Health-Related Quality Of Life (HRQOL) of oncology contains subjective experience of the positive and negative aspects of disease on the physical, emotional, social and cognitive function, and the frequency of the symptoms and side effects of the treatment. The patient is the best source for information about the quality of life and it is necessary that the patient’s value system evaluates and qualitative terms. The effect of chemotherapy is the system, which means that the blood is transported to where the whole body where reacted to the malignant cells in the process of cell division and a variety of other normal tissues. Thus become supporting undesirable advent such as fatigue, which is almost always present, loss of appetite, reduced resistance to infection, and the most common and best known, nausea, vomiting, and hair loss. All of these complications affect the reduction in quality of life, and this applies to all aspects of life: emotional status, social life, physical limitations in daily performance of physiological actions. The role of nurses in the application of chemotherapy is extremely important. From the beginning, the patient and the nurse gain a relationship of trust and security to the patient feel comfortable and safe.

Introduction/Objective Activation of insulin-like growth factor receptor (IGF-1R) results in cell transition from growth phase to synthesis phase of cell cycle. Breast cancer is categorized into prognostic and therapeutic subtypes based upon hormone receptor, estrogen receptor (ER), and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER-2) expression. The objective of this study was to examine the expression of IGF-1R in а specific subtype invasive breast cancer and its correlation with basic histopathological and immunohistochemical prognostic parameters. Methods Formalin-fixed paraffin-embedded tumor samples were obtained from 129 female patients with invasive breast cancer (I–III disease stage) with the follow-up ranging 36–108 months (average 48 months). For immunohistochemical staining, we used monoclonal antibodies for ER, PR, IGF-1R, and polyclonal antibody for HER-2. Results IGF-1R inversely correlated with tumor stage (p = 0.017), tumor grade (p = 0.001), HER-2 (p = 0.003), whereas significant positive correlation was found with multifocality/multicentricity of breast cancer (p = 0.036), ER (p = 0.001) and PR (p = 0.0001) expression. Cox-regression analysis for relapse-free survival (RFS) showed that disease stage (p = 0.039) and HER-2 (p = 0.033) were independent prognostic factors. IGF-1R did not predict clinical outcome in patients with breast cancer (p = 0.488, Kaplan–Meier test for RFS). Conclusion Patients with low stage and grade hormone-dependent breast cancer had a significantly higher IGF-1R expression than patients with triple negative or HER-2 overexpressed cancer. The present findings also highlight that IGF-1R expression in multicentric/multifocal breast cancer supports the key roles in tumor initiation.

This paper presents method for sustainability assessment of thermal power plant unit using multi-criteria analysis with aim to create base for business decision. Seven options of possible status of thermal power plant „Kolubara A” unit No. 2 with energy indicators of sustainable development were shown. Energy indicators of sustainable development consists of sets of resource preservation, economic, environmental, and social indicators. Sustainability assessment often fails to account for social influence on energy system. Considering to this, special focus will be on social indicators, their definition, forming, and impact on multi-criteria sustainability analysis. Analysis of quality of the selected options (energy systems) in respect to sustainable development by compare of their general index of sustainability is presented. Methodology of multi-criteria analyse of thermal power plant unit can show decision makers how to find best available options when the social indicators impact is leading. The aim of this paper is to choose the criteria for the evaluation of the available options, determine the relative importance of specific criteria and present methodology of multi-criteria analysis in the decision-making process.

Credit risk is the most important risk among all other risks in the banking business, because almost over 80% of bank balance sheets relate to this segment of banking risk management. One of the biggest problems of commercial banks in Bosnia and Herzegovina are non-performing loans whose share in total loans has increased significantly since the onset of the global financial crisis. The main objective of the research is to determine which of the macroeconomic variables have the strongest impact on the increase of return on average equity and whether it is possible to reduce the credit risk of banks with adequate legislation as the main factor in the slowdown in credit expansion. The main goal will be to divide the impact of an independent variable, i.e. the share of liquid assets in total assets and whether its increase indirectly affects the return on equity and indirectly, the credit risk. The quantitative model used in this study will be the Merton model. Testing will be conducted through multiple regression analysis for the period 2008-2016 with the help of the software package STATA.