Objectives The aim of this paper is to present a case of an IVF pregnancy of a 43-year old women being treated for recurrent endometrial cancer stage IA, grade I. Methods Our patient was initially treated five years ago when hysteroscopic ablation of endometrial polyp was performed. Pathologic examination of biopsy specimen reported a diagnosis of atypical polypoid adenomyoma. Two years later, patient was evaluated for recurrent local disease. At that time, pathologic examination revealed typical polypoid adenomyoma with presence of few glands with characteristics of well differentiated endometrioid adenocarcinoma stage IA, grade I. Results After a complete evaluation of cancer staging and a detailed explanation, patient rejected conventional surgical treatment and fertility preserving treatment was started. Progestin therapy via an intrauterine device (IUD) was administered. One year later, IUD was removed and patient underwent IVF cycle with a transfer of 3 embryos without success. At the age of 43, pregnancy was achieved in IVF cycle with administration of hCG. Conclusions Although there are existing evidence of effectiveness for using IUD progestin therapy in endometrial hyperplasia, studies for its use in treatment of endometrial cancer are lacking. We report a case of successful use of leveonorgestrel - IUD alone in fertility preserving treatment followed by achieved pregnancy.

Research has shown technology fosters learning environments that stimulate improved academic performance, learners' satisfaction and completion rates. For this reason, an increasing number of researchers focus on the development of tools and applications that support the learning process of children. The tool presented here is a web application for educators, therapists, parents, and children with and without disabilities. The core concept of this tool is aiding professionals in creating relevant educational content and motivating children by presenting learning materials and tasks in a modern, relevant and motivating way. A pilot study was performed with five professionals, daily delivering instruction to children, mostly diagnosed with Autism Spectrum Disorder, at an NGO in Bosnia and Herzegovina. The study findings show a general positive attitude towards the use of the web tool in the classroom and its functionalities for creating teaching material.

In this paper, we propose a two-dimensional pilot allocation scheme over frequency- and delay-time domains (2D-PFD) for channel estimation in massive multiple-input multiple-output (MIMO)/time division duplex (TDD) system, where two- dimensional pilot resources are simultaneously allocated to each user for their uplink channel estimation. We evaluate bit error rate (BER) performance of massive MIMO/TDD system using the 2D-PFD scheme by computer simulation in order to clarify the effectiveness of the proposed pilot allocation compared with single dimensional pilot allocation over either delay-time domain or frequency domain, respectively.

This paper presents a design of the mobile robot motion framework using slightly modified Vector Field Histogram (VFH) algorithm. The VFH algorithm provides both local motion planning and obstacle avoidance based on on-board sensors measurements. This framework utilizes Robot Operating System (ROS) for the software implementation and simulation purposes. The effectiveness of the proposed framework was verified in both static and dynamic unknown environments. The obtained simulation results indicate a proficiency of the VFH algorithm in navigating the mobile robot from the start to the goal position avoiding collision with obstacles. Trajectories obtained using the designed framework are smooth and without oscillations even in the presence of moving obstacles.

This paper treats a path planning problem for the mobile robot with differential constraints using modified RRT (Rapidly exploring random tree) algorithm based on Dubin’s curves. In this paper, the planning problem is considered as a problem of finding a feasible path between the initial and goal point in a static environment with obstacles. Modifications on basic RRT algorithm are necessary due to differential constraints of non-holonomic car-like robot. Dubin’s vehicle is selected as robot model, which represents special case of Simple car that moves only forward with constant velocity and can only make left and right turns. Algorithm is implemented in ROS (Robot Operating System) and tested through realistic simulations in 2D environment consisted of free space and obstacles. The simulation setup was conducted using a 2D Stage simulator in ROS and RViz tool for visualization. Pioneer 3AT robot model was used as Dubin’s car for simulation purposes.

