Architectural design decisions, such as service deployment and composition, plant layout synthesis, or production planning, are an indispensable and overarching part of an industrial manufacturing system design. In the fourth industrial revolution (Industry 4.0), frequent production changes trigger their synthesis, and preferably optimization. Yet, knowledge on architecture synthesis and optimization has been scattered around other domains, such as generic software engineering. We take a step towards synthesizing current knowledge on architectural design decisions in Industry 4.0. We developed a taxonomy describing architectural models, design decisions, and optimization possibilities. The developed taxonomy serves as a guideline for comparing different possibilities (e.g., application of different optimization algorithms) and selecting appropriate ones for a given context. Furthermore, we reviewed and mapped 30 relevant research works to the taxonomy, identifying research trends and gaps. We discuss interesting, and yet uncovered topics that emerged from our review.

A few days ago authors of the papers deposited on the ResearchGate platform informed us by a letter from the ResearchGate team titled: "A note on recent content takedowns" where has been noticed that ResearchGate recently received demands from two publishers: Elsevier and the American Chemical Society (ACS) "to remove certain content that they alleged infringed their copyrights" (1). The main statement of the ResearchGate (RG) is: "These types of requests are not new: we have received many similar requests from them in the past, and, in accordance with applicable law, have complied with them. But these most recent requests were notable because of the number of articles involved. Although privately stored files were not affected, the demands by Elsevier and ACS resulted in the removal of around 200,000 public files. In the context of a community of over 20 million researchers, this is unfortunate, rather than existential, but it has sparked an acute reaction from many of our members who believe in the importance of open science" (1). Further RG explains: "Some of you have commented on the serious nature of our communications with you regarding the removal of content. We appreciate that the tone of our messaging was rather direct. International laws require that we implement a policy regarding repeat takedown requests from publishers, and we felt duty-bound to communicate these policies to you in no uncertain terms. This is done for the protection of users and the benefit of the ResearchGate community" (1). Concerning the future work (perspectives) RG stated: "Finally, we are mindful of recent changes in European copyright law in some countries, particularly relating to Article 17 of the Directive on Copyright in the Digital Single Market (2). While we believe we are not subject to such laws due to the nature of our business, we decided to nonetheless take advantage of advancements in technology which we believe will be beneficial for researchers. In particular, we have started implementing a new system called "Jarvis" which matches publisher rights information with user content at the time of upload. Where a publisher has provided the required information, Jarvis can prevent a researcher from unintentionally uploading content that is not allowed to be public. As always, it remains the responsibility of researchers to know and confirm their rights before uploading any content" (1). The final message of the RG team sent to its users’ is: "The future of academic publishing is open. Let’s work together to unlock its true potential" (1). According to this letter and content of the message from the RG team, as an experienced former and current Editor of a few indexed journals and prolific contributor and author of a lot of papers, especially in the Science Editing field and Scientometrics (3-9), let me expressed some views and comments regarding important facts and problems within Science Editing area and concerns of the scientific and academic community. Two extremely important problems in scientific publishing represent plagiarism and predation. More and more authors of articles in this scientific field, in the absence of other opportunities to engage in science, in this period of the Corona pandemic crisis imposed as a devastating consequence, began to deal with these topics, write about plagiarism and predation, conduct meta-analyze, and recommend what and how authors, especially who are not EDITORIAL

Background: The peculiar reigning and private life of Maria Theresa in the tumultuous time of continuous wars in the then Europe was interwoven with her predominant maternal/obstetric history, as presented below. Objective: All the sixteen pregnancies of Empress Maria Theresa ended in spontaneous vaginal deliveries at term, with no information on pregnancies ended in spontaneous abortion or preterm delivery. Methods: Medicohystorical review of the obstetrical anamnesis of Empress Maria Theresia. Results: There were fifteen live births, whereas one female baby was born without signs of life. Cephalic presentation was recorded in fourteen and breech presentation in two deliveries, one of the latter with lethal fetal outcome. Thirteen deliveries were free from complications, whereas three deliveries, i.e. second, tenth and sixteenth, were very difficult, associated with obstetric complications including one manual lysis of the placenta with postpartum bleeding and two difficult deliveries with breech presentation. Maria Theresa had all her deliveries accomplished with assistance of the Court midwife (Hofhebamme), whereas the Court physician performed manual lysis of the placenta. Following delivery, the Habsburg-Lorraine archduke or archduchess was baptized by papal nuncio, but two children were baptized by the midwife in life-threatening conditions Conclusion: Considering her policy of renewing her multiethnic empire and its population that suffered great losses at various battlefields, Maria Theresa was a true representative and record-holder in perinatal contribution among the then courts worldwide.

