Null Hypothesis Significance Testing is a statistical procedure widely used in cognitive development research. There is widespread concern that the results of this statistical procedure are misinterpreted and lead to unsubstantiated claims about studies’ outcomes. Two particularly pertinent issues for research on cognitive development are: i) treating a non-significant result as evidence of no difference or no effect, and ii) treating a non-significant result in one group/condition and a significant result in another as evidence of a difference between groups/conditions. The current study focuses on quantifying the extent to which these two issues can be observed in the published literature on cognitive development. To this end, we will systematically search for empirical studies investigating cognitive development in 0-to-16-year-old children that have been published at two time points, namely in 1999 and 2019. For each of the two issues, we will extract information from 300 published articles, 150 per publication year.

Thanks to the development of more powerful computers and efficient numerical techniques, numerical modelling has become a compulsory tool in solving various problems in the field of energetic materials. In cases where measuring techniques are still unable to measure a given parameter, numerical modelling may be the only option of obtaining a value. In addition, numerical modelling helps us to better understand some phenomena, particularly in understanding the influence of input parameters on output results, as well as saving time and money. The thermochemical equilibrium code EXPLO5 is such a tool which enables theoretical prediction of performance of high explosives, propellants and pyrotechnic compositions. The code is used by more than 80 research laboratories worldwide.

Tomato (Solanum lycopersicum L.), family Solanaceae, has become in the past fifty years one of the most important and extensively grown horticultural crops in the Mediterranean region and throughout the world. In 2019, more than 180 million tonnes of tomato have been produced worldwide, out of which around 42 million tonnes in Mediterranean countries. Due to its genetic properties, tomato is afflicted by numerous plant diseases induced by fungal, bacterial, phytoplasma, virus, and viroid pathogens. Not only is its genetic inheritance of great importance to the management of the numerous tomato pathogens, but equally as important are also the present climate changes, the recently revised phytopathological control measures, and the globalization of the seed industry. Thus, the recognition of symptoms and the knowledge of the distribution and spread of the disease and of the methods for early detection of the pathogens are the major prerequisites for a successful management of the disease. In this review, we will describe the main tomato pathogens in the Mediterranean area that impact mostly the tomato yield and provide the current and perspective measures necessary for their successful management.

Background Increasing urbanization as well as global warming requires an investigation of the influence of different construction methods and ground surfaces on the urban heat island effect (UHI effect). The extent of the influence of the urban structure, the building materials used and their surfaces on the UHI effect can be significantly reduced already in the planning phase using a designated OpenFOAM-based solver “uhiSolver”. Results In the first part of this research work, it is shown that inner building details and components can be neglected while still obtaining sufficiently accurate results. For this purpose, the building model was divided into two layers: a surface layer without mass, where the interaction with radiation takes place, and a component layer, which contains all relevant components and cavities of the building represented with mass-averaged material properties. It has become apparent that the three parameters—albedo, heat capacity and thermal resistance—which have a decisive influence on the interaction, have different effects on the component temperatures and the surface temperatures. In the second part of this research work, dynamic 3D computational fluid dynamics (CFD) simulations are performed with uhiSolver for a residential block in Vienna. Comparing the simulation results with measurement data collected on site, it is shown that the simplified assumption of homogeneous material data for building bodies provides very good results for the validation case investigated. However, the influence of the greening measures in the courtyard of the residential block on the air temperature is found to be negligible. Furthermore, it was observed that due to locally higher radiation density, lower air velocities and higher air humidity, the apparent temperature in the courtyard is sometimes perceived to be higher than in the adjacent streets, despite the lower air temperature. Conclusions Simplifying the modeling process of the uhiSolver software by reducing the model complexity helps to reduce manual work for setting up appropriate boundary conditions of buildings. Compared to market competitors, good results are obtained for the validation case Kandlgasse presented in this research work, despite the simplifications proposed. Thus, uhiSolver can be used as a robust analytical tool for urban planning.

Sunscreens ensure thorough protection against sunburn. The delivery of UV filters into the stratum corneum and viable epidermis could be reduced by the use of antioxidants (such as β-carotene and trans-resveratrol, alone or combined). The presence/absence of antioxidants (trans-resveratrol and β-carotene) in formulations containing benzophenone-3 (UV-filter) and their efficiency under disinfection and neutral conditions are studied and compared. The trial was conducted on 38 people. The prepared ointments were applied to the participants’ forearms, irradiated and monitored by reflectance colorimetry after 0, 4, 6, and 8 min. Descriptive statistics were used to describe the skin color’s main characteristics and the F-ratio was used to test overall differences. The ointments containing antioxidants and benzophenone-3 were the most efficient, followed by those with benzophenone-3 alone. It was proven that photoprotection with benzophenone-3 is still effective, despite the formation of its chlorinated products. Due to the short time of exposure to disinfecting conditions, it could be assumed that benzophenone-3 was only partially chlorinated. This clinical study demonstrated that formulations containing antioxidants are likely to be more suitable for protecting skin against UVB irradiation than a UV filter alone.