Analysis of the Temple Scroll reveals another technology used to produce the Dead Sea Scrolls and potential preservation concerns. The miraculously preserved 2000-year-old Dead Sea Scrolls, ancient texts of invaluable historical significance, were discovered in the mid-20th century in the caves of the Judean desert. The texts were mainly written on parchment and exhibit vast diversity in their states of preservation. One particular scroll, the 8-m-long Temple Scroll is especially notable because of its exceptional thinness and bright ivory color. The parchment has a layered structure, consisting of a collagenous base material and an atypical inorganic overlayer. We analyzed the chemistry of the inorganic layer using x-ray and Raman spectroscopies and discovered a variety of evaporitic sulfate salts. This points toward a unique ancient production technology in which the parchment was modified through the addition of the inorganic layer as a writing surface. Furthermore, understanding the properties of these minerals is particularly critical for the development of suitable conservation methods for the preservation of these invaluable historical documents.

Abstract Paper deals with seasonal changes in heavy metal bioaccumulation (Fe, Mn, Cu, Zn and Pb) in Utricularia vulgaris L. and Salvinia natans (L.) All. of two localities (Necik and Sinjak – active fishpond basins) in the area of Bardača fishpond. According to our results, the better accumulator of Fe (3035 mg/kg) and Zn was S. natans (163.55 mg/kg), whereas Utricularia vulgaris better accumulates Mn (620 mg/kg) and Cu (10.18 mg/kg). Amounts of Pb in both investigated macrophyte were below the detection level (<0.51 mg/kg). The values of the bioaccumulation factor (BAC) of the tested metals were >1 or ~1 for both species, and the BAC values decreased in the following order in both investigated species: Fe > Mn > Cu > Zn. The results obtained indicated that tested macrophyte show very good characteristics as bioaccumulators and, thanks to this fact, they could be used in phytoremediation technique successfully in water-polluted ecosystem.

Identifying people based on their footprint has not yet gained enough attention from the researchers. Therefore, in this paper, an investigation of human identification conducted based on the footprint. Transfer Learning used as the main concept of this investigation. The aim of using Transfer Learning is to overcome the need for a large-scale dataset and achieve high accuracy with a low-scale dataset. Five well-known models used, namely, Alexnet, Vgg16, Vgg19, Googlenet, and Inception v3. Each of these models fine-tuned to fit-in the paper’s topic. A dataset of 30 individuals constructed in order to train the models. The right and left footprint of each individual captured with iPhone camera.  The models trained and evaluated based on the same settings. The evaluation shows that Inception v3 model achieved the highest accuracy compared to all other four models.

Physical activity, body mass, and dietary habits are known to be important determinants of overall health status, but there is an evident lack of studies that examine these issues specifically in preschool children. The aim of this study was to identify associations that may exist between adhering to the Mediterranean diet (MD), levels of physical activity (PA), and body composition indices in apparently healthy preschool children from southern Croatia. Participants were 5- to 6-year-old preschoolers from the Mediterranean part of the country (the Split-Dalmatia County; n = 260, 126 females). Adherence to the MD was observed by the Mediterranean Diet Quality Index (KIDMED), PA level was evaluated by the Preschool-age Children’s Physical Activity Questionnaire (Pre-PAQ), and responses were collected from the parents. The participants’ waist circumferences (in cm), waist-to-hip ratios, and body mass index (in kg/m2, and in a z-score calculated relative to the normative value for age and sex) were used as indicators of body composition. All children were of the same age and tested over a one-month period of the same year as a part of the regular examination undertaken before attending elementary school. With only 6% of the children having a low KIDMED score, adherence to the MD was high. MD adherence was higher in girls (Chi-square = 15.31, p < 0.01) and children who live on the coast of the Adriatic Sea (Chi-square = 18.51, p < 0.01). A mixed effects logistic regression (with kindergarten as random factor) identified sedentary activity to be negatively associated with MD adherence (OR per point: 0.65, 95% CI: 0.44–0.91). High adherence to the MD in the studied sample may be attributed to regulated feeding in kindergarten. Considering that most Croatian elementary schools do not provide food to their students, MD adherence should be investigated later in life and also in other parts of the country where the MD is culturally less prevalent.

