research, it was established that it is a viable lab resource that allows for the connection between theoretical and industrial robotics. It was used for the duration of four Summer Schools and university courses. Since then, it has been fully integrated into International Burch University’s Electrical and Electronics Engineering curriculum through several courses on the bachelor and master levels for multidisciplinary problem-based learning (PBL) projects.

Kajmak ist ein traditionelles Milchprodukt mit einer spezifischen Zusammensetzung und besonderen sensorischen Eigenschaften. Seine Herstellung erfolgt in ländlichen Haushalten und basiert auf einem traditionellen Verfahren. Die traditionelle Herstellung von Kajmak ist in Bezug auf die Art der Zubereitung sehr unterschiedlich, was zu großen Unterschieden in der Zusammensetzung, den Eigenschaften und der Qualität des Produkts führt. In der Verordnung über Milchprodukte und Starterkulturen ("Amtsblatt von Bosnien und Herzegowina", Nr. 21/11 und 17/19) in Abschnitt "H Kajmak" sind die grundlegenden Bestimmungen für Kajmak auf dem Markt von Bosnien und Herzegowina enthalten. Die Aufgabe dieser Arbeit besteht darin, den Unterschied zwischen industriellem Kajmak und Kajmak, der nach einer traditionellen Rezeptur und unter kontrollierten Produktionsbedingungen hergestellt wird, zu bestimmen und zu prüfen, ob die auf dem Markt befindlichen Produkte den gesetzlichen Vorschriften entsprechen. Die Proben für sensorische und chemische Analysen wurden aus den Regalen der Geschäfte in Bosnien und Herzegowina entnommen. Es wurden drei Sorten von industriellem Kajmak getestet sowie der unreife und reife Kajmak, der nach einem traditionellen Verfahren unter kontrollierten Bedingungen hergestellt wurde. Zweck dieser Untersuchung bestand darin, herauszufinden, was den Verbrauchern unter der Deklaration des Produktes angeboten wird, die sensorischen Eigenschaften des Produkts zu bewerten und das Produkt auf der Grundlage der erzielten Ergebnisse in eine bestimmte Gruppe abhängig von seiner Qualität einzuordnen. Nur eine der fünf untersuchten Proben entsprach den gesetzlichen Bestimmungen, die in Bosnien und Herzegowina in Kraft sind. Kajmak ist ein delikates Produkt, dessen Herstellung viel Aufmerksamkeit erfordert, und es stellt sich die Frage, ob die gesetzlichen Vorschriften zu streng sind oder ob die Hersteller der Art und Weise, wie dieses Produkt hergestellt wird, nicht viel Aufmerksamkeit schenken.

A inclusao de pessoas surdas tem ganhado visibilidade nas ultimas decadas, cita-se como exemplo a redacao do ENEM no ano de 2017, a implementacao dos cursos de licenciatura e bacharelado de Letras: Libras e as acoes das universidades publicas. Diante do exposto, o presente trabalho tem por objetivo compreender como se caracteriza o ethos da Universidade Federal de Goias (UFG) acerca da inclusao, especificamente no que se refere a inclusao dos sujeitos surdos. Para tanto, foi desenvolvida uma pesquisa qualitativa, de carater documental. O trabalho tem como aporte teorico os estudos acerca da Analise do Discurso e do ethos desenvolvidos por Maingueneau (2008, 2018), alem de teoricos que discorrem sobre a educacao de surdos. O corpus e formado por uma noticia acerca do seminario de avaliacao do programa UFGInclui, da Universidade Federal de Goias (UFG). Os resultados encontrados indicam que embora a instituicao busque um ethos positivo, no que se refere a comunidade surda, o ethos visado nao corresponde com o produzido. PALAVRAS-CHAVE : Surdos. Discurso. Ethos. Inclusao. DOI: https://doi.org/10.47295/mgren.v9i3.2427

