Dijeteticko istraživanje, provedeno dijeteickim upitnikom, ukazuje na prisutnost znacajnih pokazatelja nepravilne prehrane koji su mogli djelovati na patogenezu gastroezofagusne refluksne bolesti i adenokarcinoma jednjaka. Bolesnici sa Barettovim jednjakom i adenokarcinomom jednjaka uglavnom konzumiraju hranu brzo (70-85%), preferiraju jako vruce ili hladnu hranu (80-90%) te jako zacinjenu hranu (60-75%), dimljenu hranu (55-75%) te konzumiraju alkoholna pica (70-75%)i crnu kavu (100%) i pusaci su (80-90%).

Uricni artritis je recidivirajuca upala jednoga ili vise zglobova zbog hipersaturacije uricne kiseline i odlaganja kristala urata, sklona stvaranju tofa i deformacije zglobova, bubrežnih kamenaca i uricne nefropatije. Akutni uricni artritis obicno nastaje nakon dugogodisnje hiperuricemije u korelaciji s koncentracijom uricne kiseline u serumu, trajanjem hiperuricemije i staroscu bolesnika. Purinske baze, adenin, gvanin, ksantin i hipoksantin nastaju razgradnjom endogenih i egzogenih nukleoproteina i biosintezom, pod utjecajem brojnih enzima. Oksidacijom hipoksantina i ksantina pomocu ksantinoksidaze nastaje uricna kiselina. Nedostatak ili poremecaj aktivnosti pojedinih enzima uzrokuje uricni artritis, tofe, nefrolitijazom i teske neuroloske simptome, pa i teska imunoloska ostecenja. Vecina bolesnika s uricnim artritisom ima prekomjernu tjelesnu masu. Cak 68% bolesnika s uricnim artritisom je pretilo. Racuna se, da su ti bolesnici za 15 do 25% teži od normale. Pretilost i osobito naglo debljanje u mladosti povecavaju rizik za razvoj uricnog artritisa. Najveci rizik imaju najdeblji bolesnici. Dokazana je cvrsta korelacija tjelesne mase i koncentracije urata u serumu. Lijecenje asimptomatske hiperuricemije treba svesti na postupno i kontinuirano smanjenje tjelesne mase. Redukcija potrosnje hrane bogate purinima, alkohola, piva, i medicinski opravdano smanjenom primjenom lijekova koji smanjuju izlucivanje uricne kiseline, te pijenje vece kolicine vode, može se izbjeci hipersaturacija uricne kiseline u mokracnim putevima i prevenirati stvaranje uratnih kamenaca kao i kamenaca od kalcijevog oksalata i fosfata u mnogih bolesnika. U sažetku može se zakljuciti da su osnovna pravila dijetetskog tretmana od momenta otkrivanja hiperuricemije kao i u bolesnika s uricnim artritisom prehrana mora biti hipoproteinska, hipopurinska te hipolipidna i konacno postepeno smanjenje pretilosti hipokaloricnom hranom pretilih bolesnika.

Indifferentiated carcinoma of the nasopharyngs is clinicaly-histological-imunologic entity which is often diagnosed in our country. There are three clinical types, but nodal cervical type of disease is the most interesting type for surgeons while the combined type is more interesting for otolaiyngologist. Among seventy-seven patients diagnosed with undifferentiated carcinoma of the nasopharyngs with nodal cervical type of disease, on the Institute of Otolaryngology and Maxillofacial Surgery Clinical Centre of Serbia during the period between 1993-1997 there were N0-21%, N1-49%, N2-18% i N3-12%, no mater of the T category. The disease more often occurs between male population (2:1), mostly between age 41-60. The rate for five year period of surviving for two different chemioterapeutical protocols is as follows: for categories N0 and N1-20% for mono Zorubicin and 61% for the same category for Z-CDDP. The same rate for categories N2 and N3 is 11% for mono Zorubicin and 33% for the same category for Z-CDDP. Much better rate of survival in comparison with previous decades is achieved due to better diagnosing on time in which are sistematicaly ineluded epypharyngoscopy in general anestesia with biopsy, CT and NMR and EBV serology.

