Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 and includes by now 32 countries mostly in Eastern and Central Europe (ECE). Until the end of 2021, 344 inborn errors of immunity (IEI)-focused meetings were organized by the JP to raise awareness and facilitate the diagnosis and treatment of patients with IEI. Results In this study, meeting profiles and major diagnostic and treatment parameters were studied. JP center leaders reported patients’ data from 30 countries representing a total population of 506 567 565. Two countries reported patients from JP centers (Konya, Turkey and Cairo University, Egypt). Diagnostic criteria were based on the 2020 update of classification by the IUIS Expert Committee on IEI. The number of JP meetings increased from 6 per year in 2004 and 2005 to 44 and 63 in 2020 and 2021, respectively. The cumulative number of meetings per country varied from 1 to 59 in various countries reflecting partly but not entirely the population of the respective countries. Altogether, 24,879 patients were reported giving an average prevalence of 4.9. Most of the patients had predominantly antibody deficiency (46,32%) followed by patients with combined immunodeficiencies (14.3%). The percentages of patients with bone marrow failure and phenocopies of IEI were less than 1 each. The number of patients was remarkably higher that those reported to the ESID Registry in 13 countries. Immunoglobulin (IgG) substitution was provided to 7,572 patients (5,693 intravenously) and 1,480 patients received hematopoietic stem cell therapy (HSCT). Searching for basic diagnostic parameters revealed the availability of immunochemistry and flow cytometry in 27 and 28 countries, respectively, and targeted gene sequencing and new generation sequencing was available in 21 and 18 countries. The number of IEI centers and experts in the field were 260 and 690, respectively. We found high correlation between the number of IEI centers and patients treated with intravenous IgG (IVIG) (correlation coefficient, cc, 0,916) and with those who were treated with HSCT (cc, 0,905). Similar correlation was found when the number of experts was compared with those treated with HSCT. However, the number of patients treated with subcutaneous Ig (SCIG) only slightly correlated with the number of experts (cc, 0,489) and no correlation was found between the number of centers and patients on SCIG (cc, 0,174). Conclusions 1) this is the first study describing major diagnostic and treatment parameters of IEI care in countries of the JP; 2) the data suggest that the JP had tremendous impact on the development of IEI care in ECE; 3) our data help to define major future targets of JP activity in various countries; 4) we suggest that the number of IEI centers and IEI experts closely correlate to the most important treatment parameters; 5) we propose that specialist education among medical professionals plays pivotal role in increasing levels of diagnostics and adequate care of this vulnerable and still highly neglected patient population; 6) this study also provides the basis for further analysis of more specific aspects of IEI care including genetic diagnostics, disease specific prevalence, newborn screening and professional collaboration in JP countries.

The impact of geometric characteristics on traffic risk is reflected through identifying conflict points on roads,traffic accidents, and any other unforeseen situation that is inherently hazardous for traffic participants. In order to identify the road sections with the highest risk, it is necessary to consider a number of criteria that affect risk, and conduct extensive empirical research, analysis and data synthesis. This paper evaluates 9 sections of two-lane roads in the territory of Bosnia and Herzegovina (the Republic of Srpska) using an integrated Multi-Criteria Decision-Making (MCDM) model.To determine the significance of 8 criteria for the evaluation of the sections, it was applied a subjective–objective model consisting of 3 methods: (1) CRiteria Importance Through Inter-criteria Correlation (CRITIC), (2) FUll COnsistency Method (FUCOM) and (3) fuzzy PIvot Pairwise RElative Criteria Importance Assessment (PIPRECIA). The aggregation of the criterion values obtained using the methods yielded the final criterion values. Measurement Alternatives and Ranking according to COmpromise Solution (MARCOS) method was used to evaluate the sections and determine their objective diversity. The obtained results identified one location as extremely hazardous by most of analysed input parameters. The section with the highest risk is the Rudanka – Doboj section (A4), which represents a section of the road infrastructure of the 105 road. The validation of the results obtained by applying the integrated MCDM model was performed through an extensive sensitivity analysis. The weights of criteria were observed through initially individual methods implemented in the MARCOS method. Then, a comparative analysis was performed with 6 other MCDM methods and Spearman’s Correlation Coefficient (SCC) was calculated as a statistical indicator of rank correlation in a sensitivity analysis. In addition,the Standard Deviation (STDEV) of the obtained results was determined.

