Abstract Complex training (CT) is a strength training intervention performed by completing all the sets of a resistance exercise followed by a series of high-velocity/plyometric exercise/s. The purpose of this novel study was to conduct a meta-analysis on the effect of CT on vertical jump (VJ) performance. Five electronic databases were searched using terms related to CT and the VJ. Studies needed to include randomized trials comparing CT with traditional resistance training (RT)/plyometric training (PLYO)/control (CON) lasting ≥ 4 weeks and the VJ as a dependent variable. Seven studies qualified for the meta-analysis with two studies differentiating VJ performance from CT and RT, two studies comparing VJ performance of CT and PLYO, and two studies establishing the difference in VJ performance between CT and CON. Results indicated similar improvement in VJ performance from CT and RT (p = 0.88). On the other hand, greater VJ performance in CT than PLYO was identified (ES = 0.86; 95% CI 0.24, 1.47; p = 0.01). CT also showed significantly greater enhancement in VJ compared to CON (ES = 1.14; 95% CI 0.60, 1.68; p < 0.01). In conclusion, CT can serve as alternative training from RT in improving VJ performance. On the other hand, CT is a better option in VJ enhancement than PLYO and CON.

Summary Study aim: The body structure can play a determining role in the achievement of top judo performance, and it seems to influence the type of techniques applied. The aim of this study is to determine the somatotypes in male and female national level judokas across weight categories in order to observe possible differences among athletes. Material and methods: A total of 61 male judokas (23.2 ± 2.7 years old) and 37 female judokas (22.3 ± 3.3 years old) participated in this study. Anthropometric variables were used to calculate somatotypes. Somatotypes were determined according to the Heath-Carter method. Analysis of variance and Tukey’s post hoc test were used to determine differences between weight categories and obtained effect sizes (η2) were presented as well. Results: Somatotype differences among weight categories in male and female judokas were observed. Generally, all categories could be classified in three somatotypes in male and female athletes. Conclusions: The lightest categories were recognized as mesomorphic ectomorphs in females with an exception in the –48 kg category, and ectomorphic mesomorphs in male athletes. The middle ones had the endomorphic mesomorph somatotype and the heaviest athletes presented somewhat more extreme cases of endomorphic mesomorphs, both in male and female judokas. According to the results obtained, judokas have a specific body composition in different weight categories. Therefore, coaches could create a specific training programme for athletes who belong to different somatotypes.

Abstract The objectives of this research were to establish somatotype and hand-grip strength between elite cadet male and female sambo athletes divided by weight categories. A total of 97 elite cadet sambo athletes, participants of the World Cadets Sambo Championships 2018 participated in the study. Male and female sambo athletes were divided by official weight categories. Anthropometrical variables were taken in order to calculate somatotypes and hand-grip strength. A one-way analysis of variance and Tukey's post hoc tests were used to compare group differences by weight categories. Results of this study provide the first description of somatotype and hand-grip strength of elite male and female cadet sambo athletes in relation to weight category. A typical somatotype in male sambo athletes was endomorphic mesomorphs with a predominance of musculoskeletal tissue, while female athletes differed concerning weight category. Overall, an increase in handgrip strength across weight categories was noted. Hand-grip strength increases linearly from the lightest to the heaviest weight category except in −66 and −84 kg in male athletes. Differences in handgrip strength of female athletes were detected between the lightest group and last six groups in all three variables in favor of last six as well as −44 and kg −48 kg compared with the heaviest. To the best of our knowledge, this study provides the first normative data of somatotype and hand-grip strength analyses in relation to age, gender, and weight categories of cadet sambo athletes. The anthropometric profile of sambo athletes changed according to their weight category. Mesomorphy was the most dominant somatotype component in male athletes, while female had three different types of somatotype component in relation to weight category. In conclusion, we found differences in hand-grip strength related to weight category, which can be linked to the muscle mass of athletes. Future studies should focus on somatotype and strength handgrip values of international compared to national level sambo athletes.

Aside from vast deployment cost reduction, Industrial Wireless Sensor and Actuator Networks (IWSAN) introduce a new level of industrial connectivity. Wireless connection of sensors and actuators in industrial environments not only enables wireless monitoring and actuation, it also enables coordination of production stages, connecting mobile robots and autonomous transport vehicles, as well as localization and tracking of assets. All these opportunities already inspired the development of many wireless technologies in an effort to fully enable Industry 4.0. However, different technologies significantly differ in performance and capabilities, none being capable of supporting all industrial use cases. When designing a network solution, one must be aware of the capabilities and the trade-offs that prospective technologies have. This paper evaluates the technologies potentially suitable for IWSAN solutions covering an entire industrial site with limited infrastructure cost and discusses their trade-offs in an effort to provide information for choosing the most suitable technology for the use case of interest. The comparative discussion presented in this paper aims to enable engineers to choose the most suitable wireless technology for their specific IWSAN deployment.

