Aim: The objective of this study was to determine the oxidative status of saliva and plasma in diabetic children, by analyzing advanced oxidation protein products (AOPPs) and total antioxidant capacity (TAC). Materials and methods: Study included 60 patients with diabetes mellitus type I (DMT1) aged 12.45 ± 2.65 years, and 40 healthy age-matched controls. The AOPP and TAC of the plasma and saliva samples were determined using a commercial QuantiChromTM Antioxidant Assay Kit (DTAC-100) for TAC determination, and Immunodiagnostic AG [enzyme-linked immunosorbent assay kit for AOPP]. Results: Values of salivary and plasma AOPP were lower in diabetic patients than in healthy controls, while value of TAC was clinically and significantly higher in plasma of controls, and clinically higher in saliva of healthy control group, compared with diabetic patients. Average value of hemoglobin A1c (HbA1c) was 7.58 ± 0.85%. Conclusion: Results of this study showed that diabetes mellitus as a condition, with well-controlled HbA1c, has no influence on AOPP levels in saliva and plasma, while TAC levels of saliva and plasma are lower in diabetic patients, which means that DMT1 has an influence on the TAC.

Kosana D. Stanetić1, Suzana M. Savić1, Bojan M. Stanetić2, Olja M. Šiljegović3, Bojana S. Đajić4 1Primary Health Center Banja Luka, Department of family medicine, Medical faculty, University of Banja Luka, Bosnia and Herzegovina 2Department of Cardiology, University Clinical Center of the Republic of Srspka, Banja Luka, Bosnia and Herzegovina 3Primary Health Center Doboj, Bosnia and Herzegovina 4Primary Health Center Gradiška, Bosnia and Herzegovina The prevalence of polypharmacy in elderly: a cross section study from Bosnia and Herzegovina Оригинални радови / Original Articles

Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease first described in 1967 by Dr. Thomas L. Petty and colleagues as a syndrome of respiratory failure that presents with progressive arterial hypoxemia refractory to oxygen therapy, severe dyspnea caused by reduction of pulmonary compliance and diffuse bilateral pulmonary infiltrations. This clinical syndrome is characterised by acute, severe and life threatening respiratory insufficiency with high mortality rate [1-3]. The definition of ALI/ARDS was recommended by the American/ European Consensus Conference since 1994 (Table 1). The standard definition classifies the patients with bilateral pulmonary infiltrates and arterial hypoxemia, who have the ratio of PaO2 / FiO2 less than 300 mmHg. However, if the ratio is less than 200 mmHg, the diagnosis of ARDS can be made. In patients with left heart disease, the pulmonary wedge pressure less that 18 mmHg is a criterion to distinguish ARDS form cardiac failure. Recently, new Berlin classification of ARDS was accepted in 2013, where the term ALI was abandoned and ARDS was categorized [3,4].