High-harmonic generation by aligned diatomic molecules in orthogonally po-larized two-color laser fields is considered using the molecular strong-field approximation. Regions of the parameter space with large harmonic ellipticity are identified.

The search for effective coronavirus disease (COVID-19) therapy has attracted a great deal of scientific interest due to its unprecedented health care system overload worldwide. We have carried out a study to investigate the in silico effects of the most abundant pomegranate peel extract constituents on the multi-step process of serious acute respiratory syndrome coronavirus 2 (SARS-CoV-2) internalization in the host cells. Binding affinities and interactions of ellagic acid, gallic acid, punicalagin and punicalin were studied on four selected protein targets with a significant and confirmed role in the process of the entry of virus into a host cell. The protein targets used in this study were: SARS-CoV-2 spike glycoprotein, angiotensin-converting enzyme 2, furin and transmembrane serine protease 2. The results showed that the constituents of pomegranate peel extracts, namely punicalagin and punicalin had very promising potential for significant interactions with the selected protein targets and were therefore deemed good candidates for further in vitro and in vivo evaluation.

OBJECTIVE Testicular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors that may be predict a testicular salvage after TT in pediatric patients. METHODS Consecutive medical records of all children ≤16 years old with surgically confirmed TT over a period of five years (2011-2016) were collected. Patients were divided into 2 groups according to testicular viability and the type of treatment: Orchidectomy and orchidopexy. The differences between the two groups and potential predictors of testicular salvage were analyzed. RESULTS Thirty-one boys with TT met the inclusion criteria and were included in the study. The mean age was 13.6 years (range, 10 days - 15.8 years). Testicular salvage was possible in 18 (58.1%) patients. The duration of symptoms and a lesser degree of torsion indicated a testicular salvage in children and adolescents with testicular torsion, but in multivariate analysis only duration of symptoms (time to surgical detorsion) was significantly associated with the risk of non-salvage. At follow-up, testicular atrophy affected 73.3% of the patients treated with orchidopexy. CONCLUSION Duration of symptoms is the only predictor of successful testicular salvage following testicular torsion in children. It is associated with a substantial risk of testicular loss and atrophy.

The term ‘digital’ concerns not only technology but also people. This chapter emphasises the necessity of adopting a digital entrepreneurial mindset when operating in a digitised world. The chapter proposes a definition of a digital entrepreneurial mindset that is rooted in cognitive psychology, organisation theory and entrepreneurship literature. We also focus on the five trends that are shaping the digital future: mobile computing, cloud computing, social media, the Internet of Things and Big Data. The chapter discusses the challenges and opportunities that pervasive digitalisation offers for designing new digital business models and changing interactions with customers. Discussing the success stories of Domino’s Tesco and Tate Art Galleries helps to examine data-driven, cloud-enabled, platform-centric business activities, for which developing a digital entrepreneurial mindset is the first step towards success in the digital age. Collectively, the aforementioned cases suggest that businesses that rely on a digital entrepreneurial mindset enjoy better financial performance. Both managers and employees in these companies have shown the inclination and ability to discover, evaluate and exploit opportunities emerging from digital technologies. This chapter also provides a practical guide for entrepreneurs on the steps they can take to encourage a digital entrepreneurial mindset throughout their entire organisations. Finally, we elaborate on the practical implications of adopting a digital entrepreneurial mindset and its impact on society.

Abstract. Water resources and associated ecosystems are becoming highly endangered due to ongoing global environmental changes. Spatial ecological modelling is a promising toolbox for understanding the past, present and future distribution and diversity patterns in groundwater-dependent ecosystems, such as fens, springs, streams, reed beds or wet grasslands. Still, the lack of detailed water chemistry maps prevents the use of reasonable models to be applied on continental and global scales. Being major determinants of biological composition and diversity of groundwater-dependent ecosystems, groundwater pH and calcium are of utmost importance. Here we developed an up-to-date European map of groundwater pH and Ca, based on 7577 measurements of near-surface groundwater pH and calcium distributed across Europe. In comparison to the existing European groundwater maps, we included several times more sites, especially in the regions rich in spring and fen habitats, and filled the apparent gaps in eastern and southeastern Europe. We used random forest models and regression kriging to create continuous maps of water pH and calcium at the continental scale, which is freely available also as a raster map (Hájek et al., 2020b; https://doi.org/10.5281/zenodo.4139912). Lithology had a higher importance than climate for both pH and calcium. The previously recognised latitudinal and altitudinal gradients were rediscovered with much refined regional patterns, as associated with bedrock variation. For ecological models of distribution and diversity of many terrestrial ecosystems, our new map based on field groundwater measurements is more suitable than maps of soil pH, which mirror not only bedrock chemistry but also vegetation-dependent soil processes.