Public servants responsiveness and administrative responsibilities to their constituents in local communities are identified through the set of ethical standards predominantly resulting in good governance. Some researchers and practitioners in the field of integrity and ethics concur with the premise of administrative responsibility and responsiveness operating under holistic approaches to understanding climate resilience. This analysis contends with the traditional views of the theory of social choice and administrative burden to stipulate a suitable ethical framework and understanding of ethics in considering climate resilience. The research takes into consideration the principles and structure of moral expectations and measurable outcomes related to climate resilience through the Quadruple Bottom Line lens. The good governance in resilience is explored using an exploratory data analysis of local governments through resilience planning supported by the Rockefeller Foundation, which funded 100 Resilient Cities initiative. The sample size consisted of thirty cities with the obtainable resilience or climate actions plans and a review of their governance efforts through those documents and detailed plans. The research offers a preliminary report of the ongoing efforts in cities and regions to combat climate change, coupled with the ethical considerations and administrative responsibility to frame the administrators’ role in deliberation to climate resilience. The research findings assert a prototype ethical framework for review by administrators to augment administrative responsiveness to climate change threats and increase climate resilience.

BACKGROUND: Extracellular vesicles (EVs) play an important role in cell-cell communication in different types of tumors, carrying multiple layers of biological functional molecules, including proteins, RNA, DNA and lipids. We previously demonstrated that extracellular vesicles (EV) from central nervous system tumors reflect the molecular subtype of the original tumor and mediate an exchange of pro-oncogenic signals. Their implication as biomarkers in tumor disease is under current investigation. It is unclear, however, to what extent cerebrospinal fluid (CSF) EVs from intraspinal tumors are utilizable for diagnostical purposes and how their marker profiles overlap with EVs derived from non tumorous EVs. We analyzed CSF EVs of intraspinal tumors to define CSF EV profiles that allow tumor subtype classification. METHODS: EVs were isolated from CSF of patients suffering from intraspinal meningioma (n=5), ependymoma (n=7) and neurinoma (n=5). Patients suffering from normal pressure hydrocephalus were used as controls (n=5). EVs were analyzed by multiplex bead based assay, immunoblotting, electron microscopy and NTA. RESULTS: CSF EVs were 97.21 ± 3.37nm (intraspinal tumor patients) and 101.6 ± 3.68nm (controls) in sizes and showed vesicular structures by electron microscopy. Particle number were not significantly different between both groups (p = 0.103). Using our 37 protein mutliplex EV profiling kit we found 29 proteins to be expressed in a sufficient manner on CSF EVs. CSF EVs of intraspinal meningioma showed elevated CD62P, HLA-DR, CD40, CD42a and CD45 expression levels, while ependymoma showed decreased levels of CD9, CD63, CD81, whereas neurinomas had elevated levels of SSEA-3 and CD25. CONCLUSION: This is the first comprehensive analysis of CSF EV of intraspinal tumor patients. CSF EV display distinct subpopulations that may allow tumor classification and long-term surveillance. However as tumor-specific EVs may be rare, there is still the need to identify markers that can enrich tumor-specific EVs for molecular profiling.

BACKGROUND Cognitive failures impair the quality of life. Students are often exposed to stressful situations, struggle to make a balance in life, have time management issues and tend to procrastinate, feel too much pressure to succeed, and find it difficult to cope with study and exam anxiety. In this study, we investigated cognitive failures through psychosocial variables in daily life of students and relationship between anxiety and cognitive failures. A cross-sectional study was conducted among 175 students (78.29 % female and 21.71 % male). Medical students comprised 52.57 % of the sample (n = 92), while 47.43 % were psychology students (n = 83). All students were in the first year of education at University of Sarajevo. The survey used the sociodemographic questionnaire, State-Trait Anxiety (Form Y), Cognitive Failures Questionnaire CFQ. Results were obtained by independent sample test and Pearson’s correlation coefficient (r). 26) students, 130 %) statistically significantly the total of cognitive failures, forgetfulness, distractibility, and false subscales. largest total CFQ 0.453, and anxiety could cause cognitive failures. Student life in addition to the obligations and pressures created by academic engagement itself involves many changes and just thinking about it can cause anxiety symptoms. Accordingly, the undesirable outcomes that cognitive failures can cause maladaptive student habits and anxiety. It should be a treated as a critical public health issue.

