Suppurative portal vein thrombosis (pylephlebitis) is an uncommon condition usually associated with an intra-abdominal infection or inflammatory process. In this study, we aimed to synthesize data on previously published cases according to the PRISMA guidelines. A total of 103 patients were included. Patients were more commonly male (71.8%) and had a mean age of 49 years. The most common infection associated with pylephlebitis was diverticulitis (n = 29, 28.2%), and Escherichia coli was the most isolated pathogen (n = 21, 20.4%). Blood cultures were positive in 64 cases (62.1%). The most common site of thrombosis was the main portal vein (PV) in 59 patients (57.3%), followed by the superior mesenteric vein (SMV) in 40 patients (38.8%) and the right branch of the PV in 30 patients (29.1%). Sepsis developed in 60 patients (58.3%). The mortality rate in our review was 8.7%, and independent risk factors for mortality were the presence of pertinent comorbidities (OR 5.5, p = 0.02), positive blood cultures (OR 2.2, p = 0.02), and sepsis (OR 17.2, p = 0.049).

Considering the vast cultural and traditional heritage of the use of aromatic herbs and wildflowers for the treatment of light medical conditions in the Balkans, a comparison of the antioxidant capacity of wildflowers extracts from Herzegovina was studied using both cyclic voltammetry and spectrophotometry. The cyclic voltammograms taken in the potential range between 0 V and 800 mV and scan rate of 100 mV s−1 were used for the quantification of the electrochemical properties of polyphenols present in four aqueous plant extracts. Antioxidant capacity expressed as mmoL of gallic acid equivalents per gram of dried weight of the sample (mmoL GAE g−1 dw) was deduced from the area below the major anodic peaks (Q400 pH 6.0, Q500 pH 4.7, Q600 pH 3.6). The results of electrochemical measurements suggest that the major contributors of antioxidant properties of examined plants are polyphenolic compounds that contain ortho-dihydroxy-phenol or gallate groups. Using Ferric reducing-antioxidant power (FRAP) and 2,2′-azino-bis spectrophotometric methods (3-ethylbenzthiazoline-6-sulphonic acid) radical cation-scavenging activity (ABTS) additionally determined antioxidant capacity. The FRAP results ranged from 2.9702–9.9418 mmoL Fe/g dw, while the results for ABTS assays expressed as Trolox equivalents (TE) ranged from 14.1842–42.6217 mmoL TE/g dw. The Folin–Ciocalteu procedure was applied to determine the total phenolics content (TP). The TP content expressed as Gallic acid equivalents (GAE) ranged from 6.0343–9.472 mmoL GAE/g dw. The measurements of total flavonoid (TF) and total condensed tannin (TT) contents were also performed to obtain a broader polyphenolic profile of tested plant materials. Origanum vulgare L. scored the highest on each test, with the exception of TT content, followed by the Mentha × piperita L., Artemisia annua L., and Artemisia absinthium L., respectively. The highest TT content, expressed as mg of (−)catechin equivalents per gram of dried weight of sample (mg CE/g dw), was achieved with A. absinthium extract (119.230 mg CE/g dw) followed by O. vulgare (90.384 mg CE/g dw), A. annua (86.538 mg CE/g dw) and M. piperita (69.231 mg CE/g dw), respectively. In addition, a very good correlation between electrochemical and spectroscopic methods was achieved.

Rhinoviruses (RV) account for a significant number of asthma exacerbations, and RV species C may be associated with a severe course in vulnerable patient groups. Despite important evidence on the role of RV reported by clinicians and life scientists, there are still unanswered questions regarding their influence on asthma exacerbation in young patients. Thus, we measured the RVspecies-specific IgG titers in our German pediatric exacerbation cohort using a microarray-based technology. For this approach, human sera of patients with exacerbated asthma and wheeze, as well as healthy control subjects (n = 136) were included, and correlation analyses were performed. Concordantly with previously published results, we observed significantly higher cumulative levels of RV species A-specific IgG (p = 0.011) and RV-C-specific IgG (p = 0.051) in exacerbated asthma group compared to age-matched controls. Moreover, atopic wheezers had increased RV-specific IgG levels for species A (p = 0.0011) and species C (p = 0.0009) compared to non-atopic wheezers. Hypothesizing that bacterial infection positively correlates with immune memory against RV, we included nasopharyngeal swab results in our analyses and detected limited correlations. Interestingly, the eosinophil blood titer positively correlated with RV-specific IgG levels. With these observations, we add important observations to the existing data regarding exacerbation in pediatric and adolescent medicine. We propose that scientists and clinicians should pay more attention to the relevance of RV species in susceptible pediatric patients.

