O mycobacterium leprae (bacilo de hansen) possui propriedades imunogênicas especiais, responsáveis pelo alto poder incapacitante da hanseníase. Objetivou-se estudar o perfil clínico-epidemiológico de pacientes hansenianos multibacilares, de acordo com a classificação de madri, correlacionar o índice baciloscópico com o número de troncos afetados pela neurite franca no início e término do tratamento, correlacionar o grau de incapacidade com a forma clínica, à entrada e à saída desses pacientes. Selecionaram-se 158 prontuários de pacientes diagnosticados com hanseníase multibacilar, avaliados pelo exame baciloscópico e neurológico. O estudo foi realizado no centro de referência em dermatologiasanitária dr. Marcelo cândia, em marituba, pará, brasil. Desses pacientes, 52% estavam na faixa etáriade 15 a 54 anos, 80,4% eram do sexo masculino, 80% tiveram alta por cura e 84% eram casos novos. A forma clínica predominante foi a dimorfa, com 68% dos casos. A forma virchowiana (mhv) apresentou maior número de pacientes com grau de incapacidade ii. A presença de incapacidade grau zero foi estatisticamente significante na forma dimorfa (mhd), que possui aproximadamente 2,69 vezes maior probabilidade de evoluir para neurite que a mhv. Os nervos periféricos mais afetados foram: o tibialposterior, o ulnar, o fibular e o mediano. Conclui-se que a forma virchowiana tem maior potencial de produção de incapacidades tipo ii, enquanto que os portadores de mhd evoluem mais vezes para neurite; e que não há diferença no acometimento de troncos nervosos em relação ao índice baciloscópico.

The goal of our research was to determine the presence of bacterial vaginosis in sexually active women in Tuzla Canton area. Diagnosis determination for bacterial vaginosis was conducted on the basis of three out of four internationally accepted criteria according to Amsel and isolation and identification of Gardnerella vaginalis (G. vaginalis) by standard microbiological procedures. Bacterial vaginosis was diagnosed in 20,5 % (41/200) women who asked for gynaecologist's help due to their personal discomfort, since significantly higher percentage of diagnosed bacterial vaginosis of 48,80% (41/84) was determined in women with personal discomfort typical for this disease. All relevant factors, according to available literature, for genesis of bacterial vaginosis were processed in this research. In respect to the obtained outputs, bacterial vaginosis is significantly more frequent occurrence in women who are not married, since the number of sexual partners, the time of the first sexual intercourse, the use of intrauterine contraceptive device and smoking do not cause the genesis of bacterial vaginosis. According to Nugent, an increased vaginal discharge with unpleasant odour after sexual discourse, its pH>4,5, a positive amino odour test, an occurrence of clue cells in a direct microscopic concoction of vaginal discharge and assessment of the state of vaginal flora for bacterial vaginosis are significantly more frequent occurrences in women with individual discomforts. It was proved that G. vaginalis is a dominant micro organism in 95% of women with clinical signs of vaginosis although it was isolated from vaginal discharge in 40 to 50% of healthy women. In our research, G. vaginalis was isolated in 63,41% of examined women with all signs of bacterial vaginosis, in 36,59% of examined women with one or more clinical signs of bacterial vaginosis and in 2,58% of examined women of control group without clinical signs.

Tablets are one of the most popular and preferred solid dosage forms because they can be accurately dosed, easily manufactured and packaged on a large scale, have good physical and chemical stability, and can contribute to good patient compliance given their ease of administration. The ability to match doses to patients depends on the availability of multiple dose sizes and adequate dose-response information. These are not always provided, so splitting of the tablets is sometimes necessary. Tablet splitting is an accepted practice in dispensing medication. It has been used when a dosage form of the required strength is not available commercially. The aim of our study was to compare some physical parameters of whole and scored lisinopril and lisinopril/hydrochlorthiazide tablets and to accept or exclude their influence on the obtaining of required dosage. According to the results obtained, we may conclude that tablets from batch "I", "II", "III" and "IV" satisfied pharmacopeial requirements concerning crushing strength, friability, disintegration time and mass uniformity. The hardness testing showed acceptable reproducibility and indicate that the data variation was primarily from the irreversible changes in the structure of tablet samples. The act of compacting powders stores energy within the tablets, by shifting or compressing the intermolecular bonds within the particles. The tablets have a natural tendency to relax once pressure is removed, and this tendency works against the interparticle bonding formed during compression. Hardness testing procedure causes irreversible changes in this structure.