Abstract Rationale: Peutz-Jeghers syndrome (PJS), a rare autosomal dominant disorder, is characterized by mucocutaneous pigmentations, hamartomatous polyps in the gastrointestinal tract, and a high risk of developing various malignancies. To the best of our knowledge, only 1 case of appendiceal carcinoid associated with PJS has been previously reported in the pediatric population. Patient concerns: We report a 7-year-old girl who was admitted for severe, intermittent abdominal pain and cramps, nausea, and vomiting. Multiple brown melanotic macules on the lips, buccal mucosa, and the tongue were noted. Diagnosis: A plain abdominal X-ray in a standing position revealed dilated intestinal loops with multiple air-fluid levels. A computed tomography scan of the abdomen showing a “coffee bean” appearance of the jejunal loop with a transition point to the duodenal loop. Axial-contrast-enhanced computed tomography scan of the abdomen showing dilated jejunum loops, filled with fluid with the swirled appearance of mesentery typical for volvulus. The diagnosis of PJS was based on clinical findings along with the histopathologic confirmation of the hamartomatous polyps. Interventions: An emergency laparotomy was performed, revealing a jejunojejunal intussusception starting 40 cm from the duodenojejunal flexure. Jejunotomy revealed that a lead-point intussusception was a necrotic hamartomatous polyp. After resecting the involved jejunal necrotic segment, including the polyp, end-to-end jejuno-jejunal anastomosis was performed. Further exploration revealed the presence of a jejunal mass 80 cm from the duodenojejunal flexure identified as another hamartomatous pedunculated polyp. The polyp was resected, and the enterotomy was then closed transversely. The grossly normal appendix was also removed. Outcomes: Clinical findings along with the histopathologically confirmed hamartomatous polyps were consistent with PJS. An appendiceal carcinoid (well-differentiated neuroendocrine tumor, European Neuroendocrine Tumor Society stage pT2) was incidentally detected during histological examination of the appendix. The patient and parents were counseled accordingly, focusing on active surveillance and control of symptoms. Two additional hamartomatous polyps (gastric and jejunal) were detected endoscopically and resected in the fourth postoperative week. A regular, 1-year follow-up and surveillance revealed no complications or recurrences. Lessons: Unusual neoplasms can occasionally be encountered in well-defined syndromes such as PJS. Therefore, active follow-up and surveillance are mandatory for all patients with PJS.

Abstract This paper presents the study of deformations and Von-Misses stresses of the main shaft system during opening and closing operations of a rotary SF6 load break switch (LBS). The shaft consists of three axially connected parts made of steel where components are on ground potential and of plastic material, which is on high potential. The insulating shaft carries three rotating knife-blade contacts for the three phases. Static deformation of the insulating shaft is calculated by applying a defined torque between the two ends of the shaft. The results allow deducing the dynamic deformation. Maximum values of Von-Misses stresses are located at the geared connection between the plastic and the steel shaft. The rotation of the shaft system is measured synchronously by two optical rotary encoders in the front and rear sides of the LBS. The results confirm the twisting of the shaft system and provide its elastic deformation values. Travel curves obtained on both side of the LBS show different courses with respect to overtravel and rebound. Discrepancies can be explained by the deformation of the main shaft due to the acting forces, whereas manufacturing tolerances resulting in loose have a certain contribution.

Abstract The breaking capacity of a medium voltage (MV) rotary SF6 load break switch (LBS) can be improved by incorporating permanent magnets into the stationary contacts. The magnetic field is intended to blow the switching arc root towards a recessed space at the stationary contacts thereby preventing reignition of the arc after current zero. Making and breaking tests of load current 630 A were performed comparing the switching performance of load break switches equipped without a permanent magnet, with a ferrite and with a neodymium magnet. The impact of different polarity arrangements of the magnets in the three phases is also considered and analysed. In order to understand the arc behaviour caused by the effect of permanent magnet, arcing times and arc voltage were measured and evaluated. The results show that the arc voltage depends on the direction of the electromagnetic force, which is determined by the phase current direction but also by the polarity of the magnets. When the force is directed towards the recessed space at the stationary contacts, the arc voltage is notably higher than in the case where the arc is blown in the opposite direction. The higher arc voltage is a reliable indication that the length of the arc is increased, which significantly reduces the risk of both thermal and dielectric breakdowns after the first current zero. The consequences are noticed first in the reduction of the number of missed current zeroes and second in shorter minimum arcing times. An adverse arrangement of the magnet polarity in the three phases increases the number of missed current zeroes.