Cybersecurity is an important topic for Industry 4.0, which will face a lot of non-traditional challenges before it can be fully implemented to help society. The objective of the study is to recognize recent cybersecurity trends, newly occurring threats and challenges as well as their potential solutions. The articles reviewed in the paper are found through science direct, Scopus, Semantic scholar and google scholar. After reviewing them, ideas from articles were grouped together to show how different articles had similar thoughts. Through the analysis of 70 articles, it was found that cybersecurity still needs a lot of improvement in order to efficiently implement Industrial Internet of Things (IIoT), especially since many articles underline the need for security-by-design approach, followed by regular updating. Key challenges are lack of awareness and security experts, increased cybercriminal and the fact that the chain is as only as strong as its weakest point. Some of the most important solutions include incorporating security into design, stronger encryption, regular updates to patch vulnerabilities and good prevention and detection mechanisms. Once cybersecurity challenges are overcome, Industry 4.0 will be able to bloom to its full extent.

Abstract COVID-19 had undoubtedly speeded up adoption of digital technologies. Most of the theoreticians agree that changes that happened in the pandemic period would not happen in the next several years or even decades. There is almost no business operation that has not been affected by the pandemic, from customer relation and sales to supply chain. It influenced different business sectors leaving permanent change and making a significant proportion of organizations working in at least hybrid mode: combining digital and traditional pre-pandemic ways of working. COVID-19 had significantly changed the workplace and way of working. Workplace has shifted to digital or at least hybrid and employees and companies have adopted new ways of working, including usage of digital technologies but also accepting more agile and flexible procedures and rules. The research community has followed this phenomenon and tried to provide best possible recommendation to it accordance to recognized research methods. The paper provides a systematic literature review of the most significant scientific and industry publication in the years after the pandemic start. It is based on Kitchenham methodology of the systematic review with selected publication from recognized bibliographic databases. First part provides general effects of the pandemic to digital transformation of businesses all over the globe, mostly connected to analysis of the employees’ workplace preference. The second part is focused on digital workplace transformation and presents key theoretical and professional findings in the post-pandemic workplace. This part is consisted of the preview of benefits of the digital workplace transformation, identification of critical success factors and the most significant challenges of the process.

A rapid increase in development and use of Extended Reality applications for all areas of life is expected in metaverse age. Many museums are in the last decade introducing digital content in their exhibitions. They hired digital curators to establish connection with developers and IT industry. Extended Reality technologies enable museum visitors to experience the topics of exhibitions, see original appearances of exhibits and travel to the past through Virtual Reality headsets or Augmented Reality applications on mobile devices. In this paper we show an example of good practice, describing the application Battle on Neretva VR installed in the Museum in Jablanica, Bosnia and Herzegovina. We present the application design and development workflow and show the impressions of museum management and visitors after introducing it in the exhibition. This workflow can be replicated to any museum topic or collection.

our study concerning the long- term effectiveness and safety of thiopurine monotherapy in bowel the benefit– risk balance of thiopurines in real- practice and observed that thiopurine monotherapy durable for patients IBD, A reassuring prolonged effectiveness at 5 and 10 years after therapy

Research has shown that technology promotes learning environments that stimulate improved learning performance, learners satisfaction and completion rates. Virtual reality (VR) is a computer-generated environment with scenes and objects that look and feel real, making the user feel immersed in that world. This immersion provides learning and training opportunities in a variety of areas. This paper aims to investigate the perceived usefulness, ease of use and impression of the presented solution and whether it can improve the safety and effectiveness of field demining missions. A focus group study was conducted. The findings of the study are very positive, and show an affirmative attitude towards the use of the presented application for the purpose of educating and training new deminers.