Modern therapeutical protocols for treatment of T3 and T4 malignomas of the larynx are not adjusted, because there are attempts to treat these diseases with non-operative methods (such as chemo- and radiotherapy) in order to preserve the organ. The aim of the study was to establish today's results of the surgical treatement of patients with T3 and T4 laryngeal malignoma. We studied the group of patients with laryngeal carcinoma, who had undergone total laryngectomy, during the period of eight years (1990-1997). The patients' data was submitted from medical documentation, it was filled in specially designed questionnaries and was statistically reviewed. During this eight-year-period, 1054 total laryngectomies were done. The five-years survival rate, established in the group of patients who had undergone total laryngectomiy is 308/794 (39%). In the patient group where total laryngectomy was salvage surgery after radiotherapy, the five-years survival rate is 47/172 (27%). In the patient group where total laryngectomy was salvage surgery after conservative or reconstructive surgery, the five-years survival rate is 28/84 (33%). Despite diagnostical and therapeutical achievements, prognosis for T3 and T4 malygnoma of the larynx was not significantly approved in the last few decades.

Indifferentiated carcinoma of the nasopharyngs is clinicaly-histological-imunologic entity which is often diagnosed in our country .There are three clinical types, but nodal cervical type of disease is the most interesting type for surgeons while the combined type is more interesting for otolaryngologist. Among seventy-seven patients diagnosed with undifferentiated carcinoma of the nasopharyngs with nodal cervical type of disease, on the Institute of Otolaryngology and Maxillofacial Surgery Clinical Center of Serbia during the period between 1993.-1997. there were N0-21%, N1-49%, N2-18% i N3-12%, no mater of the T category .The disease more often occurs between male population (2:1), mostly between age 41 -60. The rate for five year period of surviving for two different chemioterapeutical protocols is as follows: for categories NO and N1-20% for mono Zorubicin and 61% for the same category for Z-CDDP. The same rate for categories N2 and N3 is 11% for mono Zorabicin and 33% for the same category for Z-CDDP. Much better rate of survival in comparison with previous decades is achieved due to better diagnosing on time in which are systematically included epypharyngoscopy in general anesthesia with biopsy, CT and NMR and EBV serology.

Modem therapeutical protocols for treatment of T3 and T 4 malignomas of the larynx are not adjusted, because there are attempts to treat these diseases with non-operative methods (such as chemo- and radiotherapy) in order to preserve the organ. The aim of the study was to establish today's results of the surgical treatment of patients with T3 and T4 laryngeal malignoma. We studied the group of patients with laryngeal carcinoma, who had undergone total laryngectomy, during the period of eight years (1990-1997). The patients' data was submitted from medical documentation, it was filled in specially designed questionnaires and was statistically reviewed. During this eight-year-period. 1054 total laryngectomies were done. The five-years survival rate, established in the group of patients who had undergone total laryngectomiy is 308/794 (39%). In the patient group where total laryngectomy was salvage surgery after radiotherapy, the five-years survival rate is 47/172 (27%). In the patient group where total laryngectomy was salvage surgery after conservative or reconstructive surgery, the five-years survival rate is 28/84 (33%). Despite diagnostical and therapeutical achievements, prognosis for T3 and T4 malygnoma of the larynx was not significantly approved in the last few decades.

The early stage cancer of the glottis, including Tis, T1a and T1b stages, are the most common forms with the incidence rates ranging from 25% to 85%. The therapy of early glottic cancer is usually successful for two reasons. First, true glottic cancer produces early symptoms and it is relatively easy to remove. Second, glottis is rather poor with lymph pathways so the regional metastases are rare, less than 1%. Due to role of the larynx in phonation, respiration and swallowing, the cancer of this region and its treatment has a great impact to the quality of life. Retrospective study involved ten-year period, from January 1990 to January 2004. At the Institute for Otorhinolaryngology and Maxillofacial Surgery, Clinical Center of Serbia, 858 surgical and 54 endoscopic CO2 laser-assisted resections were performed for glottic cancers of larynx of Tis-T2 stages. Glottic tumors were treated by Types III, IV and Va chordectomies according to classificaiton of endoscopic chordectomy defined by the European Laryngological Society. Analyzing the operated patients, as well as the type of the applied surgery, that is, endoscopic-laser and classic surgery, the authors attempted to clarify the dilemmas relating to the indications for one or another type of surgical intervention. The patients who had undergone primary radiotherapy were excluded from the analysis.