We present the case of a 49-year-old female of Caucasian European descent with chest tightness, fatigue, and palpitations, ultimately diagnosed with primary intracardiac angiosarcoma. Initial echocardiography revealed a significant mass within the right atrium, infiltrating the free wall. Surgical intervention included tumor excision and partial resection of the superior vena cava. Histopathological examination confirmed a high-grade angiosarcoma. Postoperative imaging identified a recurrent mass in the right atrium, suggestive of thrombus, alongside Takotsubo cardiomyopathy. Considering the elevated surgical risks and the presence of cardiomyopathy, management included anticoagulation therapy with Warfarin and adjuvant chemotherapy with Paclitaxel. Follow-up cardiac magnetic resonance imaging demonstrated a recurrent angiosarcoma with superimposed thrombus. This case presents the complex diagnostic and therapeutic landscape of angiosarcoma, highlighting the critical importance of early surgical intervention, advanced imaging techniques, and vigilant postoperative monitoring.

INTRODUCTION Adult hemangioblastomas are rare WHO central nervous system (CNS) Grade 1 tumors particularly affecting the posterior cranial fossa. They exhibit a gender bias, impacting men in their fifth and sixth decades of life and manifesting sporadically or as part of von Hippel Lindau (VHL) disease. Understanding the intricacies of CNS hemangioblastomas is crucial for clinical decision-making. METHODS A systematic review of 576 articles was conducted following PRISMA guidelines. Eligibility criteria included 3189 adult cases of CNS hemangioblastomas. Data on patient demographics, tumor characteristics, symptoms, treatment modalities, complications, and outcomes were systematically extracted and synthesized. RESULTS The review revealed a heterogeneous demographic distribution, with a male predominance. Median age at diagnosis was 44.7 years. Cranial hemangioblastomas were more commonly located in the infratentorial (73 %) than supratentorial (27%) compartments. Spinal hemangioblastomas were mostly located in the cervical spine (44.3 %), followed by thoracic (36.7 %) and lumbar spine (12 %). Clinical symptoms varied by location, emphasizing the importance of anatomical considerations. Surgical intervention-total resection (82% of cases)-was the preferred treatment modality, while radiotherapy was less common. Histological examination and immunohistochemistry aided in accurate diagnosis. Complications were location-specific, with intracranial complications more common in infratentorial tumors. Overall, favorable outcomes were prevalent (78% of cases), with low mortality rates. CONCLUSION Adult CNS hemangioblastomas present with diverse characteristics and clinical manifestations. Surgical intervention remains the mainstay treatment; ongoing research into genetic and molecular mechanisms may enhance our understanding of tumor pathology and lead to improved management strategies in the future.

Battery power is crucial for wearable devices as it ensures continuous operation, which is critical for real-time health monitoring and emergency alerts. One solution for long-lasting monitoring is energy harvesting systems. Ensuring a consistent energy supply from variable sources for reliable device performance is a major challenge. Additionally, integrating energy harvesting components without compromising the wearability, comfort, and esthetic design of healthcare devices presents a significant bottleneck. Here, we show that with a meticulous design using small and highly efficient photovoltaic (PV) panels, compact thermoelectric (TEG) modules, and two ultra-low-power BQ25504 DC-DC boost converters, the battery life can increase from 9.31 h to over 18 h. The parallel connection of boost converters at two points of the output allows both energy sources to individually achieve maximum power point tracking (MPPT) during battery charging. We found that under specific conditions such as facing the sun for more than two hours, the device became self-powered. Our results demonstrate the long-term and stable performance of the sensor node with an efficiency of 96%. Given the high-power density of solar cells outdoors, a combination of PV and TEG energy can harvest energy quickly and sufficiently from sunlight and body heat. The small form factor of the harvesting system and the environmental conditions of particular occupations such as the oil and gas industry make it suitable for health monitoring wearables worn on the head, face, or wrist region, targeting outdoor workers.

Abstract The dairy industry has been undergoing changes for years, introducing innovations and pushing the boundaries of the category and consumer experience. Numerous factors, such as economic, psychological, cultural, socio-demographic, personal and many others, influence the decision to buy and consume a certain dairy product. It is important to qualitatively research and identify factors that significantly influence consumer behavior. Consumers also set certain criteria when it comes to brand, taste, nutritional value, marketing, product origin, on the basis of which we conclude that knowing consumer preferences also means success in the market. Due to the previously stated reasons, the main goal of this paper is to determine consumer purchasing behavior towards dairy products and their preferences.The survey method was used in the research to collect primary data, and a survey questionnaire was used as a research instrument. A total of 250 respondents participated in this research, which is conducted in Bosnia and Herzegovina.

Driving feedback is an important factor that can affect the perceptions of remote drivers of the surrounding environment during teleoperation. This paper focuses on investigating the influence of motion-cueing, sound and vibration feedback on driving behaviour and experience. A prototype teleoperation station is developed with feedback from audio, vibration actuators, and motion cues. Using this prototype, the experiment is carried out in two scenarios: a low-speed disturbance scenario with 30 participants and a dynamic driving scenario with 22 participants. Objective and subjective assessment methods are used to evaluate driving behaviour and experience separately. The results indicate that the combination of motion-cueing, sound and vibration feedback provides the most favourable driving experience for the participants. Specifically, sound and vibration feedback enhance drivers’ sense of speed, while motion-cueing feedback helps in road surface sensing, leading to increased throttle reversal rate in the low-speed disturbance scenario. However, it is noteworthy that motion-cueing feedback does not significantly improve driving performance in the dynamic driving scenario of this study.

BACKGROUND Early diagnosis of previously unknown cancer (i.e., occult cancer) after an acute ischemic stroke (AIS) could result in faster initiation of cancer therapy and potentially improve clinical outcomes. Our study aimed to compare mortality rates between AIS patients with occult cancer diagnosed during the index stroke hospitalization versus those diagnosed after hospital discharge. METHODS Among consecutive AIS patients treated at our stroke center from 2015 through 2020, we identified new cancer diagnoses made within the year after the AIS. We used multivariable Cox regression analyses to evaluate the association between the timing of occult cancer diagnosis (during the AIS hospitalization versus after discharge) and long-term survival. RESULTS Of 3894 AIS patients with available long-term follow-up data, 59 (1.5%) were diagnosed with a new cancer within one year after index stroke. Of these, 27 (46%) were diagnosed during the index hospitalization and 32 (54%) were diagnosed after discharge. During a median follow-up of 406 days (interquartile range, 89-1073), 70% (n=19) of patients whose cancer was diagnosed during hospitalization had died, compared to 63% (n=20) of patients whose cancer was diagnosed after discharge (p=0.58). In our main multivariable model, there was no difference in long-term mortality between patient groups (adjusted hazard ratio, 1.16; 95% confidence interval, 0.53-2.52; p=0.71). CONCLUSIONS In this analysis, timing of a new cancer diagnosis after AIS did not seem to influence patients' long-term survival. Given the fairly small number of included patients with previously occult cancer, larger multicenter studies are needed to confirm our results.