Adverse childhood experiences (ACEs) are linked to various conduct and behavior problems within juvenile delinquents, but fewer studies focused on these associations among specific forensic typologies of offending. Utilizing data from 3382 institutionalized delinquents in Texas, logistic regression models indicated multiple associations between ACEs and forensic typologies in both adjusted and unadjusted models, with sexual abuse and physical abuse emerging as the most consistent and robust predictors. Supplemental sensitivity models confirmed the associations between sexual abuse and physical abuse among youth who fit multiple forensic typologies. Models fared poorly at identifying youth who are engaged in fire setting. Implications for total and singular ACEs are discussed, along with how those relate to more clinically meaningful, forensic forms of juvenile delinquency.

This paper describes the application of a smartphone as a detector in the determination of ethanol in distilled beverages. Digital image analysis as an analytical tool is a reality nowadays, and the use of smartphones stands out due to its high accessibility and practicality. The aim is to determine ethanol in distilled beverages using two cheap and simple methods using a smartphone as a detector. Two methods were used, with phenanthroline (method A) and with potassium dichromate (method B) as a reagents and two detectors, spectrophotometer and smartphone. Linear dependence of signal was achieved in the concentration range: from 1.0 to 65.0% (v/v) for method A and from 7.0 to 50.0% (v/v) for method B. The concentration range that is linear with the signal is wide and allows sufficient sensitivity and thus gives the possibility to determine a variety of distilled beverages. Comparison of the obtained results shows that the smartphone and the proposed reagents can be used in routine analysis in quality control of used samples. The results obtained are comparable with the results obtained using a spectrophtometer or with nominal values. The method proved to be simple and inexpensive for the determination of ethanol, does not use expensive reagents neither laborious procedures to carry out the analysis.

The issue of economic convergence has been widely analyzed by the researchers. Convergence hypothesis has been tested at different levels - global, national, regional and local. This paper is analyzing local economic convergence in Bosnia and Herzegovina (BiH) in last three decades. In this period the country was facing twofold transition: from war to peace and from socialism to market economy. The regression and distributional approach to convergence analysis are combined. The first hypothesis research is testing is that poor municipalities grow faster comparing to rich municipalities – unconditional beta convergence. Second hypothesis is that dispersion of local per capita GDP decreases over time – sigma convergence. To further investigate the issue and check the changes in the distribution, several visual inspection instruments were also used. The research findings are inconclusive. While regression analysis provides some evidence for unconditional beta-convergence, in a case of sigma convergence, results are mixed. This is related to significant structural changes country went through, firmly confirmed with the transitional probability matrix data. Findings confirm the necessity for combining different approaches and instruments while analysing convergence. From the specific country perspective, research results can be used as a strong argument for the necessity of new more balanced regional development policy.

The ability to insert a gene into a plant’s nuclear or chloroplast genome enables the transformation of higher plants (e.g. tobacco, Arabidopsis thaliana, potato, tomato, and banana) into Bioreactors for the production of plant-derived pharmaceuticals. Biopharmaceuticals are generally produced on a commercial basis by scale fermentation in bacteria, yeast, or animal cells. Several plant-derived pharmaceuticals have undergone clinical trials and are close to market authorization, with antibodies and vaccines being the front runners. Plant-derived vaccines have been produced using recombinant plant viruses as transgenic expression vectors and Agrobacterium tumefaciens transformation systems. During the last decade, several efficient plant-based expression systems have been examined, and more than 100 recombinant proteins, including plant-derived vaccine antigens. Besides, regulatory protocols are slowing down production. Industry requirements and public acceptance of the technology are important aspects in establishing successful products. This paper reviews the current status of development in the area of biopharmaceuticals and vaccines produced from transgenic plants. 

Understanding the global prevalence and phenotypic features of polycystic ovary syndrome (PCOS) is important as geographic factors and ethnic variations can significantly alter the clinical syndrome. The aim of this study was to determine and evaluate the luteinizing hormone/follicle-stimulating hormone ratio (LH/FSH) in women with PCOS during therapy on selected endocrine and biochemical parameters. Women with PCOS were included in the study and were classified into two groups: women without therapy (de novo) and women with therapy for PCOS. ESHERE/ASRM criteria that require the presence of two out of three criteria: ovulatory dysfunction, hyperandrogenism, and morphological PCOS detected by ultrasound diagnostics. Electrochemiluminescence immunoassay (ECLIA) was used for FSH and insulin analysis. The enzymatic method was used to analyze the biochemical profile. There was a significant difference between the two groups in terms of the LH/FSH ratio (2.56 vs. 2.41, P=0.043), glucose (6.23 vs. 5.12, P=0.003), insulin (19.21 vs. 7.35, P=0.000), IR (3.22 vs. 1.42, P=0.000), cholesterol (5.97 vs. 4.92, P=0.002), and LDL (3.56 vs. 2.56, P=0.001). The data suggest that patients with PCOS therapy have reduced hyperinsulinemia and insulin resistance. There was a significant correlation between the LH and FSH in the de novo group, as well as the correlation between hormone levels and LH/FSH ratio in both groups. Patients with PCOS therapy have a tendency for normal body weight and reduction of severe obesity compared to patients without therapy. Clinical features such as regular menstrual cycle and the prevalence of acne and hirsutism are not significantly different between groups. PCOS cause irregularities of the menstrual cycle, the appearance of clinical manifestations, especially changes of LH/FSH ratio. Therapy for PCOS contributes to better regulation of endocrine and biochemical parameters, especially in the reduction of hyperinsulinemia, insulin resistance, and reduced LH/FSH ratio.

