Transplantable mouse methylcholanthrene- induced fibrosarcoma (CMC4 tumour growing in CBA/HZgr mice), characterized by lung metastases developing shortly after local tumour cell transplantation, was used as an experimental model to investigate the problem of tumour metastases after local tumour treatment. Surgery and/or irradiation were performed on locally growing tumour of particular size. Further, heavily irradiated, viable but not dividing tumour cells, imitating the situation in treated tumour-bearing organism, were injected intraperitoneally in a parallel group of treated tumour-bearing mice. The animals were killed 35 days after tumour transplantation and the number and volume of lung metastases were determined. Depending on the treatment performed, when the tumour mass was reduced or even eliminated, the number of lung metastases and their volume were significantly lower than in control mice, but the addition of tumour mass (injection of heavily irradiated tumour cells) resulted in a significant increase in lung metastases parameters, pointing to a possible role of the host's immune reaction against the tumour. Further, the release of a simple molecule, such as nitric oxide, from tumour mass seems to be detrimental for the survival of tumour cells and subsequently their metastases through the induction of angiogenesis and possible suppression of immune reaction. Thus, complex mechanisms could be involved when a locally growing tumour is exposed to a particular therapeutic approach.

U cilju postavljanja standarda za Turopoljsku pasminu svinja analizirane su vrijednosti pojedinih biokemijskih i hematoloskih parametara u krvi. Istraživanje je provedeno na 19 svinja, prosjecne težine 95, 5kg i starosti 568± ; 20 dana. Svinje su proizvedene (prasenje, othrana i tov) u otvorenom sustavu držanja po tradicionalnoj hrvatskoj tehnologiji niskog unosa hrane, 0, 5kg zrna kukuruza/grlu/dnevno uz iskoristavanje prirodnih izvora kao sto su žir, tlo i trava. U krvnom serumu utvrđena je koncentracija glukoze, uree, kreatinina, triglicerida i ukupnog kolesterola te aktivnost enzima (CK, GGT, LDH, AST, ALT i AP), a u uzorcima pune krvi broj eritrocita (RBC) i bijelih krvnih zrnaca (WBC) te koncentracija hemoglobina (Hb). Rezultati analize pokazuju da su izmjerene vrijednosti glukoze i uree u Turopoljske pasmine neznatno niže u odnosu na referentne vrijednosti iz literature, dok su vrijednosti ostalih promatranih parametara bile unutar ili su neznatno odstupale izvan granica fizioloskih vrijednosti iz literature. Stanovite razlike u vrijednostima pojedinih parametra mogu se pripisati genetskoj osnovi ali i nacinu držanja/hranidbe karakteristicne za Turopoljsku pasminu svinja.