Ḥasan ibn Muṣṭafā al-Būsnawī al-Madanī, Hasan Bošnjak, was born in Medina in the last decade of the 12th century AH, and he wrote in the first half of the 13th century (the end of the 18th and the first half of the 19th century). With regards to the year of Hasan Bošnjak’s death, we might assume that he died in the mid-13th century AH. Analyzing his Divan, we come to the conclusion that he wrote tarihs in different periods of life from 1215/ 1800 to 1247/1831 – approximately in the period of thirty years. We do not come across any tarih written after the year of 1247 H, so based on that we assume that the author died in 1247 H/ 1831 or a year or two after. As a famous muhaddith (an expert on hadith, the tradition of the Prophet) he sang, among other things, about Buhari and Muslim, saying that the Mufti of Medina and later Shaykh al-Islam Ahmed Arif Hikmet commented on the works. The most significant source, after the Qur’an, is the Prophet’s tradition (al-sunnah) based on the Prophet’s words, acts, and tacit approval. From the time of the Prophet s.a.w.s. the writing down of the al-sunnah began, and in the 2nd century AH the intensive work on the codification (al-tadwin) of the Prophet’s tradition based on written and oral sources began. It was the time of flourishing the hadith sciences and in the first half of the 3rd century the greatest hadith experts lived and worked. Hundreds of works were written, among which the best-known are two hadith collections called ṣaḥīḥim. The authors are Abū ‘Abd Allāh Muḥammad ibn Ismā‘īl al-Buẖārī (194 / 810-256 / 870) and Abū al-Ḥusayn Muslim ibn al-Ḥağğāğ ibn Muslim al-Qušayrī al-Naysābūrī (- - 261/875). In Divan by Hasan Bošnjak there are, among other things, four songs, one dedicated to Buhari and three to Muslim. Keywords: Hasan Bošnjak, Buhari, Muslim, hadith, poetics, Islamic tradition.

Educational approach known as Content and Language Integrated Learning (CLIL) has become one of the most popular approaches in foreign language teaching, especially in countries with developed educational systems. One of its main aims is to help learners develop thinking skills through their simultaneous studying of the foreign language and the content of a particular subject. Since CLIL promotes the development of cognitive skills, many researchers and psychologists proposed a variety of techniques and activities which could be used for this purpose. Some of these techniques shall be discussed in this paper, along with the ways of applying them at different levels of education. Key words: CLIL, education, thinking skills, techniques

In this paper, we propose variations of Willems’ fundamental lemma that utilize second-order moments such as correlation functions in the time domain and power spectra in the frequency domain. We believe that using a formulation with estimated correlation coefficients is suitable for data compression, and possibly can reduce noise. Also, the formulations in the frequency domain can enable modeling of a system in a frequency region of interest.

We study emulation-based state estimation for non-linear plants that communicate with a remote observer over a shared wireless network subject to packet losses. To reduce bandwidth usage, a stochastic communication protocol is employed to determine which node should be given access to the network. We describe the overall wireless system as a hybrid model, which allows us to capture the behaviour both between and at transmission instants, whilst covering network features such as random transmission instants, packet losses, and stochastic scheduling. Under this setting, we provide sufficient conditions on the transmission rate that guarantee an input-to-state stability property for the corresponding estimation error system. We illustrate our results with an example of Lipschitz non-linear plants.

The heat transfer performances of ionic liquids [C4mpyrr][NTf2] and ionanofluids with Al2O3 nanoparticles under a laminar flow regime, and with constant heat flux on the tube wall is numerically modeled and analyzed for three values of initial/inlet temperature and for two Reynolds numbers. Heat transfer characteristics were considered by analyzing the temperature distribution along the upper wall, as well as by analyzing the Nusselt number and heat transfer coefficient. The results obtained numerically were validated using Shah’s equation for ionic liquid. Thermophysical properties were temperature-dependent, and obtained by curve-fitting the experimental values of the thermophysical properties. Furthermore, the same set of results was calculated for the ionic liquid and ionanofluids with constant thermophysical properties. It is concluded that the assumption that thermophysical properties are constant has a significant influence on the heat transfer performance parameters of both ionic liquid and ionanofluids, and therefore such assumptions should not be made in research.

https://doi.org/10.31952/amha.19.2.6 This review describes the first medical article written by an author from Bosnia and Herzegovina. The article was published by Fr. Franjo Gracić (1740-1799), in Latin, under the title: "Analysis theorico-practica de viribus virus febriferi, pestiferi, atque serpentin", and printed in Padua in 1795, translated as: "A Theoretical and Practical Presentation of the Effects of Fevers, Infectious Diseases, and Snake Poison". From today's standpoint, it may be said that it was a review article about some of the most frequent diseases of that time. The paper is of exceptional importance for the history of medicine in Bosnia and Herzegovina because it is the first documented medical article whose author was from Bosnia and Herzegovina. The paper contains observations of the course of diseases and treatment, in line with the medical insights of the time. The author refers to the authorities of that time, such as Samuel Auguste André Tissot, the Swiss physicist and doctor, Georg Bauer, the German doctor, and Lodovico Antonio Muratori, the Italian scholar, which makes this article a link between Bosnia and Herzegovina and the knowledge of the Europe of that time. This paper represents the beginning of medical writing in Bosnia and Herzegovina and has a very important place in the history of medicine in this country.

