CAN THE IRREGULAR ACETYLSALICYLIC ACID (ASA) THERAPY COMBINED WITH INTERVAL TRAINING EXERCISE PROGRAM INCREASE THE CLAUDICATION DISTANCE IN DIABETIC AND NON-DIABETIC PATIENTS WITH FEMORO-POPLITEAL STENOSIS AGE OVER 55

The aim of the study was to estimate the increasing capability of claudications distance in Fontaine's stage IIa of peripheral artery disease by influence of irregular acetylsalicylic acid (ASA) therapy and life style modification, combined with regular physical activity in diabetic and non-diabetic patients age over 55, in order to establish if there were any improvements in claudication distance in the both groups of patients. Method: This study was conducted from beginning of January, 2014 till end of January, 2015 at the Clinic of Vascular Surgery, Clinical Center University of Sarajevo and included 60 patients age over 55 (30 patients who have diabetes mellitus and impellers group consisting of 30 patients who were clinically confirmed not to have diabetes mellitus), male and female, in stadium IIa of peripheral artery disease, with manifestation of mild claudication symptoms. For the testing of statistical significance of differences between the exanimated groups non-parameter and parameter tests were used. The difference at a level of p<0,05 was statistically significant. Results: In all the tested patients, we investigated increasing of claudications distance in diabetic and non-diabetic patients age over 55 years after one year study. Analysis shows the statistically significant influence of antiplatelet therapy (Acetylsalicylic acid) (ASA), combined with physical activity and life style modification on claudications distance over 500 meters in 25 patients without diabetes mellitus in (83% p<0,05), compared to 12 patents with diabetes mellitus (40% p<0,05). Sixteen of non-diabetic patients (53%) were on antiplatelet therapy over 4 years, on permanent treatment, compared to 4 diabetic patients or (3%) (p<0,05). Conclusion: These clinical combined factors appeared to us as being the main strategy of the therapeutic effect on enhancement of claudication distance (Fontaine's stage II) of peripheral artery disease in patients with diabetes mellitus, as well as patients without it. Article visualizations: