Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain genes shared between the two conditions, revealing neuronal, immune, metabolic, and calcium-related mechanisms, with several genes as targets for existing drugs. These findings exhibit shared risk loci and genes are involved in tissue-specific mechanisms. Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

This study investigates the neural encoding of speech features in hearing aid users using electroencephalography (EEG) during a simulated cocktail party scenario. The objective was to investigate neural tracking of various acoustic and linguistic features and how hearing aid noise reduction influenced this tracking. The features analyzed included the acoustic envelope, phonetic features, word onset, and word surprisal, the latter derived from GPT-2. Temporal Response Functions (TRFs) were used to correlate these features with EEG signals, revealing how the brain tracks attended (target) versus unattended (masker) speech. TRFs were estimated using a boosting algorithm, with speech features as predictors and EEG signals as responses. Results revealed a significant distinction between target and masker speech. The acoustic envelope showed the strongest correlation with EEG responses. Distinct tracking patterns were observed: the acoustic envelope and phonetic features correlated with early processing stages, while word onset and word suprisal were linked to later stages. Noise reduction further influenced the tracking of these features. These findings improve our understanding of how hearing aid users process speech and provide insight for developing hearing aids that adapt to individual neural responses.

The “burnout” syndrome is a state of emotional, physical, and mental exhaustion caused by excessive and prolonged stress. It is also referred to as a disease of themodern age. It most commonly occurs after an individual experiences emotional exhaustion and an inability to meet constant demands, leading to a loss of interest and motivation in their work. The profession of a speech and language therapist is considereda helping profession that can lead to burnout syndrome. The main aim of this research was to examine the level of professional burnout in speech and language therapy practice. The sample consisted of 69 speech and language therapists of both genders, employed in various institutions. The results showed that 31 therapists (44.8%) exhibited varying degrees of professional burnout, ranging from mild burnout to burnout requiring professional assistance, while 38 therapists (55.1%) showed no signs of professional burnout. No statistically significant difference in the level of professional burnout was found in relation to the gender of the therapists, but a statistically significant difference was found in relation to the age of the therapists. The results indicated that there is no difference in the level of professional burnout in relation to years of service, nor a statistically significant correlation between the level of professional burnout and the type of institution where the therapists are employed, working hours during the week, or the number of treatments conducted during the working day. Taking care of the mental health of speech and language therapists is a very important factor that contributes to the quality and efficiency of conducting speech and language prevention, assessment, diagnostics, and treatment. Keywords:burnout syndrome, speech and language therapists, speech and language therapy practice, mental health.

Due to an epidemic of risk factors, such as hypertension, and an increase in life expectancy, cardiovascular disease (CVD) has an overwhelming morbidity and mortality burden worldwide. Various treatment options are available to disrupt pathophysiological processes along the cardiovascular continuum by focusing on distinct regions of the renin-angiotensin-aldosterone system (RAAS). As a RAAS inhibition, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are recommended first-line treatments for hypertension and CVD. Both ACE inhibitors and ARBs prevent CVD by lowering blood pressure (BP). Furthermore, a number of studies have shown that RAAS blockade can lower cardiovascular risk in ways that go beyond what could be predicted from lowering blood pressure alone. However, the ARBs are not all equally effective. Telmisartan is a long-lasting ARB that effectively controls BP over the full 24-hour period. In high cardiovascular risk patients, telmisartan reduces cardiovascular events in a manner comparable to that of the ACE inhibitor ramipril beyond lowering blood pressure alone, but with better tolerability. Research points to possible benefits for adipose tissue activity, neurovascular function, and enhancements in glucose and lipid metabolism. According to several studies, telmisartan has partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist activity, which improves insulin resistance in diabetic patients by modifying adipokine levels. The combination of telmisartan and indapamide as metabolically neutral diuretic has an additional positive antihypertensive as well as cardioprotective effects. In addition to reviewing current CVD management guidelines, this article will examine important clinical trial and clinical practice data that assess the role of telmisartan/indapamide in CVD. Keywords: arterial hypertension, angiotensin II receptor blocker, telmisartan, cardiovascular risk.

