Background: Tablet splitting is commonly used in clinical practice as a way to attain a desired drug dose and/or reduce its side effects, particularly among paediatricians and psychiatrists. However, uneven tablet scoring can lead to significant fluctuations of the administered doses, where subpotency or superpotency of drugs might harm the patients. The aim of this study was to evaluate the influence of tablet splitting on dose uniformity of diazepam by the utilisation of Ph. Eur. 9.0 and FDA recommendations. Methods: Mass variation of whole and half-tablets in parallel with the determination of their content uniformity were performed according to the pharmacopoeial methods. The weight loss after tablet splitting was assessed by employing FDA guidelines. It was also investigated if tablet splitting influenced the in vitro dissolution properties of diazepam tablets. Results: Diazepam whole tablets fulfilled the pharmacopoeial requirements in regard to all the investigated properties. The weight uniformity of scored diazepam tablets ranged from 63.80% to 122.55% label claim. The losses of mass after splitting diazepam tablets were 5.71%. Despite the average content of diazepam in half-tablets was found to be 104.24% label claim, the requirements of Ph. Eur. were not fulfilled. Diazepam content in half-tablets ranged from 0.76 mg to 1.21 mg, thus, patients might receive doses that vary by as much as 45%. However, after weight adjustment, diazepam content in each of the tested half-tablets was in the range of 85-115% of the average drug content meeting the Ph. Eur. criteria. Dissolution profiles of whole and half-tablets were found to be similar, following the Hixson-Crowell kinetic model. Conclusion: According to the results, splitting of diazepam tablets greatly influenced the drug content in the obtained parts, ie the dose accuracy was fully dependent of the ability to score the tablet into exactly equal halves.

This paper investigates the relationship between income inequality and different welfare state trajectories that three countries of the former Yugoslavia ?south of the Alps? have taken over the three decades since the breakup of the country in 1990. It is remarkable that three countries emerging from a common (socialist) system have experienced diametrically opposing outcomes regarding inequality. Slovenia has one of the lowest levels of income inequality in Europe, Croatia an average level of inequality, and Serbia one of the highest levels. The paper first examines the extent and nature of income inequality in the three countries before examining the determining causes of inequality, rooted in the evaluation of labour markets, education systems, and tax-benefit systems. It concludes that the divergent transition paths have created the different inequality outcomes observed in the three countries. This article has been corrected. Link to the correction 10.2298/EKA2024129E

: Education is a source of knowledge about social phenomena and processes and plays a significant role in the prevention of socially harmful behaviors. This paper analyzes the extent to which educational content about radicalization, violent extremism, and terrorism in elementary, secondary, and higher education (public universities) is present, and the extent to which envisaged teaching topics are tailored to the current security environment. According to the keywords “radicalization”, “violent extremism” and “terrorism”, the curricula for all three levels of education in the Republika Srpska were analyzed and quantitative and qualitative analyses were conducted thereafter. The research findings demonstrated that the topics of radicalization, violent ex-tremism, and terrorism are not addressed in primary and secondary education. Regarding higher education, there is a clear lack of courses in this field within many study programs. Topics in the study of terrorism have largely remained peripheral within the Republika Srpska education policy.

Previous research highlighted undoubtedly positive impact of transformational leadership on a wide range of performance, including its follower, individual and organizational levels. However, the focus to date has mainly been on the concept’s empirical underpinnings and, hence, the purpose of this study is to present and clarify the intellectual structure of transformational leadership – performance relationship studies. Building on the bibliometric analysis, we have provided the information on publishing trends, the most prolific countries and authors that shape this relationship, whereas term analysis provides a taxonomy for ongoing and recommended upcoming research in the field. The results showed a) the field is under a surprisingly strong influence of a diversified research context along with the focus on the well-recognized and expected Anglo-American region; b) there are five clusters which have been recognized as representatives of the field; c) scarcity of research into sales and managerial performance has been identified which indicates that there is a considerable potential for wide-ranging research in fields of marketing and management in general. In the context of contribution, this study provides a reference to researchers entering this field, as well as guidance for future research.

Received 20 March 2019 Accepted 04 June 2019