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing efforts for its early detection by screening populations at risk, the majority of lung cancer patients are still diagnosed in an advanced stage. The management of lung cancer has dramatically improved in the last decade and is no longer based on the “one-fits-all” paradigm or the general histological classification of non-small cell versus small cell lung cancer. Emerging options of targeted therapies and immunotherapies have shifted the management of lung cancer to a more personalized treatment approach, significantly influencing the clinical course and outcome of the disease. Molecular biomarkers have emerged as valuable tools in the prognosis and prediction of therapy response. In this review, we discuss the relevant biomarkers used in the clinical management of lung tumors, from diagnosis to prognosis. We also discuss promising new biomarkers, focusing on non-small cell lung cancer as the most abundant type of lung cancer.

This study aimed to generate a linguistic equivalent of the COVID Stress Scales (CSS) in the Serbian language and examine its psychometric characteristics. Data were collected from September to December 2020 among the general population of three cities in Republic of Serbia and Republic of Srpska, countries where the Serbian language is spoken. Participants completed a socio-demographic questionnaire, followed by the CSS and Perceived Stress Scale (PSS). The CSS was validated using the standard methodology (i.e., forward and backward translations, pilot testing). The reliability of the Serbian CSS was assessed using Cronbach’s alpha and McDonald’s omega coefficients and convergent validity was evaluated by correlating the CSS with PSS. Confirmatory factor analysis was performed to examine the construct validity of the Serbian CSS. This study included 961 persons (52.8% males and 47.2% females). The Cronbach’s alpha coefficient of the Serbian CSS was 0.964 and McDonald’s omega was 0.964. The Serbian CSS with 36 items and a six-factorial structure showed a measurement model with a satisfactory fit for our population (CMIN/DF = 4.391; GFI = 0.991; RMSEA = 0.025). The CSS total and all domain scores significantly positively correlated with PSS total score. The Serbian version of the CSS is a valid and reliable questionnaire that can be used in assessing COVID-19-related distress experienced by Serbian speaking people during the COVID-19 pandemic as well as future epidemics and pandemics.

Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were symptomatic and 2 died of COVID-19. In this cohort, 83% patients had S1-reactive antibodies and 82% had neutralizing antibodies against wild type SARS-CoV-2, whereas neutralizing antibody titers against the Alpha, Beta and Delta variants were substantially reduced. S1-reactive antibody levels decreased in 13% of patients, whereas neutralizing antibody titers remained stable for up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment specific, but presented compensatory cellular responses, further supported by clinical recovery in all but one patient. Overall, these findings advance the understanding of the nature and duration of the immune response to SARS-CoV-2 in patients with cancer.

Although high and simulated altitude training has become an increasingly popular training method, no study has investigated the influence of acute hypoxic exposure on balance in team-sport athletes. Therefore, the purpose of this study was to investigate whether acute exposure to normobaric hypoxia is detrimental to balance performance in highly-trained basketball players. Nine elite and nine sub-elite male basketball players participated in a randomized, single-blinded, cross-over study. Subjects performed repeated trials of a single-leg balance test (SLBT) in an altitude chamber in normoxia (NOR; approximately sea level) with FiO2 20.9% and PiO2 ranging from 146.7 to 150.4 mmHg and in normobaric hypoxia (HYP; ~3,800 m above sea level) with FiO2 13.0% and PiO2 ranging from 90.9 to 94.6 mmHg. The SLBT was performed three times: 15 min after entering the environmental chamber in NOR or HYP, then two times more interspersed by 3-min rest. Peripheral oxygen saturation (SpO2) and heart rate (HR) were recorded at four time points: after the initial 15-min rest inside the chamber and immediately after each SLBT. Across the cohort, the balance performance was 7.1% better during NOR than HYP (P < 0.01, ηp2 = 0.58). However, the performance of the elite group was not impaired by HYP, whereas the sub-elite group performed worse in the HYP condition on both legs (DL: P = 0.02, d = 1.23; NDL: P = 0.01, d = 1.43). SpO2 was lower in HYP than NOR (P < 0.001, ηp2 = 0.99) with a significant decline over time during HYP. HR was higher in HYP than NOR (P = 0.04, ηp2 = 0.25) with a significant increase over time. Acute exposure to normobaric hypoxia detrimentally affected the balance performance in sub-elite but not elite basketball players.