Este trabalho pretende mostrar como foi idealizado e como funciona na atualidade o Centro Regional de Estudos, Prevencao e Recuperacao de Dependentes Quimicos (CENPRE), um programa de extensao permanente da Universidade Federal do Rio Grande (FURG). O CENPRE surgiu a partir das atividades extensionistas desenvolvidas pelo antigo Departamento de Ciencias Fisiologicas (DCF), hoje Instituto de Ciencias Biologicas (ICB), e foi idealizado para cumprir os objetivos das diretrizes de prevencao ao uso de substâncias psicoativas. Inserido no contexto do Hospital universitario da FURG, o CENPRE conduz suas atividades utilizando uma abordagem interdisciplinar, composta pelo trabalho de um psiquiatra, tres psicologos, duas enfermeiras, um terapeuta familiar, uma assistente social e uma farmaceutica. Adicionalmente, este centro de pesquisas se mantem integrado a comunidade academica e a populacao em geral, com vistas a promocao da saude, a prevencao e ao tratamento de transtornos relacionados ao uso de substâncias psicoativas. O CENPRE se consolidou como um centro de referencia e apoio a formacao de recursos humanos por meio de acoes educativas e atividades de ensino; alem de fomentar a pesquisa por intermedio de estudos epidemiologicos em comunidades locais e regionais.

Tearful crying is a ubiquitous and likely uniquely human phenomenon. Scholars have argued that emotional tears serve an attachment function: Tears are thought to act as a social glue by evoking social support intentions. Initial experimental studies supported this proposition across several methodologies, but these were conducted almost exclusively on participants from North America and Europe, resulting in limited generalizability. This project examined the tears-social support intentions effect and possible mediating and moderating variables in a fully pre-registered study across 7,007 participants (24,886 ratings) and 41 countries spanning all populated continents. Participants were presented with four pictures out of 100 possible targets with or without digitally-added tears. We confirmed the main prediction that seeing a tearful individual elicits the intention to support, d = .49 [.43, .55]. Our data suggest that this effect could be mediated by perceiving the crying target as warmer and more helpless, feeling more connected, as well as feeling more empathic concern for the crier, but not by an increase in personal distress of the observer. The effect was moderated by the situational valence, identifying the target as part of one’s group, and trait empathic concern. A neutral situation, high trait empathic concern, and low identification increased the effect. We observed high heterogeneity across countries that was, via split-half validation, best explained by country-level GDP per capita and subjective well-being with stronger effects for higher-scoring countries. These findings suggest that tears can function as social glue, providing one possible explanation why emotional crying persists into adulthood.

1968 was a watershed year not only for the new left but even more so for the rise of the New Right. It turns out that, if 1968 “prepared” 1989 as the next turning point in European and world history, it was probably more through the new right’s forging of ideas that would eventually provide ideological justification for illiberal democracies in Central and Eastern Europe. Yugoslavia is an important site in this history not only because of its early exposure to the ideas of the new right through the work of the painter and publicist Dragoš Kalajić but also because in his seminal book The Philosophy of Parochialism (1969), Radomir Konstantinović anticipated the rise of the new right and offered a penetrating critique of its fundamental premises.

