Doxorubicin is a very potent chemotherapeutic drug, however its side effects limit its clinical use. The aim of this research was to investigate the properties of a fullerenol/doxorubicin nanocomposite, its potentially cytotoxic and genotoxic effects on malignant cell lines, as well as its toxicity towards zebra fish embryos. Chromatographic, NMR and mass spectral analysis of the nanocomposite imply that interactions between doxorubicin and fullerenol are non-covalent bonds. The stability of the nanocomposite was confirmed by the use of atomic force microscopy, dynamic light scattering and transmission electron microscopy. The nanocomposite, compared to the free doxorubicin at equivalent concentrations, significantly decreased the viability of MCF-7 and MDA-MB-231 cells. The flow cytometry results indicated that doxorubicin-loaded fullerenol could remarkably increase the uptake of doxorubicin suggesting that fullerenol might be a promising intracellular targeting carrier for the efficient delivery of antitumor drugs into tumor cells. The nanocomposite also affected cell cycle distribution. A genotoxicity test showed that the nanocomposite at all examined concentrations on MCF-7 and at lower concentrations on MDA-MB-231 cells caused DNA damage. Consequently, cell proliferation was notably reduced when compared with controls. Results of the zebrafish embryotoxicity assay showed a decreased overall toxicity, particularly cardiotoxicity and increased safety of the nanocomposite in comparison to doxorubicin alone, as manifested by a higher survival of embryos and less pericardial edema.

The present study focuses on the actions for health promotion produced by Psychology in the health care network as described in scientific journals for both the implantation and implementation of the National Health Promotion Policy. The journals, as well as the Declaration of Alma-Ata, the Ottawa Charter and the Resolution 687/06 itself, constitute the analyzed materials. The conceptual tools of this analysis are grounded on Foucauldian discussions about the regimes of truth and subjectivation policies. The discussions consider the psychological practices in primary health care as a field of experience that constitutes the group figure shaped through testimony and learning as technologies of government of both the self and the other.

Introduction: Our aim was to evaluate quality of life (QOL) as a predictor of work abilities of employees in a tobacco factory.Methods: The study was performed in the period between 2011 and 2012. The sample comprised of 270 workers, males and females, aged from 20-65, with different educational backgrounds. The study was performed as cross-sectional research, on a voluntary basis, using two standardized and anonymous questionnaires: The World Health Organization Quality of Life-Brief Version questionnaire (WHOQOL-BREF) and the Work Ability Index questionnaire (WAI).Results: The participants subjectively perceived high values of QOL in general, with the highest values in the area of living environment. The lowest value was in the area of social interactions. Statistically significant differences were observed in the subjective assessments of QOL, especially in three defined areas (physical health, mental health, and social interactions).  Workers age 50-65 years and workers with basic (primary) level of education exhibited a suboptimal (<70%) values in total value and the values of individually defined areas of QOL.Conclusions: Strong predictors of exemplary work ability of employees are good physical and mental health, younger age, and higher level of education. A link was observed between suboptimal work ability and dissatisfaction with profession and working environment, frequent illness, absenteeism, and exposure to health risks at the workplace.

A bstractWe propose a coherent explanation for the 750 GeV diphoton anomaly and the hints of deviations from Lepton Flavor Universality in B decays in terms a new strongly interacting sector with vectorlike confinement. The diphoton excess arises from the decay ofone of the pseudo-Nambu-Goldstone bosons of the new sector, while the flavor anomalies are a manifestation of the exchange of the corresponding vector resonances (with masses in the 1.5-2.5 TeV range). We provide explicit examples (with detailed particle content and group structure) of the new sector, discussing both the low-energy flavor-physics phenomenology and the signatures at high pT . We show that specific models can provide an excellent fit to all available data. A key feature of all realizations is a sizable broad excess in the tails of τ+τ− invariant mass distribution in p p → τ+τ−, that should be accessible at the LHC in the near future.