Febrile neutropenia is common chemotherapy complication significantly impacting patient’s outcomes, quality of life and costs, too. Febrile neutropenia (FN) often leads to hospitalization, the need for intravenous antibiotics and use of granulocyte colony-stimulating factors (GCSF) in order to avoid its complications. Cost of febrile neutropenia is well described in literature, but no study has been performed in Bosnia and Herzegovina. We have conducted observational cohort study with aim to describe and present costs of FN treatment from payers’ (provider’s) perspective. Only direct medical costs from one middle-sized oncology Clinic in Bosnia and Herzegovina database have been included and presented. We found that overall cost in five months period (January-May 2015) were almost 30.000 euros, or 1.0035 euro per episode/patient in average. The highest cost are allocated to hospitalization (40%), followed by GCSF (36%), while rest of costs are generated by laboratory tests performed and drug application. Proportion of costs is in line with other published studies even with huge differences in absolute values, mainly to low prices of services in Bosnia and Herzegovina. This was the first study on costs of chemotherapy induced FN in Bosnia and Herzegovina suggesting that significant costs are inquired by this conditions and that further research should be performed including larger patient population and other clinical oncology data, including pharmacoeconomic analysis.

Goal: To analyze the appearance of neurodevelopmental disorders in children delivered post-term and to find out whether prolonged pregnancy may be a cause of such disorders in a selected group participants. Patients and methods: This study included a cohort of 34 children born post-term suffering from neurodevelopmental disorders who were treated at the Service for psycho-physiological and speaking disorders in Mostar, Bosnia and Herzegovina during an 18-year period. Results: There were 59.4% of male and 40.6% female patients (P=0.002). The most common neurodevelopmental disorder in the sample was intellectual disability (38.2%), followed by epilepsy (26.4%), delayed psychomotor development (14.7%), and cerebral palsy (11.7%) (P<0.001). The correlation between mothers’ parity and post-term delivery was found (P=0.016). Conclusion: Post-term delivery may be the cause of neurodevelopmental disorders. The most common disorder among them were intellectual difficulties.

Background A combination of increasing urbanization, behaviour change, and lack of health services in slums put the urban poor specifically at risk of cardiovascular disease (CVD). This study aimed to evaluate the impact of a community-based CVD prevention intervention on blood pressure (BP) and other CVD risk factors in a slum setting in Nairobi, Kenya. Design Prospective intervention study includes awareness campaigns, household visits for screening, and referral and treatment of people with hypertension. The primary outcome was overall change in mean systolic blood pressure (SBP), while secondary outcomes were changes in awareness of hypertension and other CVD risk factors. We evaluated the intervention's impact through consecutive cross-sectional surveys at baseline and after 18 months, comparing outcomes of intervention and control group, through a difference-in-difference method. Results We screened 1,531 and 1,233 participants in the intervention and control sites. We observed a significant reduction in mean SBP when comparing before and after measurements in both intervention and control groups, −2.75 mmHg (95% CI −4.33 to −1.18, p=0.001) and −1.67 mmHg (95% CI −3.17 to −0.17, p=0.029), respectively. Among people with hypertension at baseline, SBP was reduced by −14.82 mmHg (95% CI −18.04 to −11.61, p<0.001) in the intervention and −14.05 (95% CI −17.71 to −10.38, p<0.001) at the control site. However, comparing these two groups, we found no difference in changes in mean SBP or hypertension prevalence. Conclusions We found significant declines in SBP over time in both intervention and control groups. However, we found no additional effect of a community-based intervention involving awareness campaigns, screening, referral, and treatment. Possible explanations include the beneficial effect of baseline measurements in the control group on behaviour and related BP levels, and the limited success of treatment and suboptimal adherence in the intervention group.

Let $M$ denote a finite volume, non-compact Riemann surface without elliptic points, and let $B$ denote the Lax-Phillips scattering operator. Using the superzeta function approach due to Voros, we define a Hurwitz-type zeta function $\zeta^{\pm}_{B}(s,z)$ constructed from the resonances associated to $zI -[ (1/2)I \pm B]$. We prove the meromorphic continuation in $s$ of $\zeta^{\pm}_{B}(s,z)$ and, using the special value at $s=0$, define a determinant of the operators $zI -[ (1/2)I \pm B]$. We obtain expressions for Selberg's zeta function and the determinant of the scattering matrix in terms of the operator determinants.

It is very difficult to write a cultural history of Bosnia and Herzegovina (B&H). The territory of modern-day B&H existed as a part of different imperial or quasi-imperial structures, and its formation and the present shape was affected by external rather than by internal developments. In antiquity there was neither Bosnia nor Herzegovina, but those areas belonged to the older imperial artefact of the Roman Dalmatian province. This spatial artefact in medieval times transformed into the frontier-zone between the Carolingian, Byzantine and Bulgar empires and its by-products – the kingdoms of Croatia and Serbia. Later, medieval barons of Bosnia and Hum (Chulmia, terra de Chelmo, Herzegovina/Hercegovina) were networked with their peers on the Dalmatian coast, as a southern part of the proto-imperial commonwealth known as the Hungarian arch-kingdom (Archiregnum Hungaricum). The Ottoman piecemeal conquest in the 15 and early 16 century ultimately resulted with political, cultural and population discontinuities, triggering consecutive waves of migrations. New empire created new imperial artefact – the province (eyalet, later pashaluk) Bosna in 1580. Reliquium reliquiaris of this frontier province, close to the shape of the present country, formed only after the Christian (Habsburg and Venetian) reconquista in the Great Turkish War (1683-1699) and its