ntroduction: Sleep is one of the most important components of overall health. Children with developmental disabilities are at a higher risk of having sleep problems. Purpose: The goal of the present study is to compare sleep patterns of children with developmental disabilities with those of typically developing children. In particular, we examined whether children with an intellectual disability (ID), children with an autism spectrum disorder (ASD) and typically developing children differ in sleep duration, number of night’s waking, screen time (time spent on smartphones, tablets, TV), and outdoor activities. Methods: The sample for this study consisted of 114 children (34 children with ASD, 40 children with ID and 40 typically developing children) aged 2 to 14 years (mean age= 6.4 years, SD = 3.0). Information on children’s sleep patterns was obtained through an online survey completed by the parents of the children. We also collected information regarding the strategies parents use to settle their children for sleep, as well as information regarding screen time and outdoor activities. Results: The results of this study indicate that sleep duration was shortest for children with ID and longest for children without developmental disabilities. Another finding in this study is that screen time and not the outdoor activities was associated with sleep duration. Children with ASD were more likely to use melatonin to fall asleep, while the children with ID were more likely to use medications. Conclusion: Children with ID have shorter sleep duration than children with ASD and typically developing children. Parents have several cognitive and behavioural strategies at their disposal to improve their children’s sleep.

Abstract This paper describes the advantages of using data acquisition systems and software modelling tools to support the assessment and therefore redesign of the existing medium voltage switchgear. A 38kV/630A load break linear puffer (LP) will be used as an example for this study. In house testing was conducted to capture important design parameters of the switch such as displacement, velocity of mechanical parts and gas pressure using various sensors and three different measurement setups. The first setup, which is primarily intended for no-load measurements, consists of a DAQ system equipped with different types of sensors - two rotational encoders, three laser-based distance sensors, six pressure sensors, contact separation measurement, and a high-speed camera integrated and synchronized with the measurement system. The second and third setups, which are suitable both for no-load and on-load measurements, are based on state-of-the-art DAQ systems, which use three piezo-electric based pressure sensors, two fibre-optic based pressure sensors, three laser-based distance sensors and a high speed camera synchronized with the measurement system. The data acquired by the measurement systems is used in combination with an in-house developed simulation software HV CB Simulation, which enables simulating and predicting various variables of switching devices. Moreover, high speed camera videos analysed with both commercial and in-house developed image processing software, visualize and reveal many otherwise inaccessible occurrences. In addition to a comprehensive analysis of the proposed data acquisition and simulation setups, three design improvements in the linear puffer design - increase of the opening speed, removal of the flexible conductors and the length increase of the puffer cylinder - are presented and discussed in this paper.

Alcoholic liver cirrhosis (ALC) is the most common indication for liver transplantation (LT) in Croatia and presents a risk factor for the development of hepatocellular carcinoma (HCC). However, genetic susceptibility has not yet been systematically studied. We aimed to investigate the contribution of the risk polymorphisms PNPLA3 rs738409, EGF rs4444903, TM6SF2 rs58542926, MTHFR rs1801133, previously identified in other populations and, additionally, the contribution of Notch-related polymorphisms (NOTCH1 rs3124591, NOTCH3 rs1043996 and rs1044116, NOTCH4 rs422951). The study included 401 patients. The ALC group consisted of 260 LT candidates, 128 of whom had histopathologically confirmed HCC, and 132 of whom were without HCC. The control group included 141 patients without liver disease. Genotyping was performed by PCR using Taqman assays. The patients’ susceptibility to ALC was significantly associated with PNPLA3 rs738409, TM6SF2 rs58542926, and NOTCH3 rs1043996 polymorphisms. These polymorphisms remained significantly associated with ALC occurrence in a logistic regression model, even after additional model adjustment for sex and age. Cirrhotic patients with the PNPLA3 GG genotype demonstrated higher activity of ALT aminotransferases than patients with CC or CG genotypes. The susceptibility to the development of HCC in ALC was significantly associated with PNPLA3 rs738409 and EGF rs4444903 polymorphisms, and logistic regression confirmed these polymorphisms as independent predictors.

We investigated the role of the gold nanoparticles functionalized with polyvinylpyrrolidone (PVP–AuNPs) on the innate immune response against an acute infection caused by Vibrio anguillarum in an in vitro immunological nonmammalian next-generation model, the sea urchin Paracentrotus lividus. To profile the immunomodulatory function of PVP–AuNPs (0.1 μg mL−1) in sea urchin immune cells stimulated by Vibrio (10 μg mL−1) for 3 h, we focused on the baseline immunological state of the donor, and we analysed the topography, cellular metabolism, and expression of human cell surface antigens of the exposed cells, as well as the signalling leading the interaction between PVP–AuNPs and the Vibrio-stimulated cells. PVP–AuNPs are not able to silence the inflammatory signalling (TLR4/p38MAPK/NF-κB signalling) that involves the whole population of P. lividus immune cells exposed to Vibrio. However, our findings emphasise the ability of PVP–AuNPs to stimulate a subset of rare cells (defined here as Group 3) that express CD45 and CD14 antigens on their surface, which are known to be involved in immune cell maturation and macrophage activation in humans. Our evidence on how PVP–AuNPs may stimulate sea urchin immune cells represents an important starting point for planning new research work on the topic.