Protonation states of ionizable protein residues modulate many essential biological processes. For correct modeling and understanding of these processes, it is crucial to accurately determine their pKa values. Here, we present four tree-based machine learning models for protein pKa prediction. The four models, Random Forest, Extra Trees, eXtreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM), were trained on three experimental PDB and pKa datasets, two of which included a notable portion of internal residues. We observed similar performance among the four machine learning algorithms. The best model trained on the largest dataset performs 37% better than the widely used empirical pKa prediction tool PROPKA and 15% better than the published result from the pKa prediction method DelPhiPKa. The overall root-mean-square error (RMSE) for this model is 0.69, with surface and buried RMSE values being 0.56 and 0.78, respectively, considering six residue types (Asp, Glu, His, Lys, Cys, and Tyr), and 0.63 when considering Asp, Glu, His, and Lys only. We provide pKa predictions for proteins in human proteome from the AlphaFold Protein Structure Database and observed that 1% of Asp/Glu/Lys residues have highly shifted pKa values close to the physiological pH.

ABSTRACT Since the end of 2017, Bosnia and Herzegovina has experienced a significant increase in the number of migrants transiting through the country. Based on an ethnographic reading of nineteen recollections of ‘personal migration experiences’ of Bosnians during 1992–1995 war, which form the basis for popular perception of migrants in the country, this paper explores how the concept of solidarity is imagined and lived in the context of this significant increase. We argue that Bosnians interpret these recent arrivals as a ‘test of humanity’, having been in a similar situation in the early 1990s. In this regard, the concept of solidarity opens a window onto the interactions with and between migrants and non-migrants, recognizing a shared set of concerns and orientations, rather than exceptionalizing migrants through the lens of ‘crisis’. That said, the concept of solidarity is less popular among those who do not share a so-called ‘migrant’s faith’, resulting in negative perceptions of migrants. In these perceptions, migrants’ presence in the country is criminalized, resulting in various calls for more aggressive, even violent, ‘popular’ handling of migrants transiting or settling in Bosnia and Herzegovina.

Background: Negative symptoms are core features of schizophrenia and very challenging to be treated. Identification of their structure is crucial to provide a better treatment. Increasing evidence supports the superiority of a five-factor model (alogia, blunted affect, anhedonia, avolition, and asociality as defined by the NMIH-MATRICS Consensus); however, previous data primarily used the Brief Negative Symptoms Scale (BNSS). This study, including a calibration and a cross-validation sample (n = 268 and 257, respectively) of participants with schizophrenia, used the Clinical Assessment Interview for Negative Symptoms (CAINS) to explore the latent structure of negative symptoms and to test theoretical and data-driven (from this study) models of negative symptoms. Methods: Exploratory factor analysis (EFA) was carried out to investigate the structure of negative symptoms based on the CAINS. Confirmatory factor analysis (CFA) tested in a cross-validation sample four competing theoretical (one-factor, two-factor, five-factor, and hierarchical factor) models and two EFA-derived models. Result: None of the theoretical models was confirmed with the CFA. A CAINS-rated model from EFA consisting of five factors (expression, motivation for recreational activities, social activities, vocational, and close/intimate relationships) was an excellent fit to the data (comparative fix index = 0.97, Tucker–Lewis index = 0.96, and root mean square error of approximation = 0.07). Conclusions: This study cannot support recent data on the superiority of the five-factor model defined by the NMIH-MATRICS consensus and suggests that an alternative model might be a better fit. More research to confirm the structure of negative symptoms in schizophrenia, and careful methodological consideration, should be warranted before a definitive model can put forward and shape diagnosis and treatment of schizophrenia.

Significance Our current understanding of how sleep is regulated is based upon the model of sleep homeostasis, which defines a variable called Process S as a measure of sleep need, and a so-called “flip-flop” model of state switching, which builds on a notion of a mutually antagonistic relationship between subcortical sleep-promoting and wake-promoting circuits. The neurobiological substrates of the interaction between the sleep switch and Process S are unknown. Our study identifies a previously unrecognized role of hypothalamic circuitry in tuning within-state brain activity or levels of arousal, which in turn determine the homeostatic drive for sleep. Sleep and wakefulness are not simple, homogenous all-or-none states but represent a spectrum of substates, distinguished by behavior, levels of arousal, and brain activity at the local and global levels. Until now, the role of the hypothalamic circuitry in sleep–wake control was studied primarily with respect to its contribution to rapid state transitions. In contrast, whether the hypothalamus modulates within-state dynamics (state “quality”) and the functional significance thereof remains unexplored. Here, we show that photoactivation of inhibitory neurons in the lateral preoptic area (LPO) of the hypothalamus of adult male and female laboratory mice does not merely trigger awakening from sleep, but the resulting awake state is also characterized by an activated electroencephalogram (EEG) pattern, suggesting increased levels of arousal. This was associated with a faster build-up of sleep pressure, as reflected in higher EEG slow-wave activity (SWA) during subsequent sleep. In contrast, photoinhibition of inhibitory LPO neurons did not result in changes in vigilance states but was associated with persistently increased EEG SWA during spontaneous sleep. These findings suggest a role of the LPO in regulating arousal levels, which we propose as a key variable shaping the daily architecture of sleep–wake states.

Necrotizing stomatitis is a rare, acute-onset disease that is usually associated with severely malnourished children or diminished systemic resistance. We describe a 1-year-old girl who developed necrotizing stomatitis, vasculitic rash, skin desquamation on the fingers and toes, and persistent hypertension after serologically confirmed SARS-CoV-2 infection. Her laboratory investigations revealed positive IgG anticardiolipin and IgG anti-β2 glycoprotein antibodies, and biopsy of the mucosa of the lower jaw showed necrosis and endothelial damage with mural thrombi. Swollen endothelial cells of small veins in the upper dermis were confirmed also by electron microscopy. As illustrated by our case, necrotizing stomatitis may develop as a rare complication associated with SARS-CoV-2 infection and can be considered as a part of the clinical spectrum of COVID-19 vasculopathy. The pathogenic mechanism could involve a consequence of inflammatory events with vasculopathy, hypercoagulability, and damage of endothelial cells as a response to SARS-CoV-2 infection.