<p>Istraživanje je strukturirano na način da izvr&scaron;i prikupljanje podataka<br />potrebnih za statističku obradu, plansko uvođenje blended learninga u srednje &scaron;kole.<br />Na temelju prikupljenih podataka razvija se model za odlučivanje koji ima svoju<br />primjenu u dono&scaron;enju odluka u procesu planiranja uvođenja blended learninga.<br />Učenici obuhvaćeni ovim ekspermentom na osnovu pokazatelja i statistike koju<br />bilježi LMS sistem ispituju se u vje&scaron;tini i brzini savladavanja obrazovnog programa<br />kreiranog u sistemu LMS, i kroz provedenu anketu će se iskazati faktori<br />zadovoljstva učenika prema LMS-u omjerom kojim utiče na kvalitet stečenog<br />znanja kod učenika. Isto tako će se prikazati koliko se učenici podstiću na<br />međusobnu saradnju i komunikaciju i koji faktori utiču na percepciju učenika o<br />stavovima prema LMS-u.</p>

<p>U ovom radu predstavljamo teoriju grafova i njen značaj u matematici i drugim<br />oblastima nauke i dru&scaron;tvenog života. Grafovi sečesto upotrebljavaju za opis i grafički prikaz<br />apstraktnih modela i struktura podataka. Takav pristup olak&scaron;ava njihovo razumijevanje. Budući<br />da teorija grafova ima veliku primjenu u informatici, njen razvoj zadnjih decenija je ubrzan.<br />Kroz ovaj radćemo prezentovati nekoliko jednostavnijih primjera primjene teorije grafova u<br />različitim oblastima, sa ciljem popularizacije teorije grafova.</p>

Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund multiple initiatives. Objective: Analyse antibiotic utilization patterns in the Republic of Srpska following these multiple initiatives as a basis for developing future programmes in the Republic if needed. Methods: Observational retrospective study of total outpatient antibiotic utilization from 2010 to 2015, based on data obtained from the Public Health Institute, alongside documentation of ongoing initiatives to influence utilization. The quality of antibiotic utilization principally assessed according to ESAC, ECDC, and WHO quality indicators and DU 90% (the drug utilization 90%) profile as well as vs. neighboring countries. Results: Following multiple initiatives, antibiotic utilization remained relatively stable in the Republic at 15.6 to 18.4 DIDs, with a decreasing trend in recent years, with rates comparable or lower than neighboring countries. Amoxicillin and the penicillins accounted for 29–40 and 50% of total utilization, respectively. Overall, limited utilization of co-amoxiclav (7–11%), cephalosporins, macrolides, and quinolones, as well as low use of third and fourth generation cephalosporins vs. first and second cephalosporins. However, increasing utilization of co-amoxiclav and azithromycin, as well as higher rates of quinolone utilization compared to some countries, was seen. Conclusions: Multiple interventions in the Republic of Srpska in recent years have resulted in one of the lowest utilization of antibiotics when compared with similar countries, acting as an exemplar to others. However, there are some concerns with current utilization of co-amoxiclav and azithromycin which are being addressed. This will be the subject of future research activities.

DNA methylation can mimic the effects of germline mutations in cancer predisposition genes. Recently, we identified twenty‐four heritable methylation marks associated with breast cancer risk. As breast and prostate cancer share genetic risk factors, including rare, high‐risk mutations (eg, in BRCA2), we hypothesized that some of these heritable methylation marks might also be associated with the risk of prostate cancer.