Supplier selection is an important task in supply chain management, as suppliers have a vital role in the success of organisations in a supply chain. Sustainability has emerged as a solution to decreasing resources and increasing environmental and social problems in the past few decades. It has been applied to various industrial operations, one of them is supplier selection, to mitigate unwanted effects in the future. Sustainable supplier selection is a complicated multi-criteria decision making problem, including several criteria from economic, environmental, and social perspectives. To deal with subjective judgements of decision makers, fuzzy and grey methods are widely used in multi-criteria decision making, In the case of small, limited, and incomplete data, the grey theory provides satisfactory results, compared to fuzzy methods. Therefore, this study is an integrated method including grey Best-Worst Method (BWM) and grey Weighted Sum-Product (WISP) for choosing the most sustainable supplier for a textile manufacturer, which includes three main criteria and twelve sub-criteria. According to the result of the proposed model, the supplier with the best performance was determined to be the supplier with the SP2 coded. The results of the developed model were shown to the experts, and the accuracy of the results was confirmed. According to the experts, a higher amount of product can be purchased from the supplier with the SP2 code, and a tighter relationship can be worked with this supplier. The contributions of this study are: (1) Develop a new grey MCDM model called Grey WISP. (2) Create a new integrated MCDM model with grey theory, BWM, and WISP methods that can be applied to assess supplier sustainability using this hybrid model. The proposed model can be used not just for selecting sustainable suppliers, but also for any other decision problems that have multiple criteria and alternatives. The findings suggest that the Grey WISP method achieved accurate results.

Using seismic recordings of event S1222a, we measure dispersion curves of Rayleigh and Love waves, including their first overtones, and invert these for shear velocity (VS) and radial anisotropic structure of the Martian crust. The crustal structure along the topographic dichotomy is characterized by a fairly uniform vertically polarized shear velocity (VSV) of 3.17 km/s between ∼5 and 30 km depth, compatible with the previous study by Kim et al. (2022), https://doi.org/10.1126/science.abq7157. Radial anisotropy as large as 12% (VSH > VSV) is required in the crust between 5 and 40 km depth. At greater depths, we observe a large discontinuity near 63 ± 10 km, below which VSV reaches 4.1 km/s. We interpret this velocity increase as the crust‐mantle boundary along the path. Combined gravimetric modeling suggests that the observed average crustal thickness favors the absence of large‐scale density differences across the topographic dichotomy.

Due to the computing capability and memory limitations, it is difficult to apply the traditional deep learning (DL) models to the edge devices (EDs) for realizing lightweight automatic modulation classification (AMC). Recently, many works attempt to use different ways to realize lightweight AMC methods for EDs. However, the lightweight seems to be a contradiction with the classification performance in these lightweight networks. In this article, we propose an efficient lightweight decentralized-learning-based AMC (DecentAMC) method using spatiotemporal hybrid deep neural network based on multichannels and multifunction blocks (MCMBNN). Specifically, the lightweight network is designed from the perspectives of comprehensive consideration of lightweight and classification performance, which is composed of three parts to extract different features for realizing high classification performance and they are phase estimator and transformer (PET) block, spatial feature extraction block and temporal feature extraction & Softmax block. In addition, we use a multichannel input to extract complementary features of different channels for a better classification performance. The proposed DecentAMC method is an efficient training method, which is achieved by the cooperation in which multiple EDs update and upload the model weight to a central device (CD) for model aggregation to avoid the data privacy disclosure and reduce the computing power and storage pressure of CD. Experimental results show that the proposed MCMBNN can obtain an improved classification accuracy while reducing model complexity with the contributions of three blocks. Moreover, the proposed DecentAMC method can be deployed on EDs efficiently. Thus, the method has the advantages of avoiding data leakage on EDs and relieving the computing pressure of CD with relatively lower communication overhead. The simulation code and datasets are shared on GitHub.