Campylobacter jejuni and C. coli are contaminants of broiler skin, and in unauthorized numbers cause campylobacteriosis in consumers where symptoms range from gastrointestinal to life-threatening. The number of chicken bacteria and their genetic diversity depend on the growing conditions, and the presence of antibiotic resistance genes is the result of irrational use of antibiotics. The purpose of this paper is to point out the importance of reducing the contamination of Campylobacter spp. in broiler production as well as the importance of the rational use of antibiotics in the production of broilers with a contribution to the prevention of the spread of campylobacteriosis and antibiotic resistance. The incidence of campylobacteriosis can be prevented by the concept of Hazard Analysis Critical Control Point (HACCP) in broiler production and the use of probiotics as biological preservatives in broiler meat. The spread of antibiotic resistance genes can be reduced by prohibition of antibiotic use for   prophylaxis and only permitted for medication.

Next-generation intelligent transportation systems require a communication technology that can satisfy high demands in terms of latency and reliability. One of the promising communication technologies to satisfy such demands is the fifth-generation (5G) new radio (NR) for the vehicle-to-everything (V2X). To support the development of NR-V2X systems in the 5.9 GHz band, it is essential to perform channel measurements in high-mobility scenarios. High-mobility scenarios in the 5.9 GHz band have been well investigated through drive-by measurement campaigns. Although such measurements deliver real-world results, they do not allow for controlled experiments. To investigate propagation characteristics of the 5.9GHz band, we perform controllable and repeatable channel measurements at different velocities (25, 50, 100 and 125 km/h) in an urban environment. Furthermore, we compare measured wireless channels in terms of the normalized average local scattering function.

Similar to any spoof detection systems, power grid monitoring systems and devices are subject to various cyberattacks by determined and well-funded adversaries. Many well-publicized real-world cyberattacks on power grid systems have been publicly reported. Phasor Measurement Units (PMUs) networks with Phasor Data Concentrators (PDCs) are the main building blocks of the overall wide area monitoring and situational awareness systems in the power grid. The data between PMUs and PDC(s) are sent through the legacy networks, which are subject to many attack scenarios under with no, or inadequate, countermeasures in protocols, such as IEEE 37.118-2. In this paper, we consider a stealthier data spoofing attack against PMU networks, called a mirroring attack, where an adversary basically injects a copy of a set of packets in reverse order immediately following their original positions, wiping out the correct values. To the best of our knowledge, for the first time in the literature, we consider a more challenging attack both in terms of the strategy and the lower percentage of spoofed attacks. As part of our countermeasure detection scheme, we make use of novel framing approach to make application of a 2D Convolutional Neural Network (CNN)-based approach which avoids the computational overhead of the classical sample-based classification algorithms. Our experimental evaluation results show promising results in terms of both high accuracy and true positive rates even under the aforementioned stealthy adversarial attack scenarios.

This paper presents HEP - Transmission System Operator Ltd. Line surge arrester (LSA) application pilot project on the Ston – Komolac 123 kV line. This 44 km long single circuit shielded transmission line operates in the region with a high lightning activity (keraunic level about 70 thunder days). In addition, it was very difficult to obtain good footing resistance. For these reasons, considered line used to have very bad lightning performance. It was decided to install Line surge arresters for line lightning performance improvement. In order to optimize arrester installation configuration sigma slp software simulations were performed. LSA are installed according to the results of the software simulations. LSA are installed in summer 2007 (110 gapless, IEC-class II Line arresters). Sixty one LSA are equipped with Excount - II monitoring sensors (monitoring arrester leakage current and peak of the impulse current). Based on the 8-month experience, LSA installation has improved line lightning performance. New line performance is close to the targeted once (improvement by 50 to 60 %). Surge arrester monitors collect very interesting information. Collected info will be compared with the software simulations.