Objective - The purpose of this investigation was to determine the frequencies and types of associated congenital heart disease and other cardiac lesions in children with congenital anomalies of the kidneys and urinary tract (CAKUT). Participants and method - This was a prospective cardiac evaluation of children with diagnosed CAKUT, conducted between January 2013 and December 2015 at the Department of Pediatrics of the University Clinical Hospital, Tuzla. All cases were reviewed for age, gender, consanguinity, occurrence of congenital heart disease (CHD) and CAKUT in family history. Cardiac examination included: physical examination, noninvasive blood pressure measurement, a twelve lead electrocardiogram and echocardiogram. Results - Complete cardiac examination was performed in 144 children with congenital anomalies of the kidneys and urinary tract. Clinically insignificant morphological or hemodynamical changes were noted in 13% or 9.0% children. Congenital heart disease was found in 32 (22.2%), hypertrophic cardiomyopathy in 2 and pulmonary hypertension in 1 of the 144 children. In 4 children congenital heart disease was part of other known genetic syndromes, and all of these cases had severe CHD. In twenty-six or 76.5% of the total of 32 patients it was already known, and in 6 (23.5%) CHD was discovered during this research. Ventricular septal defect was the most common malformation (13% or 40.6% of patients). Vesicoureteral reflux was the most frequent CAKUT associated with CHD. Conclusions - The results of this study showed a significant association between CAKUT and CHD. Therefore we suggest performing cardiac assessment of all children with CAKUT.

Foreign direct investment (FDI) is one of the most important international factors in relation with money movements. For this reason it has a major effect on the country’s financial development and employment increase. Various studies in the world and mainly on European developing countries show that FDI plays an important role in creating new employment positions in host countries. A lot of research has been going on regarding FDI on a world scale which issue is already documented, however further information is needed in order to have a better understanding about FDI in the Balkan Region and particularly in Macedonia. In the last two decades, Macedonia has been one of the main receivers of FDI, compared to other countries from Central and Eastern Europe. The main purpose of this study is to analyze the effect of FDI on the level of GDP in Macedonia. To conduct the study, data are gathered from World Bank, International Monetary Fund, and State Statistical Office of Macedonia, for the country over a period of seventeen years from 1998-2014. http://dx.doi.org/10.17130/ijmeb.2016icafr22428

The aims of this paper were to investigate the impact of changes in the milk payment system and the season on the hygienic quality of raw milk. The bulk cow’s milk samples were collected throughout the whole area of Bosnia and Herzegovina over the period of four years (2010-2013), from farms that deliver milk to the dairy industry. The total bacterial count (TBC) was analysed in 52,999 milk samples and the somatic cell count (SCC) in 53,363 milk samples. The results of the research showed that the proportion of bulk milk with the SCC < 300,000 mL-1 significantly increased in the observed period, as well as the proportion of farms that produce milk of EU quality (P < 0.05). The season had a significant effect (P < 0.05) on the SCC; in April the proportion of bulk milk with SCC < 300,000 mL-1 was significantly higher (P < 0.05). A significant increase (P < 0.05) in the proportion of milk with the TBC < 200,000 cfu∙mL -1 was perceived, as well as the proportion of farms which deliver that type of milk (P < 0.05). A Significant lower (P < 0.05) proportion of milk in the summer period with TBC < 200,000 cfu∙mL-1 was determined. It can be concluded that consistent appliance of regulations which determine the quality of milk, leads to the improvement of the hygienic quality of redeemed milk, as illustrated by the case of Bosnia and Herzegovina. This kind of milk payment system is important for both, the higher economic benefit of farms and the dairy processing industry.

City is a living organism in a continuous evolutive process; its historic core evolves with it as well. Current transformations create ever more tensions between the need for preservation of historic urban areas, being the identification parameters of culture and the need for modernisation and inclusion into flow of contemporary city life. This paper aims to provide insight into intricate action that will allow both, preservation and development to work together to create better living conditions. All complexities and dualities encountered though the processes of urban transformation are tools for generating guidelines and procedures concerning the interventions within a historic urban area. Systematic research and analyses of the past, of the changes that occurred in previous times, as well as their adequate evaluation is the essence of decision making in urban transformations, which is further supported by the Case study presented. In order to be successful, transformative processes must be in agreement with not only the physical manifestation of heritage, but also with the underlying processes and circumstances that created the place in all of its peculiarities and uniqueness. A methodological procedure is established and defined by actions on design projects and urban spatial entities that is a contribution to the general theoretical background of urban design.