Atopic dermatitis (AD) is a heterogeneous disease with various biological origins and clinical appearances. It is likely that different therapies or treatment intensities are not equally effective for all AD endotypes. The strongest genetic risk factor for AD is a null muta‐ tion in the filaggrin gene (FLG).1 Patients with eczema who carry a FLG null mutation are also prone to more persistent, severe eczema, and earlier onset of AD compared to patients without a FLG null mutation. Stratification of patients based on the FLG null endotype could enable more targeted treatment. Methods to determine FLG null mutations based on genotyping are time consuming and require specialized laboratory infrastructure, further complicated by the existence of over 50 different polymorphisms with widely varying prevalences between ethnic groups.2 In the stratum corneum (SC) filaggrin is enzymatically degraded into its constituting amino acids and their derivatives, together with specific salts and sugars collec‐ tively named natural moisturizing factor (NMF). Decreased NMF provides an accurate surrogate marker for the presence of FLG null polymorphisms.3 This can be measured rapidly and noninvasively by Raman spectroscopy in a clinically compatible test. We have assessed the potential of NMF as a novel clinical marker in AD by examining the association of clinically measured NMF val‐ ues with severity of AD, early onset of AD, and the co‐morbidities of AD: allergic sensitization, food allergy, bronchial hyperreactivity (BHR), asthma, and allergic rhinitis. Of 207 children with AD (0‐18 years of age), NMF values had been measured routinely during a visit to the pediatric atopy cen‐ ter KinderHaven‐Sophia Children's Hospital‐Erasmus MC University Medical Center Rotterdam in The Netherlands. The retrospective study protocol was approved by the medical ethics committee of Erasmus MC (MEC‐2016‐244). AD was diagnosed by a dermatologist according to the UK Working Party's Diagnostic Criteria for Atopic Dermatitis.4 NMF had been measured noninvasively on the palm of the hand by Raman spectroscopy using an in vivo Raman skin ana‐ lyzer (gen2‐SCA, RiverD International BV, Rotterdam). NMF values were classified as normal NMF (>1.14 arbitrary units) or decreased NMF (<0.995 arbitrary units), using a 0.07 confidence interval around the threshold of 1.07 as established by O’Regan et al.3 Patients with a NMF value between 0.995‐1.14 were excluded. The interval was the estimated 95% confidence interval, calculated as the standard error (SE) of the NMF value, averaged over the entire cohort, and multiplied by 1.96. Disease characteristics and comorbidity status were retrieved from the electronic medical patient files by two in‐ dependent researchers (see Appendix S1). Severity (mild to moderate or severe) of AD was measured by proxy of therapy based on the cri‐ teria as described by Wollenberg et al5 (Appendix S1). Associations between NMF status and the clinical parameters were tested by uni‐ variate and multivariate logistic regression models with adjustment for age and gender. Sixty‐seven out of 207 (32.4%) patients had decreased NMF. Figure 1 shows the distribution of disease severity in relation to the groups normal NMF and decreased NMF. Patients with decreased NMF had increased risk of severe AD, OR 2.12 (95% CI 1.02‐4.43), sensitization for food allergens, OR 2.27 (95%CI 1.21‐4.23), sensiti‐ zation for inhalation allergens, OR 2.22 (95%CI 1.13‐4.34), and food allergies, OR 2.79 (95% CI 1.33‐5.86; Table 1 and Table S1). Having decreased NMF did not show an association with early‐onset AD, allergic rhinitis, BHR, asthma and combined asthma, and/or BHR. In this retrospective study, we examined the associations between NMF values and the clinical parameters of the atopic syndrome. NMF

Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed vesicles made of a phospholipid bilayer and are secreted by all cell types. EVs are present in a variety of body fluids containing proteins, DNA, RNA species, and lipids, and play an important role in cell- to-cell communication and are worth being considered as biomarkers for both early diagnosis of cancer patients and real-time monitoring of treatment response. Recently, emerging evidence verified EVs to have crucial roles in cancer progression and metastasis and a great potential in therapeutic applications. In this review, we discuss the potential of EVs in monitoring the efficacy of cancer therapies.

Abstract This article uses data from the National Survey of Citizens’ Perceptions in Bosnia-Herzegovina to investigate the determinants of offering a bribe in the form of money, gifts or services to medical personnel, professors, judicial personnel, police officers and public servants. We presented evidence about the spread of corruption in these five sectors of the economy in Bosnia-Herzegovina, and analysed the effects of determinants at the individual level on the likelihood of engaging in bribery. Our results confirmed that specific personal characteristics predicted corrupt behaviour, but results varied across sectors. Logistic regression was used to generate models from which predictions could be made about the likelihood of an individual engaging in corrupt behaviour. Our research shows that corruption is a widespread phenomenon in Bosnia-Herzegovina, and more educated people, people living in urban areas, and individuals with higher incomes are more likely to engage in bribery in several sectors. Measures and policies aimed at reducing corrupt behaviour should be designed in a way that considers the specific characteristics of these individuals.