The Program for International Student Assessment (PISA) was developed by the Organization for Economic Cooperation and Development to measure students’ knowledge and skills needed for today’s society. PISA is a large-scale assessment of 15-year-old students in reading, mathematics, and science. In this analysis of PISA data from Bosnia and Herzegovina (BIH), we examined the relationship between gender, mathematics achievement, and perceived meaning in life in BIH students. The sample for this analysis comprised 6480 students (3148 females and 3332 males). The results of the analysis revealed a small but statistically significant, negative relationship between mathematics and the student’s perception of the meaning in life. Boys achieved higher scores in mathematics than girls, but the difference was relatively small. In addition, boys’ rating of meaning in life was higher than that of girls. Knowing what factors influence mathematical achievement might help educators create better intervention programs. In conclusion, we provided some possible explanations for these data.

Rational use of available land is of great importance for the economic development of every society, especially considering the fact that soil is the primary production resource, thereby placing an even greater importance on its protection and conservation, but also on the correct use of it. This paper focuses on the municipality of Bužim, located in the north/western part of Bosnia and Herzegovina, where the soil suitability for the purposes of corn cultivation were assessed and examined by using the FAO (1976) methodology of AEZ (agroecological zoning), which uses input data such as soil characteristics, climate change, relief patterns of the investigated area, and the requirements of the agricultural crops. Within the municipality of Bužim, 13,026.27 ha of the land is used for agricultural purposes. In regards with the corn, one distinguishes between two categories ofsoil suitability: the suitable classes (S1, S2, S3), which occupy more than 43.44% of the land surface, and the unsuitable class (the N class), which only occupies 0.94% of the land surface. Thus, it can be concluded that conditions necessary for corn do exist within the municipality of Bužim, in the form of land resources, and higher yields can be achieved by implementing landscaping measures and introducing new corn varieties in accordance with the latest scientific and expert achievements.

Objetivo: Avaliar qualidade de vida, ansiedade, depressão e desesperança em casais submetidos a avaliação/tratamento em serviço público de Reprodução Humana no Brasil. Método: Todos os casais estiveram em avaliação e tratamento para fertilização de setembro de 2014 a julho de 2015 foram entrevistados. Os instrumentos utilizados foram a Escala de Ansiedade e Depressão Hospitalar (HAD), o Fertility Quality of Life tool e a Escala de Desesperança de Beck. Resultados: Participaram do estudo 272 participantes (57,4% mulheres). Foram encontrados 20,9% de sintomas de ansiedade, 12,2% de depressão e 18,4% de desesperança no grupo. Os resultados mostraram que os baixos índices nas subescalas Emocional e Mente/Corpo estavam relacionados aos sintomas depressivos em mulheres, enquanto a relação com a depressão centrava-se na subescala Mente/Corpo. Nas mulheres, os baixos índices foram encontrados nas subescalas Emocional e Mente/Corpo relacionados com a desesperança, enquanto nos homens as subescalas Mente/Corpo e Tolerabilidade mostraram-se significativamente comprometidas. Conclusões: A experiência do casal pode se tornar um fator de risco maior aos danos na qualidade de vida durante o tratamento, o que aumenta a possibilidade de um impacto significativo na saúde física e mental do casal.

