We consider an active search problem in intensionally specified structured spaces. The ultimate goal in this setting is to discover structures from structurally different partitions of a fixed but unknown target class. An example of such a process is that of computer-aided de novo drug design. In the past 20 years several Monte Carlo search heuristics have been developed for this process. Motivated by these hand-crafted search heuristics, we devise a Metropolis--Hastings sampling scheme where the acceptance probability is given by a probabilistic surrogate of the target property, modeled with a max entropy conditional model. The surrogate model is updated in each iteration upon the evaluation of a selected structure. The proposed approach is consistent and the empirical evidence indicates that it achieves a large structural variety of discovered targets.

The increase in the market for fish motivated the fish industry to intensify its demand, inserting sophisticated equipment in the production systems. But little is known about the real cost of tambaquis producing with the use of these technologies. Therefore, were evaluated the economic viability of semi-intensive cultivation of tambaqui in two tanks, T1 (without aerator) and T2 (with aerator), in each tanks was inserted 275 fish (≈ 40 g), that were monitored weekly during a year, for biometric collections, realized concomitant with limnological samplings. Only dissolved oxygen (≈7.79 and ≈8.30) and total ammonia (≈0.27 and ≈0.16) differed between the tanks. In the economic analysis, the Operational Cost of Production (OCP) was used, which for the T1 was R$ 1,803.35 (dry fishmeal), while in T2 it was R$ 3,552.94 (dry fishmeal + electricity). The zootechnical variables of the tambaquis groups did not differ significantly, resulting in final biomass of 467.67 kg (T1) and 458.15 kg (T2), with an income budge of R$ 2,338.35 and R$ 2,290.75 respectively. The T1 had a gain of 22.87%, while the T2 had a deficit of -55.09%. Therefore, it is concluded that the use of aerator for the semi-intensive cultivation of tambaqui in excavated tanks is not economically achievable.

Se objetivo identificar las evidencias cientificas disponibles acerca del enfrentamiento religioso/espiritual utilizado por personas con cancer, en quimioterapia. Se trata de revision integrativa de la literatura. Se utilizo los descriptores Quimioterapia y Espiritualidad. Las bases de datos fueron: LILACS, PUBMED, ScienceDirect, EMBASE, CINAHL y BDENF. Los estudios reconocen la religion/espiritualidad como estrategia de enfrentamiento positivo, con el hecho de contribuir para la adhesion al tratamiento y reduccion del estres. El enfrentamiento negativo fue asociado a la incidencia de efectos colaterales, sufrimiento psicologico, ansiedad y depresion. Se concluye que el reconocimiento de la espiritualidad como estrategia de enfrentamiento y la identificacion de las carencias espirituales suministran a los profesionales de enfermeria un mejor objetivo de informaciones para el plan de atenciones y para una asistencia mas integral

In the financial theory it is common to make distinction between two types of corporate value creation concept: shareholder value and stakeholder value. In shareholder systems, also known as Anglo-American concept, institutional investors, who usually own small percentages of companies' shares, exert significant influence over managers. In major stakeholder systems, marked as Continental concept, influence is shared between large shareholders, employees, customers and suppliers. The aim of this paper is to analyze influence of globalization processes and economic crises on value creation theory and practice.

Given many possible forms that physics Beyond the Standard Model (BSM) could take, it is important to pursue a bottom-up approach in which as few assumptions as possible about the BSM sector are made. In this talk, we present a combined analysis of LHC Run-1 Higgs data (signal strengths) together with LEP-2 WW production measurements, in the framework of an Effective Field Theory (EFT) where the SM is extended by higher-dimensional operators suppressed by the mass scale of new physics Λ. Working under this hypothesis, important relations among Higgs and electroweak precision observables occur. We perform the first consistent analysis at the order Λ−2 in the EFT expansion keeping all the relevant operators. While the two data sets suffer from flat directions, together they impose stringent model-independent constraints on the anomalous couplings, thus showing the importance of a global analysis in the EFT framework. We also discuss challenges faced when interpreting diboson production at the LHC in the EFT context.

Under the generalized Lindel\"{o}f hypothesis, the exponent in the error term of the prime geodesic theorem for the modular surface is reduced to $\frac{5}{8}+\varepsilon $ outside a set of finite logarithmic measure.