Abstract This research investigates the technological underpinnings of Local Flexibility Markets (LFMs). It delves into the synergistic relationship between Information Technology (IT) and Operational Technology (OT) to ensure seamless LFM operations. A key focus is on the Information and Communications Technology (ICT) architecture, which plays a pivotal role in LFM functionality. The research addresses the critical aspect of interoperability within LFMs. It explores standardized data formats for electricity markets, the Common Information Model (CIM) for efficient data exchange, and relevant standards such as the Common Distribution Power System Model Profile (CDPSM) and the Common Grid Model Exchange Standard (CGMES). To ensure secure data exchange, the research investigates various ICT protocols and the significance of Internet of Things (IoT) protocols in enabling LFMs. It underscores the importance of a layered cybersecurity approach to protect LFM infrastructure and sensitive data. The findings of this research highlight the importance of a robust ICT architecture, coupled with secure data exchange mechanisms, to ensure the interoperability, reliability, and overall success of LFMs.

The paper analyzes the sound of drones, both as environmental noise and as a parameter for their detection. The reasons for the psychoacoustic character of the noise and the conditions for effective acoustic detection are examined. Comparative results of sound measurements are provided for three types of reconnaissance drones individually, while hovering at different altitudes.

N-(4-hydroxyphenyl) acetamide or paracetamol is an acylated aromatic amide used as analgesic and antipyretic to relieve pain and reduce body temperature. In medicinal chemistry, there is a growing interest in the development of drugs based on metal complexes, which are of great importance in therapeutic and diagnostic possibilities. Selected metals, magnesium and copper are elements that are extremely important for the human body. In this research, complexes of Mg(II) and Cu(II)-ions with N-(4-hydroxyphenyl) acetamide were synthesized and confirmed with FTIR, UV and MS spectroscopy. The results of the analysis of the synthesized complexes spectra indicate interactions between N-(4-hydroxyphenyl) acetamide and metal Mg(II)-ions and Cu (II)-ions via O-donor and N-donor atoms.  

Environmental noise management is a critical aspect of public health policy, particularly within the European Union, which established Directive 2002/49/EC to standardize noise assessment and mitigation efforts across member states. Serbia has integrated the Directive's provisions through its Law on Environmental Noise Protection and accompanying by-laws. This paper presents the strategic noise mapping process for Belgrade Nikola Tesla Airport, Serbia's largest international airport, marking a significant milestone as it is the first time a strategic noise map is being developed for a major airport in Serbia. The legal framework, methodology, and results of this mapping process are discussed in detail. Utilizing the CNOSSOS-EU:2015 method and the Aviation Environmental Design Tool (AEDT) for acoustic calculations, the study defines the affected areas, noise indicators, and population exposure based on 2023 air traffic data. The results indicate that the Lden noise levels exceeding 55 dB impacted 24,223 residents, while the Lnight noise levels exceeding 50 dB affected 7,493 residents. The analysis also includes the estimated number of dwellings, schools, hospitals, and people affected by different noise levels, providing necessary data for developing action plans aimed at mitigating noise pollution. Additionally, the study examines the potential health impacts, including population annoyance and sleep disturbance, using dose-effect relationships as defined by the European Commission. The results underline the importance of ongoing noise monitoring and the need for timely revisions of strategic noise maps and action plans to ensure compliance with both national and EU regulations. This research contributes to the broader effort of environmental noise management, offering insights into the methodologies and challenges of strategic noise mapping for airports in Serbia.

In the face of pressing socio-economic and environmental challenges, such as climate change, resource depletion, and social inequality, entrepreneurs are increasingly compelled to embrace innovative strategies that harmonize profitability with social and environmental stewardship. Artificial Intelligence (AI) holds promise in facilitating such solutions but requires careful examination to ensure its effective and ethical deployment in pursuit of sustainability objectives. The primary goal of this study was to ascertain whether AI significantly influences the sustainable entrepreneurial process. This comprehensive research framework integrates concepts from entrepreneurship, stakeholder theory, and digital technology, offering a multifaceted perspective. We employed the multiple regression analysis to examine data gathered from 40 entrepreneurs operating within the Bosnia and Herzegovina settings. The study's outcomes revealed that AI positively and significantly impacts the sustainable entrepreneurial process and its five sub-dimensions: “idea generation, opportunity recognition, opportunity development, venture launch, and positive impact”. This study enriches the literature on AI and sustainable entrepreneurship by offering empirical support for the impact of AI on the sustainable entrepreneurial process while also introducing and validating measurement tools for the sustainable entrepreneurial process. Additionally, entrepreneurs can utilize the findings of this research to strategically incorporate AI into their business processes and product/service innovation, improve operational efficiency, reduce costs, mitigate risks, enhance decision-making, foster collaboration across stakeholders, and capitalize on opportunities effectively.