Autonomic imbalance is one of the major pathological disturbances in chronic heart failure (CHF). Additionally, enhanced oxidative stress and inflammation are considered to be the main contributors to the disease progression. A growing body of evidence suggests cholinergic stimulation as a potential therapeutic approach in CHF, since it corrects the autonomic imbalance and alters the inflammatory response via the cholinergic anti-inflammatory pathway. Although previous research has provided some insights into the potential mechanisms behind these effects, there is a gap in knowledge regarding different cholinergic stimulation methods and their specific mechanisms of action. In the present study, an isoprenaline model (5 mg/kg/day s.c. for 7 days, followed by 4 weeks of CHF development) was used. Afterwards, rats received pyridostigmine (22 mg/kg/day in tap water for 14 days) or no treatment. Pyridostigmine treatment prevented the progression of CHF, decreasing chamber wall thinning (↑ PWDd, ↑ PWDs) and left ventricle dilatation (↓ LVIDd, ↓ LVIDs), thus improving cardiac contractile function (↑ EF). Additionally, pyridostigmine improved antioxidative status (↓ TBARS, ↓ NO2−; ↑ CAT, ↑ GSH) and significantly reduced cardiac fibrosis development, confirmed by pathohistological findings and biochemical marker reduction (↓ MMP2, ↓ MMP9). However, further investigations are needed to fully understand the exact cellular mechanisms involved in the CHF attenuation via pyridostigmine.

PEComa (Perivascular epithelioid cell tumors) are a rare type of tumor composed of cells exhibiting characteristics of smooth muscle cells and melanocytes. They most commonly occur in the female genital system. This study is a narrative review based on the differential diagnosis of tumors in the female genital system, focusing on PEComa. The aim of the research is to analyze the immunohistochemical markers characteristic of PEComa in the female genital system and compare them with markers of tumors that may appear in the differential diagnosis. Specifically, the study examines epithelioid smooth muscle tumor (STUMP), malignant melanoma, alveolar soft part sarcoma (ASPS), poorly differentiated endometrial carcinoma (EC) and trophoblastic tumors of the placenta (PSTT). Comparison of immunohistochemical markers of PEComa with markers of other tumors revealed that: PEComas show overlap in positive staining with STUMP, but are distinguished by markers such as HMB45, PNL2, MiTF, and MelanA/MART1; PEComas share some melanocytic markers with malignant melanoma, but differ in the expression of myogenic markers and hormone receptors; compared to ASPS, PEComas share some positive staining but differ in marker expression and negative staining; they differ from EC by the expression of specific markers such as MiTF and PAX8; PSTT show specificity for markers of trophoblastic differentiation and implantation, while PEComas emphasize melanocytic and myogenic differentiation. The general conclusion is that an accurate diagnosis of PEComa in the female genital system can only be achieved through a multidisciplinary approach. Immunohistochemical evaluation serves as a helpful tool, but standard morphological staining remains the gold standard. Also, the advanced diagnostic techniques, particularly next-generation sequencing, hold promise for enhancing the understanding and management of mPEComas. By uncovering the genomic landscape and facilitating targeted therapies, these methodologies may lead to more effective treatment and improved outcomes. Keywords: female genital system, epithelioid smooth muscle tumor, malignant melanoma, endometrial carcinoma, trophoblastic tumor.

Congenital anomalies of the kidney and urinary tract (CAKUT) are the third most common congenital anomaly and a significant public health concern. It is the predominant cause of chronic renal disease in pediatric populations and the principal reason for kidney replacement therapy in individuals under 20, as well as the fourth leading cause in adults. Five candidate genes, including EDA2R, PCDH9, and TRAF7 were identified as potential contributors to CAKUT. These genes had not been previously prioritized in CAKUT research, and our prior studies have demonstrated that the proteins encoded by these candidate genes display dysregulated expression across various CAKUT subgroups. Our research examined the expression patterns of EDA2R, PCDH9, and TRAF7 in yotari (Dab1−/−) mice at two embryonic stages (E13.5 and E15.5) and two postnatal stages (P4 and P14) to ascertain the potential correlation between Reelin–Dab1 signaling, previously linked to CAKUT phenotypes, and the aforementioned proteins through molecular and morphological analyses. All three observed proteins exhibited the highest area percentage at E13.5, with a trend of decline into postnatal stages, during which specific changes in protein expression were noted between the cortex and medulla of yotari mice compared to wild-type mice. For TRAF7, a statistically significant difference in area percentage at E13.5 was observed, indicating a link with Reelin–Dab1 signaling and a potentially critical role in the pathophysiology of CAKUT, also marked by our prior study.

