Introduction: The effect of statins on risk of heart failure (HF) hospitalization and lethal outcome remains dubious. Aim: To investigate whether statin therapy improves clinical outcomes in patients hospitalized for ischemic heart failure (HF), to compare the efficacy of lipophilic and hydrophilic statins and to investigate which statin subtype provides better survival and other outcome benefits. Material and Methods: Total amount of 155 patients in the study were admitted to the Clinic for Cardiology, Rheumatology and Vascular diseases in Clinical Center University of Sarajevo in the period from January 2014- December 2017. Inclusion criteria was HF caused by ischemic coronary artery disease upon admission. For each patient the following data were obtained: gender, age, comorbidities and medications on discharge. New York Heart Association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. The patients were followed for a period of two years. Outcome points were: rehospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure. Results: Overall, 58.9% of HF patients received statin therapy, with 33.9% patients receiving atorvastatin and 25.0% rosuvastatin therapy. The most frequent rehospitalization was in patients without statin therapy (66.7%), followed by patients on rosuvastatin (64.1%), and atorvastatin (13.2%), with statistically significant difference p = 0.001 between the groups. Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy, 12.8% in patients on rosuvastatin therapy and 3.8% in patients on atorvastatin therapy (p = 0.004). Conclusion: Lipophilic statin therapy is associated with substantially better long-term outcomes in patients with HF.

Title of Days of AMNuBiH 2018” and “SWEP 2018” is “Ethical Dilemmas in Science Editing and Publishing”. Why? If one wants to create a scientific work, must have on his mind that creating a scientific work requires creativity and openness, honesty, trust, and obeying the ethical principles for writing a scientific paper. While working on a an biomedical research involving human subjects medical workers should have on mind that it is the duty of the physician to remain the protector of the life and health of that person on whom biomedical research is being carried out. The World Medical Association (WMA) has developed the Declaration of Helsinki as a statement of ethical principles to provide guidance to physicians and other participants in medical research involving human subjects.

Dr. Karl (Karel) Bayer (Hradec Kralove, Czech Republic, January 23, 1850 - Sarajevo, April 12, 1914), was physician, specialist in Neuropsychiatry (Figure 1). He graduated elementary school and gymnasium in the town of Hradec Kralove (1-6). He graduated from the Faculty of Medicine at Charles University in Prague in 1876.

Acta Informatica Medica (www. actainformmed.org) is a peer-reviewed, open access journal which publish original articles, professional articles, reviews, viewpoints, and case studies, covering issues in Biomedical and Medical/Health informatics, published by the Academy of Medical Sciences of Bosnia and Herzegovina (www.amn. ba) (1). Acta Informatica Medica journal (Acta Inform Med) has founded in the year 1993 by Izet Masic and Zoran Ridjanovic, as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). This year Acta Informatica Medica has accepted as official journal of the European Federation for Medical Informatics ( www.efmi. org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 25 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. Also, we sent application for including Acta as official journal of International Medical Informatics Association (www.imia.org) and to Web of Science groups (exactly to The Emerging Sources Citation Index) and waiting result of the reviewing process. During the year 2018 in Acta Informatica Medica was published 58 papers (from total amount published papers, 76.9% was original papers), where it was more published original papers in the journal than in the year 2017 (Figure 1). The journal began with the practice to publish the articles of PhD students free of charge, and in that manner opened to this population, and began with the practice of populating biomedical information technology, both in Bosnia and Herzegovina and in the region. The journal opened to PhD students, and they embrace it through the official letter to the Editor, presenting their goals and problems. The purpose of the journal is availability in the future period, to those authors who are not able to pay a publishing fee (because the subscription fee should be secondary and the quality of the work at the first place) to publish their papers free of charge. The tendency for the future is to preserve the Open Access model, while enabling funding through the subscription and purchase of printed publications. The purpose of the journal is to continue the publishing of both its online and print edition, four times a year (ISSN: 0353-8109 (Print), ISSN: 1986-5988 (On-line)). The website of the journal is refreshed in 2018, revised by Editorial Board (new members were included) and regularly updated. The authors of the published articles in 2018 issues are from 11 countries and four continents. Acceptance rate in 2018 was 32.7% (Table 1). Scimagojr.com Index H (for 2017) for Acta Informatica Medica is 12, while scimagojr.com index (SJR) is 0.275 (2). On the aforementioned page, the total number of citations from the journal Acta Informatica Medica was 187 (it should be noted that the number is only from the journals that are covered by Scopus). Self-citation (the number of citations from a journal citing article to articles published by the same journal) was 7. For the period 2013-2017, the Google Scholar h5 index was 17 and the h5 median was the 28. The journal in its function and everyday work is Importance of “Acta Informatica Medica” Journal in Spreading of Biomedical Informatics Knowledge and Experiences in Scientific and Academic Community

On December 8th of the year 2018 in Sarajevo held meeting “Days of AMNuBiH” - Days of Academy of Medical Sciences of Bosnia and Herzegovina, and The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP–2018). Venue of the both meetings were at hotel Holiday in Sarajevo (1).