This paper addresses the problem of 3D registration of outdoor environments combining heterogeneous datasets acquired from unmanned aerial (UAV) and ground (UGV) vehicles. In order to solve this problem, we introduced a novel Scale Invariant Registration Method (SIRM) for semi-automated registration of 3D point clouds. The method is capable of coping with an arbitrary scale difference between the point clouds, without any information about their initial position and orientation. Furthermore, the SIRM does not require having a good initial overlap between two heterogeneous datasets. Our method strikes an elegant balance between the existing fully automated 3D registration systems (which often fail in the case of heterogeneous datasets and harsh outdoor environments) and fully manual registration approaches (which are labour-intensive). The experimental validation of the proposed 3D heterogeneous registration system was performed on large-scale datasets representing unstructured and harsh outdoor environments, demonstrating the potential and benefits of the proposed 3D registration system in real-world environments.

Changing the optical fiber parameters during long-term use can not be mathematically calculated. This paper analyses the change of optical fibers from the aspect of ageing under the influence of transmitted signals and the aspect of water influences. The analysis was carried out in such a way as to compare the measurements carried out after the installation of optical cables and measurements after 16 years of use. The analysis has been shown to vary greatly the loss of fiber optic splice for different wavelengths. These different loss for wavelengths 1310 nm and 1550 nm suggest that the loss of optical fiber has increased due to the impact of water.

The purpose of a car jack is lifting the car and maintaining it at a certain height during different repairs. This paper focuses on the design of car jack, which belongs to the basic equipment of cars. Cars jacks are used mainly for changing tires and small repairs of a car. The aim of this paper was to create a parametric CAD model of a car jack and carry out numerical structural analysis of the car jack using the created parametric CAD model. The development of the parametric CAD model and structural analysis was performed using the CATIA V5 system. This paper describes the modern way of creating more complex mechanisms, which support quick modification of its parameters, and thus the entire design. The whole model of the car jack was parametrized. The stresses obtained by finite element method (FEM) analysis were confirmed with the analytical calculation in characteristic parts of the design, with some exceptions. At the end of the paper, an analysis of the obtained results was performed, on the basis of which specified conclusions were made.

Objectives We sought to determine the feasibility and characterize the extinction kinetics of circulating cell-free tumor DNA (cfDNA) testing in endometrial and ovarian carcinomas (ECs, OCs) using a clinically-approved commercially-available assay. Methods Women with suspected EC/OC undergoing surgery were consented for tissue and plasma sampling including pre-operative and serial post-operative draws. Tumour tissue and patient-matched buffy coat was extracted for DNA and sequenced for somatic mutations using FINDIT™ panel assay. Plasma samples were extracted for cfDNA and sequenced using FOLLOWIT™, Illumina platform, and analyzed using Contextual Genomics’s QUALITY NEXUS analysis pipelines. Low-frequency variants were confirmed by digital droplet PCR. Results 44 individuals had sufficient tissue and follow-up for inclusion; 24 ECs (13 endometrioid, 10 high-grade serous (HGS), 1 clear cell(CC)), 18 OCs (17 HGS 1, CC), and 2 synchronous endometrial and ovarian carcinomas. Eight ECs and 15 OC cases were advanced stage (II-IV) with residual disease in 2 ECs and 5 OCs, 8 recurrence events and 3 deaths recorded. Compliance with plasma sampling was high(>95%) when requested in hospital or at routine surveillance visits but dropped to 68% for ‘extra’ study-associated visits. Analysis to date reveals cfDNA was detectable in pre-operative samples of 19 individuals (9 ECs, 10 OCs including 4 early stage) and 6/10 tested post-operatively. Normalization of conventional tumour markers post-operatively took a median of 3mo in contrast to rapid loss of detectable cfDNA. Conclusions cfDNA testing is feasible and may enhance surveillance of endometrial and ovarian carcinomas by reflecting i) volume of disease pre-/post-operatively, ii) response to therapy, and/or iii) recurrence.