In this paper we analyze the different ways in which COVID-19 is used as a carrier of cultural communication, whereupon it appears as a signifier of other socio-cultural phenomena and as a conveyer of messages of such communication. Accordingly, this paper will not observe health plan of COVID-19, nor the accompanying sociological phenomena of the epidemic in the strict sense of the word, but will focus instead on the cultural dimension of the infection. As a cultural phenomenon, the process of the planetary spread of COVID-19 infection – and hence the virus itself – can be viewed as an ambiguous symbol through which the collective experience of reality is constructed and communicated, perceived and interpreted. By relying on the decades-long tradition of Serbian ethnology and anthropology in the modified application of structural-semantic analysis, we define the use of COVID-19 as a symbolic means of cultural communication, here seen as indexical. This means that the said communication is organized on the principle that “A indicates B”, where the signifying A refers to the metaphorical and metonymic use of the disease, and B refers to various social phenomena related to it. As a metonymy, the considered phenomenon can be seen in the light of the classical binary division of purity and danger, whereupon the virus, in the cultural sense, divides the whole social reality into pure (still unpolluted) and impure aspects, one corresponding to the “normal” condition of things, and the other indicating a sense of explicit danger – not only from infection, but from the collapse of the social system and the disintegration of public health and community as well. As a metaphor, we observe the virus in relation to the official political instrumentalization of the discourse of warfare, which – depending on who employs it, and why – generates different notions on the “invisible enemy”, war victims (deceased as a consequence of infection) and “(super) heroes” (primarily, health workers, but also state officials and other public figures). COVID-19 is, however, peculiar because it can also play the role of an inverse sign, by which common cultural concepts and representations are perverted, destabilizing the shared sense of “real” and “normal”.

An amendment to this paper has been published and can be accessed via the original article.

An amendment to this paper has been published and can be accessed via the original article.

Experience in managing thromboembolic complications of distal blood vessels during coil embolization in the case of subarachnoid hemorrhage (SAH) is still limited. This is the presentation of the case of a 23-year-old man with a ruptured small aneurysm who experienced thromboembolic occlusion during coil embolization. Mechanical thrombectomy resulted in complete recanalization of the occluded branches without ischemic complications. This case should be used for the use of mechanical thrombectomies as an effective rescue strategy and treatment of distal arteries occlusions of the brain.

Introduction: The engineers of the medical radiology in radiotherapy are key professional group directly responsible for reliable delivery of radiation therapy treatment and the implementation of radiation protection measures in practice. Therefore, their knowledge and skills in this area need to be adequate and up to date. The aim of this research is the assessment of knowledge, attitudes and practice in the field of radiation protection among the engineers of medical radiology employed in radiotherapy centers within the public healthcare system in Bosnia and Herzegovina. Material and methods: The research was conducted on a sample of 30 engineers of medical radiology using a structured questionnaire which contains demographic data and sets of 10 questions related to radiotherapy devices, radiation protection in radiotherapy, risks and incidents related to use of ionizing radiation and the role of medical radiology engineers in radiation protection system. Results: The results of the research show optimal level of knowledge in the field of radiation protection (74.66%) and optimal level of awareness of the risks associated with the use of ionizing radiation (72%). The level of knowledge and awareness is significantly higher among respondents with longer working experience and those who have completed master’s degree and postgraduate education in the field of radiation protection. The application of ionizing radiation protection measures in practice has been assessed as satisfactory (2,3). Respondents are not sufficiently involved in the work of regulatory bodies (26.7%), decisionmaking (23.3%), development of procedures (23.3%) and education of other employees in the field of radiation protection (2.7%). Conclusion: Engineers of medical radiology are not fully involved in the radiation protection system as educated and trained professionals. One of the most important professional interests of engineers of medical radiology is adequate influence on the processes in the field of radiation protection.

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks. Funding Wellcome Trust, AstraZeneca Young Health Programme, EU.