Cytogenetic testing plays a major role in the diagnosis of different types of lymphadenopathies, assessment of survival prognosis, but also in the selection of adequate therapeutic strategies. Reports on aggressive head and neck lymphomas combining (cyto)genetics with pathology are rare, also lacking in Bosnia and Herzegovina. The aim of this retrospective study was to provide all chromosome aberrations data recorded in the group of patients diagnosed with malignant head and neck lymphadenopathy, and to analyze advantages and disadvantages of bone marrow (BM) cytogenetics analysis. Out of 819 patients who underwent cytogenetic analysis of BM in five years’ time spread, chromosomal abnormalities were analysed in 54 karyotypes of patients with clinically suspected head and neck lymphadenopathy. We recorded 66,6% Non-Hodgkin lymphoma, 26% Hodgkin lymphoma, 3,7% Acute lymphoblastic leukemia and 3,7% Chronic lymphocytic leukemia. Chromosomal abnormalities in the karyotype were detected in 32 (59.2%) of a total of 54 patients. A normal karyotype was observed in 14 (26%) patients. In 8 (14.8%) subjects, it was not possible to perform cytogenetic analysis. The results of this research are representative in a term of the karyotype characteristics of patients with head and neck lymphoma. This is the first work of its kind in Bosnia and Herzegovina and will continue through a multicenter study in order to characterise the diagnostic and prognostic significance of cytogenetic abnormalities in lymphoma patients.

This paper was based on the fact that educators’ social communicative competences are insufficiently discussed in professional literature, and that there is no research instrument testing them. Therefore, the goal of this paper was to develop and then empirically validate the Scale for the Assessment of Educators’ Social Communicative Competences. The first version of the instrument consisted of the following subscales: Nonviolent Communication, Self-Awareness, Awareness of Others, Self-Management-Emotion Regulation, Self-Esteem, Nonviolent Conflict Resolution. The initial version of the scale contained 70 items. The instrument was applied to a sample of 243 respondents, educators from all over Bosnia and Herzegovina, and psychometric validation was carried out, which included an item analysis, a factor analysis to check the validity and reliability of the measuring instrument. Eventually, an instrument consisting of 32 items was obtained. The following 6 factors were confirmed: Nonviolent Communication, Self-Awareness, Awareness of Others, Self-Management-Emotion Regulation, Self-esteem and Nonviolent Conflict Resolution. The reliability of all the subscales except for the Self-Awareness subscale was found to be satisfactory: Non-violent Communication (5 items; α=.697), Self-Awareness (6 items; α=.487), Awareness of Others (4 items; α=.804), Self-Management-Regulation of Emotions (5 items; α=.817), Self-Esteem (7 items; α=.701), Nonviolent Conflict Resolution (5 items; α=.771). It was concluded that the developed research instrument intended for the assessment of educators’ social communicative competences has satisfactory characteristics.

Rad obrađuje problematiku otvorenosti šuma mrežom primarne šumske prometne infrastrukture te dinamiku građenja, održavanja i rekonstrukcije šumskih cesta u Federaciji BiH od 2005. do 2020. godine. Otvorenost šuma u Federaciji BiH još je značajno ispod potrebne minimalne (15 m/ha za brdsko-planinska područja) za racionalno gospodarenje šumskim resursima. Građenje je novih šumskih cesta imperativ za šumarske tvrtke, međutim dinamika izgradnje novih cesta daleko je ispod potrebne razine. Također, rekonstrukcija postojećih šumskih cesta koje su većinom građene 70-ih i 80-ih godina prošloga stoljeća, a čija nosivost nije usklađena sa zahtjevima suvremenih kamionskih skupova, gotovo pa u potpunosti izostaje. Jedan od osnovnih problema za provođenje predmetne analize jest prikaz podataka šumarskih poduzeća u Federaciji BiH, koja rekonstrukciju, održavanje i redovitu sanaciju daju kao jedan podatak, zbog čega realne pokazatelje stvarno izvršenih radova za pojedinačne vrste radova nije moguće na pravi način opisati. Uz kvantitativne podatke koji su dani u radu, također su iskazani i financijski pokazatelji planiranih i realiziranih radova.