The research was conducted on a sample of 166 students of „Secondary Technical School Travnik”, first and second malegrade who regularly attended elementary education during the 2016/2017 school year. A total of 15 variables were used in the research to assess the level of motor skills (three variables for assessing the motor skills of basketball, volleyball, handball, volleyball and athletics).The main aim of the research was to determine the quantitative changes of the motor skills of secondary school students through the longitudinal study in one school year duration under the influence of the program contents of regular physical education. Quantitative changes in motor skills and analysis of differences between initial and final measurements were determined by analysis of changes under the difference model and SSDIF analysis (Bonacin, 2004). By projecting measurement data, a hypothetical measurement matrix is defined, and by explicating the set of linear displacements on the association matrix, a structural vector is described describing quantitative changes, taking into account the relations of initial variables.The results of the SSDIF analysis indicate that a one-year curriculum of physical education has caused statistically significant changes in motor skills at the global level (p = 0.000). According to the results of the quantitative global changes, they are not particularly significant and extend across a whole set of analyzed variables. The greater the number of variables that contribute to these quantitative changes, but the contributions of some variables to the discriminating function are relatively small, which means that the effects produced are mild, without dramatic changes, and virtually all variables contribute positively.

Background: In this clinical pharmacological research, we dealt with the action of allopurinol on triglyceride levels in hyperuricemic patients.Methods: The study included 40 hyperuricemic patients, of both genders and different age groups, that were sorted by comorbid diagnoses in several subgroups. All patients were clinically treated in the period of three years both at UCC Sarajevo, and P.I. General Hospital "Abdulah Nakaš" Sarajevo. All clinical measurements were carried out using standard IFCC methods with the appropriate analysers.Results: The study was based on mean triglyceride levels before and after three and six months of treatment with allopurinol. It was found out that the mean triglyceride levels were not significantly different from the reference values prior to treatment (p = 0.846) and after three months of therapy (p=0.153). In contrast, after six months of treatment, triglyceride levels significantly increased compared to the reference values. In patients with a diagnosis of gout and metabolic syndrome, triglycerides were statistically significantly increased during the six months of observation. A statin group of patients showed a statistically significant increase in triglyceride levels after three months of therapy (p = 0.032), while, after six months their levels had decreased (p = 0.029). In patients with diabetes mellitus type II, triglycerides rose after three months of treatment (p = 0.039) and retained the same level after six months of observation.Conclusions: The analysis shows that the use of allopurinol has an effect on triglyceride levels in hyperuricemic patients.

Recent technological advances in single cell sequencing (SCS) provide high resolution data for studying intra-tumor heterogeneity and tumor evolution. Available computational methods for tumor phylogeny inference via SCS typically aim to identify the most likely perfect phylogeny tree satisfying infinite sites assumption (ISA). However limitations of SCS technologies such as frequent allele dropout or highly variable sequence coverage, commonly result in mutational call errors and prohibit a perfect phylogeny. In addition, ISA violations are commonly observed in tumor phylogenies due to the loss of heterozygosity, deletions and convergent evolution. In order to address such limitations, we, for the first time, introduce a new combinatorial formulation that integrates single cell sequencing data with matching bulk sequencing data, with the objective of minimizing a linear combination of (i) potential false negatives (due to e.g. allele dropout or variance in sequence coverage) and (ii) potential false positives (due to e.g. read errors) among mutation calls, as well as (iii) the number of mutations that violate ISA - to define the optimal sub-perfect phylogeny. Our formulation ensures that several lineage constraints imposed by the use of variant allele frequencies (VAFs, derived from bulk sequence data) are satisfied. We express our formulation both in the form of an integer linear program (ILP) and - for the first time in the context of tumor phylogeny reconstruction - a boolean constraint satisfaction problem (CSP) and solve them by leveraging state-of-the-art ILP/CSP solvers. The resulting method, which we name PhISCS, is the first to integrate SCS and bulk sequencing data under the finite sites model. Using several simulated and real SCS data sets, we demonstrate that PhISCS is not only more general but also more accurate than the alternative tumor phylogeny inference tools. PhISCS is very fast especially when its CSP based variant is used returns the optimal solution, except in rare instances for which it provides an optimality gap. PhISCS is available at https://github.com/haghshenas/PhISCS.