Traditional medicinal plants are valued for their therapeutic potential, yet the full spectrum of their bioactive compounds often remains underexplored. Recent advances in multiomics technologies, including metabolomics, proteomics, and transcriptomics, combined with in vitro culture systems and elicitor-based strategies, have revolutionized our ability to characterize and enhance the production of valuable secondary metabolites. This review synthesizes current findings on the integration of these approaches to help us understand phytochemical pathways optimising bioactive compound yields. We explore how metabolomic profiling links chemical diversity with antioxidant and antimicrobial activities, how proteomic insights reveal regulatory mechanisms activated during elicitation, and how in vitro systems enable controlled manipulation of metabolic outputs. Both biotic and abiotic elicitors, such as methyl jasmonate and salicylic acid, are discussed as key triggers of phytochemical defense pathways. Further, we examine the potential of multiomics-informed metabolic engineering and synthetic biology to scale production and discover novel compounds. By aligning traditional ethnobotanical knowledge with modern biotechnology, this integrative framework offers a powerful avenue to unlock the pharmacological potential of medicinal plants for sustainable and innovative therapeutic development.

Recent technological advances have expanded the use of 3D-printed polymer components across industries, including a growing interest in military applications. The effective defensive use of such materials depends on a thorough understanding of polymer properties, printing techniques, structural design, and influencing parameters. This paper analyzes the ballistic resistance of 3D-printed polymer structures against 9 × 19 mm projectiles. Cuboid targets with different infill patterns—cubic, grid, honeycomb, and gyroid—were fabricated and tested experimentally using live ammunition. Post-impact, CT scans were used to non-destructively measure projectile penetration depths. The honeycomb infill demonstrated superior bullet-stopping performance. Additionally, mechanical properties were experimentally determined and applied in FEM simulations, confirming the ability of commercial software to predict projectile–target interaction in complex geometries. A simplified analytical model also produced satisfactory agreement with experimental observations. The results contribute to a better understanding of impact behavior in 3D-printed polymer structures, supporting their potential application in defense systems.

Sažetak ( sa ključnim riječima): Sažetak: Radni sporovi su pogodni za rješavanje alternativnim načinima rješavanja, pa i mirenjem propisanim Zakona o mirnom rješavanju radnih sporova iz 2021. godine. U radu se obrađuju specifičnosti radnih sporova kao posebnog parničnog postupka. Glavni fokus rada je na analizi postupku mirnog rješavanja kolektivnih radnih sporova, mirovno vijeće, način određivanja miritelja i arbitara te druga pitanja od značaja za mirno rješavanje radnih sporova za teritoriju Federacije Bosne i Hercegovine ako drugim zakonom nije drugačije određeno. Autorica naglašava važnost obveznog mirenja kod rješavanja kolektivnog radnog spora uz analizu sudske prakse te utjecaj mirenja na ishod parnice i značaj jer postignuti sporazum ima pravnu snagu ovršne isprave. Autorica analizira odnos parničnog zakonodavstva te instituta obveznog mirenja kao predstadija prije pokretanja parničnog postupka za kolektivne radne sporove u kontekstu i konvencijskih prava - prava na pristup sudu te prava na udruživanje i prava na štrajk. Poseban naglasak se stavlja na specifičnosti i značaj mirenja u kolektivnim radnim sporovima. Ključne riječi: kolektivni radni spor, Zakon o mirnom rješavanju radnih sporova, mirenje, arbitraža Summary: Labor disputes are suitable for resolution by alternative means of resolution, including mediation prescribed by the Law on the Peaceful Settlement of Labor Disputes from 2021. The paper addresses the specifics of labor disputes as a special civil procedure. The main focus of the paper is on the analysis of the procedure for the peaceful resolution of collective labor disputes, the peace council, the method of appointing conciliators and arbitrators, and other issues of importance for the peaceful resolution of labor disputes for the territory of the Federation of Bosnia and Herzegovina, unless otherwise provided for by other law. The authors emphasize the importance of mandatory mediation in resolving collective labor disputes, along with an analysis of case law and the impact of mediation on the outcome of litigation and its significance because the agreement reached has the legal force of an enforceable document. The authors analyze the relationship between civil proceeding law and the institute of mandatory mediation as a preliminary stage before initiating civil proceedings for collective labor disputes in the context of both convention rights - the right to access to court and the right to associate and the right to strike. Special emphasis is placed on the specifics and importance of mediation in collective labor disputes. Keywords: collective labor dispute, Law on Peaceful Resolution of Labor Disputes, mediation, arbitratio