Introduction: Among the female population, breast cancer is the most commonly diagnosed cancer in the world, and nearly half of women population with breast cancer develop metastatic disease during their lifetime. Breast cancer most often metastazises to the lungs, liver, bones, brain and lymph nodes. 18F-FDG PET/CT can detect metastases that are not visible in other imaging modalities, and with the newly discovered lesions, decision about adequate treatment option can be evaluated. Material and methods: The examination was conducted as a retrospective descriptive study in May and June of 2019 at the Clinic for Nuclear Medicine and Endocrinology of the University Clinical Center in Sarajevo. It included 100 female patients with the age structure of 33-79 years. The patient's reference diagnosis is breast cancer, with a suspected finding of metastatic activity. A comparison of the sensitivity and specificity of the breast imaging between PET/CT, CT and bone scintigraphy was performed. Results: PET/CT revealed significantly more positive findings on metastatic activity than other diagnostic imaging modalities, with Mann-Whitney test value of p = 0.01014. In the diagnosis of lungs and liver lesions, PET/CT sensitivity and specificity are 92.59% and 85.37%, respectively, while the statistical parameters for CT are 77.78% for sensitivity and 90.24% for specificity. The PET/CT sensitivity and specificity for bone lesions are 93.55% and 88.89%, respectively, compared to 78.57% and 100% for bone scintigraphy. Conclusion: Hybrid imaging technique, which integrates PET and CT imaging methods, has considerable advantages over other diagnostic methods in the detection of distant metastases, and based on obtained results, PET/CT may be method of choice in evaluation of metastatic activity in breast cancer.

Introduction: Today film-based technologies are largely abandoned in dental radiology. New technologies based on digital detectors are being adopted. This change is part of the global digitalization of radiological procedures. A person operating the radiological device needs to be educated and well informed about radiological procedures and technologies, as well as to know how the system operates and to be sure about the dose required for the adequate image quality. The awareness of radiation doses received by patients is necessary for the estimation of risk from ionizing radiation. Material and methods: The aim of this study was to evaluate whether patient doses in intraoral dental radiology affect image quality. The study included subjective analysis of radiological image quality for an intraoral x-ray device with possibility to use both digital and film detector. Subjective assessment of image quality is performed according to criteria taken from the literature and is expressed using the Likert scale, grade 1–5. In order to improve the quality of inferential statistics related ratings to detector quality and image quality were collected, thus introducing two variables: the detector quality index and the technique quality index. Results: Z-test proportions column shows that the number of grades four given as a contrast score is significantly higher in the RVG detector (65%) compared to the film (40%). There is also a significant difference in the number of given grades five as a rating of the apex preview. The share of grades five in film is 19%, while in RVG it is 42%. It is similar in the evaluation of the preview of the dental canal, where there is also a significant difference in the number of given grades five, so that the share in the film is 11% and in RVG 35%. Conclusion: Analysis of the subjective quality of the radiological image in devices for intraoral radiography with the possibility of recording using digital and film detectors indicates that the digital detector is superior to film in low contrast resolution, apex and dental canal preview.

Introduction: Mammography represents a very accessible diagnostic method that has been accepted as the initial method of examining women over the age of 40 worldwide. It is a method with a high percentage of accuracy (80-90%) in the detection of breast cancer in patients without symptoms. However, there may be a significant overlap of mammographic presentation of benign and malignant changes in the structural tissue of the breast. The ultrasound method of breast examination is invaluable in breaking down between solid and cystic changes, as well as for clarifying palpable lumps in the breast. In almost 98% of cases, ultrasound examination can distinguish whether it is a benign or malignant change. The aim of this study is to prove the correlation between mammography and ultrasound methods of breast examination. Material and methods: The examination was performed as a retrospective prospective descriptive study in the Department for radiological and ultrasound diagnostics of the Derventa Health Center. The study included 80 female respondents who consented to the recording. Based on the performed ultrasound and mammography images, a qualitative analysis was made. A comparison of the sensitivity of the breast imaging between mammography and ultrasound imaging was performed. Results: Comparing mammography and ultrasound examination according to BI-RADS classification, based on Pearson's correlation coefficient, we concluded that there is a strong correlation between these two tests (r = 0.743), which is statistically significant (p <0.005). The correlation, in addition to having a strong connection, moves in a positive direction, that is, by increasing the value of BI-RADS of one diagnostic procedure, there is an increase in another. Conclusion: By analyzing the obtained results, we can conclude that mammography and ultrasound methods of breast examination are complementary methods, which complement each other, and which are not perfect. However, these two methods certainly have their place in breast cancer screening.