ABSTRACT Introduction: Evolocumab is fully human monoclonal antibody which binds to proprotein convertase subtilisin/kexin type 9 (PCSK9), and prevents its blocking effect on recycling of liver low-density lipoprotein (LDL) receptors. Areas covered: The aim of this review is to assess efficacy, safety, and cost-effectiveness of evolocumab in adult patients with high cardiovascular risk. Major research databases MEDLINE, EBSCO, and CENTRAL were systematically searched for relevant study reports. Expert commentary: Even when given in full doses, statins augmented with ezetimibe and cholesterol-binding resins could not reduce cholesterol baseline level for more than 66%, while evolocumab reduces cholesterol level for 75% or even more. Up to now, evolocumab showed good safety profile, and patents tolerate it very well. The abovementioned advantages of evolocumab made it almost ideal drug for hypercholesterolemia, and probably in the future the best drug for secondary prevention of major cardiovascular events. Evolocumab is borderline cost-effective for the treatment of patients with high cardiovascular risk in European countries, while in the U.S.A. it is under debate where the underlying assumption (risk of cardiovascular disease events) determine the true value.

The aim of the research was to determine the effects of applied technical and tactical characteristics of table tennis players on their success in competitions. The representative sample consisted of 48 top senior table tennis players from Bosnia and Herzegovina, age 18 and 36, selected on the basis of a qualification tournament. The measuring instruments for this study included eight assessment tests for the table tennis players' technical and tactical characteristics and one test for assessing success in table tennis competitions. Technical and tactical characteristics of the participants were evaluated by five experts who analyzed the efficacy of technical and tactical characteristics of the players on a scale ranging from 1 to 5. The methods of processing the results included descriptive statistical procedures, the multiple correlation coefficient, the determinant coefficient and a multiple regression analysis. The results indicate that technical and tactical characteristics have a major impact on the player's performance and are essential for table tennis success. Based on the value of the regression coefficients and their significance, it may be concluded that the 5 variables statistically significantly contribute to the regression model are: the efficiency of the serve; the efficiency of preventing the attack of the opponent and preparation of the players’ own attack; confidence when attacking across the table; the efficiency in the active defence and the efficiency of movement during the game. In the hierarchy of significance, the most important variables are the serve efficiency and efficiency of preventing the attack of an opponent and preparation of the player's own attack. The efficiency of the serve allows an attacker to realize technical and tactical ideas and usually gain initiative in the game. By returning a serve we can prevent or at least make it harder for the opponent to attack again. A serve return can also allow us to take the initiative 

The aim of this research was to determine the relations of fitness parameters and morphological characteristics of seven-year-old obese children. The sample of participants consisted of 103 obese children (63 girls and 40 boys), first grade students (mean age 7.04 years) of elementary schools in Nis. The following fitness parameters were measured: HR in load, VO2max (ml), HR in peace, bend forward - bend backward - throw test, hand taping, 20m dash with a standing start, Abalakov test and forward bend on the bench test. Morphological characteristics were determined by measuring 13 parameters of longitudinal and transversal dimensions of skeleton, volume and body mass, as well as subcutaneous fat tissue. Canonical correlation analysis was used to determine the relations between the set of variables representing fitness parameters and the set of variables of morphological characteristics. Based on the coefficients of canonical correlation analysis, it can be concluded that the spaces of morphological characteristics and fitness parameters are interconnected with two pairs of statistically significant canonical factors (p˂.05 and p˂.01). The general analysis of the relationships between the first pair of canonical factors suggests that subjects with higher circular dimensionalities of the body, accentuated adiposity and body mass tend to have poorer results in motoring tasks requiring body flexibility, explosive leg strength and running speed, and also have poorer results in the parameters of cardiorespiratory fitness. It can be concluded that obesity in young school age has negative implications on the fitness parameters in children, and therefore on their overall growth and development.