Introduction: Psychological stress and changes in hypothalamic-pituitary-adrenal (HPA) axis in period after diagnosis of “de novo” Parkinson disease (PD) could be a big problem for patients. Materials and Methods: We measured psychological stress and changes in hypothalamic-pituitary-adrenal axis (HPA) in thirty patients (15:15) with “de novo” Parkinson’s disease, average age 64.17 ± 13.19 (28-82) years (Department of Neurology, University Clinical Center Tuzla). We used Impact of events scale (with 15 questions) to evaluate psychological stress. Normal level of morning cortisol was 201-681 nmol/l, and morning adrenocorticotropic hormone (ACTH) up to 50 pg/ml. Results: Almost 55% patients suffered from mild or serious psychological stress according to IES testing (Horowitz et al.). Non-iatrogenic changes in HPA axis were noticed at 30% patients. The differences between female and male patients regarding to the age (p=0.561), value of cortisol (p=0.745), value of ACTH (p=0.886) and IES testing (p=0.318) were not noticed. The value of cortisol was the predictor of value of ACTH (r=0.427). Conclusion: Psychological stress and changes in hypothalamic-pituitary-adrenal axis are present in patients with “de novo” PD. There is significant relation between values of cortisol and ACTH. Psychological stress is frequent problem for “de novo” PD patients.

Background The scientific community increasingly is recognizing the need to bolster standards of data analysis given the widespread concern that basic mistakes in data analysis are contributing to the irreproducibility of many published research findings. The aim of this study was to investigate students’ attitudes towards statistics within a multi-site medical educational context, monitor their changes and impact on student achievement. In addition, we performed a systematic review to better support our future pedagogical decisions in teaching applied statistics to medical students. Methods A validated Serbian Survey of Attitudes Towards Statistics (SATS-36) questionnaire was administered to medical students attending obligatory introductory courses in biostatistics from three medical universities in the Western Balkans. A systematic review of peer-reviewed publications was performed through searches of Scopus, Web of Science, Science Direct, Medline, and APA databases through 1994. A meta-analysis was performed for the correlation coefficients between SATS component scores and statistics achievement. Pooled estimates were calculated using random effects models. Results SATS-36 was completed by 461 medical students. Most of the students held positive attitudes towards statistics. Ability in mathematics and grade point average were associated in a multivariate regression model with the Cognitive Competence score, after adjusting for age, gender and computer ability. The results of 90 paired data showed that Affect, Cognitive Competence, and Effort scores demonstrated significant positive changes. The Cognitive Competence score showed the largest increase (M = 0.48, SD = 0.95). The positive correlation found between the Cognitive Competence score and students’ achievement (r = 0.41; p<0.001), was also shown in the meta-analysis (r = 0.37; 95% CI 0.32–0.41). Conclusion Students' subjective attitudes regarding Cognitive Competence at the beginning of the biostatistics course, which were directly linked to mathematical knowledge, affected their attitudes at the end of the course that, in turn, influenced students' performance. This indicates the importance of positively changing not only students’ cognitive competency, but also their perceptions of gained competency during the biostatistics course.

This text deals with the historical and normative trajectory of precepts / and principles of education planning in the context of post 1988 federal law On methodological basis of qualitative research with emphasis on literature (literature review) and documentary research legal basis prioritized If analyze the constitutional principles (the Constitution of 1988) and of the law of Directives and Bases of National Education No. 9394/96 on the planning of education (and school). It is worth highlighting the social relevance of participatory planning and their contributions, especially for the formulation and implementation of educational policies in the construction of the Brazilian Democratic State Law. The analysis of historical and normative trajectory of Brazilian educational planning is worth reiterating, in this textual space, the argument of the researcher Jose Silverio B. Horta (1982 p. 236) when he says that 'law and educational planning' figure as 'basic mechanism of state intervention'. Educational policy in the light of democracy requires the experience of participatory planning as an instrument / channel and democratization of Brazilian education.

This paper analyses employment segregated market, as method of discrimination that is rather common and present in Bosnia and Herzegovina’s (B&H) labor market. Data on B&H’s labor market were gathered, and examined by using a Mann Whitney test. Since this nonparametric test does not depend on normality of data, it was a best fitting test, for two independent populations, male and female population. Results of our analysis on analysis of person in employment by group of economics activities, shown that in B&H more men are employed than women, and women appear to be more economically inactive in all three groups of sections of economics activities that are selected for the analysis namely agriculture, industry and service sector. In order to resolve this problem several recommendations were given among which primary research on education attainment and employment opportunities should be conducted on the country level. It is needed to insure that gender equality law and gender action plan will be fully and equally implemented across the country, at all levels and entities.

Studies of clustering in Wireless Sensor Networks (WSNs) usually tackle the problems of designing new algorithms and compare them based on a set of properties (e.g. energy efficiency, scalability), lacking the understanding of the underlying mechanisms and communication patterns that lead to these properties. Our approach tackles this lack of understanding by applying techniques developed by complex systems scientists. Functional topology graphs, which describe the interactions between system parts, are used to represent different implementations of clustering in WSNs. We employ a complexity metric - functional complexity (CF) - to quantify the potential of the functional topology to transport information. Our analysis highlights the trade-off between scalability and energy efficiency, showing that higher values of CF indicate higher scalability and lower energy efficiency.