The focus of this study is a spatial analysis of the industry distribution and concentration, on the example of municipality of Tesanj (Bosnia and Herzegovina), based on the application of GIS methods. Municipality of Tesanj is one of the most developed municipalities in Bosnia and Herzegovina, while Tesanj?s industry significantly contributes to the economic development of this country. GIS analysis of industry was based on the field work, locating and georeferencing industrial companies, acquisition, adaptation, adjustment and validation of digital surface models and google satellite imagery, mapping of relief, hydrography and transport network. With the aim of geovisualization of spatial distribution of industry, spatial descriptive statistics and non-parametric density estimation analysis (Kernel Density Estimation) were performed. In order to determine the distribution of industry in relation to relief (elevation, slope, and aspect), hydrography and transport network, GIS techniques of reclassification, vectorization, count point in polygons, buffer and clip geoprocessing tools were used. Conducted research provided a new insight into the data mining and visualization based on principles of QGIS, the effects of geographic factors on industry distribution, and confirmed the importance of relief, hydrographic and transport network on the concentration of industry in municipality Tesanj.

The paper researches the landscape transformation of the surface mines of the Đurđevik coal basin (northeastern Bosnia region), where 35.24 Mt of brown coal were produced in the past 74 years, and 227.40 Mm3 of overburden was excavated and disposed of. This type of coal exploitation caused the formation concave and convex of anthropogenic relief forms which ultimately led to significant landscape transformation. These transformations were identified and geovisualized on the basis of field research and comparative GIS analysis of archival maps, satellite images, Digital Elevation Models and plans of this area. As a result of the research, especially comparative GIS analysis of two prepared terrain models of surface mines, the transformation of hypsometry, slope and aspect, hydrographic network, pedological as well as vegetation cover were determined. Obtained geospatial data are geo-visualized in QGIS, and as a result, thematic maps were created to provide insight into the essence of transformations. Therefore, established indicators of landscape transformation can serve as a significant factor in planning the revitalization and land re-cultivation of devastated areas in the Đurđevik coal basin.

Introduction/Objective. The diffuse axonal injury has a very important place in clinical and forensic aspects of neurotraumatology. A special challenge is proving it in situations of short survival (less than two hours) after a craniocerebral injury. The aim of this study was to determine the efficacy of beta-amyloid precursor protein (?APP) immunohistochemical staining in postmortem diagnosis of axonal injuries in head injury survival shorter than two hours, its expression and distribution through the brain tissue of the deceased. Methods. 36 adult fatalities, both sexes, injured by acceleration-deceleration mechanisms were divided into two groups: died up to two hours and died more than two hours after the injury. Immunostaining of brain tissue samples (frontal parasagittal white mass, genu and splenium of the corpus callosum and rostral pons) was used to register ?APP positivity. Data were processed by methods of descriptive and inferential nonparametric statistics, and p < 0.05 was considered statistically significant. Results. The ?APP immunopositivity was shown in 88.9% of cases (82.3% of ? two hours group vs. 94.7% of > two hours group). ?APP expression was enhanced towards the posterior structures of the brain. The shortest survival period with detected ?APP immunopositivity was 20-25 minutes, in three cases. There was an association of ?APP expression in the brainstem and interhemispheric/paramesencephalic subarachnoid hemorrhage (p = 0.035). Conclusion. ?APP immunohistochemical staining is effective in proving diffuse axonal injury in casualties that survived less than half an hour. Interhemispheric/paramesencephalic subarachnoid hemorrhage may indicate a more severe form of axonal injury.

Autophagy is a dynamic process, conserved in all eukaryotes. It is responsible for the degradation of cytoplasmic content. Autophagy is crucial in cell survival and cell death. It plays a significant role in the cell response to stress, nutrient deficiencies, embryonic development, tumor suppression, response to pathogens and aging. The process of autophagy is also involved in the pathology of human diseases, such as cancer, diabetes, cardiomyopathy, and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Autophagy is a mechanism that involves degradation of cells, proteins, damaged organelles and pathogens through the lysosomal mechanisms, thus autophagy supports cell survival during starvation, hypoxia and metabolic stress. However, if extensive and/or excessive, autophagy can promote apoptosis (type I) or function as an alternative cell-death pathway, called autophagic cell death (type II). Autophagy can either promote cancer cell death, or serve as a survival mechanism against apoptosis or necrosis induced by various anticancer treatments. Given the contradictory role of autophagy during tumor initiation and progression, the use of autophagy in therapy depends on the context and must be approached individually

The aim of this chapter is to enable marketing managers to gain basic knowledge of the capabilities of the latest data management technology, big data, which has the potential of digitally storing huge amounts of data, processing and utilizing the results of processing different types of data, as well as data of different formats in real-time. Due to the enormous potential of implementing the big data, there are also tremendous expectations in terms of the direct financial benefits of its implementation. Realizing all these expectations is a very complex task, which is set to marketing and other managers. The knowledge and skills of managers acquired by education will greatly help to understand the benefits of faster adoption and implementation of new data management paradigms. This chapter emphasizes the differences between the big data concept and conventional data processing technologies, as well as the benefits and potentials that this concept offers, especially when it comes to the process of making quick marketing decisions or making decisions in a reasonably short time.

Growth and development are indicators of good health, as well as a mirror of quality nutrition and quality of life. By monitoring growth and development, the relationship between motor abilities and morphological characteristics is recognized. The period of younger school age is characterized by strong growth and development of all anthropological dimensions, especially morphological and motor ones, which differ significantly in children, concerning adults. This transversal research aimed to determine the differences in morphological characteristics and motor abilities between lower primary school students. The research was conducted on a sample of 1233 girls, I - IV grades of primary schools from the area of the City of Tuzla. The sample of variables consisted of a set of 10 tests to assess certain anthropological dimensions (5 morphological and 5 motors), appropriate to the age of the study population. Univariate analysis of variance with multiple comparisons was used to determine the differences in the studied spaces between students of different grades, with the applied post hock Bonferroni test. The obtained results showed that there are statistically significant differences in all applied variables (morphological and motor). between treated groups at the level of significance (p≤0.05). The results of the research draw attention to the importance of early stimulation of morphological-motor development and a healthy lifestyle in female students, which are characterized by regular physical activity and a healthy diet. Optimal levels of motor skills, well-developed fundamental motor skills and a healthy body structure are of great importance for health, quality of life-related to health and overall well-being of younger school-age students.