Castleman disease (CD) includes a group of rare and heterogeneous disorders with characteristic lymph node histopathological abnormalities. CD can occur in a single lymph node station, which is referred to as unicentric CD (UCD). CD can also involve multicentric lymphadenopathy and inflammatory symptoms (multicentric CD [MCD]). MCD includes human herpesvirus-8 (HHV-8)-associated MCD, POEMS-associated MCD, and HHV-8-/idiopathic MCD (iMCD). The first-ever diagnostic and treatment guidelines were recently developed for iMCD by an international expert consortium convened by the Castleman Disease Collaborative Network (CDCN). The focus of this report is to establish similar guidelines for the management of UCD. To this purpose, an international working group of 42 experts from 10 countries was convened to establish consensus recommendations based on review of treatment in published cases of UCD, the CDCN ACCELERATE registry, and expert opinion. Complete surgical resection is often curative and is therefore the preferred first-line therapy, if possible. The management of unresectable UCD is more challenging. Existing evidence supports that asymptomatic unresectable UCD may be observed. The anti-interleukin-6 monoclonal antibody siltuximab should be considered for unresectable UCD patients with an inflammatory syndrome. Unresectable UCD that is symptomatic as a result of compression of vital neighboring structures may be rendered amenable to resection by medical therapy (eg, rituximab, steroids), radiotherapy, or embolization. Further research is needed in UCD patients with persisting constitutional symptoms despite complete excision and normal laboratory markers. We hope that these guidelines will improve outcomes in UCD and help treating physicians decide the best therapeutic approach for their patients.

Introduction: Worldwide, COVID-19 pandemic caused millions of infected people and thousands of deaths. Due to enormous pressure on health-care systems and its inadequate preparedness, utter collapse is expected. In the current epidemic response, healthcare workers’ (HCWs) knowledge and practice are crucial, while the impact on their mental health is still unknown.Methods: The cross-sectional study was conducted among HCWs redeployed to COVID points in the Public Institution Health Centre of Sarajevo Canton. According to guidelines and information provided by the World Health Organization and Ministries of Health, a questionnaire was developed. In addition, General Anxiety Disorder-7 as a screening tool for anxiety disorders was used.Results: Of 180 respondents, 26 (14.4%) were in direct contact with the sick patient. In total, 79 (43.9%) respondents consider their personal protective equipment is in accordance with the guidelines of the world health authorities. A total of 72 (39.7%) of respondents used the same mask for several days. In general, the danger from new coronavirus was considered minimal by 59 (32,6%) HCWs. Based on the achieved score for assessing the anxiety disorder, in 63 (35%) subjects, the presence of severe symptoms was detected.Conclusion: This study found that most HCWs do not have enough knowledge about the COVID-19 pandemic. We identified that there are differences in the sources of information and gap in perceptions of the native origin of the virus. Considering the frequency of anxiety symptoms among HCWs, interventions are necessary in order to preserve their mental health.

Introduction: Using computed tomography (CT) and treatment planning systems (TPS) in radiotherapy, due to the difference in photon beam energy on CT and linear accelerator, it is necessary to convert Hounsfield units (HU) to relative electron density (RED) values. The aim of this dosimetric study was to determine whether there is a significant effect of potential in the CT tube, field of view size (FOV), and phantom dimensions on the CT conversion curve CT-RED. The second aim is whether there are significant differences between the CT-RED obtained by the Computerized Imaging Reference Systems (CIRS) Thorax 002LFC phantom and the “reference” curve in the TPS, obtained by the CIRS 062M pelvis phantom, at the same CT conditions.Methods: Heterogeneous CIRS 062M and CIRS Thorax 002LFC phantoms were used, which anatomically and dimensionally represent the human pelvis, head, and thorax, with a set of known RED inserts. They were scanned on a CT LightSpeed GE simulator and obtained CT-RED.Results: The high voltage in the CT tube had a significant effect on the HU (t = 10.72, p < 0.001) for RED values >1.1, while FOV as a parameter did not show statistical significance for the 062M pelvis phantom. Comparing the slopes (062M pelvis and head) of the CT-RED for RED ≥ 1.1, the obtained value is t = 1.404 (p = 0.163). In the case of a 062M pelvis and a 002LFC phantom, we have seen a difference in RED values (for the same HU value) of 5 % in the RED region ≥ 1.1 (bone).Conclusion: Patients should be imaged on a CT simulator only at the potential of the CT tube on which the conversion curve was recorded. The influence of the FOV and scanned phantom dimensions is not statistically significant on the appearance of the calibration curve (RED ≥ 1.1).