Abstract This paper explores the impact of education-job mismatch on the net income of workers in the context of Bosnia-Herzegovina. We used an OLS linear regression method on data from the Measure BiH Youth Survey. A log-transformation of the dependent variable created the left-side semilog functional form, which is typically used in models of the earnings of individuals. Our findings strongly support the statement that education-job mismatch has a significant effect on net income. Workers can expect net income differences between 13% and 15% if their level of education does not match that required for their job. However, our results show that the impact of education-job mismatch depends on the level of schooling and age of respondents. Results regarding education-job mismatch vary across studies, but our study is the first to examine the effect of education-job mismatch on net income in the context of Bosnia-Herzegovina. Second, the effect of education-job mismatch might depend on the choice of estimation method for incidences of overeducation and undereducation. Third, we emphasise the importance of understanding interactions, and fourth, we introduce new variables to understand how they influence earnings. These include religiousness, and the importance of belonging to a family, or a particular city.

Due to the varying conditions in traffic and resource availability in networks nowadays, maintaining continuity of network service and satisfying QoS and QoE requirements became a challenging task. If considered in a highly diversified environment in terms of technology and administration, it gets even more complicated, and appropriate service and resource management solutions are mandatory. Thus, the aim of this paper is to present our specific perspective of the ongoing European H2020 5G-CARMEN project, addressing the importance of proactive reconfiguration of network services and their migration between different domains. Leveraging 5G technology and MEC platform, our management platform for automated low-latency-aware VNF placement and migration will enable orchestration of network services and resources across different administrative and technology domains.

We thank dr Yuanjun Dong for his interest in our publication.1 Dr Dong points out that previous and current stressful life events mod‐ ulate gastrointestinal (GI) symptom severity and quality of life (QoL) in patients with irritable bowel syndrome (IBS),2 which is indeed based on recent findings.3 In addition, we would like to note that abdominal pain is the predominant symptom in IBS, as per Rome IV definition. The primary treatment outcome for IBS in clinical tri‐ als, in accordance with FDA and EMA requirements, is reduction in daily abdominal pain.4 Whether a successful treatment, based on these criteria, improves patients’ life satisfaction and QoL remains an item of debate. In the current study, we performed an extensive prospective evaluation of the natural course of IBS which included demographics, gastrointestinal symptoms, symptoms of anxiety and depression, GI‐specific anxiety, satisfaction with life, and QoL. With regard to QoL, we showed among others that general anxiety and depression levels at follow‐up were independently associated with mental quality of life scores at the same time point. Furthermore, no associations were found between GI symptom severity, including abdominal pain, and the change in QoL scores over time.1 With regard to a possible interaction between GI symptoms and stress, in Table 1 we provide data on specific questions and answers from the database of Maastricht IBS cohort regarding the patients’ perspective on this matter. No statistically significant differences were found between Rome‐positive and Rome‐negative IBS patients at follow‐up. However, the current understanding on the relationship between abdominal pain and stress, whether current or related to life events, may be limited by the methods used to assess these factors. Traditionally, data from retrospective reports have been used to de‐ scribe this relationship, but it is known that these questionnaires are limited by recall and ecological bias.4 We therefore believe that the best available method to study the relationship between GI symp‐ toms, comorbid psychological complaints, and daily life stress is re‐ peated momentary symptom assessment.5 Such methodology has been used recently to assess the temporal relationship between ab‐ dominal pain and (preceding) daily life stress.6 We have developed and are currently validating specific questionnaires based on experience sampling method (ESM) which may provide additional leads in this matter.7 In a recently completed study, we demonstrate that real‐time stress scores are positively associated with concurrent abdominal pain scores in IBS, but not in healthy subjects, whereas abdominal pain could not be predicted by preceding stress levels, and vice versa, suggesting an in‐the‐moment rather than a longitudinal association.8 Taken together, we postulate that reduction in abdominal pain is not necessarily accompanied by long‐term improvement in quality of life in patients with IBS. This may indicate that the primary treat‐ ment focus in IBS should shift from solely abdominal pain reduction and improvement of bowel habits, toward a holistic approach, which includes quality of life, comorbid psychological symptoms, and im‐ provement of coping strategies with regard to GI symptoms as well as daily life stress. However, the evidence to support a change in the approach of IBS management is still inconclusive, and further research is needed.