Editor and Co-Editor of this journal was informed from anonymous reader that article which was published in Medical Archives in 2001 \'Psychotherapeutic Testimony by Refugees from Bosnia and Herzegovina: a Pilot Study\' (in Bosnian language) has been already published in \'American Journal of Psychiatry\' under the title \'Testimony Psychotherapy in Bosnian Refugees: a Pilot Study\', in 1998. (1, 2).

UDK: 639.124(497.11) Perdix perdix L. (also known as the Grey partridge, English partridge, and Hungarian partridge) populations have been declining for years in natural habitats and areas in which this species of wildlife has been introduced. Hunting grounds at the base of Mt. Fruška Gora and Sremska Rača in the Republic of Serbia provide excellent conditions for its breeding. In addition to the data from hunting records about population quantity of the P. perdix, a direct monitoring allows a relevant inside to its' quantity in hunting associations’ hunting grounds. The decline of population quantity is mostly the result of the use of chemicals for protection of agricultural crops (10%), destruction of nests and bird eggs (12.5%), and the failure to implement failure wildlife-protection measures, by forbidding the hunt of P. perdix  (5%) , and the use of poisons on agricultural crops, such as the forbidden poison Furadan (5%). Although no significant results have been obtained on the impact of predators and abandoned animals on the reduction of P. perdix population, there is a justified concern by hunting associations’ in terms of finding ecologically and biologically viable solutions for impact on predators on feathered game, and especially abandoned dogs. The results of the study were obtained by the method of directly determining the number of P. perdix in the crop fields, in the hunting grounds of L.D. "Fazan Mala Remeta", L.D. "Fazan" Jazak, L.D. "Stejanovci" Stejanovci, L.D. "Zec" Vrdnik and L.D. "Srndać" Sremska Rača. The obtained results directly the need to introduce the principle of integral protection of P. perdix, which implies control over the implementation of measures for the protection of agricultural crops and the implementation of P. perdix protection measures during the organization of hunting on other game species in hunting grounds.

Abstract The aim of this paper is to analyze the convergence process among former Socialist countries, the Central and Eastern European (CEE), Western Balkan and Eastern Partnership countries. The relationships between the selected macroeconomic variables and per capita GDP growth rate are econometrically tested to support this research. The analyzed period is 2004-2016, with two sub-periods; 2004-2008 and 2009-2013. The subdivision is made to test if the recent financial crisis affected the absolute and conditional convergence process. The empirical findings support the economic convergence hypothesis. The results show that the recent financial crisis negatively affected only the absolute convergence process. The negative effects of the crisis on conditional convergence are not identified. The poorer countries in the analyzed group should do more to attract investment, as gross fixed capital formation has a clear positive impact on per capita growth in the examined sample of countries.

Today’s modelling approaches in Systems Medicine are increasingly multiscale, containing two or more submodels, where each operates on different temporal and/or spatial scales. In addition, as these models become increasingly sophisticated, they tend to be run as multiscale computing applications using computational infrastructures such as clusters, supercomputers, grids or clouds. Constructing, validating and deploying such applications is far from trivial, and communities in different scientific disciplines have chosen very diverse approaches to address these challenges. Within this paper we reflect on the use of Multiscale Computing within the context of Systems Medicine. Multiscale Computing is widely applied within this area, and instead of summarizing the field as a whole we will highlight a set of challenges that we believe are of key relevance to the Systems Medicine community.

Ovaj rad daje osvrt na stanje standardizacije u oblasti informacijske i bibliotečke djelatnosti u Bosni i Hercegovini, kroz rad dva tehnička komiteta Instituta za standardizaciju BiH. Informatizacija društva, kakva je opisana u strateškim dokumentima iz prethodne decenije, realizirana je ne zahvaljujući, nego uprkos podršci države. Složena politička i teška socijalna situacija u BiH nisu bile prepreka da po broju korisnika interneta budemo iznad svjetskog prosjeka. Na primjeru akademskih i istraživačkih mreža pokazano je da ipak zaostajemo u brzinama pristupa internetu, koje su među najnižim u regiji. IT industrija, kao perspektivna privredna grana, sama čini napore i vrši pritisak na državu da se učini više na razvoju ove djelatnosti, prvenstveno u sektoru obrazovanja. Na kraju rada dat je kritički osvrt na pojam Big Data i njegovu primjenu u naučnim podacima, koji čine usko specijalizirani dio bibliotečke djelatnosti, te ulogu standardizacije u toj oblasti.