Introduction: Rhinoplasty is an esthetic and functional nasal reconstruction surgery. The elimination of physical disabilities directly affects mental health and leads to a better psychological balance. Therefore, patient satisfaction is considered a valuable measure of medical service outcomes. The objectives of this study were to evaluate subjective patient satisfaction 1 year after surgery and its influence on the quality of life.Methods: This was a clinical, retrospective, randomized, and single-blinded study in which patients were randomly questioned by the same examiner. All subjects underwent pre-operative preparation and post-operative flow at Eurofarm Centre from 2007 to 2010. The survey was conducted through anonymous questionnaires that were provided to each respondent at least 1 year after discharge from the hospital.Results: Overall, 20 (50%) patients had esthetic and 20 (50%) had functional nasal surgery. Most respondents were born between 1971 and 1980 (52.5%) and between 1981 and 1991 (40%), with the least born between 1951 and 1960 (2.5%). Regarding the education level, 27 had university degrees (67.5%), 1 had postgraduate education (2.5%), and 12 (30.0%) were secondary school graduates. In addition, 25 (62.5%) were unmarried and 15 (37.5%) were married.Conclusion: No statistically significant correlation was found between the subjective assessment of patient’s health based on eight dimensions of health assessment and variables such as type of surgery, age, level of education, and marital status 1 year after undergoing rhinoplasty. A statistically significant difference was found between the type of surgery and physical pain (p = 0.004 < 0.05, Mann–Whitney U test). Based on the research findings, we can conclude that patient satisfaction after undergoing rhinoplasty was moderately correlated positively with the quality of life (r = 0.180-0.345, p < 0.05).

In this paper, we try to modestly, but strictly, using a mathematical approach, show that life was created with a certain goal and that the possibility of accidental origin of life is equal to zero. To calculate the probability of accidental creation of only one protein molecule, the basic building block of living systems, we selected a hemoglobin molecule that, because it is well studied, has become the standard for protein research. For comparison, together with this calculation, we also made a calculation of the probability of the systematic stacking of chaotically scattered playing cards from a certain height on a certain surface, a probability that is generally accepted as - improbably!

Matrix factorization methods employ standard linear algebra, i.e. linear models, for recommender systems. With the introduction of the tropical semiring, we can achieve non-linearity. We review algorithms that use the tropical semiring for matrix factorization and provide their strengths and limitations. We show that the tropical matrix factorization yields better results than non-negative matrix factorization for the synthetic data created by the underlying process of the tropical semiring.

The research deals with the optimisation of CNC turning process parameters to determine the optimal parametric combination that provides the minimal surface roughness (Ra) and maximal material removal rate. The experiment was conducted by the CNC turning process of S355J2 carbon steel. Data from the Taguchi design of experiments were the subject of analysis with Grey Relational Analysis (GRA) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). In the present study, three process parameters, such as cutting speed, feed rate and depth of cut, were chosen for the experimentation. It was found that 250 m/min cutting speed, 0.10 mm/rev feed rate and 1.8 mm depth of cut presented the optimal parametric combination by both used multi-objective optimisation methods. Analysis of variance (ANOVA) at a 95 % confidence level was used to determine the most significant parameters. Finally, the accuracy of GRA and TOPSIS results were validated by confirmation experiments.

Trends of globalization very often cause the emergence of phenomena that asymmetrically affect the overall sustainability of the transport system. In order to predict certain situations and potentially be able to manage the transport system, it is necessary to manage risk situations and traffic safety in a timely manner. This study has conducted an investigation which implies defining the level of safety of a total of nine sections of two-lane roads. The main aim of the paper is to create a new multiphase model consisting of CRITIC (The CRiteria Importance Through Intercriteria Correlation), Fuzzy FUCOM (Full Consistency Method), DEA (Data Envelopment Analysis), and Fuzzy MARCOS (Measurement Alternatives and Ranking according to the COmpromise Solution) methods for determining the level of traffic safety on road sections under the conditions of uncertainty. In order for the created model to be adequately applied, eight parameters were created, and they were classified through four inputs and four outputs. To calculate the significance of the inputs, the CRITIC method based on the symmetric correlation matrix was used, and taking into account the nature of the outputs, the Fuzzy FUCOM method based on averaged values using the fuzzy Bonferroni Mean (BM) operator was applied to determine their weights. To determine the degree of safety, the DEA model was created. After that, the Fuzzy MARCOS method was used in order to determine the final ranking of the remaining five sections of the road network. Finally, the verification of results was performed through three phases of Sensitivity Analysis (SA).