Introduction: the effects of malignant tumors of oral cavity may be reflected through mental, physical, social and emotional well-being and quality of life of patients. Those suffering from malignancies show a large degree of psychological problems (fear, anxiety, depression, panic disorders, phobias) both at the time of diagnosis and during the treatment. Aim: to determine a level of depression in patients with oral cavity cancer and to link quality of life and level of depression of patients with oral cavity cancer. Patients and methods: The study was conducted at the Clinic of Maxillofacial Surgery of the Clinical Center University of Sarajevo (CCUS) in the period from July to late October 2015, through a survey of patients with verified oral cavity cancer, questionnaire related to socio-demographic characteristics of the patients, the University of Washington Quality of Life Questionnaire (UW-QOL), and the Beck Depression Inventory (BDI). Results: Majority of patients from our study, specifically 50 (56%) of them, did not suffer from depression, 8 (9%) respondents suffered from mild depression, 14 (16%) respondents had moderate depression, whereas 17 (19%) of them had severe depression. Conclusion: quality of life and level of depression of patients with oral cavity cancer are in negative and almost linear correlation. The worse the evaluation results of one’s physical or socio-emotional health, the higher degree of depression.

Vascular anomalies are heterogeneous group of congenital lesions of abnormal vascular devel‐ opment and may occur anywhere on the body. There is a primary distinction between a vascu‐ lar tumor, which grows by cellular hyperplasia, and a vascular malformation, which represents a localized defect in vascular morphogenesis. Due to the differences in biologic be‐ havior and radiographic features, malformations are further subdivided into low-flow and high-flow lesions [1]. The common characteristic feature of all vascular anomalies is extreme bleeding during surgical excision. Clinicians throughout the world use the classification by Mulliken and Glowacki (1982) to classify these lesions. This classification is based on the vascu‐ lar lesion's histology, biological behavior and clinical findings [2]. Some of the lesions cause es‐ thetic problems, while some of them are malignant; thus, the therapeutic approach is variable.

This systematic review considers the most recent attitudes and news regarding the influence of the stroma on tumor initiation and progression. It is now widely accepted that tumor stroma plays an active role in carcinogenesis. Many different signaling molecules, ligands and signaling pathways recently have been discovered. This review considers the complexity of interactions between malignant cells and its stroma (cross-talk). The recent advances and better understanding of the tumor-stroma interactions will have important impact on the new and combined therapeutic approaches and modalities.

During the treatment of sick as well as injured and operated patients it was used the therapy according to the clinical experience of doctors and possibility of the choice of some antibiotic. It was used the therapy according to antibiogram whenever it was possible. In the study the results of using of Neloren-antibiotic, linkomicin, produced in "Bosnalijek" Sarajevo, were followed up comparing to the other antibiotics. Neloren effects on Streptococcus pyogenes, Streptococcus penumoniae, S. viridian's, Staphylococcus aureus (resistant on Penicillin), Corynebacterium diphteriae, Bacillus anthracis Bateroides fragilis, Rikecia prowaseki and some dostridiaes. In developing of the study the patients were involved who had bone fracture caused by influence of different exogene ethiological factors and the patients with benign pathological process in bone structure, the most often osteomyelitis or abscess caused by dentogene source as well as the patients who were treated by functional or corrective aesthetic operations such as osteoplastic of jaw or correction of bone deformation. The results were shown by chart and graphic representation and they will be compared to the results around the world.