Dementia is a growing public health problem, particularly in low- and middle-income countries. Bosnia and Herzegovina (BiH), as a post-conflict LMIC with a complex administrative structure, currently lacks national guidelines, epidemiological data, and systematic approaches for dementia care. This study investigates healthcare workers’ attitudes toward dementia care and identifies both obstacles and practical opportunities for improving practice within BiH’s unique healthcare system. A qualitative cross-sectional study was conducted in primary healthcare settings across Bosnia and Herzegovina, with 25 participants, including family medicine doctors (n = 10), nurses (n = 10), and psychologists (n = 5). The data were analyzed using thematic analysis guided by the Consolidated Framework for Implementation Research (CFIR). Dementia care in BiH is predominantly reactive, with healthcare professionals typically responding only after families have expressed concerns. Participants reported inconsistent use of cognitive screening tools (e.g. MMSE, MoCA), largely due to insufficient training, lack of clear national guidelines, and varying institutional practices. Many clinicians felt unprepared and unsupported in managing dementia cases. Cultural stigma and widespread misperceptions of dementia as a normal part of aging contribute to delays in diagnosis and reduce the likelihood that families will seek help early. These barriers are exacerbated by a lack of national prevalence data and fragmented care pathways. The findings of this study indicate the need to change the approach to dementia care in BiH through concrete and realistic measures within the existing systemic frameworks. Practice-based guidelines, culturally adapted tools for early detection, reactivation of community-based care, accessible education, a pragmatic approach to prevention, and local initiatives for awareness-raising and multidisciplinary care are recommended.

Abstract Background Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is often linked with reproductive disorders in humans and animals. Despite this, its presence in animals in the Federation of Bosnia and Herzegovina (FB&H) remains undocumented. Objectives This study aimed to investigate the seroprevalence of T. gondii infection among domestic pigs in FB&H, assess associated risk factors for parasite transmission and provide insights into optimal management and biosafety practices for the pig industry. Methods A two‐phase random sampling approach was employed to select 87 pig farms across 10 administrative regions in FB&H. A total of 437 pigs were sampled and tested for anti‐T. gondii antibodies using an indirect ELISA kit. Epidemiological data on potential risk factors were collected through a standardised questionnaire and analysed using logistic regression models. Results The animal‐level seroprevalence was found to be 13.3% (95% CI = 10.4–16.8), with 44.8% of farms testing positive for T. gondii (95% CI: 34.8–55.3). Identified risk factors included exposure to cats, repeated occurrences of abortions within a single breeding season, swill feeding, type of housing, and type of operation. The robust association observed between recurrent abortions and Toxoplasma seropositivity indicates a significantly greater potential involvement of T. gondii in reproductive disorders among pigs in FB&H than previously acknowledged. Conclusions This study provides the first report on T. gondii infection in animals in FB&H, highlighting the need for further research to explore its presence in other meat animals and meat products consumed in the region. The findings underscore the importance of biosafety measures in mitigating T. gondii transmission and call for enhanced surveillance and management strategies in FB&H's pig industry.