Background: Chordoma is a rare malignant neoplasm that predominantly arises from the axial skeleton, but can also develop in unusual locations. However, there are also rare cases of „NOS“ chordoma involving the oropharyx and epithelial-myoepithelial carcinoma of the parotid gland in the same patient. According to contemporary research, chordoma is a rare malignant neoplasm that arises from the embryonic remnants of the notochord. and typically involves the clivus, sacrococcygeal bones or vertebrae. Studies have shown that the incidence of chordoma has been estimated to be one per one million people per year. Chordoma can occur at any age, but most commonly it is diagnosed in the 40–60 year old age group with the male predominance. Objective: The aim of this article was to review the case of a 74-year-old female patient with epithelial-myoepithelial carcinoma of the parotid gland and a case of „NOS“ chordoma involving the oropharyx. Methods: Diagnostic methods were used to examine a female patient with two primary malignant tumors: CT neck scan, CT of paranasal sinuses, ultrasound examination, scintigraphy and operative finding. Case presentzation: Due to the anatomy complexity, complete resection of the tumor through a transoral-transpharyngeal approach was not possible. Intraoperative palpation of the mass revealed well defined submucosal lesion 20x43x46mm beginning at the level of the oro- and hypopharynx and extending superiorly to the nasopharynx, and posteriorly into the spinal canal and intervertebral foramen causing near complete occlusion of the oro and hypopharynx. The patient also underwent extracapsular dissection of the parotid tumor. Postoperative palliative radiotherapy was performed. Conclusion: Surgical treatment remains the mainstay of treatment for EMC and radiation is imperative for patients who refuse surgery and for those with advanced or inoperable diseases.

The aim of the research was to examine the prevalence of unpleasant emotional states among students. An online survey was conducted in the month of April, 2023, and the participants were students of public universities in Bosnia and Herzegovina (N=170). Among the measuring instruments used was the DASS-21questionnaire (The Depression, Anxiety and Stress Scale-21, Lovibond and Lovibond 1995) and a sociodemographic questionnaire, constructed for the purposes of this research. It is expected that students will experience unpleasant emotional states such as anxiety, depression and stress, and that there will be certain differences in the manifestation of symptoms with regard to gender and age. The obtained findings showed that 34.3% of the subjects are in the category of moderate, severe and extremely severe depressive symptoms, then 49,9% of the subjects feel moderate, severe or extremly severe anxiety, while 38.2% of the subjects show moderate, severe and extremly severe symptoms of stress. As for gender and age differences, the results show that female students are more susceptible to the prevalence of unpleasant emotional states, while the hypotesis related to age differences was not confirmed. Namely, the findings indicate that there are no age differences in the manifestation of unpleasant emotional states. Considering the obtained findings, we believe that it is necessary to raise awareness about the significant growing problems of mental health among students and to highlight the need for preventive and intervention programs at universities.

Introduction: Breast cancer (BC) is a malignant disease that predominantly affects women, with known genetic components such as mutations in tumor suppressor genes BRCA1 and BRCA2. Other risk factors include unhealthy lifestyles, lack of physical activity, and consumption of alcohol and cigarettes. Aging also plays a role in BC development, with hormonal influences such as estrogen and progesterone promoting cancer growth. Material and Methods: Research was conducted using data collection tools for risk factors and tumor markers from primary healthcare unit records. The sample comprised 200 women, divided into two groups based on BC diagnosis, with complete medical documentation. Male BC cases were excluded. Results: Statistical significance was found between genetic components, family history, aging, obesity, alcohol and cigarette consumption, longer hormone exposure, and female BC development using the Chi-Square test, confirmed by Fisher's Exact test. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were useful for BC screening and metastasis detection, as determined by the One Sample T-test. In Sarajevo Canton, invasive ductal BC was the most common type among women, while lobular carcinoma in situ was the least common. Conclusion: Correlations between risk factors, including aging, unhealthy lifestyles, and hormone exposure, and increased BC risk were confirmed. Tumor markers CA 15-3, CEA, CA 19-9, and CA 125 were effective in diagnosis, screening, and metastasis detection in females, with sensitivity for regression detection at 81.8% and specificity at 100%.

The process of deep sheet metal drawing is accepted in all industrial branches. This process is, therefore, very important to maintain a certain level of quality. For this reason, measurements and tests must be carried out to determine how much sheet metal deformation occurred after the deep drawing process. For this purpose, an experiment of deep drawing of sheet metal was carried out using the example of kitchen utensils. In addition, the Taguchi method was used in this experiment to test the quality of the obtained kitchenware. In the experiment, three factors were taken with three alternatives that affect the deep drawing of sheet metal, and 27 experiments were used for the Taguchi method. The results of this experiment showed that the best results were achieved by the smallest drawing depth of 65 mm and the worst results were obtained by the drawing thickness of 70 mm. Regarding the thickness of the material, the best results were achieved by the material of 21 mm, and the material of 15 mm achieved the worst results. In addition, an analysis of variance was carried out, which determined the relationship between force and deformation of the material.

The increased need for smart management of agricultural resources resulted in the preparation and implementation of H2020 project SMARTWATER. This publication aims to present the main outcomes of SMARTWATER in three years of implementation (2021-2023), to encourage relevant target groups to participate in the action in 2024 and to promote smart management of agricultural resources. During project implementation different results were obtained. SMARTWATER team will continue with different twinning activities in 2024 aiming to promote smart agriculture practices, increase the competencies of scientists and young researchers and disseminate the project outcomes.

Large language models (LLMs) have demon-001 strated powerful capabilities in natural lan-002 guage processing, yet their vast number of pa-003 rameters poses challenges for deployment and 004 inference efficiency. Structured model pruning 005 emerges as a viable approach to reduce model 006 size and accelerate inference, without requir-007 ing specialized operators and libraries for de-008 ployment. However, structured pruning often 009 severely weakens the model’s capability. De-010 spite repetitive fine-tuning can restore the capa-011 bility to a certain extent, it impairs LLMs’ util-012 ity as versatile problem solvers. To address this 013 issue, we propose a novel structured pruning 014 algorithm tailored for LLMs. It derives the im-015 portance of different components, namely rows 016 and columns in parameter matrices, based on in-017 termediate data dependencies. Then it removes 018 coupled components across different layers si-019 multaneously and preserves dependency rela-020 tionships within remaining parameters, avoid-021 ing significant performance degradation. The 022 pruned model requires only few epochs of fine-023 tuning to restore its performance, ensuring the 024 model’s ability to generalize. Empirical eval-025 uations on LLaMA, Vicuna, and ChatGLM3 026 demonstrate our algorithm’s efficacy, yielding 027 20% parameter reduction while retaining at 028 least 94.4% of original performance metrics. 029