Background: This cost-of-illness (COI) study provides deep insight in direct and indirect costs of multiple sclerosis (MS) in Bosnia and Herzegovina (BH). Aim: Objective of this study was to analyze the costs and quality of life (QoL) of patients with MS in BH. Patients and methods: We applied the same methodology already used in study conducted across nine European countries. Sixty-two patients participated with EDSS score not higher than 6.5. Costs are collected using a questionnaire quality of life was measured by EQ-5D and MSQOL-54 questionnaires. Results: Mean age of respondents was 39.8 The mean utility measured by EQ-5D-3L was 0.68 at the beginning and 0.63 at the end of the study. QoL measured by MSQoL-54 showed improvement at the end of the trial. Costs are presented from the societal and payer perspective. Cost of MS in Bosnia and Herzegovina annually amount 124.8 million BAM. Cost driver where indirect and DMDs costs, with significant differences among subgroups. Conclusions: This study provides an in-depth analysis of MS costs in BH providing data for health policies development and information for future cost-effectiveness evaluations of new therapeutic options as well as for comparison of MS costs with other countries.

Introduction: Cervical erosion and squamouse intraepithelial lesion of low grade are most common gynecological problems of women. These changes on cervix are cause of painful coitus and enhanced vaginal secretion. Cryotherapy is widely accepted method in treating these changes and sympthoms. Aim: The aim of this study is to examine the efficiency of cryotherapy in eliminating erosion of cervics and LSIL, as well as conditions following these states. Patients and methods: Cryotherapy was performed in 124 women with cervical erosion (N-74) and LSIL (N-50). Sympthoms that were followed are: vaginal secretion, abnormal vaginal bleeding and pain. Assessment of epithelisation of cervix and evaluation of sympthoms were done 4 and 6 weeks after cryotherapy and PAP test after 4 months in women with LSIL. Statistical method used in result processing was X2 test. Results: The average age of examined women is 37,75±8,2. Enhanced vaginal secretion had 87,09% (N-120), painful coitus 61,29% (N-76), pain in lesser pelvis 52,41% (N-65) and abnormal vaginal bleeding 28,22% (N-35). Erosion of cervix had 14% (N-7) of women with LSIL. After cryotherapy, enhanced vaginal secretion remained in 21,77% (N-27) of women, painful coitus remained in 8,06% (N-10), pain in lesser pelvis remained in 5,6% (N-7) and abnormal vaginal bleeding in 6,4% (N-8). Four weeks after cryotherapy, complete epithelisation of cervix was in 87,90% (N-109) and after six weeks in 93,54% (N-116) of examined women. LSIL was eliminated in 92% (N-46) of women after cryotherapy and in 8% (N-4) results remained the same. Conclusion: Cryotherapy is successful method of elimination of cervical erosion, LSIL and pains with enhanced vaginal secretion.

Abstract Patient satisfaction is a key indicator to assess the quality of gastrointestinal endoscopy. The aim of this study was to examine the Serbian translation and cross-cultural validation of the questionnaire for the assessment of satisfaction in patients who underwent gastrointestinal endoscopy. After obtaining the consent of the author of the original questionnaire, translation and cross-cultural validation of the GESQ (Gastrointestinal Endoscopy Satisfaction Questionnaire) were carried out in accordance with the conductors of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). The study was conducted in the Center for Gastroenterohepatology (GEH) of the Kragujevac Clinical Center and included 165 patients. The reliability of the Serbian translation of the GESQ was estimated by calculating Cronbach’s alpha for the whole questionnaire in order to implement the structural validation. The overall score of the questionnaire was compared and correlated with the total scores on the Short Subjective Well-being scale (KSB) and visual analogue scale (VAS), which were administered to the same patients. The Serbian translation of the GESQ showed high reliability with a Cronbach’s alpha coefficient of 0.763, good structure and homogeneity by randomly sharing the questionnaire into two parts. Exploratory factor analysis indicated the existence of four factors that explain 57.200% of the variability. The Serbian version of the GESQ showed similar psychometric characteristics to the original English questionnaire, with a similar factor structure, and represented a valid, reliable and acceptable tool for the assessment of patient satisfaction with the endoscopic examination of the digestive tract.