U oblasti javnog zdravstva mnogo je nerazjasnjenih pitanja koja su cesto prouzrokovana kompleksnim, međusobno uslovljenim pojavama, sto namece potrebu za sve cescom primjenom kvalitativnih naucnih istraživanja. Ovakava istraživanja se, prije svega, fokusiraju na nacin na koji pojedinci ili grupe shvataju svijet oko sebe i omogucavaju formiranje njihovih stavova i prakse povodom određenih istraživackih pitanja. Kako je cilj kvalitativnih istraživanja razumijevanje nekog aspekta drustvenog života, ona se prevashodno bave analizom rijeci, umjesto brojeva, sto dobijene rezultate cini komplikovanijim za interpretaciju. Pružajuci osnovni uvid u nacin formulisanja istraživackog pitanja, odabir uzorka, prikupljanje i analizu dobijenih podataka, ovaj rad ce kroz nekoliko jednostavnih koraka omoguciti sagledavanje metoda kvalitativnih istraživanja.

Topological phases of matter that have an insulating bulk and robust gapless boundary states can exist both in static materials and when system parameters are changed periodically in time. In the latter case, the periodic driving can lead to so called ``anomalous'' topological phases. Here, the authors show that, in the newly introduced higher-order topological insulators, anomalous phases can exist even if the system is static, and provide an example of such behavior using a two-dimensional model with topological corner charges. This work opens up the possibility of studying anomalous phases without the inherent difficulties associated with time-periodic changes of a material, such as the risk that it will ``heat up'' due to the driving field and lose its topological features.

Noise pollution is one of the main environmental problems today.The main source of environmental noise is traffic noise, especially the noise of road vehicles. The continuing expansion of motorized transport in Europe and Republic of Srpska today, and especially the sharp increase in the use of private cars raises concerns about the health risks.The aim of the case study was to determine the noise level at the location „Borik“ in Banja Luka. The measured values indicate that the noise level in this street is alarming. This paper discusses health and well-being related impacts of traffic noise pollution as well as the economic and social benefits associated with its reduction. It summarizes the latest scientific evidence on the impact of road traffic-induced noise on physical and mental health as a reaction to the high level of traffic noise risks. According to the scientific evidence, road traffic is the main source of noise pollution in Europe that cause harmful health such as impaired communication and disturbed sleep, as well as adverse after effects such as fatigue and decreased performance, annoyance, hearing impairment, ischemic heart disease and hypertension. The effects of unhealthy noise level are reflected on living and working conditions, consequently affecting the economy.This paper highlights economic implications and health benefits linked to cross-functionalities in the process of noise reduction in urbanism, architecture and vehicle design and methods for its evaluation. Cost-benefit analysis would be a pivotal decision-making tool for the city road traffic and land-use decisions. Economic valuation is about identifying all preferences and translating them into a money measure, to create a common denominator for comparing the pros and cons. Any decision implicitly include a money value into health effects. A holistic approach is crucial, considering the various health and economic consequences together.

This paper deals with direct effects ofbrand image, satisfaction and value on consumer loyaltytowards branded chocolates. In the empirical research, a model with these four brand dimensions was established to examine different direct effects - how brand image is related to brand satisfaction and its value, and how brand satisfaction is related to brand value. The research was conducted in Bosnia and Herzegovina andincluded 432 respondents based on a snowball sample. The results show that the established structural model is factual,enabling the acceptance of set hypotheses. It has also been proven that the brand satisfaction has the greatest impact on brand loyalty.Based on the findings, the paper additionally contains practical recommendations for production to creating a brand of chocolate.