The aim of this paper is to present a case of infective endocarditis (IE) caused by Staphylococcus aureus (S. aureus), focusing on diagnostic and therapeutic approaches. The paper highlights the importance of 2D transesophageal echocardiography (TOE) and discusses the capabilities and advances of appliance of the 3D TOE in patient evaluation, better understanding of the diagnosis, and timely treatment. The use of this advance echocardiographic modality allows clear visualization of complex and destructive tissue lesions, such as the perforation observed and presented in this case.

The study was conducted on the Obedska Bara Ramsar site at two localities, Krstonošića okno and canal Vok, to provide insight into fish community status by analysing fish biomass, biodiversity, and changes after restoration measures. A total of 685 fish samples were examined across four periods, from 2011 to 2023. Biodiversity index, relative biomass, and non-native species were analysed to evaluate the restoration measures’ influence. All parameters showed a negative trend until the restoration works were implemented, after which they increased. This study also provides recommendations to improve the site considering the Mission Restore our Ocean and Waters by 2030.

Objective Despite lack of evidence supporting efficacy, prophylactic fresh frozen plasma and Octaplas transfusions may be administered to very preterm infants to reduce bleeding risk. International variation in plasma transfusion practices in neonatal intensive care units (NICUs) is poorly understood, therefore, we aimed to describe neonatal plasma transfusion practice in Europe. Design Prospective observational study. Setting 64 NICUs in 22 European countries, with a 6-week study period per centre between September 2022 and August 2023. Patients Preterm infants born below 32 weeks of gestational age. Interventions Admission to the NICU. Main outcome measures Plasma transfusion prevalence, cumulative incidence, indications, transfusion volumes and infusion rates and adverse effects. Results A total of 92 of 1143 infants included (8.0%) received plasma during the study period, collectively receiving 177 transfusions. Overall prevalence was 0.3 plasma transfusion days per 100 admission days, and rates varied substantially across Europe. By day 28 of life, 13.5% (95% CI 10.0% to 16.9%) of infants received at least one plasma transfusion, accounted for competing risks of death or discharge. Transfusions were given for a broad range of indications, including active bleeding (29.4%), abnormal coagulation screen results (23.7%) and volume replacement/hypotension (21.5%). Transfusion volumes and infusion rates varied significantly; the most common volume was 15 mL/kg (range: 5–30 mL/kg) and the most common duration was 2 hours (range: 30 min to 6 hours). Conclusions We found wide variation in plasma transfusion practices in Europe, highlighting the need for evidence to inform neonatologists in daily practice and guidelines, in particular for non-bleeding indications. Trial registration number ISRCTN17267090.

Tumour DNA methylation has been investigated as a potential marker for breast cancer survival, but findings often lack replication across studies. This study sought to replicate previously reported associations for individual CpG sites and multi-CpG signatures using an Australian sample of 425 women with breast cancer from the Melbourne Collaborative Cohort Study (MCCS). Candidate methylation sites (N = 22) and signatures (N = 3) potentially associated with breast cancer survival were identified from five prior studies that used The Cancer Genome Atlas (TCGA) methylation dataset, which shares key characteristics with the MCCS: comparable sample size, tissue type (formalin-fixed paraffin-embedded; FFPE), technology (Illumina HumanMethylation450 array), and participant characteristics (age, ancestry, and disease subtype and severity). Cox proportional hazard regression analyses were conducted to assess associations between these markers and both breast cancer-specific survival and overall survival, adjusting for relevant participant characteristics. Our findings revealed partial replication for both individual CpG sites (9 out of 22) and multi-CpG signatures (2 out of 3). These associations were maintained after adjustment for participant characteristics and were stronger for breast cancer-specific mortality than for overall mortality. In fully-adjusted models, strong associations were observed for a CpG in PRAC2 (per standard deviation [SD], HR = 1.67, 95%CI: 1.24–2.25) and a signature based on 28 CpGs developed using elastic net (per SD, HR = 1.48, 95%CI: 1.09–2.00). While further studies are needed to confirm and expand on these findings, our study suggests that DNA methylation markers hold promise for improving breast cancer prognostication.

This study introduces a translation perspective to analyze the policy harmonization process, highlighting imitation, brokering, and editing in shaping policy dynamics at EU and national levels. The translation perspective emphasizes that while policy development is ongoing, the protracted process signals a shift in EU‐wide coordination of skilled labor migration. We show how ongoing translation efforts have transformed the coordination of skilled labor migration across the EU, as labor migration policies have translated into each other, resulting in mutual transformation. The study provides insights into the complex processes of policy harmonization via the Blue Card, enhancing understanding of EU labor migration policy. The findings demonstrate the continuous nature of policy translation between multiple contexts. The article traces developments surrounding the EU Blue Card Directive, including a parallel scheme in Austria, offering insights into skilled migration policy dynamics beyond linear diffusion models.

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain and customizable designs, making them suitable for personalized medicine. Understanding the key design parameters and the challenges during contact with biofluids is crucial to optimizing their use across applications. This review summarizes the current fabrication techniques and design considerations tailored to meet the distinct requirements for drug delivery and biosensing applications. We further underscore the current state of theranostic MNs that integrate drug delivery and biosensing and propose future directions for advancing MNs toward clinical use.